Björn Wieslander

Björn Wieslander

Affiliated to Research
Visiting address: Eugeniavägen 3, Karolinska universitetssjukhuset, NKS A8:01, 17176 Stockholm
Postal address: K1 Molekylär medicin och kirurgi, K1 MMK Klinisk fysiologi, 171 76 Stockholm

About me

  • The core focus of my research is on developing and improving the use of magnetic resonance imaging (MRI) in charaterizing lung disease and its cardiovascular causes and consequences. I am particularly interested in the interplay between the lungs and the heart as disease in one organ often affects the other by altering hemodynamic conditions, i.e. the pressure and flow of the blood as it passes through both organs. I find pulmonary and cardiovascular MRI to be a very exciting field to be a part of an contribute because the technological development is rapid. MRI is a very versatile tool when it comes assessing pulmonary and cardiac disease as it is suited to both assessing the properties of soft tissue as well as measuring flow in three dimensions over time.

    I am also a resident physician (ST-läkare) in clinical physiology, a specialty in which a number of other methods are used to examine the heart and lungs including electrocardiography (ECG), echocardiography among others. Beyond MRI, I frequently conduct of collaborate in research involving those methods as well whenever they are appropriate to provide answers to clinical problems I encounter in my everyday work. 

    My background in brief: I studied medicine until 2014, during which time I became involved with Karolinska Institutet’s cardiac MRI research group. I defended my PhD thesis in 2016 with comparison between ECG and MRI. Alongside my clinical research internship (Forskar-AT), I conducted postdoctoral research at Karolinska Institutet studing pulmonary hypertension using MRI. I then spent almost two years during 2020–2022 conducting postdoctoral research as a research fellow at the US National Institutes of Health, primarily working with low-field MRI (0.55 tesla) and the use of oxygen as a contrast agent for lung imaging. Since 2022, I have been a resident physician in clinical physiology at Karolinska University Hospital and later Växjö Hospital in Region Kronoberg, while continuing my research at Karolinska Institutet supported primarily by the Swedish Heart-Lung Foundation and the Swedish Society of Medicine.

Research

Teaching

  • My teaching experience primarily consists of teaching medical students in the fourth semester clinical ECG interpretation skills and finding ways to improve how that can be taught. That is how I have spent 250+ scheduled teaching hours of lectures, seminars, demonstrations and examinations since 2015. Other than that, I have supervised a number of medical students and PhD students.

Articles

All other publications

Grants

  • Swedish Heart-Lung Foundation
    1 January 2024 - 31 December 2026
    Background Late diagnosis of pulmonary hypertension (PH) causes poor outcomes. Echocardiography lacks accuracy for PH. Definitive diagnosis requires invasive right heart catheterization, while magnetic resonance imaging (MRI) provides gold standard characterization of prognostic cardiovascular variables. A novel contrast- and radiation-free MRI 4D-flow technique can accurately diagnose PH by estimating mean pulmonary arterial pressure. Objective To achieve the overall goal of a safe, non-invasive, contrast-free accurate <2-minute automated MRI- based method of determining mPAP, the following specific hypotheses will be tested: 1. The coefficient of determination (R2) between MRI-determined pulmonary artery vortex duration in images acquired using a phase-contrast sequence with compressed sensing, and simultaneously measured invasive mPAP is between 0.8 and 0.95 in patients with suspected PH without atrial fibrillation. 2. Reduction of mPAP following clinically motivated pharmacological pulmonary vasodilation is reflected in MRI-determined mPAP. 3. The addition of arrhythmia rejection to the MRI pulse sequence results in a similar correlation with invasive mPAP as for patients without arrhythmia. 4. The minimum scan duration that allows sufficient signal-to-noise ratio for accurate mPAP-estimation can be identified through comparison of retrospective reconstruction of MRI 4D-flow images with varying amounts of data. 5. An interpretation algorithm can be identified to determine the duration of vortical blood flow on MRI 4D-flow images and thereby estimate mPAP automatically. Workplan One-hundred patients with suspected PH will undergo clinically motivated interventional MRI at Karolinska University Hospital during 2023-2024. Gold standard interventional measurements will be compared to non-invasive MRI-based estimates of mean pulmonary artery pressure (mPAP). Significance The combination of availability of interventional MRI, the experience of the applicant, international collaborations, and sufficient volume of patients with PH provides a unique opportunity to optimize and validate this MRI-method in the short term (2023-2025). This would allow the medium term (2026-) acquisition of standardized data necessary for further validation and improved automation of image interpretation. The results could improve the diagnosis and care of patients with PH, as well as facilitate research the role of PH in left heart failure and lung disease.
  • Diagnosis and follow-up of pulmonary hypertension using MRI
    Swedish Heart and Lung Foundation
    1 January 2024 - 1 January 2026
  • Diagnosis and follow-up of pulmonary hypertension using MRI
    Swedish Society of Medicine
    1 January 2024 - 30 June 2026
  • Swedish Heart-Lung Foundation
    1 January 2023 - 31 December 2024
  • Diagnosis and follow-up of pulmonary hypertension using MRI
    Swedish Heart and Lung Foundation
    1 January 2023 - 1 December 2024
  • Swedish Heart-Lung Foundation
    1 January 2020 - 31 December 2021

Employments

  • Affiliated to Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2024-2027

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2017
  • Degree Of Master Of Science In Medicine, Karolinska Institutet, 2014

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