Birgitta Agerberth

About me
Publications
CV
Public outreach and news

About me

Birgitta Agerberth was appiointed Professor of Medical Microbial Pathogenesis at Karolinska Institutet in 2008. A central question in her research has been how the innate immune system manages to keep us healthy despite all the bacteria we are surrounded by.

Articles

Article: JOURNAL OF INNATE IMMUNITY. 2022;14(5):477-492

The Novel Inducer of Innate Immunity HO53 Stimulates Autophagy in Human Airway Epithelial Cells.

Myszor IT; Sigurdsson S; Viktorsdottir AR; Agerberth B; Eskelinen E-L; Ogmundsdottir MH; Gudmundsson GH
Article: EMBO MOLECULAR MEDICINE. 2021;13(8):e14059

Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy.

Ren Z; Pan L-L; Huang Y; Chen H; Liu Y; Liu H; Tu X; Liu Y; Li B; Dong X; Pan X; Li H; Fu YV; Agerberth B; Diana J; Sun J
Article: JOURNAL OF IMMUNOLOGY. 2021;207(3):974-984

Citrullination Alters the Antibacterial and Anti-Inflammatory Functions of the Host Defense Peptide Canine Cathelicidin K9CATH In Vitro.

Al Adwani S; Padhi A; Karadottir H; Mörman C; Gräslund A; Végvári Á; Johansson J; Rising A; Agerberth B; Bergman P
Article: JOURNAL OF INFECTIOUS DISEASES. 2021;224(2):332-344

Immunomodulatory Agents Combat Multidrug-Resistant Tuberculosis by Improving Antimicrobial Immunity.

Rao Muvva J; Ahmed S; Rekha RS; Kalsum S; Groenheit R; Schön T; Agerberth B; Bergman P; Brighenti S
Article: BMC INFECTIOUS DISEASES. 2020;20(1):933

Slow radiological improvement and persistent low-grade inflammation after chemotherapy in tuberculosis patients with type 2 diabetes.

Mily A; Sarker P; Taznin I; Hossain D; Haq MA; Kamal SMM; Agerberth B; Brighenti S; Raqib R
Article: INFECTION AND IMMUNITY. 2020;88(8):e00186-e00120

Innate Effector Systems in Primary Human Macrophages Sensitize Multidrug-Resistant Klebsiella pneumoniae to Antibiotics.

Rekha RS; Karadottir H; Ahmed S; Gudmundsson GH; Agerberth B; Bergman P
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2020;177(12):2726-2742

Cathelicidin-related antimicrobial peptide protects against ischaemia reperfusion-induced acute kidney injury in mice.

Pan L-L; Liang W; Ren Z; Li C; Chen Y; Niu W; Fang X; Liu Y; Zhang M; Diana J; Agerberth B; Sun J
Article: SCIENTIFIC REPORTS. 2020;10(1):2376

Studies on citrullinated LL-37: detection in human airways, antibacterial effects and biophysical properties.

Al-Adwani S; Wallin C; Balhuizen MD; Veldhuizen EJA; Coorens M; Landreh M; Végvári Á; Smith ME; Qvarfordt I; Lindén A; Gräslund A; Agerberth B; Bergman P
Article: THERANOSTICS. 2020;10(14):6167-6181

The anti-microbial peptide LL-37/CRAMP levels are associated with acute heart failure and can attenuate cardiac dysfunction in multiple preclinical models of heart failure.

Zhou Q; Pan L-L; Xue R; Ni G; Duan Y; Bai Y; Shi C; Ren Z; Wu C; Li G; Agerberth B; Sluijter JP; Sun J; Xiao J
Article: INFECTION AND IMMUNITY. 2019;88(1):e00756-e00719

Klebsiella pneumoniae Expressing VIM-1 Metallo-β-Lactamase Is Resensitized to Cefotaxime via Thiol-Mediated Zinc Chelation.

Karadottir H; Coorens M; Liu Z; Wang Y; Agerberth B; Giske CG; Bergman P
Article: MOLECULAR NUTRITION & FOOD RESEARCH. 2019;63(21):e1900307

Low Methoxyl Pectin Protects against Autoimmune Diabetes and Associated Caecal Dysfunction.

Wu C; Pan L-L; Luo Y; Niu W; Fang X; Liang W; Li J; Li H; Pan X; Yang G; Chen W; Zhang H; Lakey JRT; Agerberth B; de Vos P; Sun J
Article: SCIENTIFIC REPORTS. 2019;9(1):7114

Novel aroylated phenylenediamine compounds enhance antimicrobial defense and maintain airway epithelial barrier integrity.

