Birgitta Henriques-Normark

About me
Publications
CV
Public outreach and news

About me

Professor in Clinical Microbiology
Head Physician (överläkare) Karolinska Unviersity Hospital
President of the Royal Swedish Academy of Sciences

Academic honours, awards and prizes:
President (Preses) of the Royal Swedish Academy of Sciences (KVA)
Member of the European Academy of Microbiology Executive board
Prix Aboensis Prize 2022 together with Staffan Normark, Turku, Finland
Pettenkofer Award 2021, Munich, Germany
Torsten Söderbergs Academy-professorship in Medicine
Member of EMBO (European Molecular Biology Organization)
Member of the Nobel assembly at KI, awarding the Nobel prize in Physiology or Medicine
Member of the Royal Swedish Academy of Sciences (KVA)
Member of the American Academy of Microbiology (AAM)
Member of the European Academy of Microbiology (EAM)
Previously Academic Vice president for Research at KI
Previously Chairman of the Committee for Research at KI

Articles

Article: JOURNAL OF IMMUNOLOGY. 2024;212(1):69-80
STAT3 Deficiency Alters the Macrophage Activation Pattern and Enhances Matrix Metalloproteinase 9 Expression during Staphylococcal Pneumonia
Farmand S; Sender V; Karlsson J; Merkl P; Normark S; Henriques-Normark B
Article: LANCET DIGITAL HEALTH. 2023;5(9):e582-e593
Trends in invasive bacterial diseases during the first 2 years of the COVID-19 pandemic: analyses of prospective surveillance data from 30 countries and territories in the IRIS Consortium
Shaw D; Abad R; Amin-Chowdhury Z; Bautista A; Bennett D; Broughton K; Cao B; Casanova C; Choi EH; Chu Y-W; Claus H; Coelho J; Corcoran M; Cottrell S; Cunney R; Cuypers L; Dalby T; Davies H; de Gouveia L; Deghmane A-E; Demczuk W; Desmet S; Domenech M; Drew R; du Plessis M; Duarte C; Erlendsdottir H; Fry NK; Fuursted K; Hale T; Henares D; Henriques-Normark B; Hilty M; Hoffmann S; Humphreys H; Ip M; Jacobsson S; Johnson C; Johnston J; Jolley KA; Kawabata A; Kozakova J; Kristinsson KG; Krizova P; Kuch A; Ladhani S; Lam T-T; Leon ME; Lindholm L; Litt D; Maiden MCJ; Martin I; Martiny D; Mattheus W; Mccarthy N; Meehan M; Meiring S; Moelling P; Morfeldt E; Morgan J; Mulhall R; Munoz-Almagro C; Murdoch D; Murphy J; Musilek M; Mzabi A; Novakova L; Oftadeh S; Perez-Arguello A; Perez-Vazquez M; Perrin M; Perry M; Prevost B; Roberts M; Rokney A; Ron M; Sanabria OM; Scott KJ; Sheppard C; Siira L; Sintchenko V; Skoczynska A; Sloan M; Slotved H-C; Smith AJ; Steens A; Taha M-K; Toropainen M; Tzanakaki G; Vainio A; van der Linden MPG; van Sorge NM; Varon E; Vohrnova S; von Gottberg A; Yuste J; Zanella R; Zhou F; Brueggemann AB
Article: NATURE COMMUNICATIONS. 2023;14(1):3170
The divisome but not the elongasome organizes capsule synthesis in Streptococcus pneumoniae
Nakamoto R; Bamyaci S; Blomqvist K; Normark S; Henriques-Normark B; Sham L-T
Article: CHEMICAL ENGINEERING JOURNAL. 2023;454:139971
Highly durable photocatalytic titanium suboxide-polymer nanocomposite films with visible light-triggered antibiofilm activity
Bletsa E; Merkl P; Thersleff T; Normark S; Henriques-Normark B; Sotiriou GA
Article: CURRENT OPINION IN CHEMICAL ENGINEERING. 2022;38:100872
Inorganic nanoparticle engineering against bacterial infections
Tsikourkitoudi V; Henriques-Normark B; Sotiriou GA
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2022;198(6):1023-1031
The human cathelicidin hCAP-18 in serum of children with haemato-oncological diseases
Jackmann N; Englund S; Frisk P; Makitie O; Utriainen P; Mortberg A; Henriques-Normark B; Putsep K; Harila-Saari A
Article: JOURNAL OF INTERNAL MEDICINE. 2022;292(2):350-364
Bacterial meningitis: Aetiology, risk factors, disease trends and severe sequelae during 50 years in Sweden
Block N; Naucler P; Wagner P; Morfeldt E; Henriques-Normark B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(23):e2122386119
Membrane particles evoke a serotype-independent cross-protection against pneumococcal infection that is dependent on the conserved lipoproteins MalX and PrsA
Narciso AR; Iovino F; Thorsdottir S; Mellroth P; Codemo M; Spoerry C; Righetti F; Muschiol S; Normark S; Nannapaneni P; Henriques-Normark B
Article: CLINICAL INFECTIOUS DISEASES. 2022;74(8):1338-1349
Chronic Disease and Immunosuppression Increase the Risk for Nonvaccine Serotype Pneumococcal Disease: A Nationwide Population-based Study
Naucler P; Galanis I; Petropoulos A; Granath F; Morfeldt E; Ortqvist A; Henriques-Normark B
Article: ONCOGENE. 2022;41(15):2173-2186
Enterobacteria impair host p53 tumor suppressor activity through mRNA destabilization
Aschtgen M-S; Fragkoulis K; Sanz G; Normark S; Selivanova G; Henriques-Normark B; Peuget S
Article: EMERGING INFECTIOUS DISEASES. 2022;28(1):137-138
Serotype Replacement after Introduction of 10-Valent and 13-Valent Pneumococcal Conjugate Vaccines in 10 Countries, Europe
Hanquet G; Krizova P; Dalby T; Ladhani SN; Nuorti JP; Danis K; Mereckiene J; Knol MJ; Winje BA; Ciruela P; de Miguel S; Eugenia Portillo M; MacDonald L; Morfeldt E; Kozakova J; Valentiner-Branth P; Fry NK; Rinta-Kokko H; Varon E; Corcoran M; van der Ende A; Vestrheim DF; Munoz-Almagro C; Sanz J-C; Castilla J; Smith A; Henriques-Normark B; Colzani E; Pastore-Celentano L; Savulescu C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(47):e2108244118
THCz: Small molecules with antimicrobial activity that block cell wall lipid intermediates
Reithuber E; Wixe T; Ludwig KC; Muller A; Uvell H; Grein F; Lindgren AEG; Muschiol S; Nannapaneni P; Eriksson A; Schneider T; Normark S; Henriques-Normark B; Almqvist F; Mellroth P
Article: LANCET DIGITAL HEALTH. 2021;3(6):e360-e370
Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiative: a prospective analysis of surveillance data
Brueggemann AB; van Rensburg MJJ; Shaw D; McCarthy ND; Jolley KA; Maiden MCJ; van der Linden MPG; Amin-Chowdhury Z; Bennett DE; Borrow R; Brandileone M-CC; Broughton K; Campbell R; Cao B; Casanova C; Choi EH; Chu YW; Clark SA; Claus H; Coelho J; Corcoran M; Cottrell S; Cunney RJ; Dalby T; Davies H; de Gouveia L; Deghmane A-E; Demczuk W; Desmet S; Drew RJ; du Plessis M; Erlendsdottir H; Fry NK; Fuursted K; Gray SJ; Henriques-Normark B; Hale T; Hilty M; Hoffmann S; Humphreys H; Ip M; Jacobsson S; Johnston J; Kozakova J; Kristinsson KG; Krizova P; Kuch A; Ladhani SN; Lam T-T; Lebedova V; Lindholm L; Litt DJ; Martin I; Martiny D; Mattheus W; McElligott M; Meehan M; Meiring S; Molling P; Morfeldt E; Morgan J; Mulhall RM; Munoz-Almagro C; Murdoch DR; Murphy J; Musilek M; Mzabi A; Perez-Arguello A; Perrin M; Perry M; Redin A; Roberts R; Roberts M; Rokney A; Ron M; Scott KJ; Sheppard CL; Siira L; Skoczynska A; Sloan M; Slotved H-C; Smith AJ; Song JY; Taha M-K; Toropainen M; Tsang D; Vainio A; van Sorge NM; Varon E; Vlach J; Vogel U; Vohrnova S; von Gottberg A; Zanella RC; Zhou F
Article: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE. 2021;25:5-7
Antimicrobial resistance research in a post-pandemic world: Insights on antimicrobial resistance research in the COVID-19 pandemic
