Anna Plym

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About me

I am a dedicated cancer researcher, epidemiologist, and an Assistant Professor at
the Department of Medical Epidemiology and Biostatistics (MEB) at Karolinska
Institutet. I also have an adjunct faculty position at Harvard T.H. Chan
School of Public Health and a research affiliation at Brigham and Women's
Hospital, Boston, MA.

Career Highlights:
2023 Adjunct Assistant Professor at Harvard T.H. Chan School of Public Health
2022 Assistant Professor at Karolinska Institutet
2022 Postdoc at Karolinska Institutet
2019-2021 Postdoc at Harvard T.H. Chan School of Public Health and Brigham and Women's Hospital
2019 PhD Cancer Epidemiology (Karolinska Institutet)
2013 MSc Public Health Epidemiology (Karolinska Institutet)
2007 MSc Biomedical Science (Uppsala University)

Research

My research aims at generating evidence-based knowledge that can be used in a
genetic-risk based prevention strategy for prostate cancer. My research
centers around evaluating and improving genetic risk-stratification for
aggressive prostate cancer, and on identifying ways for prevention among men
at high genetic risk.

In my research, I have demonstrated that close to 50% of men with a high
polygenic risk score will be diagnosed with prostate cancer during their
lifetime, as compared with less than 10% among men with a low polygenic risk
score. My research also indicates that a high polygenic risk score is not
deterministic for a poor prostate cancer outcome and that factors linked to a
healthy lifestyle may compensate for a high genetic risk for prostate
cancer.

Selected awards:
2021 Young Investigator Award, Prostate Cancer Foundation (PCF) US
2021 Scholar-in-Training Award, American Association for Cancer Research (AACR)

