Ann-Sofie Backman
Affiliated to Research | Docent
E-mail: ann-sofie.backman@ki.se
Visiting address: Karolinska Universitetssjukhuset Huddinge, C177, 14186 Huddinge
Postal address: H7 Medicin, Huddinge, H7 Avdelningen för Gastroenterologi och nutrition, 171 77 Stockholm
Part of:
Research
- This is found under my research groups page:
https://ki.se/en/medh/backman-group-inflammation-and-cancer-in-the-gi-system
Articles
- Article: FAMILIAL CANCER. 2024;23(4):599-605Frank A; Bernstedt SW; Jamizadeh N; Forsberg A; Hedin C; Blom J; Backman A-S
- Article: ENDOSCOPY INTERNATIONAL OPEN. 2024;12(07):e854-e860Bernstedt SW; Haxhijaj A; Jamizadeh N; Bjoerk J; Andreasson A; Forsberg AM; Backman A-S
- Journal article: JOURNAL OF CROHNS & COLITIS. 2024;18:i218-i220Verstockt B; Taelman T; Vavricka SR; Zabana Y; Lenfant M; Macaigne G; Maillard MH; Savarino E; Teich N; Kiudelis V; Negro JDLR; Ribaldone DG; Barreiro-de Acosta M; Wildt S; Riviere P; Fumery M; Truyens M; Amiot A; Marsal J; Levartovsky A; Vieujean S; Somers M; Cremer A; Lutakov I; Cohen NA; Dewit S; Bajer L; Rahier JF; Backman AS; Nancey S; Choden T; Van Dongen J; Munch A; Julsgaard M
- Journal article: PROCEDIA COMPUTER SCIENCE. 2024;246:3457-3466Roy M; Håkansson A; Backman A-S; Wijkström C; Varkey J; Salih NM; Papachrysos N; Mannheimer O; Schmidt PT; Brackmann S; de Lange T
- Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2023;58(7):709-717Tornkvist NT; Backman A-S; Linder M; Altman M; Simren M; Olen O; Tornblom H
- Journal article: JOURNAL OF CROHNS & COLITIS. 2023;17(6):1025
- Article: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 2023;21(3):771-788.e10Peyrin-Biroulet L; Rahier J-F; Kirchgesner J; Abitbol V; Shaji S; Armuzzi A; Karmiris K; Gisbert JP; Bossuyt P; Helwig U; Burisch J; Yanai H; Doherty GA; Magro F; Molnar T; Lowenberg M; Halfvarson J; Zagorowicz E; Rousseau H; Baumann C; Baert F; Beaugerie L
- Article: EUROPEAN JOURNAL OF CANCER PREVENTION. 2023;32(2):113-118Bryant P; Bernstedt SW; Thutkawkorapin J; Backman A-S; Lindblom A; Lagerstedt-Robinson K
- Article: FRONTIERS IN ONCOLOGY. 2023;13:1127707Jamizadeh N; Bernstedt SW; Haxhijaj A; Andreasson A; Bjork J; Forsberg A; Backman A-S
- Article: JOURNAL OF CROHNS & COLITIS. 2023;17(1):37-48Amiot A; Rahier J-F; Baert F; Nahon S; Hart A; Viazis N; Biancone L; Domenech E; Reenears C; Peyrin-Biroulet L; Beaugerie L; Burisch J
- Article: LAKARTIDNINGEN. 2022;119:22073Thorlacius H; Sjöberg D; Backman A-S; Palmqvist R; Toth E
- Article: HEREDITARY CANCER IN CLINICAL PRACTICE. 2022;20(1):36Moller P; Seppala T; Dowty JG; Haupt S; Dominguez-Valentin M; Sunde L; Bernstein I; Engel C; Aretz S; Nielsen M; Capella G; Evans DG; Burn J; Holinski-Feder E; Bertario L; Bonanni B; Lindblom A; Levi Z; Macrae F; Winship I; Plazzer J-P; Sijmons R; Laghi L; Della Valle A; Heinimann K; Half E; Lopez-Koestner F; Alvarez-Valenzuela K; Scott RJ; Katz L; Laish I; Vainer E; Vaccaro CA; Carraro DM; Gluck N; Abu-Freha N; Stakelum A; Kennelly R; Winter D; Rossi BM; Greenblatt M; Bohorquez M; Sheth H; Tibiletti MG; Lino-Silva LS; Horisberger K; Portenkirchner C; Nascimento I; Rossi NT; da Silva LA; Thomas H; Zarand A; Mecklin J-P; Pylvanainen K; Renkonen-Sinisalo L; Lepisto A; Peltomaki P; Therkildsen C; Lindberg LJ; Thorlacius-Ussing O; von Knebel Doeberitz M; Loeffler M; Rahner N; Steinke-Lange