Myszor IT; Parveen Z; Ottosson H; Bergman P; Agerberth B; Strömberg R; Gudmundsson GH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(15):6027-6041

Innate lymphoid cell type 3-derived interleukin-22 boosts lipocalin-2 production in intestinal epithelial cells via synergy between STAT3 and NF-κB.

Coorens M; Rao A; Gräfe SK; Unelius D; Lindforss U; Agerberth B; Mjösberg J; Bergman P
Article: BMC MEDICINE. 2019;17(1):42

Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury.

Bei Y; Pan L-L; Zhou Q; Zhao C; Xie Y; Wu C; Meng X; Gu H; Xu J; Zhou L; Sluijter JPG; Das S; Agerberth B; Sun J; Xiao J
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2697

Cathelicidin Contributes to the Restriction of Leishmania in Human Host Macrophages.

Crauwels P; Bank E; Walber B; Wenzel UA; Agerberth B; Chanyalew M; Abebe M; König R; Ritter U; Reiling N; van Zandbergen G
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1733

Modulation of Gut Microbiota by Low Methoxyl Pectin Attenuates Type 1 Diabetes in Non-obese Diabetic Mice.

Wu C; Pan L-L; Niu W; Fang X; Liang W; Li J; Li H; Pan X; Chen W; Zhang H; Lakey JRT; Agerberth B; de Vos P; Sun J
Article: MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. 2018;93:782-789

A novel cysteine-linked antibacterial surface coating significantly inhibits bacterial colonization of nasal silicone prongs in a phase one pre-clinical trial.

Odeberg J; Wirsén A; Norberg Å; Frie J; Printz G; Lagercrantz H; Gudmundsson GH; Agerberth B; Jonsson B
Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(3):292-306

Daily adjunctive therapy with vitamin D3 and phenylbutyrate supports clinical recovery from pulmonary tuberculosis: a randomized controlled trial in Ethiopia.

Bekele A; Gebreselassie N; Ashenafi S; Kassa E; Aseffa G; Amogne W; Getachew M; Aseffa A; Worku A; Raqib R; Agerberth B; Hammar U; Bergman P; Aderaye G; Andersson J; Brighenti S
Article: BMC INFECTIOUS DISEASES. 2018;18(1):303

Immune responses in the treatment of drug-sensitive pulmonary tuberculosis with phenylbutyrate and vitamin D3 as host directed therapy.

Rekha RS; Mily A; Sultana T; Haq A; Ahmed S; Mostafa Kamal SM; van Schadewijk A; Hiemstra PS; Gudmundsson GH; Agerberth B; Raqib R
Article: FASEB JOURNAL. 2018;32(5):2827-2840

Prostaglandin E2 suppresses hCAP18/LL-37 expression in human macrophages via EP2/EP4: implications for treatment of Mycobacterium tuberculosis infection.

Wan M; Tang X; Rekha RS; Muvva SSVJR; Brighenti S; Agerberth B; Haeggström JZ
Article: EUROPEAN JOURNAL OF ORAL SCIENCES. 2018;126(2):93-100

The host defense peptide LL-37 is detected in human parotid and submandibular/sublingual saliva and expressed in glandular neutrophils.

Svensson D; Aidoukovitch A; Anders E; Agerberth B; Andersson F; Ekblad E; Ericson D; Nebel D; Voss U; Nilsson B-O
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:751

Lactose Induces Phenotypic and Functional Changes of Neutrophils and Macrophages to Alleviate Acute Pancreatitis in Mice.

Pan L-L; Deng Y-Y; Wang R; Wu C; Li J; Niu W; Yang Q; Bhatia M; Gudmundsson GH; Agerberth B; Diana J; Sun J
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2017;61(7):e02570-e02516

Treatment with Entinostat Heals Experimental Cholera by Affecting Physical and Chemical Barrier Functions of Intestinal Epithelia.

Sarker P; Banik A; Stromberg R; Gudmundsson GH; Raqib R; Agerberth B
Article: JOURNAL OF AUTOIMMUNITY. 2017;78:46-56

The host defense peptide LL-37 a possible inducer of the type I interferon system in patients with polymyositis and dermatomyositis.

Lu X; Tang Q; Lindh M; Dastmalchi M; Alexanderson H; Popovic Silwerfeldt K; Agerberth B; Lundberg IE; Wick C
Article: METHODS IN MOLECULAR BIOLOGY. 2017;1548:271-281

Assays for Identifying Inducers of the Antimicrobial Peptide LL-37.

