Björn Önfelt

About me
Publications
Public outreach and news

About me

Björn Önfelt is Visiting Professor of Molecular Immunology with focus on
Cellular Immunotherapy at the Department of Medicine, Huddinge, Karolinska
Institutet.

Articles

Article: BONE MARROW TRANSPLANTATION. 2019;54(10):1562-1574
T-cell frequencies of CD8⁺ γδ and CD27⁺ γδ cells in the stem cell graft predict the outcome after allogeneic hematopoietic cell transplantation
Gaballa A; Stikvoort A; Onfelt B; Mattsson J; Sundin M; Watz E; Uhlin M
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:189
Individualization of Hematopoietic Stem Cell Transplantation Using Alpha/Beta T-Cell Depletion
Radestad E; Sundin M; Torlen J; Thunberg S; Onfelt B; Ljungman P; Watz E; Mattsson J; Uhlin M
Article: JOURNAL OF IMMUNOLOGY. 2018;201(7):2028-2041
Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1
Walwyn-Brown K; Guldevall K; Saeed M; Pende D; Onfelt B; MacDonald AS; Davis DM
Article: JOURNAL OF CELL BIOLOGY. 2018;217(9):3267-3283
Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells
Srpan K; Ambrose A; Karampatzakis A; Saeed M; Cartwright ANR; Guldevall K; De Matos GDSC; Onfelt B; Davis DM
Article: LAB ON A CHIP. 2018;18(16):2466-2476
Acoustic formation of multicellular tumor spheroids enabling on-chip functional and structural imaging
Olofsson K; Carannante V; Ohlin M; Frisk T; Kushiro K; Takai M; Lundqvist A; Onfelt B; Wiklund M
Article: BLOOD ADVANCES. 2018;2(12):1459-1469
161533 TriKE stimulates NK-cell function to overcome myeloid-derived suppressor cells in MDS
Sarha D; Brandt L; Felices M; Guldevall K; Lenvik T; Hinderlie P; Curtsinger J; Warlick E; Spellma SR; Blazar BR; Weisdorf DJ; Cooley S; Vallera DA; Onfelt B; Miller JS
Article: CANCER IMMUNOLOGY RESEARCH. 2018;6(4):467-480
Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors
Oei VYS; Siernicka M; Graczyk-Jarzynka A; Hoel HJ; Yang W; Palacios D; Almasbak H; Bajor M; Clement D; Brandt L; Onfelt B; Goodridge J; Winiarska M; Zagozdzon R; Olweus J; Kyte J-A; Malmberg K-J
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2018;24(3):467-477
Risk Factors for Severe Acute Graft-versus-Host Disease in Donor Graft Composition
Stikvoort A; Gaballa A; Solders M; Nederlof I; Onfelt B; Sundberg B; Remberger M; Sundin M; Mattsson J; Uhlin M
Article: SCIENTIFIC REPORTS. 2017;7(1):13433
Laboratory cryo x-ray microscopy for 3D cell imaging
Fogelqvist E; Kordel M; Carannante V; Onfelt B; Hertz HM
Article: JOURNAL OF CELL BIOLOGY. 2016;215(6):875-889
NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing
Hsu H-T; Mace EM; Carisey AF; Viswanath DI; Christakou AE; Wiklund M; Onfelt B; Orange JS
Article: METHODS IN MOLECULAR BIOLOGY. 2016;1441:87-106
Microwell-Based Live Cell Imaging of NK Cell Dynamics to Assess Heterogeneity in Motility and Cytotoxic Response.
Vanherberghen B; Frisk T; Forslund E; Olofsson PE; Guldevall K; Önfelt B
Article: FRONTIERS IN IMMUNOLOGY. 2016;7:119
Microchip screening Platform for single cell assessment of NK cell cytotoxicity
Guldevall K; Brandt L; Forslund E; Olofsson K; Frisk TW; Olofsson PE; Gustafsson K; Manneberg O; Vanherberghen B; Brismar H; Karre K; Uhlin M; Onfelt B
Article: JOURNAL OF IMMUNOLOGY. 2015;195(7):3374-3381
Microchip-Based Single-Cell Imaging Reveals That CD56^dim CD57^-KIR^-NKG2A⁺ NK Cells Have More Dynamic Migration Associated with Increased Target Cell Conjugation and Probability of Killing Compared to CD56^dimCD57^-KIR^-NKG2A^- NK Cells
Forslund E; Sohlberg E; Enqvist M; Olofsson PE; Malmberg K-J; Onfelt B
Article: LAB ON A CHIP. 2015;15(15):3222-3231
Ultrasonic three-dimensional on-chip cell culture for dynamic studies of tumor immune surveillance by natural killer cells
Christakou AE; Ohlin M; Onfelt B; Wiklund M
Article: JOURNAL OF IMMUNOLOGY. 2015;194(9):4518-4527
Coordinated Expression of DNAM-1 and LFA-1 in Educated NK Cells
