Birgitta Agerberth

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Public outreach and news

About me

Birgitta Agerberth was appiointed Professor of Medical Microbial Pathogenesis at Karolinska Institutet in 2008. A central question in her research has been how the innate immune system manages to keep us healthy despite all the bacteria we are surrounded by.

Articles

Article: JOURNAL OF INNATE IMMUNITY. 2022;14(5):477-492
The Novel Inducer of Innate Immunity HO53 Stimulates Autophagy in Human Airway Epithelial Cells
Myszor IT; Sigurdsson S; Viktorsdottir AR; Agerberth B; Eskelinen E-L; Ogmundsdottir MH; Gudmundsson GH
Article: EMBO MOLECULAR MEDICINE. 2021;13(8):e14059
Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy
Ren Z; Pan L-L; Huang Y; Chen H; Liu Y; Liu H; Tu X; Liu Y; Li B; Dong X; Pan X; Li H; Fu YV; Agerberth B; Diana J; Sun J
Article: JOURNAL OF IMMUNOLOGY. 2021;207(3):974-984
Citrullination Alters the Antibacterial and Anti-Inflammatory Functions of the Host Defense Peptide Canine Cathelicidin K9CATH In Vitro
Al Adwani S; Padhi A; Karadottir H; Morman C; Graslund A; Vegvari A; Johansson J; Rising A; Agerberth B; Bergman P
Article: JOURNAL OF INFECTIOUS DISEASES. 2021;224(2):332-344
Immunomodulatory Agents Combat Multidrug-Resistant Tuberculosis by Improving Antimicrobial Immunity
Muvva JR; Ahmed S; Rekha RS; Kalsum S; Groenheit R; Schon T; Agerberth B; Bergman P; Brighenti S
Article: BMC INFECTIOUS DISEASES. 2020;20(1):933
Slow radiological improvement and persistent low-grade inflammation after chemotherapy in tuberculosis patients with type 2 diabetes
Mily A; Sarker P; Taznin I; Hossain D; Haq MA; Kamal SMM; Agerberth B; Brighenti S; Raqib R
Article: INFECTION AND IMMUNITY. 2020;88(8):e00186-e00120
Innate Effector Systems in Primary Human Macrophages Sensitize Multidrug-Resistant Klebsiella pneumoniae to Antibiotics
Rekha RS; Karadottir H; Ahmed S; Gudmundsson GH; Agerberth B; Bergman P
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2020;177(12):2726-2742
Cathelicidin-related antimicrobial peptide protects against ischaemia reperfusion-induced acute kidney injury in mice
Pan L-L; Liang W; Ren Z; Li C; Chen Y; Niu W; Fang X; Liu Y; Zhang M; Diana J; Agerberth B; Sun J
Article: SCIENTIFIC REPORTS. 2020;10(1):2376
Studies on citrullinated LL-37: detection in human airways, antibacterial effects and biophysical properties
Al-Adwani S; Wallin C; Balhuizen MD; Veldhuizen EJA; Coorens M; Landreh M; Vegvari A; Smith ME; Qvarfordt I; Linden A; Graslund A; Agerberth B; Bergman P
Article: THERANOSTICS. 2020;10(14):6167-6181
The anti-microbial peptide LL-37/CRAMP levels are associated with acute heart failure and can attenuate cardiac dysfunction in multiple preclinical models of heart failure
Zhou Q; Pan L-L; Xue R; Ni G; Duan Y; Bai Y; Shi C; Ren Z; Wu C; Li G; Agerberth B; Sluijter JP; Sun J; Xiao J
Article: INFECTION AND IMMUNITY. 2019;88(1):e00756-e00719
Klebsiella pneumoniae Expressing VIM-1 Metallo-β-Lactamase Is Resensitized to Cefotaxime via Thiol-Mediated Zinc Chelation
Karadottir H; Coorens M; Liu Z; Wang Y; Agerberth B; Giske CG; Bergman P
Article: MOLECULAR NUTRITION & FOOD RESEARCH. 2019;63(21):e1900307
Low Methoxyl Pectin Protects against Autoimmune Diabetes and Associated Caecal Dysfunction
Wu C; Pan L-L; Luo Y; Niu W; Fang X; Liang W; Li J; Li H; Pan X; Yang G; Chen W; Zhang H; Lakey JRT; Agerberth B; de Vos P; Sun J
Article: SCIENTIFIC REPORTS. 2019;9(1):7114
Novel aroylated phenylenediamine compounds enhance antimicrobial defense and maintain airway epithelial barrier integrity
Myszor IT; Parveen Z; Ottosson H; Bergman P; Agerberth B; Stromberg R; Gudmundsson GH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(15):6027-6041