Nylén F; Bergman P; Gudmundsson GH; Agerberth B
Article: SCIENTIFIC REPORTS. 2016;6:36692

Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections.

Ottosson H; Nylén F; Sarker P; Miraglia E; Bergman P; Gudmundsson GH; Raqib R; Agerberth B; Strömberg R
Article: SCIENTIFIC REPORTS. 2016;6:33274

Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors.

Miraglia E; Nylén F; Johansson K; Arnér E; Cebula M; Farmand S; Ottosson H; Strömberg R; Gudmundsson GH; Agerberth B; Bergman P
Article: FASEB JOURNAL. 2016;30(2):884-894

Cathelicidins positively regulate pancreatic β-cell functions.

Sun J; Xu M; Ortsäter H; Lundeberg E; Juntti-Berggren L; Chen YQ; Haeggström JZ; Gudmundsson GH; Diana J; Agerberth B
Article: IMMUNOBIOLOGY. 2016;221(2):245-252

Glucocorticoid dexamethasone down-regulates basal and vitamin D3 induced cathelicidin expression in human monocytes and bronchial epithelial cell line.

Kulkarni NN; Gunnarsson HI; Yi Z; Gudmundsdottir S; Sigurjonsson OE; Agerberth B; Gudmundsson GH
Article: AUTOPHAGY. 2015;11(9):1688-1699

Phenylbutyrate induces LL-37-dependent autophagy and intracellular killing of Mycobacterium tuberculosis in human macrophages.

Rekha RS; Rao Muvva SSVJ; Wan M; Raqib R; Bergman P; Brighenti S; Gudmundsson GH; Agerberth B
Article: IMMUNITY. 2015;43(2):304-317

Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota.

Sun J; Furio L; Mecheri R; van der Does AM; Lundeberg E; Saveanu L; Chen Y; van Endert P; Agerberth B; Diana J
Article: MOLECULAR IMMUNOLOGY. 2015;63(2):530-539

Phenylbutyrate induces cathelicidin expression via the vitamin D receptor: Linkage to inflammatory and growth factor cytokines pathways.

Kulkarni NN; Yi Z; Huehnken C; Agerberth B; Gudmundsson GH
Article: PLOS ONE. 2015;10(9):e0138340

Significant Effects of Oral Phenylbutyrate and Vitamin D3 Adjunctive Therapy in Pulmonary Tuberculosis: A Randomized Controlled Trial.

Mily A; Rekha RS; Kamal SMM; Arifuzzaman ASM; Rahim Z; Khan L; Haq MA; Zaman K; Bergman P; Brighenti S; Gudmundsson GH; Agerberth B; Raqib R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(35):E3735-E3744

Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns.

Bergman P; Adori C; Vas S; Kai-Larsen Y; Sarkanen T; Cederlund A; Agerberth B; Julkunen I; Horvath B; Kostyalik D; Kalmár L; Bagdy G; Huutoniemi A; Partinen M; Hökfelt T
Article: FASEB JOURNAL. 2014;28(8):3456-3467

Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in vivo.

Wan M; Soehnlein O; Tang X; van der Does AM; Smedler E; Uhlén P; Lindbom L; Agerberth B; Haeggström JZ
Article: ANTIBIOTICS-BASEL. 2014;3(3):353-374

Ciprofloxacin Affects Host Cells by Suppressing Expression of the Endogenous Antimicrobial Peptides Cathelicidins and Beta-Defensin-3 in Colon Epithelia.

Sarker P; Mily A; Mamun AA; Jalal S; Bergman P; Raqib R; Gudmundsson GH; Agerberth B
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2014;95(6):971-981

Antimicrobial peptide LL-37 promotes bacterial phagocytosis by human macrophages.

Wan M; van der Does AM; Tang X; Lindbom L; Agerberth B; Haeggström JZ
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2014;95(6):883-891

Vitamin D₃ and phenylbutyrate promote development of a human dendritic cell subset displaying enhanced antimicrobial properties.

van der Does AM; Kenne E; Koppelaar E; Agerberth B; Lindbom L
Article: INNATE IMMUNITY. 2014;20(4):364-376

Boosting innate immunity: development and validation of a cell-based screening assay to identify LL-37 inducers.

Nylén F; Miraglia E; Cederlund A; Ottosson H; Strömberg R; Gudmundsson GH; Agerberth B
Article: MSPHERE. 2014;13(4):438-451

Characterization of biofilm formation and the role of BCR1 in clinical isolates of Candida parapsilosis.

