Anders Mälarstig

About me
Publications
Public outreach and news

About me

Our team performs research on causal risk factors by integrating human genetics with large-scale proteomics, with focus on identifying novel disease etiologies and drug targets in cancer.

About me
M.S. Organic chemistry and Molecular biology, Uppsala University, 2001

PhD Medical Sciences "Tissue factor and CD40 ligand -interplay between coagulation and inflammation", Uppsala University, 2006

PostDoc, Department of Medicine, Cardiovascular research unit, Karolinska Institute, 2006-2009

Group Leader, Human genetics, Pfizer Worldwide research and development, Sandwich &
Cambridge, United Kingdom, 2009-2014

Senior research associate, Cardiovascular Epidemiology unit, Cambridge University, UK, 2011-2013

Director, Human Genetics, Pfizer Worldwide Research, Development and Medical, Stockholm, 2014-

Associate researcher, Dept of Medicine, Cardiovascular Epidemiology unit, 2014-2020

Senior Researcher, Department of Medical Epidemiology and Biostatistics, 2020-

Articles

Article: NATURE COMMUNICATIONS. 2023;14(1):7680
Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation
Malarstig A; Grassmann F; Dahl L; Dimitriou M; McLeod D; Gabrielson M; Smith-Byrne K; Thomas CE; Huang T-H; Forsberg SKG; Eriksson P; Ulfstedt M; Johansson M; Sokolov AV; Schioth HB; Hall P; Schwenk JM; Czene K; Hedman AK
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2021;41(5):1777-1788
Plasma Protein Profile of Carotid Artery Atherosclerosis and Atherosclerotic Outcomes Meta-Analyses and Mendelian Randomization Analyses
Lind L; Gigante B; Borne Y; Feldreich T; Leppert J; Hedberg P; Ostgren CJ; Nystrom FH; Sundstrom J; Arnlov J; Baldassarre D; Tremoli E; Veglia F; Hamsten A; O'Donnell CJ; Franceschini N; Orho-Melander M; Nilsson J; Melander O; Engstrom G; Malarstig A
Article: SCIENTIFIC REPORTS. 2021;11(1):1965
Accelerated inflammatory aging in Alzheimer's disease and its relation to amyloid, tau, and cognition
Cullen NC; Malarstig A; Stomrud E; Hansson O; Mattsson-Carlgren N
Article: GENES. 2020;11(11):E1243-1243
Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease Do Not Associate with Measures of Sub-Clinical Atherosclerosis: Results from the IMPROVE Study
Castaldo L; Laguzzi F; Strawbridge RJ; Baldassarre D; Veglia F; Vigo L; Tremoli E; de Faire U; Eriksson P; Smit AJ; Aubrecht J; Leander K; Pirro M; Giral P; Ritieni A; Di Minno G; Malarstig A; Gigante B
Article: NATURE METABOLISM. 2020;2(10):1135-1148
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
Folkersen L; Gustafsson S; Wang Q; Hansen DH; Hedman AK; Schork A; Page K; Zhernakova DV; Wu Y; Peters J; Eriksson N; Bergen SE; Boutin TS; Bretherick AD; Enroth S; Kalnapenkis A; Gadin JR; Suur BE; Chen Y; Matic L; Gale JD; Lee J; Zhang W; Quazi A; Ala-Korpela M; Choi SH; Claringbould A; Danesh J; Smith GD; de Masi F; Elmstahl S; Engstrom G; Fauman E; Fernandez C; Franke L; Franks PW; Giedraitis V; Haley C; Hamsten A; Ingason A; Johansson A; Joshi PK; Lind L; Lindgren CM; Lubitz S; Palmer T; Macdonald-Dunlop E; Magnusson M; Melander O; Michaelsson K; Morris AP; Magi R; Nagle MW; Nilsson PM; Nilsson J; Orho-Melander M; Polasek O; Prins B; Palsson E; Qi T; Sjogren M; Sundstrom J; Surendran P; Vosa U; Werge T; Wernersson R; Westra H-J; Yang J; Zhernakova A; Arnlov J; Fu J; Smith JG; Esko T; Hayward C; Gyllensten U; Landen M; Siegbahn A; Wilson JF; Wallentin L; Butterworth AS; Holmes MV; Ingelsson E; Malarstig A
Article: SCIENTIFIC REPORTS. 2020;10(1):8233
CDH6 and HAGH protein levels in plasma associate with Alzheimer's disease in APOE ε4 carriers