Innate lymphoid cell type 3-derived interleukin-22 boosts lipocalin-2 production in intestinal epithelial cells via synergy between STAT3 and NF-B
Coorens M; Rao A; Grafe SK; Unelius D; Lindforss U; Agerberth B; Mjosberg J; Bergman P
Article: BMC MEDICINE. 2019;17(1):42
Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury
Bei Y; Pan L-L; Zhou Q; Zhao C; Xie Y; Wu C; Meng X; Gu H; Xu J; Zhou L; Sluijter JPG; Das S; Agerberth B; Sun J; Xiao J
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1733
Modulation of Gut Microbiota by Low Methoxyl Pectin Attenuates Type 1 Diabetes in Non-obese Diabetic Mice
Wu C; Pan L-L; Niu W; Fang X; Liang W; Li J; Li H; Pan X; Chen W; Zhang H; Lakey JRT; Agerberth B; de Vos P; Sun J
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2697
Cathelicidin Contributes to the Restriction of Leishmania in Human Host Macrophages
Crauwels P; Bank E; Walber B; Wenzel UA; Agerberth B; Chanyalew M; Abebe M; Koenig R; Ritter U; Reiling N; van Zandbergen G
Article: MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. 2018;93:782-789
A novel cysteine-linked antibacterial surface coating significantly inhibits bacterial colonization of nasal silicone prongs in a phase one pre-clinical trial
Odeberg J; Wirsen A; Norberg A; Frie J; Printz G; Lagercrantz H; Gudmundsson GH; Agerberth B; Jonsson B
Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(3):292-306
Daily adjunctive therapy with vitamin D₃ and phenylbutyrate supports clinical recovery from pulmonary tuberculosis: a randomized controlled trial in Ethiopia
Bekele A; Gebreselassie N; Ashenafi S; Kassa E; Aseffa G; Amogne W; Getachew M; Aseffa A; Worku A; Raqib R; Agerberth B; Hammar U; Bergman P; Aderaye G; Andersson J; Brighenti S
Article: BMC INFECTIOUS DISEASES. 2018;18(1):303
Immune responses in the treatment of drug-sensitive pulmonary tuberculosis with phenylbutyrate and vitamin D₃ as host directed therapy
Rekha RS; Mily A; Sultana T; Haq A; Ahmed S; Kamal SMM; van Schadewijk A; Hiemstra PS; Gudmundsson GH; Agerberth B; Raqib R
Article: FASEB JOURNAL. 2018;32(5):2827-2840
Prostaglandin E₂ suppresses hCAP18/LL-37 expression in human macrophages via EP2/EP4: implications for treatment of Mycobacterium tuberculosis infection
Wan M; Tang X; Rekha RS; Muvva SSVJR; Brighenti S; Agerberth B; Haeggstrom JZ
Article: EUROPEAN JOURNAL OF ORAL SCIENCES. 2018;126(2):93-100
The host defense peptide LL-37 is detected in human parotid and submandibular/sublingual saliva and expressed in glandular neutrophils
Svensson D; Aidoukovitch A; Anders E; Agerberth B; Andersson F; Ekblad E; Ericson D; Nebel D; Voss U; Nilsson B-O
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:751
Lactose Induces Phenotypic and Functional Changes of Neutrophils and Macrophages to Alleviate Acute Pancreatitis in Mice
Pani L-L; Deng Y-Y; Wang R; Wu C; Li J; Niu W; Yang Q; Bhatia M; Gudmundsson GH; Agerberth B; Diana J; Sun J
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2017;61(7):e02570-e02516
Treatment with Entinostat Heals Experimental Cholera by Affecting Physical and Chemical Barrier Functions of Intestinal Epithelia
Sarker P; Banik A; Stromberg R; Gudmundsson GH; Raqib R; Agerberth B
Article: JOURNAL OF AUTOIMMUNITY. 2017;78:46-56
The host defense peptide LL-37 a possible inducer of the type I interferon system in patients with polymyositis and dermatomyositis
Lu X; Tang Q; Lindh M; Dastmalchi M; Alexanderson H; Silwerfeldt KP; Agerberth B; Lundberg IE; Wick C
Article: METHODS IN MOLECULAR BIOLOGY. 2017;1548:271-281
Assays for Identifying Inducers of the Antimicrobial Peptide LL-37.