Pannanusorn S; Ramírez-Zavala B; Lünsdorf H; Agerberth B; Morschhäuser J; Römling U
Article: JOURNAL OF INNATE IMMUNITY. 2014;6(3):365-376

Label-free quantitative mass spectrometry reveals novel pathways involved in LL-37 expression.

Cederlund A; Nylén F; Miraglia E; Bergman P; Gudmundsson GH; Agerberth B
Article: ALLERGY. 2014;69(1):104-112

Protein biomarkers in vernix with potential to predict the development of atopic eczema in early childhood.

Holm T; Rutishauser D; Kai-Larsen Y; Lyutvinskiy Y; Stenius F; Zubarev RA; Agerberth B; Alm J; Scheynius A
Article: PLOS ONE. 2014;9(12):e115474

No evidence of pathogenic involvement of cathelicidins in patient cohorts and mouse models of lupus and arthritis.

Kienhöfer D; Hahn J; Schubert I; Reinwald C; Ipseiz N; Lang SC; Borràs ÈB; Amann K; Sjöwall C; Barron AE; Hueber AJ; Agerberth B; Schett G; Hoffmann MH
Article: MICROBES AND INFECTION. 2013;15(13):939-950

Treatment with phenylbutyrate in a pre-clinical trial reduces diarrhea due to enteropathogenic Escherichia coli: link to cathelicidin induction.

Al-Mamun A; Mily A; Sarker P; Tiash S; Navarro A; Akter M; Talukder KA; Islam MF; Agerberth B; Gudmundsson GH; Cravioto A; Raqib R
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2013;33(8):1965-1972

Cathelicidin LL-37 induces angiogenesis via PGE2-EP3 signaling in endothelial cells, in vivo inhibition by aspirin.

Salvado MD; Di Gennaro A; Lindbom L; Agerberth B; Haeggström JZ
Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(7):1239-1248

The cathelicidins LL-37 and rCRAMP are associated with pathogenic events of arthritis in humans and rats.

Hoffmann MH; Bruns H; Bäckdahl L; Neregård P; Niederreiter B; Herrmann M; Catrina AI; Agerberth B; Holmdahl R
Article: BMC PULMONARY MEDICINE. 2013;13:23

Oral intake of phenylbutyrate with or without vitamin D3 upregulates the cathelicidin LL-37 in human macrophages: a dose finding study for treatment of tuberculosis.

Mily A; Rekha RS; Kamal SMM; Akhtar E; Sarker P; Rahim Z; Gudmundsson GH; Agerberth B; Raqib R
Article: ALLERGY. 2013;68(3):304-311

The antimicrobial peptide LL-37 induces synthesis and release of cysteinyl leukotrienes from human eosinophils--implications for asthma.

Sun J; Dahlén B; Agerberth B; Haeggström JZ
Article: NATURE MEDICINE. 2013;19(1):65-73

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes.

Diana J; Simoni Y; Furio L; Beaudoin L; Agerberth B; Barrat F; Lehuen A
Article: PLOS ONE. 2013;8(1):e53876

Lactose in human breast milk an inducer of innate immunity with implications for a role in intestinal homeostasis.

Cederlund A; Kai-Larsen Y; Printz G; Yoshio H; Alvelius G; Lagercrantz H; Strömberg R; Jörnvall H; Gudmundsson GH; Agerberth B
Article: BMC INFECTIOUS DISEASES. 2012;12:111

Efficacy of sodium butyrate adjunct therapy in shigellosis: a randomized, double-blind, placebo-controlled clinical trial.

Raqib R; Sarker P; Mily A; Alam NH; Arifuzzaman ASM; Rekha RS; Andersson J; Gudmundsson GH; Cravioto A; Agerberth B
Article: BMJ OPEN. 2012;2(6):e001663

Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study.

Bergman P; Norlin A-C; Hansen S; Rekha RS; Agerberth B; Björkhem-Bergman L; Ekström L; Lindh JD; Andersson J
Article: SCIENCE TRANSLATIONAL MEDICINE. 2011;3(103):103ra98

Neutrophil-derived cathelicidin protects from neointimal hyperplasia.

Soehnlein O; Wantha S; Simsekyilmaz S; Döring Y; Megens RTA; Mause SF; Drechsler M; Smeets R; Weinandy S; Schreiber F; Gries T; Jockenhoevel S; Möller M; Vijayan S; van Zandvoort MAMJ; Agerberth B; Pham CT; Gallo RL; Hackeng TM; Liehn EA; Zernecke A; Klee D; Weber C
Article: JOURNAL OF HEALTH POPULATION AND NUTRITION. 2011;29(5):429-437

Differential host immune responses to epidemic and endemic strains of Shigella dysenteriae type I.