Enqvist M; Ask EH; Forslund E; Carlsten M; Abrahamsen G; Beziat V; Andersson SA; Schaffer M; Spurkland A; Bryceson Y; Onfelt B; Malmberg K-J
Article: FRONTIERS IN IMMUNOLOGY. 2015;6:196
Single-cell characterization of in vitro migration and interaction dynamics of T cells expanded with IL-2 and IL-7
Tauriainen J; Gustafsson K; Gothlin M; Gertow J; Buggert M; Frisk TW; Karlsson AC; Uhlin M; Onfelt B
Article: FRONTIERS IN IMMUNOLOGY. 2014;5:80
Distinct migration and contact cynamics of resting and IL-2-activated human natural killer cells
Olofsson PE; Forslund E; Vanherberghen B; Chechet K; Mickelin O; Ahlin AR; Everhorn T; Onfelt B
Article: INTEGRATIVE BIOLOGY. 2013;5(4):712-719
Live cell imaging in a micro-array of acoustic traps facilitates quantification of natural killer cell heterogeneity
Christakou AE; Ohlin M; Vanherberghen B; Khorshidi MA; Kadri N; Frisk T; Wiklund M; Onfelt B
Article: JOURNAL OF MICROMECHANICS AND MICROENGINEERING. 2013;23(3):035008
Influence of acoustic streaming on ultrasonic particle manipulation in a 100-well ring-transducer microplate
Ohlin M; Christakou AE; Frisk T; Onfelt B; Wiklund M
Article: BLOOD. 2013;121(8):1326-1334
Classification of human natural killer cells based on migration behavior and cytotoxic response
Vanherberghen B; Olofsson PE; Forslund E; Sternberg-Simon M; Khorshidi MA; Pacouret S; Guldevall K; Enqvist M; Malmberg K-J; Mehr R; Onfelt B
Article: FRONTIERS IN IMMUNOLOGY. 2013;4:65
Natural killer cell inhibitory receptor expression in humans and mice: a closer look
Sternberg-Simon M; Brodin P; Pickman Y; Onfelt B; Karre K; Malmberg K-J; Hoglund P; Mehr R
Article: NANOSCALE. 2012;4(23):7383-7393
Visualization of custom-tailored iron oxide nanoparticles chemistry, uptake, and toxicity
Wilkinson K; Ekstrand-Hammarstrom B; Ahlinder L; Guldevall K; Pazik R; Kepinski L; Kvashnina KO; Butorin SM; Brismar H; Onfelt B; Osterlund L; Seisenbaeva GA; Kessler VG
Article: KIDNEY INTERNATIONAL. 2012;82(10):1071-1083
Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics
Perisic L; Lal M; Hulkko J; Hultenby K; Onfelt B; Sun Y; Duner F; Patrakka J; Betsholtz C; Uhlen M; Brismar H; Tryggvason K; Wernerson A; Pikkarainen T
Article: METHODS IN MOLECULAR BIOLOGY. 2012;853:177-196
Ultrasonic manipulation of single cells.
Wiklund M; Onfelt B
Article: FRONTIERS IN IMMUNOLOGY. 2012;3:300
Novel microchip-based tools facilitating live cell imaging and assessment of functional heterogeneity within NK cell populations
Forslund E; Guldevall K; Olofsson PE; Frisk T; Christakou AE; Wiklund M; Onfelt B
Article: CHEMICAL COMMUNICATIONS. 2011;47(39):11020-11022
Light-induced cytotoxicity of a photochromic spiropyran
Nilsson JR; Li S; Onfelt B; Andreasson J
Article: BIOMEDICAL MICRODEVICES. 2011;13(4):683-693
A silicon-glass microwell platform for high-resolution imaging and high-content screening with single cell resolution
Frisk TW; Khorshidi MA; Guldevall K; Vanherberghen B; Onfelt B
Article: INTEGRATIVE BIOLOGY. 2011;3(7):770-778
Analysis of transient migration behavior of natural killer cells imaged in situ and in vitro
Khorshidi MA; Vanherberghen B; Kowalewski JM; Garrod KR; Lindstrom S; Andersson-Svahn H; Brismar H; Cahalan MD; Onfelt B
Article: PLOS ONE. 2010;5(11):e15453
Imaging Immune Surveillance of Individual Natural Killer Cells Confined in Microwell Arrays
Guldevall K; Vanherberghen B; Frisk T; Hurtig J; Christakou AE; Manneberg O; Lindstrom S; Andersson-Svahn H; Wiklund M; Onfelt B
Article: LAB ON A CHIP. 2010;10(20):2727-2732
Ultrasound-controlled cell aggregation in a multi-well chip
Vanherberghen B; Manneberg O; Christakou A; Frisk T; Ohlin M; Hertz HM; Onfelt B; Wiklund M
Article: LAB ON A CHIP. 2009;9(6):833-837
Flow-free transport of cells in microchannels by frequency-modulated ultrasound
Manneberg O; Vanherberghen B; Onfelt B; Wiklund M
Article: BIOPHYSICAL JOURNAL. 2009;96(2):L13-L15