Nylén F; Bergman P; Gudmundsson GH; Agerberth B
Article: SCIENTIFIC REPORTS. 2016;6:36692
Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections
Ottosson H; Nylen F; Sarker P; Miraglia E; Bergman P; Gudmundsson GH; Raqib R; Agerberth B; Stromberg R
Article: SCIENTIFIC REPORTS. 2016;6:33274
Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors
Miraglia E; Nylen F; Johansson K; Arner E; Cebula M; Farmand S; Ottosson H; Stromberg R; Gudmundsson GH; Agerberth B; Bergman P
Article: FASEB JOURNAL. 2016;30(2):884-894
Cathelicidins positively regulate pancreatic β-cell functions
Sun J; Xu M; Ortsater H; Lundeberg E; Juntti-Berggren L; Chen YQ; Haeggstrom JZ; Gudmundsson GH; Diana J; Agerberth B
Article: IMMUNOBIOLOGY. 2016;221(2):245-252
Glucocorticoid dexamethasone down-regulates basal and vitamin D3 induced cathelicidin expression in human monocytes and bronchial epithelial cell line
Kulkarni NN; Gunnarsson HI; Yi Z; Gudmundsdottir S; Sigurjonsson OE; Agerberth B; Gudmundsson GH
Article: AUTOPHAGY. 2015;11(9):1688-1699
Phenylbutyrate induces LL-37-dependent autophagy and intracellular killing of Mycobacterium tuberculosis in human macrophages
Rekha RS; Muvva SSVJR; Wan M; Raqib R; Bergman P; Brighenti S; Gudmundsson GH; Agerberth B
Article: IMMUNITY. 2015;43(2):304-317
Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota
Sun J; Furio L; Mecheri R; van der Does AM; Lundeberg E; Saveanu L; Chen Y; van Endert P; Agerberth B; Diana J
Article: MOLECULAR IMMUNOLOGY. 2015;63(2):530-539
Phenylbutyrate induces cathelicidin expression via the vitamin D receptor: Linkage to inflammatory and growth factor cytokines pathways
Kulkarni NN; Yi Z; Huehnken C; Agerberth B; Gudmundsson GH
Article: PLOS ONE. 2015;10(9):e0138340
Significant Effects of Oral Phenylbutyrate and Vitamin D3 Adjunctive Therapy in Pulmonary Tuberculosis: A Randomized Controlled Trial
Mily A; Rekha RS; Kamal SMM; Arifuzzaman ASM; Rahim Z; Khan L; Haq MA; Zaman K; Bergman P; Brighenti S; Gudmundsson GH; Agerberth B; Raqib R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(35):E3735-E3744
Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns
Bergman P; Adori C; Vas S; Kai-Larsen Y; Sarkanen T; Cederlund A; Agerberth B; Julkunen I; Horvath B; Kostyalik D; Kalmar L; Bagdy G; Huutoniemi A; Partinen M; Hokfelt T
Article: FASEB JOURNAL. 2014;28(8):3456-3467
Cathelicidin LL-37 induces time-resolved release of LTB₄ and TXA₂ by human macrophages and triggers eicosanoid generation in vivo
Wan M; Soehnlein O; Tang X; van der Does AM; Smedler E; Uhlen P; Lindbom L; Agerberth B; Haeggstrom JZ
Article: ANTIBIOTICS-BASEL. 2014;3(3):353-374
Ciprofloxacin Affects Host Cells by Suppressing Expression of the Endogenous Antimicrobial Peptides Cathelicidins and Beta-Defensin-3 in Colon Epithelia.