Rodriguez-Bano J; Rossolini GM; Schultsz C; Tacconelli E; Murthy S; Ohmagari N; Holmes A; Bachmann T; Goossens H; Canton R; Roberts AP; Henriques-Normark B; Clancy CJ; Huttner B; Fagerstedt P; Lahiri S; Kaushic C; Hoffman SJ; Warren M; Zoubiane G; Essack S; Laxminarayan R; Plant L
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2021;99(6):817-829
Clarithromycin impairs tissue-resident memory and Th17 responses to macrolide-resistant Streptococcus pneumoniae infections
Lindenberg M; Almeida L; Dhillon-LaBrooy A; Siegel E; Henriques-Normark B; Sparwasser T
Article: PLOS PATHOGENS. 2021;17(4):e1009513
RNA thermosensors facilitate Streptococcus pneumoniae and Haemophilus influenzae immune evasion
Eichner H; Karlsson J; Spelmink L; Pathak A; Sham L-T; Henriques-Normark B; Loh E
Article: PLOS PATHOGENS. 2021;17(3):e1009432
Neuronal death in pneumococcal meningitis is triggered by pneumolysin and RrgA interactions with β-actin
Tabusi M; Thorsdottir S; Lysandrou M; Narciso AR; Minoia M; Srambickal CV; Widengren J; Henriques-Normark B; Iovino F
Article: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2021;11:808601
The Role of Minor Pilins in Assembly and Function of the Competence Pilus of Streptococcus pneumoniae
Oliveira V; Aschtgen M-S; van Erp A; Henriques-Normark B; Muschiol S
Article: BIOSENSORS & BIOELECTRONICS. 2021;171:112732
Biofilm interfacial acidity evaluation by pH-Responsive luminescent nanoparticle films
Merkl P; Aschtgen M-S; Henriques-Normark B; Sotiriou GA
Article: MBIO. 2020;11(6):e03027-e03020
The Bactericidal Fatty Acid Mimetic 2CCA-1 Selectively Targets Pneumococcal Extracellular Polyunsaturated Fatty Acid Metabolism
Reithuber E; Nannapaneni P; Rzhepishevska O; Lindgren AEG; Ilchenko O; Normark S; Almqvist F; Henriques-Normark B; Mellroth P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(49):31386-31397
Capillary leakage provides nutrients and antioxidants for rapid pneumococcal proliferation in influenza-infected lower airways
Sender V; Hentrich K; Pathak A; Ler ATQ; Embaie BT; Lundstrom SL; Gaetani M; Bergstrand J; Nakamoto R; Sham L-T; Widengren J; Normark S; Henriques-Normark B
Article: EMBO MOLECULAR MEDICINE. 2020;12(11):e12695
Mannose receptor-derived peptides neutralize pore-forming toxins and reduce inflammation and development of pneumococcal disease
Subramanian K; Iovino F; Tsikourkitoudi V; Merkl P; Ahmed S; Berry SB; Aschtgen M-S; Svensson M; Bergman P; Sotiriou GA; Henriques-Normark B
Article: MBIO. 2020;11(5):e01774-e01720
Sex Steroids Induce Membrane Stress Responses and Virulence Properties in Pseudomonas aeruginosa
Vidaillac C; Yong VFL; Aschtgen M-S; Qu J; Yang S; Xu G; Seng ZJ; Brown AC; Ali MK; Jaggi TK; Sankaran J; Foo YH; Righetti F; Nedumaran AM; Mac Aogain M; Roizman D; Richard J-A; Rogers TR; Toyofuku M; Luo D; Loh E; Wohland T; Czarny B; Horvat JC; Hansbro PM; Yang L; Li L; Normark S; Normark BH; Chotirmall SH
Article: CHEMICAL COMMUNICATIONS. 2020;56(51):6989-6992
Silica-coated phosphorescent nanoprobes for selective cell targeting and dynamic bioimaging of pathogen-host cell interactions
Iovino F; Merkl P; Spyrogianni A; Henriques-Normark B; Sotiriou GA
Article: EMBO JOURNAL. 2020;39(9):e103852
Grad-seq in a Gram-positive bacterium reveals exonucleolytic sRNA activation in competence control
Hoer J; Garriss G; Di Giorgio S; Hack L-M; Vanselow JT; Foerstner KU; Schlosser A; Henriques-Normark B; Vogel J
Article: MOLECULES. 2020;25(7):1747
Flame-Made Calcium Phosphate Nanoparticles with High Drug Loading for Delivery of Biologics
Tsikourkitoudi V; Karlsson J; Merkl P; Loh E; Henriques-Normark B; Sotiriou GA
Article: CELL HOST & MICROBE. 2020;27(4):544-555.e3
Proton Motive Force Disruptors Block Bacterial Competence and Horizontal Gene Transfer
Domenech A; Brochado AR; Sender V; Hentrich K; Henriques-Normark B; Typas A; Veening J-W
Article: JOURNAL OF CLINICAL MICROBIOLOGY. 2020;58(4):e01993-e01919
Reduced In Vitro Susceptibility of Streptococcus pyogenes to β-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread
Musser JM; Beres SB; Zhu L; Olsen RJ; Vuopio J; Hyyrylainen H-L; Grondahl-Yli-Hannuksela K; Kristinsson KG; Darenberg J; Henriques-Normark B; Hoffmann S; Caugant DA; Smith AJ; Lindsay DSJ; Boragine DM; Palzkill T
Article: SCIENTIFIC REPORTS. 2020;10(1):3670
Gradient acoustic focusing of sub-micron particles for separation of bacteria from blood lysate
Van Assche D; Reithuber E; Qiu W; Laurell T; Henriques-Normark B; Mellroth P; Ohlsson P; Augustsson P
Article: JOURNAL OF INTERNAL MEDICINE. 2019;286(6):689-701
The changing epidemiology of community-acquired pneumonia: nationwide register-based study in Sweden
Naucler P; Henriques-Normark B; Hedlund J; Galanis I; Granath F; Ortqvist A
Article: MBIO. 2019;10(3):e01286-e01219
Genomic Characterization of the Emerging Pathogen Streptococcus pseudopneumoniae
Garriss G; Nannapaneni P; Simoes AS; Browall S; Subramanian K; Sa-Leao R; Goossens H; de Lencastre H; Henriques-Normark B
Article: BMC INFECTIOUS DISEASES. 2019;19(1):409
Serotype and molecular diversity of nasopharyngeal Streptococcus pneumoniae isolates from children before and after vaccination with the ten-valent pneumococcal conjugate vaccine (PCV10) in Ethiopia
Sime WT; Aseffa A; Woldeamanuel Y; Brovall S; Morfeldt E; Henriques-Normark B
Article: BIOSENSORS & BIOELECTRONICS. 2019;132:286-293
Luminescent CeO₂:Eu³⁺ nanocrystals for robust in situ H₂O₂ real-time detection in bacterial cell cultures
Henning DF; Merkl P; Yun C; Iovino F; Xie L; Mouzourakis E; Moularas C; Deligiannakis Y; Henriques-Normark B; Leifer K; Sotiriou GA
Article: THORAX. 2019;74(5):473-482
Effect of childhood pneumococcal conjugate vaccination on invasive disease in older adults of 10 European countries: implications for adult vaccination
Hanquet G; Krizova P; Valentiner-Branth P; Ladhani SN; Nuorti JP; Lepoutre A; Mereckiene J; Knol M; Winje BA; Ciruela P; Ordobas M; Guevara M; McDonald E; Morfeldt E; Kozakova J; Slotved H-C; Fry NK; Rinta-Kokko H; Varon E; Corcoran M; van der Ende A; Vestrheim DF; Munoz-Almagro C; Latasa P; Castilla J; Smith A; Henriques-Normark B; Whittaker R; Celentano LP; Savulescu C
Article: MICROBIOLOGY SPECTRUM. 2019;7(1):10.1128/microbiolspec.psi
Gram-Positive Type IV Pili and Competence
Muschiol S; Aschtgen M-S; Nannapaneni P; Henriques-Normarkt B
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1968:195-202
IVIS Spectrum CT to Image the Progression of Pneumococcal Infections In Vivo.
Sierakowiak A; Henriques-Normark B; Iovino F
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1968:173-181
In Vivo Mouse Models to Study Pneumococcal Host Interaction and Invasive Pneumococcal Disease.
Iovino F; Sender V; Henriques-Normark B
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1968:53-59
High-Resolution and Super-Resolution Immunofluorescent Microscopy Ex Vivo to Study Pneumococcal Interactions with the Host.
Iovino F; Henriques-Normark B
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1968:35-39
Immunofluorescent Staining and High-Resolution Microscopy to Study the Pneumococcal Cell.
