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Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements
Allum F, Hedman Åk, Shao X, Cheung Wa, Vijay J, Guénard F, et al
Nature communications 2019;10(1):1209-

A DNA methylation biomarker of alcohol consumption
Liu C, Marioni Re, Hedman Åk, Pfeiffer L, Tsai Pc, Reynolds Lm, et al
Molecular psychiatry 2018;23(2):422-433

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins
Wang Y, Karlsson R, Lampa E, Zhang Q, Hedman Åk, Almgren M, et al
Epigenetics 2018;13(9):975-987

Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach
Mendelson Mm, Marioni Re, Joehanes R, Liu Cy, Hedman Ak, Aslibekyan S, et al
PLOS MEDICINE 2017;14(1):e1002215-

Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies
Hedman Åk, Mendelson Mm, Marioni Re, Gustafsson S, Joehanes R, Irvin Mr, et al
Circulation. Cardiovascular genetics 2017;10(1):-

Tea and coffee consumption in relation to DNA methylation in four European cohorts
Epigenome-wide Assoc Study Cons, Ek We, Tobi Ew, Ahsan M, Lampa E, Ponzi E, et al
HUMAN MOLECULAR GENETICS 2017;26(16):3221-3231

DNA methylation patterns associated with oxidative stress in an ageing population
Hedman Ak, Zilmer M, Sundstrom J, Lind L, Ingelsson E

Genome-wide DNA methylation study identifies genes associated with the cardiovascular biomarker GDF-15
Ek We, Hedman Ak, Enroth S, Morris Ap, Lindgren Cm, Mahajan A, et al

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
Kilpelainen To, Carli Jfm, Skowronski Aa, Sun Q, Kriebel J, Feitosa Mf, et al

Higher chylomicron remnants and LDL particle numbers associate with CD36 SNPs and DNA methylation sites that reduce CD36
Love-gregory L, Kraja At, Allum F, Aslibekyan S, Hedman Åk, Duan Y, et al
Journal of lipid research 2016;57(12):2176-2184

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Lu Yc, Day Fr, Gustafsson S, Buchkovich Ml, Na Jb, Bataille V, et al

Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants
Multiple Tissue Human Expression R, Allum F, Shao Xj, Guenard F, Simon Mm, Busche S, et al

DNA Methylation of Lipid-Related Genes Affects Blood Lipid Levels
Pfeiffer L, Wahl S, Pilling Lc, Reischl E, Sandling Jk, Kunze S, et al

Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci
Demerath Ew, Guan Wh, Grove Ml, Aslibekyan S, Mendelson M, Zhou Yh, et al
HUMAN MOLECULAR GENETICS 2015;24(15):4464-79

Genetic studies of body mass index yield new insights for obesity biology
Agen-bmi Working Group, Icbp, Glgc, Ckdgen Consortium, Cardiogramplusc4d Consortium, Adipogen Consortium, et al
Nature 2015;518(7538):197-206

Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci
International Endogene Consortium (iec) The Giant Consortium, Rahmioglu N, Macgregor S, Drong Aw, Hedman Åk, Harris Hr, et al
Human molecular genetics 2015;24(4):1185-99

New genetic loci link adipose and insulin biology to body fat distribution
Reprogen Consortium, Adipogen Consortium, Cardiogramplusc4d Consortium, Ckdgen Consortium, Gefos Consortium, Genie Consortium, et al
Nature 2015;518(7538):187-196

Expression of Phosphofructokinase in Skeletal Muscle Is Influenced by Genetic Variation and Associated With Insulin Sensitivity
Muther Consortium, Diagram Consortium, Magic Consortium, Keildson S, Fadista J, Ladenvall C, et al
DIABETES 2014;63(3):1154-65

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Type 2 Diabet Genetic Exploration, Mexican Amer Type 2 Diabet Mat2d C, South Asian Type Diabet Sat2d Cons, Asian Genetic Epidemiology Network, Diabet Genetics Replication & Meta, Mahajan A, et al
NATURE GENETICS 2014;46(3):234-44

Large-scale metabolomic profiling identifies novel biomarkers for incident coronary heart disease
Ganna A, Salihovic S, Sundström J, Broeckling Cd, Hedman Ak, Magnusson Pk, et al
PLoS genetics 2014;10(12):e1004801-

Gene expression changes with age in skin, adipose tissue, blood and brain
Muther Consortium, Uk Brain Expression Consortium, Glass D, Vinuela A, Davies Mn, Ramasamy A, et al
GENOME BIOLOGY 2013;14(7):R75-

Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements
Multiple Tissue Human Expression R, Grundberg E, Meduri E, Sandling Jk, Hedman Ak, Keildson S, et al

The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue
Molpage Consortia, Drong Aw, Nicholson G, Hedman Ak, Meduri E, Grundberg E, et al
PloS one 2013;8(2):e55923-

Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population
Muther Consortium, Bell Jt, Tsai Pc, Yang Tp, Pidsley R, Nisbet J, et al
PLOS GENETICS 2012;8(4):e1002629-

Extent, causes, and consequences of small RNA expression variation in human adipose tissue
Muther Consortium, Parts L, Hedman Åk, Keildson S, Knights Aj, Abreu-goodger C, et al
PLoS genetics 2012;8(5):e1002704-

Mapping cis- and trans-regulatory effects across multiple tissues in twins
Multiple Tissue Human Expression R, Grundberg E, Small Ks, Hedman Ak, Nica Ac, Buil A, et al
NATURE GENETICS 2012;44(10):1084-9

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
Muther Consortium, Diagram Consortium, Cho Ys, Chen Ch, Hu C, Long Jr, et al
NATURE GENETICS 2012;44(1):67-72

Transcriptional Profiling of Serogroup B Neisseria meningitidis Growing in Human Blood: An Approach to Vaccine Antigen Discovery
Hedman Ak, Li Ms, Langford Pr, Kroll Js
PLOS ONE 2012;7(6):e39718-

Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms
Muther Consortium, Zhai Gj, Teumer A, Stolk L, Perry Jrb, Vandenput L, et al
PLOS GENETICS 2011;7(4):e1002025-

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
Diagram, Muther, Kooner Js, Saleheen D, Sim X, Sehmi J, et al
Nature genetics 2011;43(10):984-9

Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
Muther Consortium, Diagram Consortium, Magic Investigators, Giant Consortium, Small Ks, Hedman Ak, et al
NATURE GENETICS 2011;43(6):561-4

The Architecture of Gene Regulatory Variation across Multiple Human Tissues: The MuTHER Study
Muther Consortium, Nica Ac, Parts L, Glass D, Nisbet J, Barrett A, et al
PLOS GENETICS 2011;7(2):e1002003-

SW-ARRAY: a dynamic programming solution for the identification of copy-number changes in genomic DNA using array comparative genome hybridization data
Price Ts, Regan R, Mott R, Hedman A, Honey B, Daniels Rj, et al
NUCLEIC ACIDS RESEARCH 2005;33(11):3455-64

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