Sayem MA; Ahmad SM; Rekha RS; Sarker P; Agerberth B; Talukder KA; Raqib R
Article: JOURNAL OF HEALTH POPULATION AND NUTRITION. 2011;29(3):183-190

L-isoleucine-supplemented oral rehydration solution in the treatment of acute diarrhoea in children: a randomized controlled trial.

Alam NH; Raqib R; Ashraf H; Qadri F; Ahmed S; Zasloff M; Agerberth B; Salam MA; Gyr N; Meier R
Article: FASEB JOURNAL. 2011;25(5):1697-1705

Leukotriene B4/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A4 and resolvin E1.

Wan M; Godson C; Guiry PJ; Agerberth B; Haeggström JZ
Article: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY. 2011;35(3):296-303

Cod cathelicidin: isolation of the mature peptide, cleavage site characterisation and developmental expression.

Broekman DC; Frei DM; Gylfason GA; Steinarsson A; Jörnvall H; Agerberth B; Gudmundsson GH; Maier VH
Article: PLOS ONE. 2011;6(12):e29316

Impaired release of antimicrobial peptides into nasal fluid of hyper-IgE and CVID patients.

Cederlund A; Olliver M; Rekha RS; Lindh M; Lindbom L; Normark S; Henriques-Normark B; Andersson J; Agerberth B; Bergman P
Article: PLOS ONE. 2011;6(6):e20637

Phenylbutyrate counteracts Shigella mediated downregulation of cathelicidin in rabbit lung and intestinal epithelia: a potential therapeutic strategy.

Sarker P; Ahmed S; Tiash S; Rekha RS; Stromberg R; Andersson J; Bergman P; Gudmundsson GH; Agerberth B; Raqib R
Article: PLOS PATHOGENS. 2010;6(7):e1001010

Uropathogenic Escherichia coli modulates immune responses and its curli fimbriae interact with the antimicrobial peptide LL-37.

Kai-Larsen Y; Lüthje P; Chromek M; Peters V; Wang X; Holm A; Kádas L; Hedlund K-O; Johansson J; Chapman MR; Jacobson SH; Römling U; Agerberth B; Brauner A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):116-119

Battle and balance at mucosal surfaces--the story of Shigella and antimicrobial peptides.

Gudmundsson GH; Bergman P; Andersson J; Raqib R; Agerberth B
Article: JOURNAL OF INNATE IMMUNITY. 2010;2(6):508-521

Specificity in killing pathogens is mediated by distinct repertoires of human neutrophil peptides.

Cederlund A; Agerberth B; Bergman P
Article: NEUROGASTROENTEROLOGY AND MOTILITY. 2010;22(1):70-e29

Differential expression of enteric neuroimmune-network in invasive and acute watery diarrhoea.

Sarker P; Bhuiyan TR; Qadri F; Alam NH; Wretlind B; Bishop AE; Mathan M; Agerberth B; Andersson J; Raqib R
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2009;53(12):5127-5133

Phenylbutyrate induces antimicrobial peptide expression.

Steinmann J; Halldórsson S; Agerberth B; Gudmundsson GH
Article: BRITISH JOURNAL OF DERMATOLOGY. 2009;161(1):40-47

Enhanced expression of the antimicrobial peptide LL-37 in lesional skin of adults with atopic eczema.

Ballardini N; Johansson C; Lilja G; Lindh M; Linde Y; Scheynius A; Agerberth B
Article: JOURNAL OF CLINICAL INVESTIGATION. 2008;118(10):3491-3502

Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages.

Soehnlein O; Kai-Larsen Y; Frithiof R; Sorensen OE; Kenne E; Scharffetter-Kochanek K; Eriksson EE; Herwald H; Agerberth B; Lindbom L
Article: MOLECULAR IMMUNOLOGY. 2008;45(15):3947-3955

PU.1 and bacterial metabolites regulate the human gene CAMP encoding antimicrobial peptide LL-37 in colon epithelial cells.

Termén S; Tollin M; Rodriguez E; Sveinsdóttir SH; Jóhannesson B; Cederlund A; Sjövall J; Agerberth B; Gudmundsson GH
Article: INFECTION AND IMMUNITY. 2008;76(8):3399-3404

Cathelicidin LL-37 in severe Streptococcus pyogenes soft tissue infections in humans.

Johansson L; Thulin P; Sendi P; Hertzén E; Linder A; Akesson P; Low DE; Agerberth B; Norrby-Teglund A
Article: FRONTIERS IN BIOSCIENCE - LANDMARK. 2008;13:3760-3767

The role of the multifunctional peptide LL-37 in host defense.