V; Schmiegel W; Vangala D; Perne C; Hueneburg R; de Vargas AF; Latchford A; Gerdes A-M; Backman A-S; Guillen-Ponce C; Snyder C; Lautrup CK; Amor D; Palmero E; Stoffel E; Duijkers F; Hall MJ; Hampel H; Williams H; Okkels H; Lubinski J; Reece J; Ngeow J; Guillem JG; Arnold J; Wadt K; Monahan K; Senter L; Rasmussen LJ; van Hest LP; Ricciardiello L; Kohonen-Corish MRJ; Ligtenberg MJL; Southey M; Aronson M; Zahary MN; Samadder NJ; Poplawski N; Hoogerbrugge N; Morrison PJ; James P; Lee G; Chen-Shtoyerman R; Ankathil R; Pai R; Ward R; Parry S; Debniak T; John T; van Overeem Hansen T; Caldes T; Yamaguchi T; Barca-Tierno V; Garre P; Cavestro GM; Weitz J; Redler S; Buettner R; Heuveline V; Hopper JL; Win AK; Lindor N; Gallinger S; Le Marchand L; Newcomb PA; Figueiredo J; Buchanan DD; Thibodeau SN; ten Broeke SW; Hovig E; Nakken S; Pineda M; Duenas N; Brunet J; Green K; Lalloo F; Newton K; Crosbie EJ; Mints M; Tjandra D; Neffa F; Esperon P; Kariv R; Rosner G; Pavicic WH; Kalfayan P; Torrezan GT; Bassaneze T; Martin C; Moslein G; Ahadova A; Kloor M; Sampson JR; Jenkins MA
- Journal article: MEDICAL RESEARCH ARCHIVES. 2022;10(4)Linkage and association analysis define novel regions for the risk of adenomas and colorectal cancerLiu W; Gonn M; Holst S; Thutkawkorapin J; Jiao X; Björk2 J; Backman A-S; Lagerstedt-Robinson K; Lindblom A
- Article: LANCET ONCOLOGY. 2021;22(7):1014-1022Jenkins MA
- Article: HEREDITARY CANCER IN CLINICAL PRACTICE. 2021;19(1):18Bernstedt SW; Bjork J; Fritzell K; Spigelman AD; Bjorck E; Backman A-S
- Journal article: GASTROENTEROLOGY. 2021;160(3):952-954.e4Thomas LE; Hurley JJ; Sanchez AA; Aznarez MR; Backman A-S; Bjork J; Capella G; Clark SK; Colas C; Dekker E; Dolwani S; Ghorbanoghli Z; Gonn M; Romero SG; Hes FJ; Jundi H; Kelland S; Latchford AR; Brito HL; Lynch PM; Meuser E; Mork ME; Mort M; Garcia MN; Nielsen M; Parc Y; Ricci MT; Saurin J-C; van der Tuin K; Vasen H; Vilar E; Vinet O; Vitellaro M; Walton S-J; West HD; Sampson JR
- Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2020;55(10):1185-1192Kulmala KA; Bjork J; Andersson S; Backman A-S; Eberhardson M; Bresso F; Hedin CRH
- Article: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2019;114(2):291-304Ludvigsson JF; Mahl M; Sachs MC; Bjork J; Michaelsson K; Ekbom A; Askling J; Backman A-S; Olen O
- Article: NEUROGASTROENTEROLOGY AND MOTILITY. 2018;30(11):e13436Olen O; Stephansson O; Backman A-S; Tornblom H; Simren M; Altman M
- Journal article: JOURNAL OF CROHNS & COLITIS. 2018;12(supplement_1):s310Kulmala K; Björk J; Andersson S; Backman A-S; Hedin CRH; Bresso F
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2017;102(11):3928-3932Bengtsson D; Joost P; Aravidis C; Stenmark MA; Backman A-S; Melin B; von Salome J; Zagoras T; Gebre-Medhin S; Burman P
- Article: EMERGENCY MEDICINE JOURNAL. 2012;29(12):1004-1006Backman A-S; Lagerlund M; Svensson T; Blomqvist P; Adami J
- Article: INTERNAL AND EMERGENCY MEDICINE. 2010;5(6):539-546Backman A-S; Blomqvist P; Svensson T; Adami J
- Article: AMERICAN JOURNAL OF MANAGED CARE. 2010;16(5):361-368Backman A-S; Blomqvist P; Lagerlund M; Adami J
- Article: SCANDINAVIAN JOURNAL OF PRIMARY HEALTH CARE. 2008;26(3):181-187Backman A-S; Blomqvist P; Lagerlund M; Carlsson-Holm E; Adami J
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All other publications