Iovino F; Henriques-Normark B
Article: NATURE MICROBIOLOGY. 2019;4(1):62-70
Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival
Subramanian K; Neill DR; Malak HA; Spelmink L; Khandaker S; Marchiori GDL; Dearing E; Kirby A; Yang M; Achour A; Nilvebrant J; Nygren P-A; Plant L; Kadioglu A; Henriques-Normark B
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2018;48(12):1975-1988
Eosinophilia and reduced STAT3 signaling affect neutrophil cell death in autosomal-dominant Hyper-IgE syndrome
Farmand S; Kremer B; Haeffner M; Puetsep K; Bergman P; Sundin M; Ritterbusch H; Seidl M; Follo M; Henneke P; Henriques-Normark B
Article: CLINICAL MICROBIOLOGY AND INFECTION. 2018;24(11):1158-1163
Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries
Ieven M; Coenen S; Loens K; Lammens C; Coenjaerts E; Vanderstraeten A; Henriques-Normark B; Crook D; Huygen K; Butler CC; Verheij TJM; Little P; Zlateva K; van Loon A; Claas ECJ; Goossens H
Article: BRITISH JOURNAL OF GENERAL PRACTICE. 2018;68(674):e627-e632
Clinical relevance of bacterial resistance in lower respiratory tract infection in primary care: secondary analysis of a multicentre European trial
Teepe J; Broekhuizen BDL; Goossens H; Hordijk PM; Loens K; Lammens C; Leven M; Little P; Butler CC; Coenen S; Godycki-Cwirko M; Henriques-Normark B; Verheij TJM
Article: NATURE COMMUNICATIONS. 2018;9(1):3398
Factor H binding proteins protect division septa on encapsulated Streptococcus pneumoniae against complement C3b deposition and amplification
Pathak A; Bergstrand J; Sender V; Spelmink L; Aschtgen M-S; Muschiol S; Widengren J; Henriques-Normark B
Article: JOURNAL OF INFECTIOUS DISEASES. 2018;218(3):476-484
Receptor Blockade: A Novel Approach to Protect the Brain From Pneumococcal Invasion
Iovino F; Thorsdottir S; Henriques-Normark B
Article: MBIO. 2018;9(2):e00559-e00518
Immunomodulatory Effects of Pneumococcal Extracellular Vesicles on Cellular and Humoral Host Defenses
Codemo M; Muschiol S; Iovino F; Nannapaneni P; Plant L; Wai SN; Henriques-Normark B
Article: ANALYTICA CHIMICA ACTA. 2018;1000:223-231
Separation of pathogenic bacteria by chain length
Beech JP; Ho BD; Garriss G; Oliveira V; Henriques-Normark B; Tegenfeldt JO
Article: ELIFE. 2018;7:e29213
Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood
Toepfner N; Herold C; Otto O; Rosendahl P; Jacobi A; Kraeter M; Staechele J; Menschner L; Herbig M; Ciuffreda L; Ford-Cartwright L; Grzybek M; Coskun U; Reithuber E; Garriss G; Mellroth P; Henriques-Normark B; Tregay N; Suttorp M; Bornhaeuser M; Chilvers ER; Berner R; Guck J
Article: CLINICAL INFECTIOUS DISEASES. 2017;65(11):1780-1789
Comparison of the Impact of Pneumococcal Conjugate Vaccine 10 or Pneumococcal Conjugate Vaccine 13 on Invasive Pneumococcal Disease in Equivalent Populations (Publication with Expression of Concern. See vol. 68, pg. 534, 2019)
Naucler P; Galanis I; Morfeldt E; Darenberg J; Ortqvist A; Henriques-Normark B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(34):14134-14146
Structure of the competence pilus major pilin ComGC in Streptococcus pneumoniae
Muschiol S; Erlendsson S; Aschtgen M-S; Oliveira V; Schmieder P; de Lichtenberg C; Teilum K; Boesen T; Akbey U; Henriques-Normark B
Article: LANCET RESPIRATORY MEDICINE. 2017;5(8):648-656
Effect of high-valency pneumococcal conjugate vaccines on invasive pneumococcal disease in children in SpIDnet countries: an observational multicentre study
Savulescu C; Krizova P; Lepoutre A; Mereckiene J; Vestrheim DF; Ciruela P; Ordobas M; Guevara M; McDonald E; Morfeldt E; Kozakova J; Varon E; Cotter S; Winje BA; Munoz-Almagro C; Garcia L; Castilla J; Smith A; Henriques-Normark B; Celentano LP; Hanquet G
Article: CELL REPORTS. 2017;20(1):251-263
Analysis of IAV Replication and Co-infection Dynamics by a Versatile RNA Viral Genome Labeling Method
Dou D; Hernandez-Neuta I; Wang H; Ostbye H; Qian X; Thiele S; Resa-Infante P; Kouassi NM; Sender V; Hentrich K; Mellroth P; Henriques-Normark B; Gabriel G; Nilsson M; Daniels R
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(6):1619-1630
pIgR and PEC AM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion
Iovino F; Engelen-Lee J-Y; Brouwer M; van de Beek D; van der Ende A; Seron MV; Mellroth P; Muschiol S; Bergstrand J; Widengren J; Henriques-Normark B
Article: VACCINE. 2017;35(20):2654-2660
The Pneumocell-study: Vaccination of IgG1-and IgG2-deficient patients with Prevnar13
Zangenah S; Bjorkhem-Bergman L; Norlin A-C; Hansen S; Lindqvist L; Henriques-Normark B; Bergman P
Article: EPIDEMIOLOGY AND INFECTION. 2017;145(6):1203-1209
Coeliac disease and invasive pneumococcal disease: a population-based cohort study
Tjernberg AR; Bonnedahl J; Inghammar M; Egesten A; Kahlmeter G; Naucler P; Henriques-Normark B; Ludvigsson JF
Article: JOURNAL OF INNATE IMMUNITY. 2017;9(4):375-386
Vitamin D Promotes Pneumococoal Killing and Modulates Inflammatory Responses in Primary Human Neutrophils
Subramanian K; Bergman P; Henriques-Normark B
Article: INFECTION AND IMMUNITY. 2016;84(12):3445-3457
Influenza A Virus Infection Predisposes Hosts to Secondary Infection with Different Streptococcus pneumoniae Serotypes with Similar Outcome but Serotype-Specific Manifestation
Sharma-Chawla N; Sender V; Kershaw O; Gruber AD; Volckmar J; Henriques-Normark B; Stegemann-Koniszewski S; Bruder D
Article: MBIO. 2016;7(5):e01783-e01716
Impact of AmpC Derepression on Fitness and Virulence: the Mechanism or the Pathway?
Perez-Gallego M; Torrens G; Castillo-Vera J; Moya B; Zamorano L; Cabot G; Hultenby K; Alberti S; Mellroth P; Henriques-Normark B; Normark S; Oliver A; Juan C
Article: CELL HOST & MICROBE. 2016;20(3):307-317
Streptococcus pneumoniae Senses a Human-like Sialic Acid Profile via the Response Regulator CiaR
Hentrich K; Lofling J; Pathak A; Nizet V; Varki A; Henriques-Normark B
Article: SCIENTIFIC REPORTS. 2016;6:32371
The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation
Schulte T; Mikaelsson C; Beaussart A; Kikhney A; Deshmukh M; Wolniak S; Pathak A; Ebel C; Lofling J; Fogolari F; Henriques-Normark B; Dufrene YF; Svergun D; Nygren P-A; Achour A
Article: MOLECULAR MICROBIOLOGY. 2016;101(6):954-967
The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity
Sandalova T; Lee M; Henriques-Normark B; Hesek D; Mobashery S; Mellroth P; Achour A
Article: MUCOSAL IMMUNOLOGY. 2016;9(5):1288-1302
Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection
Dudek M; Puttur F; Arnold-Schrauf C; Kuehl AA; Holzmann B; Henriques-Normark B; Berod L; Sparwasser T
Article: VACCINE. 2016;34(38):4565-4571
Unaltered pneumococcal carriage prevalence due to expansion of non-vaccine types of low invasive potential 8 years after vaccine introduction in Stockholm, Sweden
Lindstrand A; Galanis I; Darenberg J; Morfeldt E; Naucler P; Blennow M; Alfven T; Henriques-Normark B; Ortqvist A
Article: JOURNAL OF CLINICAL INVESTIGATION. 2016;126(8):2821-2826
Pneumococcal meningitis is promoted by single cocci expressing pilus adhesin RrgA
Iovino F; Hammarlof DL; Garriss G; Brovall S; Nannapaneni P; Henriques-Normark B
Article: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. 2016;85(2):141-148
lytA-based identification methods can misidentify Streptococcus pneumoniae
Simoes AS; Tavares DA; Rolo D; Ardanuy C; Goossens H; Henriques-Normark B; Linares J; de Lencastre H; Sa-Leao R
Article: EUROPEAN RESPIRATORY JOURNAL. 2016;47(4):1208-1218
Effects of PCV7 and PCV13 on invasive pneumococcal disease and carriage in Stockholm, Sweden
Galanis I; Lindstrand A; Darenberg J; Browall S; Nannapaneni P; Sjostrom K; Morfeldt E; Naucler P; Blennow M; Ortqvist A; Henriques-Normark B
Article: INFECTION AND IMMUNITY. 2016;84(4):894-905
Variation in Inflammatory Response during Pneumococcal Infection Is Influenced by Host-Pathogen Interactions but Associated with Animal Survival
Jonczyk MS; Escudero L; Sylvius N; Norman M; Henriques-Normark B; Andrew PW
Article: MBIO. 2016;7(2):e00168-e00116
Toll-Like Receptor 3/TRIF-Dependent IL-12p70 Secretion Mediated by Streptococcus pneumoniae RNA and Its Priming by Influenza A Virus Coinfection in Human Dendritic Cells
Spelmink L; Sender V; Hentrich K; Kuri T; Plant L; Henriques-Normark B
Article: PLOS ONE. 2016;11(8):e0160734
Cinobufagin Modulates Human Innate Immune Responses and Triggers Antibacterial Activity
Xie S; Spelmink L; Codemo M; Subramanian K; Putsep K; Henriques-Normark B; Olliver M
Article: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2016;6:158
N-acetylglucosamine-Mediated Expression of nagA and nagB in Streptococcus pneumoniae
Afzal M; Shafeeq S; Manzoor I; Henriques-Normark B; Kuipers OP
Article: PLOS ONE. 2016;11(11):e0166018
Pneumococcal Carriage in Children under Five Years in Uganda-Will Present Pneumococcal Conjugate Vaccines Be Appropriate?
Lindstrand A; Kalyango J; Alfven T; Darenberg J; Kadobera D; Bwanga F; Peterson S; Henriques-Normark B; Kallander K
Article: PLOS PATHOGENS. 2015;11(10):e1005206
BCG Skin Infection Triggers IL-1R-MyD88-Dependent Migration of EpCAM^low CD11b^high Skin Dendritic cells to Draining Lymph Node During CD4+T-Cell Priming
Bollampalli VP; Yamashiro LH; Feng X; Bierschenk D; Gao Y; Blom H; Henriques-Normark B; Nylen S; Rothfuchs AG
Article: THORAX. 2015;70(9):847-853
Respiratory viruses associated with community-acquired pneumonia in children: matched case-control study
Rhedin S; Lindstrand A; Hjelmgren A; Ryd-Rinder M; Ohrmalm L; Tolfvenstam T; Ortqvist A; Rotzen-Ostlund M; Zweygberg-Wirgart B; Henriques-Normark B; Broliden K; Naucler P
Article: GENOMICS DATA. 2015;4:57-59
Transcriptional profiling of UlaR-regulated genes in Streptococcus pneumoniae.