Articles

Article: JOURNAL OF CLINICAL ONCOLOGY. 2024;42(32):3806-3816
Stockholm3 in a Multiethnic Cohort for Prostate Cancer Detection (SEPTA): A Prospective Multicentered Trial.
Vigneswaran HT; Eklund M; Discacciati A; Nordström T; Hubbard RA; Perlis N; Abern MR; Moreira DM; Eggener S; Yonover P; Chow AK; Watts K; Liss MA; Thoreson GR; Abreu AL; Sonn GA; Palsdottir T; Plym A; Wiklund F; Grönberg H; Murphy AB; SEPTA STHLM3 Study Group
Article: CANCER. 2024;130(20):3496-3505
Healthy lifestyle and prostate cancer risk in the Million Veteran Program
Pagadala MS; Lui A; Lynch J; Karunamuni R; Lee KM; Plym A; Rose BS; Carter H; Kibel AS; Duvall SL; Vassy J; Gaziano JM; Panizzon MS; Hauger RL; Seibert TM
Article: JAMA NETWORK OPEN. 2024;7(7):e2420034
Early Prostate Cancer Deaths Among Men With Higher vs Lower Genetic Risk
Plym A; Zhang Y; Stopsack KH; Ugalde-Morales E; Seibert TM; Conti DV; Haiman CA; Baras A; Stocks T; Drake I; Penney KL; Giovannucci E; Kibel AS; Wiklund F; Mucci LA
Article: INTERNATIONAL JOURNAL OF CANCER. 2024;155(1):71-80
Healthy dietary patterns and risk of prostate cancer in men at high genetic risk
Zhang Y; Stopsack KH; Song M; Mucci LA; Liu B; Penney KL; Tabung FK; Giovannucci E; Plym A
Article: JOURNAL OF UROLOGY. 2024;211(6):754-764
Impact of Family History and Germline Genetic Risk Single Nucleotide Polymorphisms on Long-Term Outcomes of Favorable-Risk Prostate Cancer
Rumpf F; Plym A; Vaselkiv JB; Penney KL; Preston MA; Kibel AS; Mucci LA; Salari K
Article: ACTA ONCOLOGICA. 2024;63:373-378
Agent orange exposure and prostate cancer risk in the million veteran program
Pagadala MS; Lui AJ; Zhong AY; Lynch JA; Karunamuni R; Lee KM; Plym A; Rose BS; Carter HK; Kibel AS; Duvall SL; Gaziano JM; Panizzon MS; Hauger RL; Seibert TM
Article: JNCI CANCER SPECTRUM. 2024;8(2):pkae014
Combining magnetic resonance imaging with a multi-ancestry polygenic risk score to improve identification of clinically significant prostate cancer
Plym A; Madueke I; Naik S; Isabelle M; Conti DV; Haiman CA; Penney KL; Mucci LA; Khorasani R; Kibel AS
Article: CARCINOGENESIS. 2024;45(1-2):35-44
SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and prostate cancer outcomes: a prospective cohort study and meta-analysis
Rajanala SH; Plym A; Vaselkiv JB; Ebot EM; Matsoukas K; Lin Z; Chakraborty G; Markt SC; Penney KL; Lee G-SM; Mucci LA; Kantoff PW; Stopsack KH
Article: NATURE GENETICS. 2023;55(12):2065-2074
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
Wang A; Shen J; Rodriguez AA; Saunders EJ; Chen F; Janivara R; Darst BF; Sheng X; Xu Y; Chou AJ; Benlloch S; Dadaev T; Brook MN; Plym A; Sahimi A; Hoffman TJ; Takahashi A; Matsuda K; Momozawa Y; Fujita M; Laisk T; Figueredo J; Muir K; Ito S; Liu X; Uchio Y; Kubo M; Kamatani Y; Lophatananon A; Wan P; Andrews C; Lori A; Choudhury PP; Schleutker J; Tammela TLJ; Sipeky C; Auvinen A; Giles GG; Southey MC; MacInnis RJ; Cybulski C; Wokolorczyk D; Lubinski J; Rentsch CT; Cho K; Mcmahon BH; Neal DE; Donovan JL; Hamdy FC; Martin RM; Nordestgaard BG; Nielsen SF; Weischer M; Bojesen SE; Roder A; Stroomberg HV; Batra J; Chambers S; Horvath L; Clements JA; Tilly W; Risbridger GP; Gronberg H; Aly M; Szulkin R; Eklund M; Nordstrom T; Pashayan N; Dunning AM; Ghoussaini M; Travis RC; Key TJ; Riboli E; Park JY; Sellers TA; Lin H-Y; Albanes D; Weinstein S; Cook MB; Mucci LA; Giovannucci E; Lindstrom S; Kraft P; Hunter DJ; Penney KL; Turman C; Tangen CM; Goodman PJ; Thompson IMJ; Hamilton RJ; Fleshner NE; Finelli A; Parent M-E; Stanford JL; Ostrander EA; Koutros S; Freeman LEB; Stampfer M; Wolk A; Hakansson N; Andriole GL; Hoover RN; Machiela MJ; Sorensen KD; Borre M; Blot WJ; Zheng W; Yeboah ED; Mensah JE; Lu Y-J; Zhang H-W; Feng N; Mao X; Wu Y; Zhao S-C; Sun Z; Thibodeau SN; McDonnell SK; Schaid DJ; West CML; Barnett G; Maier C; Schnoeller T; Luedeke M; Kibel AS; Drake BF; Cussenot O; Cancel-Tassin G; Menegaux F; Truong T; Koudou YA; John EM; Grindedal EM; Maehle L; Khaw K-T; Ingles SA; Stern MC; Vega A; Gomez-Caamano A; Fachal L; Rosenstein BS; Kerns SL; Ostrer H; Teixeira MR; Paulo P; Brandao A; Watya