- Conference publication: GASTROENTEROLOGY. 2024;166(5):S281-S282Verstockt B; Taelman T; Vavricka SR; Zabana Y; Lenfant M; Macaigne G; Maillard MH; Savarino E; Teich N; Kiudelis V; Negro JDLR; Ribaldone DG; Barreiro-De-Acosta M; Wildt S; Riviere P; Fumery M; Truyens M; Amiot A; Marsal J; Levartovsky A; Vieujean S; Somers M; Cremer A; Lyutakov I; Cohen NA; De Wit S; Bajer L; Rahier J-F; Backman A-S; Nancey S; Choden T; Van Dongen J; Munch A; Julsgaard M
- Conference publication: JOURNAL OF CROHNS & COLITIS. 2024;18:I218-I220Verstockt B; Taelman T; Vavricka SR; Zabana Y; Lenfant M; Macaigne G; Maillard MH; Savarino E; Teich N; Kiudelis V; Negro JDLR; Ribaldone DG; Barreiro-de Acosta M; Wildt S; Riviere P; Fumery M; Truyens M; Amiot A; Marsal J; Levartovsky A; Vieujean S; Somers M; Cremer A; Lutakov I; Cohen NA; Dewit S; Bajer L; Rahier JF; Backman AS; Nancey S; Choden T; Van Dongen J; Muench A; Julsgaard M
- Book chapter: DUODENUM AND SMALL BOWEL. 2022;p. 155-164Duodenal adenomas and small bowel polyps, including familial adenomatous polyposisLatchford A; Backman A-S; Spigelman A
- Other: FAMILIAL CANCER. 2022;21(4):557-636
- Other: LAKARTIDNINGEN. 2018;115:E7MIBjörck E; Walton Bernstedt S; Mints M; Björk J; Backman A-S
- Conference publication: GASTROENTEROLOGY. 2018;154(6):s-603Ludvigsson JF; Mahl M; Sachs MC; Björk J; Michaelsson K; Ekbom A; Askling J; Backman A-S; Olen O
- Conference publication: GASTROENTEROLOGY. 2018;154(6):S603Ludvigsson JF; Mahl M; Sachs MC; Bjork J; Michaelsson K; Ekbom A; Askling J; Backman A-S; Olen O
- Review: LAKARTIDNINGEN. 2018;115:EY3CWalton Bernstedt S; Björk J; Mints M; Björck E; Backman A-S
- Conference publication: JOURNAL OF CROHNS & COLITIS. 2018;12:S310Kulmala K; Bjork J; Andersson S; Backman A-S; Hedin CRH; Bresso F
- Meeting abstract: GASTROENTEROLOGY. 2016;150(4):S364Backman A-S; Walton-Bernstedt S; Bjork J
- Conference publication: GASTROENTEROLOGY. 2014;146(5):S543Jossan N; Backman A-S; Linder M; Altman M; Simren M; Olen O; Toernblom H
- Conference publication: GASTROENTEROLOGY. 2014;146(5):S178Olen O; Stephansson O; Backman A-S; Toernblom H; Simren M; Altman M
- Conference publication: GASTROENTEROLOGY. 2014;146(5):s-543Jossan N; Backman A-S; Linder M; Altman M; Simren M; Olen O; Törnblom H
- Conference publication: GASTROENTEROLOGY. 2014;146(5):s-178Olen O; Stephansson O; Backman A-S; Törnblom H; Simren M; Altman M
- Doctoral thesis: 2010Emergency care seeking behaviour : in relation to patients' and providers' perceptions and attitudesBackman A-S
Grants
- Swedish Research Council1 December 2024 - 30 November 2028Due to implementation of organized colorectal cancer screening in Sweden and many other European countries, the number of patients with early-stage colon cancer are rapidly growing. This is a positive outcome of screening but demands more sophisticated minimally invasive treatment techniques.The SCAR trial is a randomized head-to-head comparison trial of patients who have undergone incomplete endoscopic removal (polypectomy, EMR) of early colon cancer (P) for complete and definitive treatment of the cancer. A novel minimally invasive treatment with colonoscope - endoscopic full-thickness resection (I) - will be compared to standard-of-care surgery (C). The 160 patients needed in each allocation arm, will be asked to be included in the trial at the