Barbara Leibiger

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Articles

Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2024;(205)
In Vivo Imaging of Liver Spheroids Engrafted in the Anterior Chamber of the Mouse Eye
Lazzeri-Barcelo F; Ciardo P; Leibiger B; Leibiger IB; Berggren P-O; Moruzzi N
Article: NATURE COMMUNICATIONS. 2024;15(1):767
Intraocular liver spheroids for non-invasive high-resolution in vivo monitoring of liver cell function
Lazzeri-Barcelo F; Oliva-Vilarnau N; Baniol M; Leibiger B; Bergmann O; Lauschke VM; Leibiger IB; Moruzzi N; Berggren P-O
Article: CELL TRANSPLANTATION. 2024;33:09636897241241995
Transplantation and Noninvasive Longitudinal In Vivo Imaging of Parathyroid Cells: A Proof-of-Concept Study
Branstrom R; van Krieken PP; Frobom R; Juhlin CC; Shabo I; Leibiger B; Leibiger IB; Berggren P-O; Aspinwall CA
Article: BIOMOLECULES. 2023;13(6):885
Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling
Yu J; Leibiger B; Yang S-N; Shears SBB; Leibiger IBB; Berggren P-O; Barker CJJ
Article: LIFE SCIENCE ALLIANCE. 2022;5(12):e202201505
Mitochondrial impairment and intracellular reactive oxygen species alter primary cilia morphology
Moruzzi N; Valladolid-Acebes I; Kannabiran SA; Bulgaro S; Burtscher I; Leibiger B; Leibiger IB; Berggren P-O; Brismar K
Article: BIOCHEMISTRY AND BIOPHYSICS REPORTS. 2022;30:101260
Inward and outward currents of native and cloned K(ATP) channels (Kir6.2/SUR1) share single-channel kinetic properties
Branstrom R; Berglund E; Frobom R; Leibiger IB; Leibiger B; Aspinwall CA; Larsson O; Berggren P-O
Article: SCIENTIFIC REPORTS. 2021;11(1):21539
Expression of truncated Kir6.2 promotes insertion of functionally inverted ATP-sensitive K⁺ channels
Heitz BA; Branstrom R; Yang W; Huang Y; Moede T; Leibiger IB; Leibiger B; Chen LQ; Yu J; Yang S-N; Larsson O; Saavedra SS; Berggren P-O; Aspinwall CA
Article: METABOLITES. 2021;11(6):387
Ectopic Leptin Production by Intraocular Pancreatic Islet Organoids Ameliorates the Metabolic Phenotype of ob/ob Mice
Leibiger B; Moede T; Valladolid-Acebes I; Paschen M; Visa M; Leibiger IB; Berggren P-O
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2021;25(10):4800-4813
Tissue-specific expression of insulin receptor isoforms in obesity/type 2 diabetes mouse models
Moruzzi N; Lazzeri-Barcelo F; Valladolid-Acebes I; Moede T; Paschen M; Leibiger B; Berggren P-O; Leibiger IB
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(4):1813
Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes
Mir-Coll J; Moede T; Paschen M; Neelakandhan A; Valladolid-Acebes I; Leibiger B; Biernath A; Ammala C; Leibiger IB; Yesildag B; Berggren P-O
Article: SCIENTIFIC REPORTS. 2020;10(1):20145
Glucokinase intrinsically regulates glucose sensing and glucagon secretion in pancreatic alpha cells
Moede T; Leibiger B; Sanchez PV; Dare E; Kohler M; Muhandiramlage TP; Leibiger IB; Berggren P-O
Article: THE FASEB JOURNAL. 2020;34(1):945-959
In vivo Ca²⁺ dynamics in single pancreatic β cells
Jacob S; Kohler M; Troster P; Visa M; Garcia-Prieto CF; Alanentalo T; Moede T; Leibiger B; Leibiger IB; Berggren P-O
Article: THE FASEB JOURNAL. 2019;33(1):204-218
Diet-induced -cell insulin resistance results in reversible loss of functional -cell mass
Paschen M; Moede T; Valladolid-Acebes I; Leibiger B; Moruzzi N; Jacob S; Garcia-Prieto CF; Brismar K; Leibiger IB; Berggren P-O
Article: CELL METABOLISM. 2018;27(3):549-558.e4
Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point
Rodriguez-Diaz R; Molano RD; Weitz JR; Abdulreda MH; Berman DM; Leibiger B; Leibiger IB; Kenyon NS; Ricordi C; Pileggi A; Caicedo A; Berggren P-O