Sarker P; Mily A; Mamun AA; Jalal S; Bergman P; Raqib R; Gudmundsson GH; Agerberth B
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2014;95(6):883-891
Vitamin D₃ and phenylbutyrate promote development of a human dendritic cell subset displaying enhanced antimicrobial properties
van der Does AM; Kenne E; Koppelaar E; Agerberth B; Lindbom L
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2014;95(6):971-981
Antimicrobial peptide LL-37 promotes bacterial phagocytosis by human macrophages
Wan M; van der Does AM; Tang X; Lindbom L; Agerberth B; Haeggstrom JZ
Article: INNATE IMMUNITY. 2014;20(4):364-376
Boosting innate immunity: Development and validation of a cell-based screening assay to identify LL-37 inducers
Nylen F; Miraglia E; Cederlund A; Ottosson H; Stromberg R; Gudmundsson GH; Agerberth B
Article: MSPHERE. 2014;13(4):438-451
Characterization of Biofilm Formation and the Role of BCR1 in Clinical Isolates of Candida parapsilosis
Pannanusorn S; Ramirez-Zavala B; Luensdorf H; Agerberth B; Morschhaeuser J; Romling U
Article: PLOS ONE. 2014;9(12):e115474
No Evidence of Pathogenic Involvement of Cathelicidins in Patient Cohorts and Mouse Models of Lupus and Arthritis
Kienhofer D; Hahn J; Schubert I; Reinwald C; Ipseiz N; Lang SC; Borras EB; Amann K; Sjowall C; Barron AE; Hueber AJ; Agerberth B; Schett G; Hoffmann MH
Article: JOURNAL OF INNATE IMMUNITY. 2014;6(3):365-376
Label-Free Quantitative Mass Spectrometry Reveals Novel Pathways Involved in LL-37 Expression
Cederlund A; Nylen F; Miraglia E; Bergman P; Gudmundsson GH; Agerberth B
Article: ALLERGY. 2014;69(1):104-112
Protein biomarkers in vernix with potential to predict the development of atopic eczema in early childhood
Holm T; Rutishauser D; Kai-Larsen Y; Lyutvinskiy Y; Stenius F; Zubarev RA; Agerberth B; Alm J; Scheynius A
Article: MICROBES AND INFECTION. 2013;15(13):939-950
Treatment with phenylbutyrate in a pre-clinical trial reduces diarrhea due to enteropathogenic Escherichia coli: link to cathelicidin induction
Al-Mamun A; Mily A; Sarker P; Tiash S; Navarro A; Akter M; Talukder KA; Islam MF; Agerberth B; Gudmundsson GH; Cravioto A; Raqib R
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2013;33(8):1965-1972
Cathelicidin LL-37 Induces Angiogenesis via PGE₂-EP3 Signaling in Endothelial Cells, In Vivo Inhibition by Aspirin
Salvado MD; Di Gennaro A; Lindbom L; Agerberth B; Haeggstrom JZ
Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(7):1239-1248
The cathelicidins LL-37 and rCRAMP are associated with pathogenic events of arthritis in humans and rats
Hoffmann MH; Bruns H; Baeckdahl L; Neregard P; Niederreiter B; Herrmann M; Catrina AI; Agerberth B; Holmdahl R
Article: BMC PULMONARY MEDICINE. 2013;13:23
Oral intake of phenylbutyrate with or without vitamin D₃ upregulates the cathelicidin LL-37 in human macrophages: a dose finding study for treatment of tuberculosis
Mily A; Rekha RS; Kamal SMM; Akhtar E; Sarker P; Rahim Z; Gudmundsson GH; Agerberth B; Raqib R
Article: ALLERGY. 2013;68(3):304-311
The antimicrobial peptide LL-37 induces synthesis and release of cysteinyl leukotrienes from human eosinophils implications for asthma
Sun J; Dahlen B; Agerberth B; Haeggstrom JZ
Article: PLOS ONE. 2013;8(1):e53876
Lactose in Human Breast Milk an Inducer of Innate Immunity with Implications for a Role in Intestinal Homeostasis
Cederlund A; Kai-Larsen Y; Printz G; Yoshio H; Alvelius G; Lagercrantz H; Stromberg R; Jornvall H; Gudmundsson GH; Agerberth B
Article: NATURE MEDICINE. 2013;19(1):65-73
Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes
Diana J; Simoni Y; Furio L; Beaudoin L; Agerberth B; Barrat F; Lehuen A
Article: BMC INFECTIOUS DISEASES. 2012;12:111
Efficacy of sodium butyrate adjunct therapy in shigellosis: a randomized, double-blind, placebo-controlled clinical trial
Raqib R; Sarker P; Mily A; Alam NH; Arifuzzaman ASM; Rekha RS; Andersson J; Gudmundsson GH; Cravioto A; Agerberth B
Article: BMJ OPEN. 2012;2(6):e001663
Vitamin D₃ supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study
Bergman P; Norlin A-C; Hansen S; Rekha RS; Agerberth B; Bjorkhem-Bergman L; Ekstrom L; Lindh JD; Andersson J
Article: SCIENCE TRANSLATIONAL MEDICINE. 2011;3(103):103ra98
Neutrophil-Derived Cathelicidin Protects from Neointimal Hyperplasia