endoscopy centers after eligibility assessment by the local multidisciplinary tumor board. The co-primary outcomes are adverse events (O1) and cancer recurrence (O2), estimated after 30 days of treatment and 3 years of follow-up (T), respectively. The secondary outcomes are quality of life, cost-effectiveness, and ecological footprint.With successful analyses in approximately 5 years after trial start, the results may lead to complete re-thinking of treatment approaches in these patients. There would be a tremendous potential in decreasing overtreatment with the advanced surgery used today, in favor of an as effective, but safer, endoscopic treatment that improves quality of life and that can be performed in an out-patient setting.
- Swedish Cancer Society1 January 2023Colon cancer that runs in the family often causes the onset of cancer at a young age and leads to major consequences both on a human level and socioeconomically. The preventive strategy that prevails today is based on frequent colonoscopy examinations. In the event of cancer, it leads to extensive operations, often with lifelong gastrointestinal problems following. The possibilities for medical preventive treatment are incompletely studied and a tolerable preparation for lifelong preventive treatment is missing. In addition to preventive treatment, there is no possibility of early identification of cancer via other examinations such as blood tests instead of colonoscopies. The study investigates whether the drug Mesalamine can be used preventively to reduce the risk of colon cancer compared to an inactive substance (placebo). Mesalamine is a well-tolerated drug and has been used for over 30 years to treat inflammatory bowel disease. The drug appears to reduce the risk of developing colon cancer when examining the effect on tumors in animal experiments. Mesalamine is similar to aspirin, which is known to reduce cell changes in the intestine, but does not have the side effects, such as stomach ulcers and increased risk of bleeding, that aspirin has. The effect of Mesalamine on intestinal flora will be investigated. Early markers for cancer will be mapped in blood. The best cancer is the one that never occurs. Finding an effective and well-tolerated drug that prevents cancer development with the least possible side effects is especially important in this high-risk group, which needs to start life-long preventive treatment at a young age. We need to be able to offer an alternative to aspirin, which is linked to bleeding and gastrointestinal side effects. We will look at the number and type of new polyps in treated and untreated groups and the goal is to see if Mesalamine prevents malignant polyps and if the drug contributes to creating an environment in the intestine between intestinal flora and mucosa that prevents cell changes.
- Swedish Research Council1 January 2018 - 31 December 2020
Employments
- Affiliated to Research, Department of Medicine, Huddinge, Karolinska Institutet, 2023-2026
Degrees and Education
- Docent, Gastroenterology, Karolinska Institutet, 2024
- Degree Of Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2010
- University Medical Degree, Karolinska Institutet, 1997
Leadership and responsibility assignments
- Head of Unit of Education Stockholm Region, Education Region Stockholm, Stockholm Region, 2024-