Kai-Larsen Y; Agerberth B
Article: FASEB JOURNAL. 2007;21(11):2897-2905

Leukotriene B4 triggers release of the cathelicidin LL-37 from human neutrophils: novel lipid-peptide interactions in innate immune responses.

Wan M; Sabirsh A; Wetterholm A; Agerberth B; Haeggström JZ
Article: CURRENT HIV RESEARCH. 2007;5(4):410-415

The antimicrobial peptide LL-37 inhibits HIV-1 replication.

Bergman P; Walter-Jallow L; Broliden K; Agerberth B; Söderlund J
Article: PEDIATRIC RESEARCH. 2007;61(5 Pt 1):530-536

Antimicrobial components of the neonatal gut affected upon colonization.

Kai-Larsen Y; Bergsson G; Gudmundsson GH; Printz G; Jörnvall H; Marchini G; Agerberth B
Article: INFECTION AND IMMUNITY. 2006;74(12):6982-6991

Induction of the antimicrobial peptide CRAMP in the blood-brain barrier and meninges after meningococcal infection.

Bergman P; Johansson L; Wan H; Jones A; Gallo RL; Gudmundsson GH; Hökfelt T; Jonsson A-B; Agerberth B
Article: PEDIATRIC RESEARCH. 2006;60(4):430-434

Proteome analysis of vernix caseosa.

Tollin M; Jägerbrink T; Haraldsson A; Agerberth B; Jörnvall H
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2006;26(7):1551-1557

Involvement of the antimicrobial peptide LL-37 in human atherosclerosis.

Edfeldt K; Agerberth B; Rottenberg ME; Gudmundsson GH; Wang X-B; Mandal K; Xu Q; Yan Z-Q
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(24):9178-9183

Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic.

Raqib R; Sarker P; Bergman P; Ara G; Lindh M; Sack DA; Nasirul Islam KM; Gudmundsson GH; Andersson J; Agerberth B
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2006;63(6):410-419

Antimicrobial peptide LL-37 internalized by immature human dendritic cells alters their phenotype.

Bandholtz L; Ekman GJ; Vilhelmsson M; Buentke E; Agerberth B; Scheynius A; Gudmundsson GH
Article: NATURE MEDICINE. 2006;12(6):636-641

The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection.

Chromek M; Slamová Z; Bergman P; Kovács L; Podracká L; Ehrén I; Hökfelt T; Gudmundsson GH; Gallo RL; Agerberth B; Brauner A
Article: ALLERGY. 2006;61(4):422-430

Malassezia sympodialis differently affects the expression of LL-37 in dendritic cells from atopic eczema patients and healthy individuals.

Agerberth B; Buentke E; Bergman P; Eshaghi H; Gabrielsson S; Gudmundsson GH; Scheynius A
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2005;62(19-20):2390-2399

Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions.

Tollin M; Bergsson G; Kai-Larsen Y; Lengqvist J; Sjövall J; Griffiths W; Skúladóttir GV; Haraldsson A; Jörnvall H; Gudmundsson GH; Agerberth B
Article: FEBS JOURNAL. 2005;272(19):4960-4969

Isolation and identification of antimicrobial components from the epidermal mucus of Atlantic cod (Gadus morhua).

Bergsson G; Agerberth B; Jörnvall H; Gudmundsson GH
Article: JOURNAL OF IMMUNOLOGY. 2005;175(1):433-440

Human-like immune responses in CD46 transgenic mice.

Johansson L; Rytkönen A; Wan H; Bergman P; Plant L; Agerberth B; Hökfelt T; Jonsson A-B
Article: CELLULAR MICROBIOLOGY. 2005;7(7):1009-1017

Neisseria gonorrhoeae downregulates expression of the human antimicrobial peptide LL-37.

Bergman P; Johansson L; Asp V; Plant L; Gudmundsson GH; Jonsson A-B; Agerberth B
Article: JOURNAL OF NEUROCHEMISTRY. 2005;93(5):1132-1140

The antimicrobial peptide rCRAMP is present in the central nervous system of the rat.

Bergman P; Termén S; Johansson L; Nyström L; Arenas E; Jonsson A-B; Hökfelt T; Gudmundsson GH; Agerberth B
Article: JOURNAL OF IMMUNOLOGY. 2005;174(3):1608-1615

Expression and activity of beta-defensins and LL-37 in the developing human lung.