S; Lubwama A; Bensen JT; Butler EN; Mohler JL; Taylor JA; Kogevinas M; Dierssen-Sotos T; Castano-Vinyals G; Cannon-Albright L; Teerlink CC; Huff CD; Pilie P; Yu Y; Bohlender RJ; Gu J; Strom SS; Multigner L; Blanchet P; Brureau L; Kaneva R; Slavov C; Mitev V; Leach RJ; Brenner H; Chen X; Holleczek B; Schoettker B; Klein EA; Hsing AW; Kittles RA; Murphy AB; Logothetis CJ; Kim J; Neuhausen SL; Steele L; Ding YC; Isaacs WB; Nemesure B; Hennis AJM; Carpten J; Pandha H; Michael A; De Ruyck K; De Meerleer G; Ost P; Xu J; Razack A; Lim J; Teo S-H; Newcomb LF; Lin DW; Fowke JH; Neslund-Dudas CM; Rybicki BA; Gamulin M; Lessel D; Kulis T; Usmani N; Abraham A; Singhal S; Parliament M; Claessens F; Joniau S; Van den Broeck T; Gago-Dominguez M; Castelao JE; Martinez ME; Larkin S; Townsend PA; Aukim-Hastie C; Bush WS; Aldrich MC; Crawford DC; Srivastava S; Cullen J; Petrovics G; Casey G; Wang Y; Tettey Y; Lachance J; Tang W; Biritwum RB; Adjei AA; Tay E; Truelove A; Niwa S; Yamoah K; Govindasami K; Chokkalingam AP; Keaton JM; Hellwege JN; Clark PE; Jalloh M; Gueye SM; Niang L; Ogunbiyi O; Shittu O; Amodu O; Adebiyi AO; Aisuodionoe-Shadrach OI; Ajibola HO; Jamda MA; Oluwole OP; Nwegbu M; Adusei B; Mante S; Darkwa-Abrahams A; Diop H; Gundell SM; Roobol MJ; Jenster G; van Schaik RHN; Hu JJ; Sanderson M; Kachuri L; Varma R; McKean-Cowdin R; Torres M; Preuss MH; Loos RJF; Zawistowski M; Zollner S; Lu Z; Van Den Eeden SK; Easton DF; Ambs S; Edwards TL; Magi R; Rebbeck TR; Fritsche L; Chanock SJ; Berndt SI; Wiklund F; Nakagawa H; Witte JS; Gaziano JM; Justice AC; Mancuso N; Terao C; Eeles RA; Kote-Jarai Z; Madduri RK; Conti DV; Haiman CA
Article: JOURNAL OF NUTRITION EDUCATION AND BEHAVIOR. 2023;55(9):644-650
Food Insecurity Is Associated With Dysfunctional Eating Behaviors Among Adults in Puerto Rico
Xu W; Lopez-Cepero A; O'Neill HJ; Plym A; Austin SB; Mattei J
Article: EUROPEAN UROLOGY. 2023;83(4):343-351
A Healthy Lifestyle in Men at Increased Genetic Risk for Prostate Cancer
Plym A; Zhang Y; Stopsack KH; Delcoigne B; Wiklund F; Haiman C; Kenfield SA; Kibel AS; Giovannucci E; Penney KL; Mucci LA
Article: EUROPEAN UROLOGY OPEN SCIENCE. 2023;50:27-30
Addition of a Genetic Risk Score for Identification of Men with a Low Prostate-specific Antigen Level in Midlife at Risk of Developing Lethal Prostate Cancer
Ma C; Ericsson C; Carlsson SV; Lilja H; Kibel A; Graff RE; Plym A; Giovannucci E; Mucci LA; Preston MA; Penney KL
Article: CANCER PREVENTION RESEARCH. 2022;15(12):815-825
Differences in Prostate Cancer Transcriptomes by Age at Diagnosis: Are Primary Tumors from Older Men Inherently Different?
Zhou CD; Pettersson A; Plym A; Tyekucheva S; Penney KL; Sesso HD; Kantoff PW; Mucci LA; Stopsack KH
Article: CLINICAL CANCER RESEARCH. 2022;28(22):4926-4933
Family History of Prostate and Breast Cancer Integrated with a Polygenic Risk Score Identifies Men at Highest Risk of Dying from Prostate Cancer before Age 75 Years
Plym A; Zhang Y; Stopsack KH; Jee YH; Wiklund F; Kibel AS; Kraft P; Giovannucci E; Penney KL; Mucci LA
Article: ELIFE. 2022;11:e78304
Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations.
Chen F; Darst BF; Madduri RK; Rodriguez AA; Sheng X; Rentsch CT; Andrews C; Tang W; Kibel AS; Plym A; Cho K; Jalloh M; Gueye SM; Niang L; Ogunbiyi OJ; Popoola O; Adebiyi AO; Aisuodionoe-Shadrach OI; Ajibola HO; Jamda MA; Oluwole OP; Nwegbu M; Adusei B; Mante S; Darkwa-Abrahams A; Mensah JE; Adjei AA; Diop H; Lachance J; Rebbeck TR; Ambs S; Gaziano JM; Justice AC; Conti DV; Haiman CA
Article: CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION. 2022;31(7):1460-1465
5-Alpha Reductase Inhibitors and Prostate Cancer Mortality among Men with Regular Access to Screening and Health Care
Vaselkiv JB; Ceraolo C; Wilson KM; Pernar CH; Rencsok EM; Stopsack KH; Grob ST; Plym A; Giovannucci EL; Olumi AF; Kibel AS; Preston MA; Mucci LA
Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2022;114(5):771-774
Evaluation of a Multiethnic Polygenic Risk Score Model for Prostate Cancer
Plym A; Penney KL; Kalia S; Kraft P; Conti DV; Haiman C; Mucci LA; Kibel AS