Article: SCIENTIFIC REPORTS. 2016;6:21448
Non-invasive cell type selective in vivo monitoring of insulin resistance dynamics
Paschen M; Moede T; Leibiger B; Jacob S; Bryzgalova G; Leibiger IB; Berggren P-O
Article: CELL REPORTS. 2015;13(1):15-22
PI3K-C2α Knockdown Results in Rerouting of Insulin Signaling and Pancreatic Beta Cell Proliferation
Leibiger B; Moede T; Paschen M; Yunn N-O; Lim JH; Ryu SH; Pereira T; Berggren P-O; Leibiger IB
Article: PLOS GENETICS. 2015;11(9):e1005500
Outer Hair Cell Lateral Wall Structure Constrains the Mobility of Plasma Membrane Proteins
Yamashita T; Hakizimana P; Wu S; Hassan A; Jacob S; Temirov J; Fang J; Mellado-Lagarde M; Gursky R; Horner L; Leibiger B; Leijon S; Centonze VE; Berggren P-O; Frase S; Auer M; Brownell WE; Fridberger A; Zuo J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(20):E2611-E2619
Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes
Avall K; Ali Y; Leibiger IB; Leibiger B; Moede T; Paschen M; Dicker A; Dare E; Kohler M; Ilegems E; Abdulreda MH; Graham M; Crooke RM; Tay VSY; Refai E; Nilsson SK; Jacob S; Selander L; Berggren P-O; Juntti-Berggren L
Article: NATURE COMMUNICATIONS. 2014;5:5308
Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents
Gerdes JM; Christou-Savina S; Xiong Y; Moede T; Moruzzi N; Karlsson-Edlund P; Leibiger B; Leibiger IB; Ostenson C-G; Beales PL; Berggren P-O
Article: CELL. 2014;158(1):41-53
Adipsin Is an Adipokine that Improves β Cell Function in Diabetes
Lo JC; Ljubicic S; Leibiger B; Kern M; Leibiger IB; Moede T; Kelly ME; Bhowmick DC; Murano I; Cohen P; Banks AS; Khandekar MJ; Dietrich A; Flier JS; Cinti S; Blueher M; Danial NN; Berggren P-O; Spiegelman BM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(51):20925-20930
Glucagon regulates its own synthesis by autocrine signaling
Leibiger B; Moede T; Muhandiramlage TP; Kaiser D; Sanchez PV; Leibiger IB; Berggren P-O
Article: INTEGRATIVE BIOLOGY (UNITED KINGDOM). 2012;4(2):209-219
One-step purification of functional human and rat pancreatic alpha cells
Koehler M; Dare E; Ali MY; Rajasekaran SS; Moede T; Leibiger B; Leibiger IB; Tibell A; Juntti-Berggren L; Berggren P-O
Article: THE FASEB JOURNAL. 2010;24(6):1824-1837
Insulin-feedback via PI3K-C2α activated PKBα/Akt1 is required for glucose-stimulated insulin secretion
Leibiger B; Moede T; Uhles S; Barker CJ; Creveaux M; Domin J; Berggren P-O; Leibiger IB
Article: CANCER RESEARCH. 2008;68(17):7156-7164
CREB3L2-PPARγ fusion mutation identifies a thyroid signaling pathway regulated by intramembrane proteolysis
Lui W-O; Zeng L; Rehmann V; Deshpande S; Tretiakova M; Kaplan EL; Leibiger I; Leibiger B; Enberg U; Hoog A; Larsson C; Kroll TG
Article: NATURE MEDICINE. 2008;14(5):574-578
Noninvasive in vivo imaging of pancreatic islet cell biology
Speier S; Nyqvist D; Cabrera O; Yu J; Molano RD; Pileggi A; Moede T; Kohler M; Wilbertz J; Leibiger B; Ricordi C; Leibiger IB; Caicedo A; Berggren P-O
Article: SCIENCE. 2007;318(5854):1299-1302
Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic β cells
Illies C; Gromada J; Fiume R; Leibiger B; Yu J; Juhl K; Yang S-N; Barma DK; Falck JR; Saiardi A; Barker CJ; Berggren P-O
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2007;64(22):2985-2993
Arachidonic acid signaling is of imidazoline-induced K_ATP involved in the mechanism channel-independent stimulation of insulin secretion
Sharoyko VV; Zaitseva II; Leibiger B; Efendic S; Berggren P-O; Zaitsev SV
Article: DIABETOLOGIA. 2007;50(8):1670-1677
Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters:: indications for a long-chain acyl-CoA ester binding motif