Shafeeq S; Afzal M; Henriques-Normark B; Kuipers OP
Article: BIOESSAYS. 2015;37(4):426-435
Uptake of extracellular DNA: Competence induced pili in natural transformation of Streptococcus pneumoniae
Muschiol S; Balaban M; Normark S; Henriques-Normark B
Article: MICROBIOLOGY-SGM. 2015;161(Pt 1):41-49
UlaR activates expression of the ula operon in Streptococcus pneumoniae in the presence of ascorbic acid
Afzal M; Shafeeq S; Henriques-Normark B; Kuipers OP
Article: BMC INFECTIOUS DISEASES. 2014;14:3859
Prevalence of community-acquired bacteraemia in Guinea-Bissau: an observational study
Isendahl J; Manjuba C; Rodrigues A; Xu W; Henriques-Normark B; Giske CG; Naucler P
Article: EUROPEAN RESPIRATORY JOURNAL. 2014;44(6):1646-1657
Clinical manifestations of invasive pneumococcal disease by vaccine and non-vaccine types
Browall S; Backhaus E; Naucler P; Galanis I; Sjostrom K; Karlsson D; Berg S; Luthander J; Eriksson M; Spindler C; Ejdeback M; Trollfors B; Darenberg J; Kalin M; Ortqvist A; Andersson R; Henriques-Normark B
Article: PEDIATRICS. 2014;134(6):E1528-E1536
Sinusitis and Pneumonia Hospitalization After Introduction of Pneumococcal Conjugate Vaccine
Lindstrand A; Bennet R; Galanis I; Blennow M; Ask LS; Dennison SH; Rinder MR; Eriksson M; Henriques-Normark B; Ortqvist A; Alfven T
Article: EPIDEMIOLOGY AND INFECTION. 2014;142(11):2251-2260
Human isolates of Listeria monocytogenes in Sweden during half a century (1958-2010)
Lopez-Valladares G; Tham W; Parihar VS; Helmersson S; Andersson B; Ivarsson S; Johansson C; Ringberg H; Tjernberg I; Henriques-Normark B; Danielsson-Tham M-L
Article: CLINICAL INFECTIOUS DISEASES. 2014;59(6):851-857
Clinical Efficacy of Polyspecific Intravenous Immunoglobulin Therapy in Patients With Streptococcal Toxic Shock Syndrome: A Comparative Observational Study
Linner A; Darenberg J; Sjolin J; Henriques-Normark B; Norrby-Teglund A
Article: JOURNAL OF INFECTIOUS DISEASES. 2014;210(1):4-13
Emergence of Hypervirulent Mutants Resistant to Early Clearance During Systemic Serotype 1 Pneumococcal Infection in Mice and Humans
Syk A; Norman M; Fernebro J; Gallotta M; Farmand S; Sandgren A; Normark S; Henriques-Normark B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(17):E1768-E1776
Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences
Nasser W; Beres SB; Olsen RJ; Dean MA; Rice KA; Long W; Kristinsson KG; Gottfredsson M; Vuopio J; Raisanen K; Caugant DA; Steinbakk M; Low DE; McGeer A; Darenberg J; Henriques-Normark B; Van Beneden CA; Hoffmann S; Musser JM
Article: PEDIATRICS. 2014;133(3):e538-e545
Clinical Utility of PCR for Common Viruses in Acute Respiratory Illness
Rhedin S; Lindstrand A; Rotzen-Ostlund M; Tolfvenstam T; Ohrmalm L; Rinder MR; Zweygberg-Wirgart B; Ortqvist A; Henriques-Normark B; Broliden K; Naucler P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(7):E758-E765
Secretion of a pneumococcal type II secretion system pilus correlates with DNA uptake during transformation
Balaban M; Battig P; Muschiol S; Tirier SM; Wartha F; Normark S; Henriques-Normark B
Article: MBIO. 2014;5(1):e01120-e01113
Structural and Functional Insights into Peptidoglycan Access for the Lytic Amidase LytA of Streptococcus pneumoniae
Mellroth P; Sandalova T; Kikhney A; Vilaplana F; Hesek D; Lee M; Mobashery S; Normark S; Svergun D; Henriques-Normark B; Achour A
Article: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY. 2014;42(2):345-353
Adult zebrafish model for pneumococcal pathogenesis
Saralahti A; Piippo H; Parikka M; Henriques-Normark B; Ramet M; Rounioja S
Article: JOURNAL OF INFECTIOUS DISEASES. 2014;209(3):377-388
Intraclonal Variations Among Streptococcus pneumoniae Isolates Influence the Likelihood of Invasive Disease in Children
Browall S; Norman M; Tangrot J; Galanis I; Sjostrom K; Dagerhamn J; Hellberg C; Pathak A; Spadafina T; Sandgren A; Battig P; Franzen O; Andersson B; Ortqvist A; Normark S; Henriques-Normark B
Article: OPEN BIOLOGY. 2014;4(1):130090
The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold
Schulte T; Lofling J; Mikaelsson C; Kikhney A; Hentrich K; Diamante A; Ebel C; Normark S; Svergun D; Henriques-Normark B; Achour A
Article: BMJ OPEN RESPIRATORY RESEARCH. 2014;1(1):e000038
Improvement of CRB-65 as a prognostic tool in adult patients with community-acquired pneumonia.
Dwyer R; Hedlund J; Henriques-Normark B; Kalin M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(50):20230-20235
Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis
Kandaswamy K; Liew TH; Wang CY; Huston-Warren E; Meyer-Hoffert U; Hultenby K; Schroeder JM; Caparon MG; Normark S; Henriques-Normark B; Hultgren SJ; Kline KA
Article: CLINICAL MICROBIOLOGY AND INFECTION. 2013;19(12):E559-E567
Oral bacterial community dynamics in paediatric patients with malignancies in relation to chemotherapy-related oral mucositis: a prospective study
Ye Y; Carlsson G; Agholme MB; Wilson JAL; Roos A; Henriques-Normark B; Engstrand L; Modeer T; Putsep K
Article: JOURNAL OF INFECTIOUS DISEASES. 2013;208(9):1474-1481
Immunomodulatory Effects of Vitamin D on Innate and Adaptive Immune Responses to Streptococcus pneumoniae
Olliver M; Spelmink L; Hiew J; Meyer-Hoffert U; Henriques-Normark B; Bergman P
Article: JOURNAL OF BACTERIOLOGY. 2013;195(19):4484-4495
Pilin and Sortase Residues Critical for Endocarditis- and BiofilmAssociated Pilus Biogenesis in Enterococcus faecalis
Nielsen HV; Flores-Mireles AL; Kau AL; Kline KA; Pinkner JS; Neiers F; Normark S; Henriques-Normark B; Caparon MG; Hultgren SJ
Article: CELLULAR MICROBIOLOGY. 2013;15(8):1385-1400
Influenza A virus-mediated priming enhances cytokine secretion by human dendritic cells infected with Streptococcus pneumoniae
Kuri T; Sorensen AS; Thomas S; Hedestam GBK; Normark S; Henriques-Normark B; McInerney GM; Plant L
Article: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. 2013;3(7):a010215
The Pneumococcus: Epidemiology, Microbiology, and Pathogenesis
Henriques-Normark B; Tuomanen EI
Article: THORAX. 2013;68(6):571-579
Contribution of host, bacterial factors and antibiotic treatment to mortality in adult patients with bacteraemic pneumococcal pneumonia
Naucler P; Darenberg J; Morfeldt E; Ortqvist A; Normark BH
Article: EUROSURVEILLANCE. 2013;18(14):20443-13
Increased incidence of invasive group A streptococcal infections in Sweden, January 2012-February 2013
Darenberg J; Henriques-Normark B; Lepp T; Tegmark-Wisell K; Tegnell A; Widgren K
Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2013;45(4):279-284
Low rate of pneumococci non-susceptible to penicillin in healthy Swedish toddlers
Skovbjerg S; Soderstrom A; Hynsjo L; Normark BH; Ekdahl K; Ahren C
Article: PLOS GENETICS. 2013;9(10):e1003868
Dominant Role of Nucleotide Substitution in the Diversification of Serotype 3 Pneumococci over Decades and during a Single Infection
Croucher NJ; Mitchell AM; Gould KA; Inverarity D; Barquist L; Feltwell T; Fookes MC; Harris SR; Dordel J; Salter SJ; Browall S; Zemlickova H; Parkhill J; Normark S; Henriques-Normark B; Hinds J; Mitchell TJ; Bentley SD
Article: JOURNAL OF INNATE IMMUNITY. 2013;5(1):84-96
TLR7 Contributes to the Rapid Progression but Not to the Overall Fatal Outcome of Secondary Pneumococcal Disease following Influenza A Virus Infection
Stegemann-Koniszewski S; Gereke M; Orrskog S; Lienenklaus S; Pasche B; Bader SR; Gruber AD; Akira S; Weiss S; Henriques-Normark B; Bruder D; Gunzer M
Article: PLOS ONE. 2013;8(5):e64422
Comprehensive Antigen Screening Identifies Moraxella catarrhalis Proteins That Induce Protection in a Mouse Pulmonary Clearance Model
Smidt M; Battig P; Verhaegh SJC; Niebisch A; Hanner M; Selak S; Schueler W; Morfeldt E; Hellberg C; Nagy E; Lundberg U; Hays JP; Meinke A; Henriques-Normark B
Article: MBIO. 2012;4(1):e00535-e00512
Pilus Adhesin RrgA Interacts with Complement Receptor 3, Thereby Affecting Macrophage Function and Systemic Pneumococcal Disease
Orrskog S; Rounioja S; Spadafina T; Gallotta M; Norman M; Hentrich K; Falker S; Ygberg-Eriksson S; Hasenberg M; Johansson B; Uotila LM; Gahmberg CG; Barocchi M; Gunzer M; Normark S; Henriques-Normark B
Article: MBIO. 2012;3(4):e00177-e00112
The Metal Ion-Dependent Adhesion Site Motif of the Enterococcus faecalis EbpA Pilin Mediates Pilus Function in Catheter-Associated Urinary Tract Infection
Nielsen HV; Guiton PS; Kline KA; Port GC; Pinkner JS; Neiers F; Normark S; Henriques-Normark B; Caparon MG; Hultgren SJ
Article: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES. 2012;31(5):849-857
Description of macrolide-resistant and potential virulent clones of Streptococcus pyogenes causing asymptomatic colonization during 2000-2006 in the Lisbon area.
