Buster Mannheimer

My research involves the adverse effects following drug treatment. Lately,
two major aims have been to study warfarin interactions and different aspects
of drug related hyponatremia.
I was born in 1973 and educated at the University of Gothenburg taking my
doctors exam in 2002. I then performed my specialization at Södersjukhuset,
qualifying as a specialist in Internal Medicine in 2007 and as a specialist
in Endocrinology and Diabetes in 2010. Since my specialization I have
continued working at Södersjukhuset and been a consultant since 2016.
I defended my thesis at Karolinska Institutet in 2009 becoming an Associate
Professor in 2016. Since 2018 I’m part time employed as the Director of
Doctoral Education of the Department of Clinical Science and Education at
Karolinska Institutet.

In 2009 I defended my thesis ”Drug-related problems with special emphasis
on drug-drug interactions”. The thesis includes pharmacogenetic,
pharmacokinetic as well as epidemiologic aspects on mainly adverse effects
due to the treatment with psychotropic drugs. Since then I have moved towards
a mainly register based research. Several projects have included the use of
the Swedish Prescribed Drug Register (SPDR) and investigated prescription
patterns but also associations with clinical outcome.

 
Thus, by combining the SPDR with Auricula and Journalia, registries containing data on 
individuals treated with anticoagulantia we have established a cohort of
over 100 000 patients treated with warfarin. The cohort enables a unique
epidemiologic therapeutic drug monitoring approach, efficiently targeting the
effects of any added drug with regard to changes in INR and warfarin doses.

Another project focuses on different aspects of hyponatremia. We recently
established a cohort of over 14 000 individuals hospitalized due to
hyponatremia. Using a case control design we studied the associations between
antidepressants and other drugs and hospitalization due to hyponatremia. 

I am the principal investigator for the Stockholm Sodium Cohort (SSC). SSC involves not only various health data but also a wide range of laboratory data on over 1 600 000 individuals in the Stockholm region and enable adressing the effects of dysnatraemia but also other research areas.

The residency and following development towards consultant in internal medicine, diabetes and endocrinology at Södersjukhuset has provided an extensive clinical experience. The academic career including a doctoral education and further development into an associate professor and independent researcher at Karolinska Institutet has been, and continues to be, full of challenges. These include my previous role as director of doctoral studies at the department of clinical science and education, Södersjukhuset. Furthermore, the teaching and tutoring of medical students has been a growing interest. Since 2021, my engagement as examinator and director at the course in Clinical Medicine, Karolinska Institutet Södersjukhuset, has been very gratifying. Both the intensive work developing the current course aiming at the new 6-year doctors programme, as well as teaching medical students.