Live Cell Linear Dichroism Imaging Reveals Extensive Membrane Ruffling within the Docking Structure of Natural Killer Cell Immune Synapses
Benninger RKP; Vanherberghen B; Young S; Taner SB; Culley FI; Schnyder T; Neil MAA; Wuestner D; French PMW; Davis DM; Onfelt B
Article: APPLIED PHYSICS LETTERS. 2008;93(6):063901
A three-dimensional ultrasonic cage for characterization of individual cells
Manneberg O; Vanherberghen B; Svennebring J; Hertz HM; Onfelt B; Wiklund M
Article: NATURE CELL BIOLOGY. 2008;10(2):211-219
Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission
Sowinski S; Jolly C; Berninghausen O; Purbhoo MA; Chauveau A; Koehler K; Oddos S; Eissmann P; Brodsky FM; Hopkins C; Oenfelt B; Sattentau Q; Davis DM
Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2007;46(13):2228-2231
Fluorescence-lifetime imaging of DNA-dye interactions within continuous-flow microfluidic systems.
Benninger RKP; Hofmann O; Onfelt B; Munro I; Dunsby C; Davis DM; Neil MAA; French PMW; de Mello AJ
Article: JOURNAL OF IMMUNOLOGY. 2007;178(6):3418-3426
The activating NKG2D ligand MHC class I-related chain A transfers from target cells to NK cells in a manner that allows functional consequences.
McCann FE; Eissmann P; Onfelt B; Leung R; Davis DM
Article: JOURNAL OF IMMUNOLOGY. 2006;177(12):8476-8483
Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria.
Onfelt B; Nedvetzki S; Benninger RKP; Purbhoo MA; Sowinski S; Hume AN; Seabra MC; Neil MAA; French PMW; Davis DM
Article: BIOPHYSICAL JOURNAL. 2005;88(1):609-622
Fluorescence imaging of two-photon linear dichroism: cholesterol depletion disrupts molecular orientation in cell membranes.
Benninger RKP; Onfelt B; Neil MAA; Davis DM; French PMW
Article: JOURNAL OF PHYSICS D-APPLIED PHYSICS. 2004;37(23):3296-3303
An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy
Dunsby C; Lanigan PMP; McGinty J; Elson DS; Requejo-Isidro J; Munro I; Galletly N; McCann F; Treanor B; Önfelt B; Davis DM; Neil MAA; French PMW
Article: JOURNAL OF PHYSICAL CHEMISTRY A. 2004;108(20):4391-4398
Three-state light switch of [Ru(phen)₂dppz]²⁺:: Distinct excited-state species with two, one, or no hydrogen bonds from solvent
Olofsson J; Önfelt B; Lincoln P
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2004;199(7):1005-1010
Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D.
Eleme K; Taner SB; Onfelt B; Collinson LM; McCann FE; Chalupny NJ; Cosman D; Hopkins C; Magee AI; Davis DM
Article: JOURNAL OF PHYSICAL CHEMISTRY A. 2003;107(7):1000-1009
Picosecond and steady-state emission of [Ru(phen)₂dppz]²⁺ in glycerol:: Anomalous temperature dependence
Önfelt B; Olofsson J; Lincoln P; Nordén B
Article: MUTAGENESIS. 2002;17(4):317-320
Cell studies of the DNA bis-intercalator Delta-Delta [mu-C4(cpdppz)(2)-(phen)(4)Ru(2)](4+): toxic effects and properties as a light emitting DNA probe in V79 Chinese hamster cells.
Onfelt B; Göstring L; Lincoln P; Nordén B; Onfelt A
Article: JOURNAL OF PHYSICAL CHEMISTRY B. 2001;105(50):12653-12664
Picosecond time-resolved resonance Raman probing of the light-switch states of [Ru(Phen)₂dppz]²⁺
Coates CG; Olofsson J; Coletti M; McGarvey JJ; Önfelt B; Lincoln P; Norden B; Tuite E; Matousek P; Parker AW
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2001;123(16):3630-3637
Enantioselective DNA threading dynamics by phenazine-linked.
Onfelt B; Lincoln P; Nordén B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(11):5708-5713
Femtosecond linear dichroism of DNA-intercalating chromophores: solvation and charge separation dynamics of [Ru(phen)2dppz]2+ systems.
Onfelt B; Lincoln P; Nordén B; Baskin JS; Zewail AH
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 1999;121(46):10846-10847
A molecular staple for DNA:: Threading bis-intercalating [Ru(phen)₂dppz]²⁺ dimer
Önfelt B; Lincoln P; Nordén B
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All other publications