Soehnlein O; Wantha S; Simsekyilmaz S; Doering Y; Megens RTA; Mause SF; Drechsler M; Smeets R; Weinandy S; Schreiber F; Gries T; Jockenhoevel S; Moeller M; Vijayan S; van Zandvoort MAMJ; Agerberth B; Pham CT; Gallo RL; Hackeng TM; Liehn EA; Zernecke A; Klee D; Weber C
Article: JOURNAL OF HEALTH POPULATION AND NUTRITION. 2011;29(5):429-437
Differential Host Immune Responses to Epidemic and Endemic Strains of Shigella dysenteriae Type 1
Abu Sayem M; Ahmad SM; Rekha RS; Sarker P; Agerberth B; Talukder KA; Raqib R
Article: JOURNAL OF HEALTH POPULATION AND NUTRITION. 2011;29(3):183-190
L-isoleucine-supplemented Oral Rehydration Solution in the Treatment of Acute Diarrhoea in Children: A Randomized Controlled Trial
Alam NH; Raqib R; Ashraf H; Qadri F; Ahmed S; Zasloff M; Agerberth B; Salam MA; Gyr N; Meier R
Article: FASEB JOURNAL. 2011;25(5):1697-1705
Leukotriene B₄/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A₄ and resolvin E1
Wan M; Godson C; Guiry PJ; Agerberth B; Haeggstrom JZ
Article: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY. 2011;35(3):296-303
Cod cathelicidin: Isolation of the mature peptide, cleavage site characterisation and developmental expression
Broekman DC; Frei DM; Gylfason GA; Steinarsson A; Jornvall H; Agerberth B; Gudmundsson GH; Maier VH
Article: PLOS ONE. 2011;6(6):e20637
Phenylbutyrate Counteracts Shigella Mediated Downregulation of Cathelicidin in Rabbit Lung and Intestinal Epithelia: A Potential Therapeutic Strategy
Sarker P; Ahmed S; Tiash S; Rekha RS; Stromberg R; Andersson J; Bergman P; Gudmundsson GH; Agerberth B; Raqib R
Article: PLOS ONE. 2011;6(12):e29316
Impaired Release of Antimicrobial Peptides into Nasal Fluid of Hyper-IgE and CVID Patients
Cederlund A; Olliver M; Rekha RS; Lindh M; Lindbom L; Normark S; Henriques-Normark B; Andersson J; Agerberth B; Bergman P
Article: PLOS PATHOGENS. 2010;6(7):e1001010
Uropathogenic Escherichia coli Modulates Immune Responses and Its Curli Fimbriae Interact with the Antimicrobial Peptide LL-37
Kai-Larsen Y; Luthje P; Chromek M; Peters V; Wang X; Holm A; Kadas L; Hedlund K-O; Johansson J; Chapman MR; Jacobson SH; Romling U; Agerberth B; Brauner A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):116-119
Battle and balance at mucosal surfaces - The story of Shigella and antimicrobial peptides
Gudmundsson GH; Bergman P; Andersson J; Raqib R; Agerberth B
Article: JOURNAL OF INNATE IMMUNITY. 2010;2(6):508-521
Specificity in Killing Pathogens Is Mediated by Distinct Repertoires of Human Neutrophil Peptides
Cederlund A; Agerberth B; Bergman P
Article: NEUROGASTROENTEROLOGY AND MOTILITY. 2010;22(1):70-e29
Differential expression of enteric neuroimmune-network in invasive and acute watery diarrhoea
Sarker P; Bhuiyan TR; Qadri F; Alam NH; Wretlind B; Bishop AE; Mathan M; Agerberth B; Andersson J; Raqib R
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2009;53(12):5127-5133
Phenylbutyrate Induces Antimicrobial Peptide Expression
Steinmann J; Halldorsson S; Agerberth B; Gudmundsson GH
Article: BRITISH JOURNAL OF DERMATOLOGY. 2009;161(1):40-47
Enhanced expression of the antimicrobial peptide LL-37 in lesional skin of adults with atopic eczema
Ballardini N; Johansson C; Lilja G; Lindh M; Linde Y; Scheynius A; Agerberth B
Article: JOURNAL OF CLINICAL INVESTIGATION. 2008;118(10):3491-3502
Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages
Soehnlein O; Kai-Larsen Y; Frithiof R; Sorensen OE; Kenne E; Scharffetter-Kochanek K; Eriksson EE; Herwald H; Agerberth B; Lindbom L
Article: MOLECULAR IMMUNOLOGY. 2008;45(15):3947-3955
PU.1 and bacterial metabolites regulate the human gene CAMP encoding antimicrobial peptide LL-37 in colon epithelial cells
Termen S; Tollin M; Rodriguez E; Sveinsdottir SH; Johannesson B; Cederlund A; Sjovall J; Agerberth B; Gudmundsson GH
Article: INFECTION AND IMMUNITY. 2008;76(8):3399-3404
Cathelicidin LL-37 in severe Streptococcus pyogenes soft tissue infections in humans
Johansson L; Thulin P; Sendi P; Hertzen E; Linder A; Akesson P; Low DE; Agerberth B; Norrby-Teglund A
Article: FRONTIERS IN BIOSCIENCE - LANDMARK. 2008;13:3760-3767
The role of the multifunctional peptide LL-37 in host defense
Kai-Larsen Y; Agerberth B
Article: FASEB JOURNAL. 2007;21(11):2897-2905