Starner TD; Agerberth B; Gudmundsson GH; McCray PB
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2004;48(6):2097-2100

Antibacterial activities of the cathelicidins prophenin (residues 62 to 79) and LL-37 in the presence of a lung surfactant preparation.

Wang Y; Walter G; Herting E; Agerberth B; Johansson J
Article: SCIENCE. 2003;301(5631):373-375

CD46 in meningococcal disease.

Johansson L; Rytkonen A; Bergman P; Albiger B; Källström H; Hökfelt T; Agerberth B; Cattaneo R; Jonsson A-B
Article: GUT. 2003;52(5):735-741

Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways.

Schauber J; Svanholm C; Termén S; Iffland K; Menzel T; Scheppach W; Melcher R; Agerberth B; Lührs H; Gudmundsson GH
Article: PEPTIDES. 2003;24(4):523-530

Antimicrobial peptides in the first line defence of human colon mucosa.

Tollin M; Bergman P; Svenberg T; Jörnvall H; Gudmundsson GH; Agerberth B
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2003;60(3):536-549

Phylogeny, processing and expression of the rat cathelicidin rCRAMP: a model for innate antimicrobial peptides.

Termén S; Tollin M; Olsson B; Svenberg T; Agerberth B; Gudmundsson GH
Article: RAPID COMMUNICATIONS IN MASS SPECTROMETRY. 2003;17(3):183-191

Identification of a potent antibacterial factor isolated from bronchoalveolar lavage fluid: guanidine, N-[3-[(aminoiminomethyl)amino]propyl]-N-dodecyl-, a potential source of error in the analysis of antibacterial agents.

Abraham-Nordling M; Gudmundsson GH; Grunewald J; Agerberth B; Griffiths WJ
Article: PEDIATRIC RESEARCH. 2003;53(2):211-216

Antimicrobial polypeptides of human vernix caseosa and amniotic fluid: implications for newborn innate defense.

Yoshio H; Tollin M; Gudmundsson GH; Lagercrantz H; Jornvall H; Marchini G; Agerberth B
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2003;60(2):422-429

Hsp90 binds CpG oligonucleotides directly: implications for hsp90 as a missing link in CpG signaling and recognition.

Bandholtz L; Guo Y; Palmberg C; Mattsson K; Ohlsson B; High A; Shabanowitz J; Hunt DF; Jörnvall H; Wigzell H; Agerberth B; Gudmundsson GH
Article: FEBS JOURNAL. 2002;269(2):512-518

Antibacterial peptides in stimulated human granulocytes: characterization of ubiquitinated histone H1A.

Wang Y; Griffiths WJ; Jörnvall H; Agerberth B; Johansson J
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2001;117(1):91-97

Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus.

Dorschner RA; Pestonjamasp VK; Tamakuwala S; Ohtake T; Rudisill J; Nizet V; Agerberth B; Gudmundsson GH; Gallo RL
Article: NATURE MEDICINE. 2001;7(2):180-185

Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator.

Islam D; Bandholtz L; Nilsson J; Wigzell H; Christensson B; Agerberth B; Gudmundsson G
Article: BLOOD. 2000;96(9):3086-3093

The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations.

Agerberth B; Charo J; Werr J; Olsson B; Idali F; Lindbom L; Kiessling R; Jörnvall H; Wigzell H; Gudmundsson GH
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2000;57(6):976-981

Decreased pulmonary levels of the anti-inflammatory Clara cell 16 kDa protein after induction of airway inflammation in asthmatics.

Lensmar C; Nord M; Gudmundsson GH; Roquet A; Andersson O; Jörnvall H; Eklund A; Grunewald J; Agerberth B
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 1999;232(1-2):45-54

Neutrophil antibacterial peptides, multifunctional effector molecules in the mammalian immune system.

Gudmundsson GH; Agerberth B
Article: BIOCHEMICAL JOURNAL. 1999;341 ( Pt 3)(Pt 3):501-513

Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity.

Oren Z; Lerman JC; Gudmundsson GH; Agerberth B; Shai Y
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 1999;160(1):283-290

Antibacterial components in bronchoalveolar lavage fluid from healthy individuals and sarcoidosis patients.

Agerberth B; Grunewald J; Castaños-Velez E; Olsson B; Jörnvall H; Wigzell H; Eklund A; Gudmundsson GH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(50):33115-33118

Apolipoprotein A-I binds and inhibits the human antibacterial/cytotoxic peptide LL-37.

Wang Y; Agerberth B; Löthgren A; Almstedt A; Johansson J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(6):3718-3724

Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37.