Pires R; Rolo D; Morais A; Brito-Avô A; Johansson C; Henriques-Normark B; Gonçalo-Marques J; Santos-Sanches I
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(14):11018-11029
LytA, Major Autolysin of Streptococcus pneumoniae, Requires Access to Nascent Peptidoglycan
Mellroth P; Daniels R; Eberhardt A; Ronnlund D; Blom H; Widengren J; Normark S; Henriques-Normark B
Article: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY. 2012;36(2):342-348
Defense of zebrafish embryos against Streptococcus pneumoniae infection is dependent on the phagocytic activity of leukocytes
Rounioja S; Saralahti A; Rantala L; Parikka M; Henriques-Normark B; Silvennoinen O; Ramet M
Article: EUROSURVEILLANCE. 2011;16(50):20038-11
A case of diphtheria in Sweden, October 2011
Fredlund H; Noren T; Lepp T; Morfeldt E; Normark BH
Article: INFECTION AND IMMUNITY. 2011;79(10):4210-4217
Human Monocytes Promote Th1 and Th17 Responses to Streptococcus pneumoniae
Olliver M; Hiew J; Mellroth P; Henriques-Normark B; Bergman P
Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2011;43(6-7):448-455
Improvement of CRB-65 as a prognostic scoring system in adult patients with bacteraemic pneumococcal pneumonia
Dwyer R; Hedlund J; Darenberg J; Henriques-Normark B; Naucler P; Runesdotter S; Kalin M
Article: MUCOSAL IMMUNOLOGY. 2011;4(3):325-334
Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes
Duerr CU; Salzman NH; Dupont A; Szabo A; Normark BH; Normark S; Locksley RM; Mellroth P; Hornef MW
Article: INFECTION AND IMMUNITY. 2011;79(2):571-580
Identification of a Family of Effectors Secreted by the Type III Secretion System That Are Conserved in Pathogenic Chlamydiae
Muschiol S; Boncompain G; Vromman F; Dehoux P; Normark S; Henriques-Normark B; Subtil A
Article: PLOS ONE. 2011;6(8):e24394
Studies on the Antibacterial Effects of Statins - In Vitro and In Vivo
Bergman P; Linde C; Putsep K; Pohanka A; Normark S; Henriques-Normark B; Andersson J; Bjorkhem-Bergman L
Article: PLOS ONE. 2011;6(10):e24581
Effects of Streptococcus pneumoniae Strain Background on Complement Resistance
Hyams C; Opel S; Hanage W; Yuste J; Bax K; Henriques-Normark B; Spratt BG; Brown JS
Article: PLOS ONE. 2011;6(12):e29316
Impaired Release of Antimicrobial Peptides into Nasal Fluid of Hyper-IgE and CVID Patients
Cederlund A; Olliver M; Rekha RS; Lindh M; Lindbom L; Normark S; Henriques-Normark B; Andersson J; Agerberth B; Bergman P
Article: JOURNAL OF INFECTIOUS DISEASES. 2010;202(8):1287-1295
Influenza Enhances Susceptibility to Natural Acquisition of and Disease due to Streptococcus pneumoniae in Ferrets
McCullers JA; McAuley JL; Browall S; Iverson AR; Boyd KL; Normark BH
Article: INFECTION AND IMMUNITY. 2010;78(5):1943-1951
Characterization of a Novel Murine Model of Staphylococcus saprophyticus Urinary Tract Infection Reveals Roles for Ssp and SdrI in Virulence
Kline KA; Ingersoll MA; Nielsen HV; Sakinc T; Henriques-Normark B; Gatermann S; Caparon MG; Hultgren SJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(5):3300-3309
Disulfide Bond Formation and Cysteine Exclusion in Gram-positive Bacteria
Daniels R; Mellroth P; Bernsel A; Neiers F; Normark S; von Heijne G; Henriques-Normark B
Article: VACCINE. 2009;27:G27-G32
The epidemiology of pneumococcal infections-The Swedish experience
Darenberg J; Normark BH
Article: JOURNAL OF MOLECULAR BIOLOGY. 2009;393(3):704-716
Two Crystal Structures of Pneumococcal Pilus Sortase C Provide Novel Insights into Catalysis and Substrate Specificity
Neiers F; Madhurantakam C; Falker S; Manzano C; Dessen A; Normark S; Henriques-Normark B; Achour A
Article: EMBO MOLECULAR MEDICINE. 2009;1(4):211-222
Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression
Littmann M; Albiger B; Frentzen A; Normark S; Henriques-Normark B; Plant L
Article: JOURNAL OF IMMUNOLOGY. 2009;182(12):7865-7877
Clinical Isolates of Streptococcus pneumoniae Bind the Complement Inhibitor Cob-Binding Protein in a PspC Allele-Dependent Fashion
Dieudonne-Vatran A; Krentz S; Blom AM; Meri S; Henriques-Normark B; Riesbeck K; Albiger B
Article: FEMS MICROBIOLOGY LETTERS. 2009;296(2):235-240
Resistance to bacitracin in Streptococcus pyogenes from oropharyngeal colonization and noninvasive infections in Portugal was caused by two clones of distinct virulence genotypes.
Pires R; Rolo D; Mato R; Feio de Almeida J; Johansson C; Henriques-Normark B; Morais A; Brito-Avô A; Gonçalo-Marques J; Santos-Sanches I
Article: JOURNAL OF BACTERIOLOGY. 2009;191(10):3237-3247
Mechanism for Sortase Localization and the Role of Sortase Localization in Efficient Pilus Assembly in Enterococcus faecalis
Kline KA; Kau AL; Chen SL; Lim A; Pinkner JS; Rosch J; Nallapareddy SR; Murray BE; Henriques-Normark B; Beatty W; Caparon MG; Hultgren SJ
Article: BMC MICROBIOLOGY. 2009;9:75
Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells
Muschiol S; Normark S; Henriques-Normark B; Subtil A
Article: JOURNAL OF INFECTIOUS DISEASES. 2009;199(7):1032-1042
Pattern of Accessory Regions and Invasive Disease Potential in Streptococcus pneumoniae
Blomberg C; Dagerhamn J; Dahlberg S; Browall S; Fernebro J; Albiger B; Morfeldt E; Normark S; Henriques-Normark B
Article: JOURNAL OF CLINICAL MICROBIOLOGY. 2009;47(4):1155-1165
Clinical and Microbiological Characteristics of Severe Streptococcus pyogenes Disease in Europe
Luca-Harari B; Darenberg J; Neal S; Siljander T; Strakova L; Tanna A; Creti R; Ekelund K; Koliou M; Tassios PT; van der Linden M; Straut M; Vuopio-Varkila J; Bouvet A; Efstratiou A; Schalen C; Henriques-Normark B; Jasir A
Article: PLOS ONE. 2009;4(3):e4840
Increased Susceptibility for Superinfection with Streptococcus pneumoniae during Influenza Virus Infection Is Not Caused by TLR7-Mediated Lymphopenia
Stegemann S; Dahlberg S; Kroeger A; Gereke M; Bruder D; Henriques-Normark B; Gunzer M
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2009;65(Pt 1):55-58
Cloning, expression, purification, crystallization and preliminary X-ray analysis of the pilus-associated sortase C from Streptococcus pneumoniae
Neiers F; Madhurantakam C; Falker S; Normark S; Henriques-Normark B; Achour A
Article: FOODBORNE PATHOGENS AND DISEASE. 2008;5(6):755-761
Characterization of Human Invasive Isolates of Listeria monocytogenes in Sweden 1986-2007
Parihar VS; Lopez-Valladares G; Danielsson-Tham M-L; Peiris I; Helmersson S; Unemo M; Andersson B; Arneborn M; Bannerman E; Barbuddhe S; Bille J; Hajdu L; Jacquet C; Johansson C; Lofdahl M; Mollerberg G; Ringberg H; Rocourt J; Tjernberg I; Ursing J; Henriques-Normark B; Tham W
Article: MOLECULAR MICROBIOLOGY. 2008;70(3):595-607
Sortase-mediated assembly and surface topology of adhesive pneumococcal pili
Falker S; Nelson AL; Morfeldt E; Jonas K; Hultenby K; Ries J; Melefors O; Normark S; Henriques-Normark B
Article: VACCINE. 2008;26(43):5541-5546
Effects of a large-scale introduction of the pneumococcal polysaccharide vaccine among elderly persons in Stockholm, Sweden
Spindler C; Hedlund J; Jasir A; Normark BH; Ortqvist A
Article: CELLULAR SIGNALLING. 2008;20(10):1873-1881
Bacterial ligand of TLR2 signals Stat activation via induction of IRF1/2 and interferon-α production
Liljeroos M; Vuolteenaho R; Rounioja S; Henriques-Normark B; Hallman M; Ojaniemi M
Article: INFECTION AND IMMUNITY. 2008;76(8):3710-3716
The capsule sensitizes Streptococcus pneumoniae to α-defensins human neutrophil proteins 1 to 3
Beiter K; Wartha F; Hurwitz R; Normark S; Zychlinsky A; Henriques-Normark B
Article: JOURNAL OF CLINICAL MICROBIOLOGY. 2008;46(7):2359-2367
Epidemiology of severe Streptococcus pyogenes disease in Europe
Lamagni TL; Darenberg J; Luca-Harari B; Siljander T; Efstratiou A; Henriques-Normark B; Vuopio-Varkila J; Bouvet A; Creti R; Ekelund K; Koliou M; Reinert RR; Stathi A; Strakova L; Ungureanu V; Schalen C; Jasir A
Article: FASEB JOURNAL. 2008;22(7):2427-2434
Identification of heparin/heparan sulfate interacting protein as a major broad-spectrum antimicrobial protein in lung and small intestine
Meyer-Hoffert U; Hornef M; Henriques-Normark B; Normark S; Andersson M; Putsep K
Article: BMC INFECTIOUS DISEASES. 2008;8:83
An individual-based network model to evaluate interventions for controlling transmission
Karlsson D; Jansson A; Normark BH; Nilsson P
Article: GUT. 2008;57(6):764-771
Secreted enteric antimicrobial activity localises to the mucus surface layer
Meyer-Hoffert U; Hornef MW; Henriques-Normark B; Axelsson L-G; Midtvedt T; Putsep K; Andersson M
Article: SCIENCE SIGNALING. 2008;1(21):pe25
ETosis : A Novel Cell Death Pathway
Wartha F; Henriques-Normark B
Article: BMC MICROBIOLOGY. 2008;8:65
The influence of in vitro fitness defects on pneumococcal ability to colonize and to cause invasive disease
Fernebro J; Blomberg C; Morfeldt E; Wolf-Watz H; Normark S; Normark BH
Article: JOURNAL OF CLINICAL MICROBIOLOGY. 2008;46(3):863-868
Determination of accessory gene patterns predicts the same relatedness among strains of Streptococcus pneumoniae as sequencing of housekeeping genes does and represents a novel a approach in molecular epidemiology
Dagerhamn J; Blomberg C; Browall S; Sjostrom K; Morfeldt E; Henriques-Normark B
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2008;205(1):183-193
Developmental switch of intestinal antimicrobial peptide expression
Menard S; Foerster V; Lotz M; Guetle D; Duerr CU; Gallo RL; Henriques-Normark B; Puetsep K; Andersson M; Glocker EO; Hornef MW
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2008;205(1):117-131
Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies
Giefing C; Meinke AL; Hanner M; Henics T; Minh DB; Gelbmann D; Lundberg U; Senn BM; Schunn M; Habel A; Henriques-Normark B; Oetqvist A; Kalin M; von Gabain A; Nagy E
Article: MOLECULAR MICROBIOLOGY. 2007;66(2):329-340
RrgA is a pilus-associated adhesin in Streptococcus pneumoniae
Nelson AL; Ries J; Bagnoli F; Dahlberg S; Falker S; Rounioja S; Tschop J; Morfeldt E; Ferlenghi I; Hilleringmann M; Holden DW; Rappuoli R; Normark S; Barocchi MA; Henriques-Normark B
Article: CLINICAL INFECTIOUS DISEASES. 2007;45(4):450-458
Molecular and clinical characteristics of invasive group A streptococcal infection in Sweden
Darenberg J; Luca-Harari B; Jasir A; Sandgren A; Pettersson H; Schalen C; Norgren M; Romanus V; Norrby-Teglund A; Normark BH
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(31):12907-12912
Clonal success of piliated penicillin nonsusceptible pneumococci
Sjoestroem K; Blomberg C; Fernebro J; Dagerhamn J; Morfeldt E; Barocchi MA; Browall S; Moschioni M; Andersson M; Henriques F; Albiger B; Rappuoli R; Normark S; Henriques-Normark B
Article: BIOSYSTEMS. 2007;90(1):211-223
Modeling the regulation of the competence-evoking quorum sensing network in Streptococcus pneumoniae
Karlsson D; Karlsson S; Gustafsson E; Normark BH; Nilsson P
Article: CELLULAR MICROBIOLOGY. 2007;9(5):1162-1171
Capsule and D-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps
Wartha F; Beiter K; Albiger B; Fernebro J; Zychlinsky A; Normark S; Henriques-Normark B
Article: JOURNAL OF CLINICAL MICROBIOLOGY. 2007;45(4):1175-1179
International quality assurance study for characterization of Streptococcus pyogenes.