Braenstroem R; Leibiger IB; Leibiger B; Klement G; Nilsson J; Arhem P; Aspinwall CA; Corkey BE; Larsson O; Berggren R-O
Article: THE FASEB JOURNAL. 2007;21(7):1609-1621
Selective gene activation by spatial segregation of insulin receptor B signaling
Uhles S; Moede T; Leibiger B; Berggren P-O; Leibiger IB
Article: ENDOCRINE-RELATED CANCER. 2006;13(2):509-523
Loss of parafibromin expression in a subset of parathyroid adenomas
Juhlin C; Larsson C; Yakoleva T; Leibiger I; Leibiger B; Alimov A; Weber G; Hoog A; Villablanca A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2005;338(3):1455-1459
Monomeric G-protein, Rhes, is not an imidazoline-regulated protein in pancreatic β-cells
Sharoyko VV; Zaitseva II; Varsanyi M; Portwood N; Leibiger B; Leibiger I; Berggren PO; Efendic S; Zaitsev SV
Article: CELL. 2004;119(2):273-284
Removal of Ca²⁺ channel β₃ Subunit enhances Ca²⁺ oscillation frequency and insulin exocytosis
Berggren PO; Yang SN; Murakami M; Efanov AM; Uhles S; Köhler M; Moede T; Fernström A; Appelskog LB; Aspinwall CA; Zaitsev SV; Larsson O; de Vargas LM; Fecher-Trost C; Weissgerber P; Ludwig A; Leibiger B; Juntti-Berggren L; Barker CJ; Gromada J; Freichel M; Leibiger IB; Flockerzi V
Article: JOURNAL OF CELL BIOLOGY. 2003;163(6):1327-1337
Isoform-specific insulin receptor signaling involves different plasma membrane domains
Uhles S; Moede T; Leibiger B; Berggren PO; Leibiger IB
Article: DIABETES. 2003;52(12):2943-2950
On-line monitoring of apoptosis in insulin-secreting cells
Köhler M; Zaitsev SV; Zaitseva II; Leibiger B; Leibiger IB; Turunen M; Kapelioukh IL; Bakkman L; Appelskog IB; de Monvel JB; Imreh G; Berggren PO
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(47):46210-46218
Cytosolic multiple inositol polyphosphate phosphatase in the regulation of cytoplasmic free Ca²⁺ concentration
Yu J; Leibiger B; Yang SN; Caffery JJ; Shears SB; Leibiger IB; Barker CJ; Berggren PO
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(45):44753-44757
Rapid association of protein kinase C-ε with insulin granules is essential for insulin exocytosis
Mendez CF; Leibiger IB; Leibiger B; Hoy M; Gromada J; Berggren PO; Bertorello AM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(46):44108-44114
Relevance of dopamine signals anchoring dynamin-2 to the plasma membrane during Na⁺,K⁺-ATPase endocytosis
Efendiev R; Yudowski GA; Zwiller J; Leibiger B; Katz AI; Berggren PO; Pedemonte CH; Leibiger IB; Bertorello AM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(10):6773-6777
Inositol hexakisphosphate promotes dynamin mediated endocytosis
Hoy M; Efanov AM; Bertorello AM; Zaitsev SV; Olsen HL; Bokvist K; Leibiger B; Leibiger IB; Zwiller J; Berggren PO; Gromada J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(19):17108-17111
Tyrosine 537 within the Na⁺,K⁺-ATPase α-subunit is essential for AP-2 binding and clathrin-dependent endocytosis
Doné SC; Leibiger IB; Efendiev R; Katz AI; Leibiger B; Berggren PO; Pedemonte CH; Bertorello AM
Article: MAMMALIAN GENOME. 2002;13(1):20-23
Characterization of a putative murine mitochondrial transporter homology of hMRS3/4
Li FY; Leibiger B; Leibiger I; Larsson C
Article: FEBS LETTERS. 2001;494(1-2):79-84
Characterization of a novel human putative mitochondrial transporter homologous to the yeast mitochondrial RNA splicing proteins 3 and 4
Li FY; Nikali K; Gregan J; Leibiger I; Leibiger B; Schweyen R; Larsson C; Suomalainen A
Article: MOLECULAR CELL. 2001;7(3):559-570
Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic β cells
Leibiger B; Leibiger IB; Moede T; Kemper S; Kulkarni RN; Kahn CR; de Vargas LM; Berggren PO
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(39):30153-30156
Glucose-stimulated insulin biosynthesis depends on insulin-stimulated insulin gene transcription
Leibiger B; Wåhlander K; Berggren PO; Leibiger IB
Article: FEBS LETTERS. 1999;461(3):229-234
Identification of a nuclear localization signal, RRMKWKK, in the homeodomain transcription factor PDX-1
Moede T; Leibiger B; Pour HG; Berggren PO; Leibiger IB
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(18):10164-10169
Syntaxin 1 interacts with the L_D subtype of voltage-gated Ca²⁺ channels in pancreatic β cells
Yang SN; Larsson O; Bränström R; Bertorello AM; Leibiger B; Leibiger IB; Moede T; Köhler M; Meister B; Berggren PO
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(47):31395-31400
Long chain coenzyme A esters activate the pore-forming subunit (Kir6.2) of the ATP-regulated potassium channel
Bränström R; Leibiger IB; Leibiger B; Corkey BE; Berggren PO; Larsson O
Article: EMBO JOURNAL. 1998;17(17):5048-5058
Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating β-cell exocytosis
Brown H; Larsson O; Bränström R; Yang SN; Leibiger B; Leibiger I; Fried G; Moede T; Deeney JT; Brown GR; Jacobsson G; Rhodes CJ; Braun JEA; Scheller RH; Corkey BE; Berggren PO; Meister B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(16):9307-9312
Short-term regulation of insulin gene transcription by glucose
Leibiger B; Moede T; Schwarz T; Brown GR; Köhler M; Leibiger IB; Berggren PO
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(11):6145-6150
In situ activation of the type 2 ryanodine receptor in pancreatic beta cells requires cAMP-dependent phosphorylation
Islam MS; Leibiger I; Leibiger B; Rossi D; Sorrentino V; Ekström TJ; Westerblad H; Andrade FH; Berggren PO
Article: MOLECULAR CELL. 1998;1(6):933-938
Exocytosis of insulin promotes insulin gene transcription via the insulin receptor PI-3 kinase p70 s6 kinase and CaM kinase pathways
Leibiger IB; Leibiger B; Moede T; Berggren PO
Article: MAMMALIAN GENOME. 1998;9(4):310-311
Mapping of the human Ca²⁺ channel β₄ subunit to 2q22-23 and its expression in developing mouse
Betz R; Leibiger B; Farnebo F; Lagercrantz S; Piehl F; Leibiger I; Larsson C
Article: DIABETOLOGIA. 1996;39(10):1165-1172
Dual function of the intron of the rat insulin I gene in regulation of gene expression
Damert A; Leibiger B; Leibiger IB
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Review: ADVANCES IN BIOLOGICAL REGULATION. 2023;87:100919
Novel aspects of intra-islet communication: Primary cilia and filopodia
Moruzzi N; Leibiger B; Barker CJ; Leibiger IB; Berggren P-O
Review: ANNUAL REVIEW OF NUTRITION. 2008;28:233-251
Insulin signaling in the pancreatic β-cell
Leibiger IB; Leibiger B; Berggren P-O
Review: FEBS LETTERS. 2002;532(1-2):1-6
Insulin feedback action on pancreatic β-cell function
Leibiger IB; Leibiger B; Berggren PO
Review: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2002;283(6):E1113-E1122
Phosphorylated inositol compounds in β-cell stimulus-response coupling
Barker CJ; Leibiger IB; Leibiger B; Berggren PO
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 2002;30(2):312-317
Short-term regulation of insulin gene transcription
Leibiger B; Moede T; Uhles S; Berggren PO; Leibiger IB
Published conference paper: DIABETES. 2001;50:S15-S19
Online monitoring of stimulus-induced gene expression in pancreatic β-cells
Moede T; Leibiger B; Berggren PO; Leibiger IB

Employments

Senior Research Specialist, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2005

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