Johansson J; Gudmundsson GH; Rottenberg ME; Berndt KD; Agerberth B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(24):15258-15263

The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders.

Frohm M; Agerberth B; Ahangari G; Stâhle-Bäckdahl M; Lidén S; Wigzell H; Gudmundsson GH
Article: FEBS JOURNAL. 1996;238(2):325-332

The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes.

Gudmundsson GH; Agerberth B; Odeberg J; Bergman T; Olsson B; Salcedo R
Article: FEBS JOURNAL. 1996;237(1):86-92

Biochemical and antibacterial analysis of human wound and blister fluid.

Frohm M; Gunne H; Bergman AC; Agerberth B; Bergman T; Boman A; Lidén S; Jörnvall H; Boman HG
Article: TRENDS IN MICROBIOLOGY. 1996;4(3):94

Cytotoxic T cells: More weapons for new targets?

Anderson M; Agerberth B; Gudmundsson GH
Article: EMBO JOURNAL. 1995;14(8):1615-1625

NK-lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activity.

Andersson M; Gunne H; Agerberth B; Boman A; Bergman T; Sillard R; Jörnvall H; Mutt V; Olsson B; Wigzell H
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(1):195-199

FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis.

Agerberth B; Gunne H; Odeberg J; Kogner P; Boman HG; Gudmundsson GH
Show more

All other publications

Review: ANTIBIOTICS-BASEL. 2020;9(1):E21-21

Host-Directed Therapy as a Novel Treatment Strategy to Overcome Tuberculosis: Targeting Immune Modulation.

Ahmed S; Raqib R; Guðmundsson GH; Bergman P; Agerberth B; Rekha RS
Review: FRONTIERS IN IMMUNOLOGY. 2020;11:1209

Host Directed Therapy Against Infection by Boosting Innate Immunity.

Bergman P; Raqib R; Rekha RS; Agerberth B; Gudmundsson GH
Review: ACTA PAEDIATRICA. 2014;103(10):1000-1008

A review of the innate immune defence of the human foetus and newborn, with the emphasis on antimicrobial peptides.

Kai-Larsen Y; Gudmundsson GH; Agerberth B
Review: JOURNAL OF LEUKOCYTE BIOLOGY. 2012;92(4):735-742

Induction of the human cathelicidin LL-37 as a novel treatment against bacterial infections.

van der Does AM; Bergman P; Agerberth B; Lindbom L
Review: FEBS JOURNAL. 2011;278(20):3942-3951

Antimicrobial peptides important in innate immunity.

Cederlund A; Gudmundsson GH; Agerberth B
Review: LAKARTIDNINGEN. 2008;105(34):2254-2259

[Natural immunity--first line defense. New treatment against infections and autoimmune diseases in sight].

Bergman P; Gudmundsson GH; Agerberth B
Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 2006;306:67-90

Host antimicrobial defence peptides in human disease.

Agerberth B; Gudmundsson GH
Published conference paper: SEMINARS IN PERINATOLOGY. 2004;28(4):304-311

First line of defense in early human life.

Yoshio H; Lagercrantz H; Gudmundsson GH; Agerberth B
Published conference paper: BRITISH JOURNAL OF DERMATOLOGY. 2002;147(6):1127-1134

The newborn infant is protected by an innate antimicrobial barrier: peptide antibiotics are present in the skin and vernix caseosa.

Marchini G; Lindow S; Brismar H; Ståbi B; Berggren V; Ulfgren A-K; Lonne-Rahm S; Agerberth B; Gudmundsson GH
Published conference paper: PROTEIN JOURNAL. 1998;17(6):522-523

Structure and activity of cathelicidin antibacterial proteins.

Wang Y; Agerberth B; Johansson J
Published conference paper: VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY. 1996;54(1-4):127-131

PR-39, a proline-rich peptide antibiotic from pig, and FALL-39, a tentative human counterpart.

Agerberth B; Gunne H; Odeberg J; Kogner P; Boman HG; Gudmundsson GH
Published conference paper: VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY. 1996;54(1-4):123-126

NK-lysin, structure and function of a novel effector molecule of porcine T and NK cells.

Andersson M; Gunne H; Agerberth B; Boman A; Bergman T; Olsson B; Dagerlind A; Wigzell H; Boman HG; Gudmundsson GH

Employments

Affiliated to Research, Department of Laboratory Medicine, Karolinska Institutet, 2021-2024
Professor, Senior, Department of Laboratory Medicine, Karolinska Institutet, 2014-2021

Degrees and Education

Docent, Karolinska institutet, 1998

About me

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI