Cecilia Götherström

Cecilia Götherström

Principal Researcher | Docent
Telephone: +46852483395
Visiting address: Hälsovägen, Enheten för obstetrik och gynekologi K65, 14186 Stockholm
Postal address: H9 Klinisk vetenskap, intervention och teknik, H9 CLINTEC Obstetrik o gynekologi, 141 52 Huddinge
Part of:

About me

  • My goal is to develop cell therapies that will have an impact on the health
    of persons with severe disorders. An evidence of this is that I have brought
    a cell therapy from the bench to the bedside.
    I am driven by challenges, which has led me to initiate, lead and
    successfully fulfill several complex projects and educations in the field of
    regenerative medicine in the academia, the health care sector and in the
    industry. My motto in life and work is courage and passion, courage for
    daring to discover new paths, and passion, which is to always go the extra
    mile.
    * Established and lead Sweden’s altruistic Umbilical Cord Blood Bank at
    Karolinska University Hospital 2010-2016.
    * Secured >
  • 73 million SEK as main Principle Investigator &
  • >
  • 30 million
    SEK as co-Principle Investigator.
    * Established an approved GMP-production of mesenchymal stem cells.
    * Initiated and lead the European Horizon 2020 BOOSTB4 project and clinical
    trial.
    * Established two approved and ongoing clinical trials investigating MSC
    transplantation as a treatment of brittle bone disease (Osteogenesis
    Imperfecta) in children.
    * Initiated the first clinical trial on prenatal stem cell transplantation
    in the world.
    *Associate Professor (Docent) 2014, Karolinska Institutet, Stockholm,
    Sweden*.
    Subject: Stem Cell Science
    *PhD 2004, Karolinska Institutet, Stockholm, Sweden.*
    Subject: Allogeneic stem cell transplantation &
  • transplantation research
    Thesis: Characterization of human fetal mesenchymal stem cells
    *MSc 2001, Södertörns University College, Stockholm, Sweden.*
    Subject: Molecular Cell Biology
    Degree thesis: Clinical aspects on maternal cells in the fetus

Research

  • Cells derived from the fetal and perinatal tissues have more potential than
    cells derived from adult tissues. Promising candidates for clinical
    translation are mesenchymal stem cells (MSC).
    My interest in these cells is based on their multipotentiality, low
    immunogenicity and tissue repairing effects in combination with a minimal
    oncogeneic risk.
    *1. BOOSTB4 and BOOST2B: Developing MSC as a therapy for Osteogenesis
    Imperfecta*
    In the BOOSTB4 and BOOST2B clinical trials fetal MSC are investigated as a
    therapy for severe types of Osteogenesis Imperfecta (inherited brittle bone
    disease). Previous case studies performed by us at KI have demonstrated a
    potential positive effect. The manufacturing of the MSC is led by Dr
    Götherström and is performed at Karolinska Center for Cell Therapy at
    Karolinska University Hospital.
    Boost Brittle Bones Before Birth (*BOOSTB4*) is a European consortium lead
    by Dr Götherström. The trial is investigating the safety and efficacy of
    this innovation in the treatment of Osteogenesis Imperfecta in the
    pediatric population. In the project we will also evaluate ethical standards
    and risks, acceptability and stakeholders views and experiences and health
    economics.
    Four doses of fetal MSC will be administered after birth (group 1,

Teaching

  • * Director of Studies, Doctoral Program in Regenerative Medicine,
    Karolinska Institutet 2008-2015.
    * Organizer of 5 doctoral courses and 9 scientific conferences in the
    regenerative medicine field.
    * 250+ hours of teaching on all levels.
    * PhD thesis examiner >
  • 10 times, halftime examiner 6 times, and defence
    chair 5 times.
    * Main supervisor for 2 graduated PhD students 2018, and co-supervisor for 3
    PhD students 2009-2014.
    * Supervisor of >
  • 10 Master, Bachelor, foreign exchange and summer project
    students 2005-2023.

Articles

All other publications

Employments

  • Principal Researcher, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2022-

Degrees and Education

  • Docent, Karolinska Institutet, 2014
  • Doctor Of Philosophy, Department of Laboratory Medicine, Karolinska Institutet, 2004

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