Neal S; Beall B; Ekelund K; Henriques-Normark B; Jasir A; Johnson D; Kaplan E; Lovgren M; Reinert RR; Strep-EURO Study Group; International Streptococcus Reference Laboratories; Efstratiou A
Article: CELLULAR MICROBIOLOGY. 2007;9(3):633-644
Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection
Albiger B; Dahlberg S; Sandgren A; Wartha F; Beiter K; Katsuragi H; Akira S; Normark S; Henriques-Normark B
Article: FEBS LETTERS. 2007;581(4):587-595
Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle
Bailey L; Gylfe A; Sundin C; Muschiol S; Elofsson M; Nordstrom P; Henriques-Normark B; Lugert R; Waldenstrom A; Wolf-Watz H; Bergstrom S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(39):14566-14571
A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis
Muschiol S; Bailey L; Gylfe A; Sundin C; Hultenby K; Bergstrom S; Elofsson M; Wolf-Watz H; Normark S; Henriques-Normark B
Article: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES. 2006;25(8):518-521
Addition of a macrolide to a β-lactam in bacteremic pneumococcal pneumonia
Dwyer R; Ortqvist A; Aufwerber E; Henriques Normark B; Marrie TJ; Mufson MA; Torres A; Woodhead MA; Alenius M; Kalin M
Article: CURRENT BIOLOGY. 2006;16(4):401-407
An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps
Beiter K; Wartha F; Albiger B; Normark S; Zychlinsky A; Henriques-Normark B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(8):2857-2862
A pneumococcal pilus influences virulence and host inflammatory responses
Barocchi MA; Rie J; Zogaj X; Hemsley C; Albiger B; Kanth A; Dahlberg S; Fernebro J; Moschioni M; Masignani V; Hultenby K; Taddei AR; Beiter K; Wartha F; von Euler A; Covacci A; Holden DW; Normark S; Rappuoli R; Henriques-Normark B
Article: CLINICAL INFECTIOUS DISEASES. 2006;42(4):451-459
Clonal and capsular types decide whether pneumococci will act as a primary or opportunistic pathogen
Sjöström K; Spindler C; Ortqvist A; Kalin M; Sandgren A; Kühlmann-Berenzon S; Henriques-Normark B
Article: MICROBIAL DRUG RESISTANCE. 2006;12(1):16-22
Penicillin-resistant pneumococci in Sweden 1997-2003:: Increased multiresistance despite stable prevalence and decreased antibiotic use
Högberg L; Ekdahl K; Sjöström K; Olsson-Liljequist B; Walder M; Melander E; Ringberg H; Normark BH
Article: CELLULAR MICROBIOLOGY. 2005;7(11):1603-1615
Myeloid differentiation factor 88-dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice
Albiger B; Sandgren A; Katsuragi H; Meyer-Hoffert U; Beiter K; Wartha F; Hornef M; Normark S; Normark BH
Article: MICROBIAL DRUG RESISTANCE. 2005;11(4):360-370
Group A Streptococci from carriage and disease in Portugal: evolution of antimicrobial resistance and T antigenic types during 2000-2002.
Pires R; Rolo D; Gama-Norton L; Morais A; Lito L; Salgado MJ; Johansson C; Möllerberg G; Henriques-Normark B; Gonçalo-Marques J; Santos-Sanches I
Article: CLINICAL INFECTIOUS DISEASES. 2004;38(6):836-842
Differences in potency of intravenous polyspecific immunoglobulin G against streptococcal and staphylococcal superantigens:: Implications for therapy of toxic shock syndrome
Darenberg J; Söderquist B; Normark BH; Norrby-Teglund A
Article: JOURNAL OF INFECTIOUS DISEASES. 2004;189(5):785-796
Effect of clonal and serotype-specific properties on the invasive capacity of Streptococcus pneumoniae
Sandgren A; Sjöström K; Olsson-Liljequist BO; Christensson B; Samuelsson A; Kronvall G; Normark BH
Article: JOURNAL OF INFECTIOUS DISEASES. 2004;189(2):328-338
Capsular expression in Streptococcus pneumoniae negatively affects spontaneous and antibiotic-induced lysis and contributes to antibiotic tolerance.
Fernebro J; Andersson I; Sublett J; Morfeldt E; Novak R; Tuomanen E; Normark S; Normark BH
Article: BONE MARROW TRANSPLANTATION. 2004;33(1):79-85
Viridans streptococcal septicaemia in neutropenic patients:: role of proinflammatory cytokines
Ihendyane N; Sparrelid E; Wretlind B; Remberger M; Andersson J; Ljungman P; Ringdén O; Normark BH; Allen U; Low DE; Norrby-Teglund A
Article: JOURNAL OF INFECTIOUS DISEASES. 2003;188(10):1578-1586
Toxin-gene profile heterogeneity among endemic invasive European group A streptococcal isolates
Schmitz FJ; Beyer A; Charpentier E; Normark BH; Schade M; Fluit AC; Hafner D; Novak R
Article: CLINICAL INFECTIOUS DISEASES. 2003;37(9):1189-1193
Group A streptococcal infections in Sweden:: A comparative study of invasive and noninvasive infections and analysis of dominant T28 emm28 isolates
Eriksson BKG; Norgren M; McGregor K; Spratt BG; Normark BH
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2003;198(8):1225-1235
Intracellular recognition of lipopolysaccharide by Toll-like receptor 4 in intestinal epithelial cells
Hornef MW; Normark BH; Vandewalle A; Normark S
Article: MICROBIAL DRUG RESISTANCE. 2003;9(4):337-344
Clonal analysis of Streptococcus pneumoniae nonsusceptible to penicillin at day-care centers with index cases, in a region with low incidence of resistance:: Emergence of an invasive type 35B clone among carriers
Normark BH; Christensson B; Sandgren A; Noreen B; Sylvan S; Burman LG; Olsson-Liljequist B
Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2003;35(8):452-458
Capsular types and antibiotic susceptibility of invasive Streptococcus pneumoniae among children in Sweden
Hedlund J; Sörberg M; Normark BH; Kronvall G
Article: COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES. 2003;26(1):25-35
RAPD-PCR and PFGE as tools in the investigation of an outbreak of beta-haemolytic Streptococcus group A in a Swedish hospital
González-Rey C; Belin AM; Jörbeck H; Norman M; Krovacek K; Henriques B; Källenius G; Svenson SB
Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2001;33(11):848-850
Changes in serotype distribution may hamper efficacy of pneumococcal conjugate vaccines in children
Normark BH; Örtqvist Å; Kalin M; Olsson-Liljequist B; Hedlund J; Svenson SB; Källenius G
Article: ACTA PAEDIATRICA, INTERNATIONAL JOURNAL OF PAEDIATRICS, SUPPLEMENT. 2000;89(435):35-39
Epidemiology of pneumococcal infections in Swedish children.
Eriksson M; Henriques B; Ekdahl K
Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2000;32(6):609-614
Invasive group A streptococcal infections in Sweden in 1994 and 1995:: Epidemiology and clinical spectrum
Svensson N; Öberg S; Henriques B; Holm S; Källenius G; Romanus V; Giesecke J
Article: NATURE. 1999;399(6736):590-593
Emergence of vancomycin tolerance in Streptococcus pneumoniae
Novak R; Henriques B; Charpentier E; Normark S; Tuomanen E
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All other publications

Editorial comment: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2023;208(8):832-834
Immunization with Attenuated Pneumococcal Strains Provides Protection against Pneumococcal Colonization in Humans
Narciso AR; Henriques-Normark B
Letter: CLINICAL MICROBIOLOGY AND INFECTION. 2023;29(7):944-946
A case of meningitis caused by Streptococcus pseudopneumoniae in Sweden
Garriss G; Marking UW; Nannapaneni P; Henriques-Normark B; Blomqvist K
Editorial comment: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(7):e2221546120
Single-cell recordings reveal subpopulations that grow and generate resistance at bactericidal concentrations of antibiotics
Henriques-Normark B; Normark S
Preprint: MEDRXIV. 2022
Sustained reductions in life-threatening invasive bacterial diseases during the first two years of the COVID-19 pandemic: analyses of prospective surveillance data from 30 countries participating in the IRIS Consortium
Shaw D; Abad R; Amin-Chowdhury Z; Bautista A; Bennett D; Broughton K; Cao B; Casanova C; Choi EH; Chu Y-W; Claus H; Coelho J; Corcoran M; Cottrell S; Cunney R; Cuypers L; Dalby T; Davies H; de Gouveia L; Deghmane A-E; Demczuk W; Desmet S; Domenech M; Drew R; du Plessis M; Duarte C; Erlendsdóttir H; Fry N; Fuursted K; Hale T; Henares D; Henriques-Normark B; Hilty M; Hoffmann S; Humphreys H; Ip M; Jacobsson S; Johnson C; Johnston J; Jolley KA; Kawabata A; Kozakova J; Kristinsson KG; Krizova P; Kuch A; Ladhani S; Lâm T-T; Eugenia LM; Lindholm L; Litt D; Maiden MC; Martin I; Martiny D; Mattheus W; McCarthy ND; McElligott M; Meehan M; Meiring S; Mölling P; Morfeldt E; Morgan J; Mulhall R; Muñoz-Almagro C; Murdoch D; Murphy J; Musilek M; Mzabi A; Novakova L; Oftadeh S; Perez-Arguello A; Pérez-Vázquez M; Perrin M; Perry M; Prevost B; Roberts M; Rokney A; Ron M; Sanabria OM; Scott KJ; Sheppard C; Siira L; Sintchenko V; Skoczyńska A; Sloan M; Slotved H-C; Smith AJ; Steens A; Taha M-K; Toropainen M; Tzanakaki G; Vainio A; van der Linden MP; van Sorge NM; Varon E; Vohrnova S; von Gottberg A; Yuste J; Zanella R; Zhou F; Brueggemann AB
Letter: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022;206(12):1564-1567
Metatranscriptomics of Nasopharyngeal Microbiota and Host Distinguish between Pneumonia and Health
Nannapaneni P; Sundh J; Prast-Nielsen S; Rhedin S; Ortqvist A; Naucler P; Henriques-Normark B
Editorial comment: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022;206(11):1312-1314
An Experimental Human Colonization Model with Pneumococcal Serotype 3 has the Potential to be Used for Vaccine Studies
Henriques-Normark B; Narciso AR
Review: TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE. 2021;115(10):1122-1129
Key considerations on the potential impacts of the COVID-19 pandemic on antimicrobial resistance research and surveillance
Rodriguez-Bano J; Maria Rossolini G; Schultsz C; Tacconelli E; Murthy S; Ohmagari N; Holmes A; Bachmann T; Goossens H; Canton R; Roberts AP; Henriques-Normark B; Clancy CJ; Huttner B; Fagerstedt P; Lahiri S; Kaushic C; Hoffman SJ; Warren M; Zoubiane G; Essack S; Laxminarayan R; Plant L
Editorial comment: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021;203(5):539-540
Experimental Model for Studies of Pneumococcal Colonization in Older Adults
Iovino F; Henriques-Normark B
Review: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2021;11:643326
Virus-Induced Changes of the Respiratory Tract Environment Promote Secondary Infections With Streptococcus pneumoniae
Sender V; Hentrich K; Henriques-Normark B
Preprint: MEDRXIV. 2020
The Invasive Respiratory Infection Surveillance (IRIS) Initiative reveals significant reductions in invasive bacterial infections during the COVID-19 pandemic
Brueggemann AB; van Rensburg MJJ; Shaw D; McCarthy N; Jolley KA; Maiden MC; van der Linden MP; Amin-Chowdhury Z; Bennett DE; Borrow R; Brandileone M-CC; Broughton K; Campbell R; Cao B; Casanova C; Choi EH; Chu YW; Clark SA; Claus H; Coelho J; Corcoran M; Cottrell S; Cunney RJ; Dalby T; Davies H; de Gouveia L; Deghmane A-E; Demczuk W; Desmet S; Drew RJ; du Plessis M; Erlendsdottir H; Fry NK; Fuursted K; Gray SJ; Henriques-Normark B; Hale T; Hilty M; Hoffmann S; Humphreys H; Ip M; Jacobsson S; Johnston J; Kozakova J; Kristinsson KG; Krizova P; Kuch A; Ladhani SN; Lâm T-T; Lebedova V; Lindholm L; Litt D; Martin I; Martiny D; Mattheus W; McElligott M; Meehan M; Meiring S; Mölling P; Morfeldt E; Morgan J; Mulhall RM; Muñoz-Almagro C; Murdoch DR; Murphy J; Musilek M; Mzabi A; Perez-Argüello A; Perrin M; Perry M; Redin A; Roberts R; Roberts M; Rokney A; Ron M; Scott K; Sheppard CL; Siira L; Skoczyńska A; Sloan M; Slotved H-C; Smith AJ; Song JY; Taha M-K; Toropainen M; Tsang D; Vainio A; van Sorge NM; Varon E; Vlach J; Vogel U; Vohrnova S; von Gottberg A; Zanella RC; Zhou F
Corrigendum: MBIO. 2020;11(6):e02809-e02820
Sex Steroids Induce Membrane Stress Responses and Virulence Properties in Pseudomonas aeruginosa (vol 11, e01774-20, 2020)
Vidaillac C; Yong VFL; Aschtgen M-S; Qu J; Yang S; Xu G; Seng ZJ; Brown AC; Ali MK; Jaggi TK; Sankaran J; Foo YH; Righetti F; Nedumaran AM; Mac Aogain M; Roizman D; Richard J-A; Rogers TR; Toyofuku M; Luo D; Loh E; Wohland T; Czarny B; Horvat JC; Hansbro PM; Yang L; Li L; Normark S; Henriques-Normark B; Chotirmall SH
Review: MICROORGANISMS. 2020;8(10):E1546-1546
Lysogeny in Streptococcus pneumoniae
Garriss G; Henriques-Normark B
Preprint: BIORXIV. 2020
Neuronal death in pneumococcal meningitis is triggered by pneumolysin and pilus-1 interactions with β-actin
Tabusi M; Thorsdottir S; Lysandrou M; Narciso AR; Minoia M; Henriques-Normark B; Iovino F
Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2020;287(3):336-338
The rise of hyper-virulence
Aschtgen M-S; Henriques-Normark B; Normark S
Review: MOLECULAR MICROBIOLOGY. 2020;113(3):650-658
The impact of the ancillary pilus-1 protein RrgA of Streptococcus pneumoniae on colonization and disease
Iovino F; Nannapaneni P; Henriques-Normark B; Normark S
Review: CELLULAR MICROBIOLOGY. 2019;21(11):e13077
Emerging concepts in the pathogenesis of the Streptococcus pneumoniae: From nasopharyngeal colonizer to intracellular pathogen
Subramanian K; Henriques-Normark B; Normark S
Book chapter: PROTEIN SECRETION IN BACTERIA. 2019;p. 129-135
Gram‐Positive Type IV Pili and Competence
Muschiol S; Aschtgen M-S; Nannapaneni P; Henriques-Normark B
Preprint: BIORXIV. 2019
Fighting the spread of antibiotic resistance with bacterial competence inhibitors
Domenech A; Brochado AR; Sender V; Hentrich K; Henriques-Normark B; Typas A; Veening J-W
Review: JOURNAL OF INTERNAL MEDICINE. 2019;285(6):635-652
Pathogenesis and prevention of risk of cardiovascular events in patients with pneumococcal community-acquired pneumonia
Feldman C; Normark S; Henriques-Normark B; Anderson R
Preprint: BIORXIV. 2019
Meningitis pathogens evade immune responses by thermosensing
Eichner H; Spelmink L; Pathak A; Henriques-Normark B; Loh E
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49:102-103
Bacterial-strain dependency in secondary pneumococcal pneumonia in the post-influenza lung - a role for alveolar type II epithelial cells?
Boehme JD; Sharma-Chawla N; Jeron A; Sender V; Henriques-Normark B; Stegemann-Koniszewski S; Bruder D
Review: FRONTIERS IN MICROBIOLOGY. 2019;10:576
The Role of Microglia in Bacterial Meningitis: Inflammatory Response, Experimental Models and New Neuroprotective Therapeutic Strategies
Thorsdottir S; Henriques-Normark B; Iovino F
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2019;90(6)
Pneumolysin interaction with the mannose receptor promotes pneumococcal invasion of the airways by blocking inflammatory responses
Subramanian K; Neill DR; Malak HA; Spelmink L; Khandaker S; Marchiori GDL; Dearing E; Kirby A; Yang M; Achour A; Nilvebrant J; Nygren P-A; Plant L; Kadioglu A; Henriques-Normark B
Preprint: BIORXIV. 2018
Comparative genomic analysis of the emerging pathogen Streptococcus pseudopneumoniae: novel insights into virulence determinants and identification of a novel species-specific molecular marker
Garriss G; Nannapaneni P; Simões A; Browall S; Sá-Leão R; Goossens H; de Lencastre H; Henriques-Normark B
Letter: CLINICAL INFECTIOUS DISEASES. 2018;66(10):1642-1643
Comparing the Impact of 10-Valent and 13-Valent Pneumococcal Conjugate Vaccines on Invasive Pneumococcal Disease Reply
Naucler P; Galanis I; Morfeldt E; Darenberg J; Ortqvist A; Henriques-Normark B
Preprint: BIORXIV. 2017
Detection of human disease conditions by single-cell morpho-rheological phenotyping of whole blood
Toepfner N; Herold C; Otto O; Rosendahl P; Jacobi A; Kräter M; Stächele J; Menschner L; Herbig M; Ciuffreda L; Ranford-Cartwright L; Grzybek M; Coskun Ü; Reithuber E; Garriss G; Mellroth P; Henriques-Normark B; Tregay N; Suttorp M; Bornhäuser M; Chilvers ER; Berner R; Guck J
Review: TRENDS IN MICROBIOLOGY. 2016;24(4):307-315
How Does Streptococcus pneumoniae Invade the Brain?
Iovino F; Seinen J; Henriques-Normark B; van Diji JM
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46:790
BCG skin infection triggers IL-1R-MyD88-dependent migration of EpCAM^low CD11b^high skin dendritic cells to draining lymph node during CD4⁺ T-cell priming
Bollampalli VP; Yamashiro LH; Feng X; Bierschenk D; Gao Y; Blom H; Henriques-Normark B; Nylen S; Rothfuchs AG
Editorial comment: CELL HOST & MICROBE. 2015;18(4):390-391
Streptococcal M1 Strikes by Neutralizing Cathelicidins
Henriques-Normark B; Normark S
Conference publication: ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2015;71:S277
The keratin-10 binding region of the pneumococcal scrinc rich repeat protein (PsrP) forms a domain-swapped dimcr and intermolecular 13-sheets implications for biofilm formation of Streptococcus pneumonicte
Schulte T; Lofling J; Mikaelsson C; Kikhney A; Hentrich K; Diamante A; Ebel C; Normark S; Svergun D; Heniques-Normark B; Achour A
Conference publication: ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2015;71:S225
Structural basis of the peptidoglycan binding to LytA, the major pneumococcal autolysin
Sandalova T; Henriques-Normark B; Hesek D; Lee M; Mobashery S; Kikhney A; Svergun D; Mellroth P; Achour A
Letter: CLINICAL INFECTIOUS DISEASES. 2015;60(2):324-325
Efficacy of Polyspecific Intravenous Immunoglobulin Therapy in Streptococcal Toxic Shock Syndrome Reply
Linner A; Sjolin J; Darenberg J; Henriques-Normark B; Norrby-Teglund A
Corrigendum: OPEN BIOLOGY. 2014;4(10):140172
The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold (vol 4, 130090, 2014)
Schulte T; Lofling J; Mikaelsson C; Kikhney A; Hentrich K; Diamante A; Ebel C; Normark S; Svergun D; Henriques-Normark B; Achour A
Review: UPSALA JOURNAL OF MEDICAL SCIENCES. 2014;119(2):205-208
Bacterial vaccines and antibiotic resistance
Henriques-Normark B; Normark S
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(6):471
A Single Point Mutation in the spxB Gene of Streptococcus pneumoniae Dramatically Alters the Interaction with Macrophages and Increases the Severity of Infection
Norman M; Syk A; Fernebro J; Gallotta M; Farmand S; Sandgren A; Normark S; Henriques-Normark B
Book chapter: THE PROKARYOTES. 2013;p. 401-427
Meningitis
Tønjum T; Brandtzæg P; Henriques-Normark B
Review: CELLULAR MICROBIOLOGY. 2011;13(2):186-197
Cellular interactions by LPxTG-anchored pneumococcal adhesins and their streptococcal homologues
Lofling J; Vimberg V; Battig P; Henriques-Normark B
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1408-1414
Commensal pathogens, with a focus on Streptococcus pneumoniae, and interactions with the human host
Henriques-Normark B; Normark S
Book chapter: BACTERIAL VIRULENCE. 2010;p. 103-138
Two Important Bacterial Pathogens Causing Community Acquired Pneumonia: Streptococcus pneumoniae and Legionella pneumophila
Henriques‐Normark B; Buchrieser C
Letter: JOURNAL OF INFECTIOUS DISEASES. 2009;200(7):1181-1182
Role Played by psrP-secY2A2 (Accessory Region 34) in the Invasive Disease Potential of Streptococcus pneumoniae Reply
Henriques-Normark B
Review: CELL HOST & MICROBE. 2009;5(6):580-592
Bacterial Adhesins in Host-Microbe Interactions
Kline KA; Falker S; Dahlberg S; Normark S; Henriques-Normark B
Review: NATURE REVIEWS MICROBIOLOGY. 2008;6(11):827-837
The rise and fall of bacterial clones: Streptococcus pneumoniae
Henriques-Normark B; Blomberg C; Dagerhamn J; Battig P; Normark S
Book chapter: HORIZONTAL GENE TRANSFER IN THE EVOLUTION OF PATHOGENESIS. 2008;p. 217-236
Genomic or Pathogenicity Islands in Streptococcus pneumoniae
Albiger B; Blomberg C; Dagerhamn J; Normark S; Henriques-Normark B
Review: CURRENT OPINION IN INFECTIOUS DISEASES. 2008;21(3):304-312
The function and biological role of toll-like receptors in infectious diseases: an update
Hornef MW; Henriques-Normark B; Normark S
Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2008;197(6):888-896
Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related
Moschioni M; Donati C; Muzzi A; Masignani V; Censini S; Hanage WP; Bishop CJ; Reis JN; Normark S; Henriques-Normark B; Covacci A; Rappuoli R; Barocchi MA
Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2008;197(2):225-234
Lysogenic transfer of group A Streptococcus superantigen gene among streptococci
Vojtek I; Pirzada ZA; Henriques-Normark B; Mastny M; Janapatla RP; Charpentier E
Conference publication: WIENER KLINISCHE WOCHENSCHRIFT. 2008;120:148-149
TLR7 triggered lymphopenia does not influence susceptibility to post-influenza pneumococcal infection
Stegemann S; Dahlberg S; Bruder D; Henriques-Normark B; Gunzer M
Review: JOURNAL OF INTERNAL MEDICINE. 2007;261(6):511-528
Role of the innate immune system in host defence against bacterial infections: focus on the Toll-like receptors
Albiger B; Dahlberg S; Henriques-Normark B; Normark S
Review: CURRENT OPINION IN MICROBIOLOGY. 2007;10(1):52-56
Neutrophil extracellular traps: casting the NET over pathogenesis
Wartha F; Beiter K; Normark S; Henriques-Normark B
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2007;65(6):608
PI3 kinase and Btk modulate the activity of IRF and Stat proteins in TLR2 signalling
Liljeroos M; Rounioja S; Vuolteenaho R; Henriques-Normark B; Hallman M; Ojaniemi M
Review: FEMS MICROBIOLOGY REVIEWS. 2006;30(6):841-852
The fallacies of hope: will we discover new antibiotics to combat pathogenic bacteria in time?
Vicente M; Hodgson J; Massidda O; Tonjum T; Henriques-Normark B; Ron EZ
Published conference paper: CLINICAL MICROBIOLOGY AND INFECTION. 2006;12(4):338-344
Endocarditis and pericarditis complicating pneumococcal bacteraemia, with special reference to the adhesive abilities of pneumococci: results from a prospective study
Kan B; Ries J; Normark BH; Chang FY; Feldman C; Ko WC; Rello J; Snydman DR; Yu VL; Ortqvist A
Letter: JOURNAL OF INFECTIOUS DISEASES. 2006;193(3):477-478
Pneumococcal serotypes and virulence - Reply
Henriques-Normark B
Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2005;192(5):791-800
Virulence in mice of pneumococcal clonal types with known invasive disease potential in humans.
Sandgren A; Albiger B; Orihuela CJ; Tuomanen E; Normark S; Henriques-Normark B
Editorial comment: SCIENCE. 2005;307(5713):1211-1212
Microbiology - A pathogen attacks while keeping up defense
Normark S; Nilsson C; Normark BH
Book chapter: CHEMICAL IMMUNOLOGY AND ALLERGY. 2005;p. 72-98
Bacterial evasion of innate defense at epithelial linings.
Hornef MW; Normark S; Henriques-Normark B; Rhen M
Editorial comment: NATURE MEDICINE. 2004;10(8):780-781
Staphylococcal protein A inflames the lungs
Normark BH; Normark S; Norrby-Teglund A
Published conference paper: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2004;36(9):629-635
The impact of active intervention on the spread of penicillin-resistant streptococcus pneumoniae in Swedish day-care centres
Högberg L; Normark BH; Ringberg H; Stenqvist K; Fredlund H; Geli P; Grabowska K; Melander E; Laurell M; Åhrén C; Törnqvist E; Fält R; Höglund D; Möllerberg G; Ekdahl K
Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2003;90:63-89
Persistent infection with Helicobacter pylori and the development of gastric cancer
Normark S; Nilsson C; Normark BH; Hornef MW
Editorial comment: NATURE MEDICINE. 2002;8(12):1349-1350
Hosting for the cruel and the inconsequential
Normark BH; Normark S
Review: CLINICAL MICROBIOLOGY AND INFECTION. 2002;8(10):613-622
Antibiotic tolerance in pneumococci
Normark BH; Normark S
Review: JOURNAL OF INTERNAL MEDICINE. 2002;252(2):91-106
Evolution and spread of antibiotic resistance
Normark BH; Normark S
Editorial comment: NATURE MEDICINE. 2001;7(11):1182-1184
How neutrophils recognize bacteria and move toward infection
Normark S; Normark BH; Hornef M
Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2001;184(7):861-869
Dynamics of penicillin-susceptible clones in invasive pneumococcal disease
Normark BH; Kalin M; Örtqvist Å; Åkerlund T; Liljequist BO; Hedlund J; Svenson SB; Zhou J; Spratt BG; Normark S; Källenius G
Published conference paper: CLINICAL INFECTIOUS DISEASES. 2001;32(4):552-558
Clinical isolates of Streptococcus pneumoniae that exhibit tolerance of vancomycin
Normark BH; Novak R; Örtqvist Å; Källenius G; Tuomanen E; Normark S
Thesis / dissertation: 2000
Streptococcus pneumoniae : molecular epidemiology of isolates causing invasive disease and characterization of tolerance responses to lytic antibiotics
Henriques Normark, Birgitta
Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2000;182(3):840-847
Prospective study of prognostic factors in community-acquired bacteremic pneumococcal disease in 5 countries
Kalin M; Örtqvist Å; Almela M; Aufwerber E; Dwyer R; Henriques B; Jorup C; Julander I; Marrie TJ; Mufson MA; Riquelme R; Thalme A; Torres A; Woodhead MA
Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2000;182(3):833-839
Molecular epidemiology of Streptococcus pneumoniae causing invasive disease in 5 countries
Henriques B; Kalin M; Örtqvist Å; Liljequist BO; Almela M; Marrie TJ; Mufson MA; Torres A; Woodhead MA; Svenson SB; Källenius G
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Employments

Professor/Senior Physician, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2010-

Degrees and Education

Doctor Of Philosophy, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2000

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