Article: PROSTATE CANCER AND PROSTATIC DISEASES. 2022;25(2):320-326
Metabolic syndrome and its pharmacologic treatment are associated with the time to castration-resistant prostate cancer
Geng J-H; Plym A; Penney KL; Pomerantz M; Mucci LA; Kibel AS
Article: JNCI CANCER SPECTRUM. 2022;6(1):pkab097
DNA Repair Pathways and Their Association With Lethal Prostate Cancer in African American and European American Men
Plym A; Diossy M; Szallasi Z; Sartor O; Silberstein J; Powell IJ; Rebbeck TR; Penney KL; Mucci LA; Pomerantz MM; Kibel AS
Article: EPIDEMIOLOGY. 2021;32(4):607-615
An Aggregated Comorbidity Measure Based on History of Filled Drug Prescriptions: Development and Evaluation in Two Separate Cohorts
Gedeborg R; Sund M; Lambe M; Plym A; Fredriksson I; Syrja J; Holmberg L; Robinson D; Stattin P; Garmo H
Article: BREAST CANCER RESEARCH AND TREATMENT. 2020;182(3):699-707
Impact of chemotherapy, radiotherapy, and endocrine therapy on sick leave in women with early-stage breast cancer during a 5-year period: a population-based cohort study
Plym A; Johansson ALV; Bower H; Wennstig A-K; Fredriksson I; Ahlgren J; Lambe M
Article: ALZHEIMER'S AND DEMENTIA. 2020;16(7):1003-1012
Association of diabetes with stroke and post-stroke dementia: A population-based cohort study
Shang Y; Fratiglioni L; Marseglia A; Plym A; Welmer A-K; Wang H-X; Wang R; Xu W
Article: BMJ OPEN. 2020;10(3):e032914
Duration of sick leave after active surveillance, surgery or radiotherapy for localised prostate cancer: a nationwide cohort study
Plym A; Clements M; Voss M; Holmberg L; Stattin P; Lambe M
Article: BREAST. 2019;45:48-55
Causes of sick leave, disability pension, and death following a breast cancer diagnosis in women of working age
Plym A; Johansson ALV; Bower H; Voss M; Holmberg L; Fredriksson I; Lambe M
Article: BRITISH JOURNAL OF CANCER. 2018;118(5):738-743
Loss in working years after a breast cancer diagnosis
Plym A; Bower H; Fredriksson I; Holmberg L; Lambert PC; Lambe M
Article: EUROPEAN UROLOGY. 2016;70(1):64-71
Work Disability After Robot-assisted or Open Radical Prostatectomy: A Nationwide, Population-based Study
Plym A; Chiesa F; Voss M; Holmberg L; Johansson E; Stattin P; Lambe M
Article: JOURNAL OF AMERICAN ACADEMY OF DERMATOLOGY. 2014;71(6):1093-1101
Mortality in women with pregnancy-associated malignant melanoma
Johansson ALV; Andersson TM-L; Plym A; Ullenhag GJ; Moller H; Lambe M
Article: JOURNAL OF SEXUAL MEDICINE. 2014;11(8):2100-2108
Drug Prescription for Erectile Dysfunction Before and After Diagnosis of Localized Prostate Cancer
Plym A; Folkvaljon Y; Garmo H; Holmberg L; Johansson E; Fransson P; Stattin P; Lambe M
Article: ACTA ONCOLOGICA. 2014;53(5):688-696
Clinical characteristics, management and survival in young adults diagnosed with malignant melanoma: A population-based cohort study
Plym A; Ullenhag GJ; Breivald M; Lambe M; Berglund A
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All other publications

Editorial comment: CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION. 2023;32(5):585-587
The Imperative for Population-based Cancer Registration of All Metastatic Cancers
Stopsack KH; Plym A; Mucci LA
Review: EUROPEAN UROLOGY. 2023;83(3):241-248
Genetic Risk Prediction for Prostate Cancer: Implications for Early Detection and Prevention.
Seibert TM; Garraway IP; Plym A; Mahal BA; Giri V; Jacobs MF; Cheng HH; Loeb S; Helfand BT; Eeles RA; Morgan TM
Thesis / dissertation: 2018
Breast and prostate cancer : the impact of diagnosis and treatment on sick leave and work
Plym, Anna
Editorial comment: EUROPEAN UROLOGY. 2016;70(1):73-74
Reply from Authors re: Matthew T. Gettman. Assessing Work Disability After Radical Prostatectomy. Eur Urol 2016;70:72-3 The Challenge of Assessing Work Disability
Plym A; Voss M; Stattin P; Lambe M

Employments

Assistant Professor, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2022-2028

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2019
Degree Of Master Of Medical Science 120 Credits, Karolinska Institutet, 2013

About me

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