Leukotriene B₄ triggers release of the cathelicidin LL-37 from human neutrophils:: novel lipid-peptide interactions in innate immune responses
Wan M; Sabirsh A; Wetterholm A; Agerberth B; Haeggstrom JZ
Article: CURRENT HIV RESEARCH. 2007;5(4):410-415
The antimicrobial peptide LL-37 inhibits HIV-1 replication
Bergman P; Walter-Jallow L; Broliden K; Agerberth B; Soderlund J
Article: PEDIATRIC RESEARCH. 2007;61(5):530-536
Antimicrobial components of the neonatal gut affected upon colonization
Kai-Larsen Y; Bergsson G; Gudmundsson GH; Printz G; Jornvall H; Marchini G; Agerberth B
Article: INFECTION AND IMMUNITY. 2006;74(12):6982-6991
Induction of the antimicrobial peptide CRAMP in the blood-brain barrier and meninges after meningococcal infection
Bergman P; Johansson L; Wan H; Jones A; Gallo RL; Gudmundsson GH; Hokfelt T; Jonsson A-B; Agerberth B
Article: PEDIATRIC RESEARCH. 2006;60(4):430-434
Proteome analysis of vernix caseosa
Tollin M; Jagerbrink T; Haraldsson A; Agerberth B; Jornvall H
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2006;26(7):1551-1557
Involvement of the antimicrobial peptide LL-37 in human atherosclerosis
Edfeldt K; Agerberth B; Rottenberg ME; Gudmundsson GH; Wang X-B; Mandal K; Xu Q; Yan Z-Q
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(24):9178-9183
Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic
Raqib R; Sarker P; Bergman P; Ara G; Lindh M; Sack DA; Islam KMN; Gudmundsson GH; Andersson J; Agerberth B
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2006;63(6):410-419
Antimicrobial peptide LL-37 internalized by immature human dendritic cells alters their phenotype
Bandholtz L; Ekman GJ; Vilhelmsson M; Buentke E; Agerberth B; Scheynius A; Gudmundsson GH
Article: NATURE MEDICINE. 2006;12(6):636-641
The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection
Chromek M; Slamova Z; Bergman P; Kovacs L; Podracka L; Ehren I; Hokfelt T; Gudmundsson GH; Gallo RL; Agerberth B; Brauner A
Article: ALLERGY. 2006;61(4):422-430
Malassezia sympodialis differently affects the expression of LL-37 in dendritic cells from atopic eczema patients and healthy individuals
Agerberth B; Buentke E; Bergman P; Eshaghi H; Gabrielsson S; Gudmundsson GH; Scheynius A
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2005;62(19-20):2390-2399
Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions
Tollin M; Bergsson G; Kai-Larsen Y; Lengqvist J; Sjövall J; Griffiths W; Skúladóttir GV; Haraldsson A; Jörnvall H; Gudmundsson GH; Agerberth B
Article: FEBS JOURNAL. 2005;272(19):4960-4969
Isolation and identification of antimicrobial components from the epidermal mucus of Atlantic cod (Gadus morhua)
Bergsson G; Agerberth B; Jörnvall H; Gudmundsson GH
Article: JOURNAL OF IMMUNOLOGY. 2005;175(1):433-440
Human-like immune responses in CD46 transgenic mice
Johansson L; Rytkönen A; Wan H; Bergman P; Plant L; Agerberth B; Hökfelt T; Jonsson AB
Article: CELLULAR MICROBIOLOGY. 2005;7(7):1009-1017
Neisseria gonorrhoeae downregulates expression of the human antimicrobial peptide LL-37
Bergman P; Johansson L; Asp V; Plant L; Gudmundsson GH; Jonsson AB; Agerberth B
Article: JOURNAL OF NEUROCHEMISTRY. 2005;93(5):1132-1140
The antimicrobial peptide rCRAMP is present in the central nervous system of the rat
Bergman P; Termén S; Johansson L; Nyström L; Arenas E; Jonsson AB; Hökfelt T; Gudmundsson GH; Agerberth B
Article: JOURNAL OF IMMUNOLOGY. 2005;174(3):1608-1615
Expression and activity of β-defensins and LL-37 in the developing human lung
Starner TD; Agerberth B; Gudmundsson GH; McCray PB
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2004;48(6):2097-2100
Antibacterial activities of the cathelicidins prophenin (Residues 62 to 79) and LL-37 in the presence of a lung surfactant preparation
Wang YQ; Walter G; Herting E; Agerberth B; Johansson J
Article: SCIENCE. 2003;301(5631):373-375
CD46 in meningococcal disease
Johansson L; Rytkönen A; Bergman P; Albiger B; Källström H; Hökfelt T; Agerberth B; Cattaneo R; Jonsson AB
Article: GUT. 2003;52(5):735-741
Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes:: relevance of signalling pathways
Schauber J; Svanholm C; Termén S; Iffland K; Menzel T; Scheppach W; Melcher R; Agerberth B; Lührs H; Gudmundsson GH
Article: PEPTIDES. 2003;24(4):523-530
Antimicrobial peptides in the first line defence of human colon mucosa
Tollin M; Bergman P; Svenberg T; Jörnvall H; Gudmundsson GH; Agerberth B
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2003;60(3):536-549
Phylogeny, processing and expression of the rat cathelicidin rCRAMP:: a model for innate antimicrobial peptides
Termén S; Tollin M; Olsson B; Svenberg T; Agerberth B; Gudmundsson GH
Article: RAPID COMMUNICATIONS IN MASS SPECTROMETRY. 2003;17(3):183-191
Identification of a potent antibacterial factor isolated from bronchoalveolar lavage fluid:: guanidine, N-[3-[(aminoiminomethyl)amino]propyl]-N-dodecyl-, a potential source of error in the analysis of antibacterial agents
Abraham-Nordling M; Gudmundsson GH; Grunewald J; Agerberth B; Griffiths WJ
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2003;60(2):422-429
Hsp90 binds CpG oligonucleotides directly:: implications for Hsp90 as a missing link in CpG signaling and recognition
Bandholtz L; Guo Y; Palmberg C; Mattsson K; Ohlsson B; High A; Shabanowitz J; Hunt DF; Jörnvall H; Wigzell H; Agerberth B; Gudmundsson GH
Article: PEDIATRIC RESEARCH. 2003;53(2):211-216
Antimicrobial polypeptides of human vernix caseosa and amniotic fluid:: Implications for newborn innate defense
Yoshio H; Tollin M; Gudmundsson GH; Lagercrantz H; Jörnvall H; Marchini G; Agerberth B
Article: FEBS JOURNAL. 2002;269(2):512-518
Antibacterial peptides in stimulated human granulocytes -: Characterization of ubiquitinated histone H1A
Wang YQ; Griffiths WJ; Jörnvall H; Agerberth B; Johansson J
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2001;117(1):91-97
Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus
Dorschner RA; Pestonjamasp VK; Tamakuwala S; Ohtake T; Rudisill J; Nizet V; Agerberth B; Gudmundsson GH; Gallo RL
Article: NATURE MEDICINE. 2001;7(2):180-185
Downregulation of bactericidal peptides in enteric infections: A novel immune escape mechanism with bacterial DNA as a potential regulator
Islam D; Bandholtz L; Nilsson J; Wigzell H; Christensson B; Agerberth B; Gudmundsson GH
Article: BLOOD. 2000;96(9):3086-3093
The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations
Agerberth B; Charo J; Werr J; Olsson B; Idali F; Lindbom L; Kiessling R; Jörnvall H; Wigzell H; Gudmundsson GH
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2000;57(6):976-981
Decreased pulmonary levels of the anti-inflammatory Clara cell 16 kDa protein after induction of airway inflammation in asthmatics
Lensmar C; Nord M; Gudmundsson GH; Roquet A; Andersson O; Jörnvall H; Eklund A; Grunewald J; Agerberth B
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 1999;232(1-2):45-54
Neutrophil antibacterial peptides, multifunctional effector molecules in the mammalian immune system
Gudmundsson GH; Agerberth B
Article: BIOCHEMICAL JOURNAL. 1999;341(Pt 3):501-513
Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity
Oren Z; Lerman JC; Gudmundsson GH; Agerberth B; Shai Y
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 1999;160(1):283-290
Antibacterial components in bronchoalveolar lavage fluid from healthy in individuals and sarcoidosis patients
Agerberth B; Grunewald J; Castaños-Velez E; Olsson B; Jörnvall H; Wigzell H; Eklund A; Gudmundsson GH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(50):33115-33118
Apolipoprotein A-I binds and inhibits the human antibacterial/cytotolic peptide LL-37
Wang YQ; Agerberth B; Löthgren A; Almstedt A; Johansson J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(6):3718-3724
Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37
Johansson J; Gudmundsson GH; Rottenberg ME; Berndt KD; Agerberth B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(24):15258-15263
The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders
Frohm M; Agerberth B; Ahangari G; StahleBackdahl M; Liden S; Wigzell H; Gudmundsson GH
Article: FEBS JOURNAL. 1996;238(2):325-332
The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes
Gudmundsson GH; Agerberth B; Odeberg J; Bergman T; Olsson B; Salcedo R
Article: FEBS JOURNAL. 1996;237(1):86-92
Biochemical and antibacterial analysis of human wound and blister fluid
Frohm M; Gunne H; Bergman AC; Agerberth B; Bergman T; Boman A; Liden S; Jornvall H; Boman HG
Article: TRENDS IN MICROBIOLOGY. 1996;4(3):94
Cytotoxic T cells: More weapons for new targets?
Anderson M; Agerberth B; Gudmundsson GH
Article: EMBO JOURNAL. 1995;14(8):1615-1625
NK-LYSIN, A NOVEL EFFECTOR PEPTIDE OF CYTOTOXIC T-CELLS AND NK-CELLS - STRUCTURE AND CDNA CLONING OF THE PORCINE FORM, INDUCTION BY INTERLEUKIN-2, ANTIBACTERIAL AND ANTITUMOR-ACTIVITY
ANDERSSON M; GUNNE H; AGERBERTH B; BOMAN A; BERGMAN T; SILLARD R; JORNVALL H; MUTT V; OLSSON B; WIGZELL H; DAGERLIND A; BOMAN HG; GUDMUNDSSON GH
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(1):195-199
FALL-39, A PUTATIVE HUMAN PEPTIDE ANTIBIOTIC, IS CYSTEINE-FREE AND EXPRESSED IN BONE-MARROW AND TESTIS
AGERBERTH B; GUNNE H; ODEBERG J; KOGNER P; BOMAN HG; GUDMUNDSSON GH
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Review: ANTIBIOTICS-BASEL. 2020;9(1):E21-21
Host-Directed Therapy as a Novel Treatment Strategy to Overcome Tuberculosis: Targeting Immune Modulation
Ahmed S; Raqib R; Gudmundsson GH; Bergman P; Agerberth B; Rekha RS
Review: FRONTIERS IN IMMUNOLOGY. 2020;11:1209
Host Directed Therapy Against Infection by Boosting Innate Immunity
Bergman P; Raqib R; Rekha RS; Agerberth B; Gudmundsson GH
Review: ACTA PAEDIATRICA. 2014;103(10):1000-1008
A review of the innate immune defence of the human foetus and newborn, with the emphasis on antimicrobial peptides
Kai-Larsen Y; Gudmundsson GH; Agerberth B
Review: JOURNAL OF LEUKOCYTE BIOLOGY. 2012;92(4):735-742
Induction of the human cathelicidin LL-37 as a novel treatment against bacterial infections
van der Does AM; Bergman P; Agerberth B; Lindbom L
Review: FEBS JOURNAL. 2011;278(20):3942-3951
Antimicrobial peptides important in innate immunity
Cederlund A; Gudmundsson GH; Agerberth B
Review: LAKARTIDNINGEN. 2008;105(34):2254-2259
[Natural immunity--first line defense. New treatment against infections and autoimmune diseases in sight].
Bergman P; Gudmundsson GH; Agerberth B
Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 2006;306:67-90
Host antimicrobial defence pepticles in human disease
Agerberth B; Gudmundsson GH
Published conference paper: SEMINARS IN PERINATOLOGY. 2004;28(4):304-311
First line of defense in early human life
Yoshio H; Lagercrantz H; Gudmundsson GH; Agerberth B
Published conference paper: BRITISH JOURNAL OF DERMATOLOGY. 2002;147(6):1127-1134
The newborn infant is protected by an innate antimicrobial barrier:: peptide antibiotics are present in the skin and vernix caseosa
Marchini G; Lindow S; Brismar H; Ståbi B; Berggren V; Ulfgren AK; Lonne-Rahm S; Agerberth B; Gudmundsson GH
Published conference paper: PROTEIN JOURNAL. 1998;17(6):522-523
Structure and activity of cathelicidin antibacterial proteins.
Wang YQ; Agerberth B; Johansson J
Published conference paper: VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY. 1996;54(1-4):127-131
PR-39, a proline-rich peptide antibiotic from pig, and FALL-39, a tentative human counterpart
Agerberth B; Gunne H; Odeberg J; Kogner P; Boman HG; Gudmundsson GH
Published conference paper: VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY. 1996;54(1-4):123-126
NK-lysin, structure and function of a novel effector molecule of porcine T and NK cells
Andersson M; Gunne H; Agerberth B; Boman A; Bergman T; Olsson B; Dagerlind A; Wigzell H; Boman HG; Gudmundsson GH

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Affiliated to Research, Department of Laboratory Medicine, Karolinska Institutet, 2024-2025

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Docent, Karolinska institutet, 1998

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