Review: IMMUNOLOGICAL REVIEWS. 2015;267(1):197-213
Newtonian cell interactions shape natural killer cell education
Goodridge JP; Onfelt B; Malmberg K-J
Review: MICROMACHINES. 2014;5(1):27-49
Ultrasound-Induced Cell-Cell Interaction Studies in a Multi-Well Microplate
Wiklund M; Christakou AE; Ohlin M; Iranmanesh I; Frisk T; Vanherberghen B; Onfelt B
Review: FEBS JOURNAL. 2013;280(12):2775-2784
Consequences of membrane topography
Parmryd I; Onfelt B
Editorial comment: LAB ON A CHIP. 2012;12(18):3221-3234
Acoustofluidics 18: Microscopy for acoustofluidic micro-devices
Wiklund M; Brismar H; Onfelt B
Review: WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY. 2010;2(3):260-276
Intercellular nanotubes: insights from imaging studies and beyond
Hurtig J; Chiu DT; Onfelt B
Corrigendum: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2007;46(45):8536
Fluorescence-lifetime imaging of DNA-Dye interactions within continuous-flow microfluidic systems (vol 46, pg 8525, 2007)
Benninger RKP; Hofmann O; Onfelt B; Munro I; Dunsby C; Davis DM; Neil MAA; French PMW; de Mello AJ
Review: SCIENCES STKE [ELECTRONIC RESOURCE] : SIGNAL TRANSDUCTION KNOWLEDGE ENVIRONMENT. 2005;2005(313):pe55
Long-distance calls between cells connected by tunneling nanotubules.
Onfelt B; Purbhoo MA; Nedvetzki S; Sowinski S; Davis DM
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 2004;32(Pt 5):676-678
Can membrane nanotubes facilitate communication between immune cells?
Onfelt B; Davis DM
Review: TRAFFIC. 2004;5(9):651-661
Control of immune responses by trafficking cell surface proteins, vesicles and lipid rafts to and from the immunological synapse.
Taner SB; Onfelt B; Pirinen NJ; McCann FE; Magee AI; Davis DM
Published conference paper: JOURNAL OF IMMUNOLOGY. 2004;173(3):1511-1513
Cutting edge: Membrane nanotubes connect immune cells.
Onfelt B; Nedvetzki S; Yanagi K; Davis DM
Published conference paper: JOURNAL OF INORGANIC BIOCHEMISTRY. 2002;91(1):286-297
Picosecond Kerr-gated time-resolved resonance Raman spectroscopy of the [Ru(phen)(2)dppz](2+) interaction with DNA.
Olofsson J; Onfelt B; Lincoln P; Nordén B; Matousek P; Parker AW; Tuite E
Published conference paper: JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS. 2000;17 Suppl 1:277-283
Probing DNA conductivity with photoinduced electron transfer and scanning tunneling microscopy.
Tuite E; Lincoln P; Olofsson J; Becker HC; Onfelt B; Erts D; Nordén B

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