Ahmad S; Milan MDC; Hansson O; Demirkan A; Agustin R; Saez ME; Giagtzoglou N; Cabrera-Socorro A; Bakker MHM; Ramirez A; Hankemeier T; Stomrud E; Mattsson-Carlgren N; Scheltens P; van der Flier WM; Ikram MA; Malarstig A; Teunissen CE; Amin N; van Duijn CM
Article: HEART. 2020;106(5):342-349
Identification of novel pheno-groups in heart failure with preserved ejection fraction using machine learning
Hedman AK; Hage C; Sharma A; Brosnan MJ; Buckbinder L; Gan L-M; Shah SJ; Linde CM; Donal E; Daubert J-C; Malarstig A; Ziemek D; Lund L
Article: ATHEROSCLEROSIS. 2020;295:25-30
The plasma protein profile and cardiovascular risk differ between intima-media thickness of the common carotid artery and the bulb: A meta-analysis and a longitudinal evaluation
Lind L; Gigante B; Borne Y; Malarstig A; Sundstrom J; Arnlov J; Ingelsson E; Baldassarre D; Tremoli E; Veglia F; Hamsten A; Orho-Melander M; Nilsson J; Melander O; Engstrom G
Article: NATURE COMMUNICATIONS. 2020;11(1):163
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Shah S; Henry A; Roselli C; Lin H; Sveinbjornsson G; Fatemifar G; Hedman AK; Wilk JB; Morley MP; Chaffin MD; Helgadottir A; Verweij N; Dehghan A; Almgren P; Andersson C; Aragam KG; Arnlov J; Backman JD; Biggs ML; Bloom HL; Brandimarto J; Brown MR; Buckbinder L; Carey DJ; Chasman DI; Chen X; Chen X; Chung J; Chutkow W; Cook JP; Delgado GE; Denaxas S; Doney AS; Doerr M; Dudley SC; Dunn ME; Engstrom G; Esko T; Felix SB; Finan C; Ford I; Ghanbari M; Ghasemi S; Giedraitis V; Giulianini F; Gottdiener JS; Gross S; Gudbjartsson DF; Gutmann R; Haggerty CM; van der Harst P; Hyde CL; Ingelsson E; Jukema JW; Kavousi M; Khaw K-T; Kleber ME; Kober L; Koekemoer A; Langenberg C; Lind L; Lindgren CM; London B; Lotta LA; Lovering RC; Luan J; Magnusson P; Mahajan A; Margulies KB; Maerz W; Melander O; Mordi IR; Morgan T; Morris AD; Morris AP; Morrison AC; Nagle MW; Nelson CP; Niessner A; Niiranen T; O'Donoghue ML; Owens AT; Palmer CNA; Parry HM; Perola M; Portilla-Fernandez E; Psaty BM; Rice KM; Ridker PM; Romaine SPR; Rotter JI; Salo P; Salomaa V; van Setten J; Shalaby AA; Smelser DT; Smith NL; Stender S; Stott DJ; Svensson P; Tammesoo M-L; Taylor KD; Teder-Laving M; Teumer A; Thorgeirsson G; Thorsteinsdottir U; Torp-Pedersen C; Trompet S; Tyl B; Uitterlinden AG; Veluchamy A; Voelker U; Voors AA; Wang X; Wareham NJ; Waterworth D; Weeke PE; Weiss R; Wiggins KL; Xing H; Yerges-Armstrong LM; Yu B; Zannad F; Zhao JH; Hemingway H; Samani NJ; McMurray JJV; Yang J; Visscher PM; Newton-Cheh C; Malarstig A; Holm H; Lubitz SA; Sattar N; Holmes MV; Cappola TP; Asselbergs FW; Hingorani AD; Kuchenbaecker K; Ellinor PT; Lang CC; Stefansson K; Smith JG; Vasan RS; Swerdlow DI; Lumbers RT; Abecasis G; Backman J; Bai X; Balasubramanian S; Banerjee N; Baras A; Barnard L; Beechert C; Blumenfeld A; Cantor M; Chai Y; Chung J; Coppola G; Damask A; Dewey F; Economides A; Eom G; Forsythe C; Fuller ED; Gu Z; Gurski L; Guzzardo PM; Habegger L; Hahn Y; Hawes A; van Hout C; Jones MB; Khalid S; Lattari M; Li A; Lin N; Liu D; Lopez A; Manoochehri K; Marchini J; Marcketta A; Maxwell EK; McCarthy S; Mitnaul LJ; O'Dushlaine C; Overton JD; Padilla MS; Paulding C; Penn J; Pradhan M; Reid JG; Schleicher TD; Schurmann C; Shuldiner A; Staples JC; Sun D; Toledo K; Ulloa RH; Widom L; Wolf SE; Yadav A; Ye B
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2019;7(1):169
Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer's disease
Whelan CD; Mattsson N; Nagle MW; Vijayaraghavan S; Hyde C; Janelidze S; Stomrud E; Lee J; Fitz L; Samad TA; Ramaswamy G; Margolin RA; Malarstig A; Hansson O
Article: NATURE GENETICS. 2019;51(7):1082-1091
A genetics-led approach defines the drug target landscape of 30 immune-related traits
Fang H; Beckmann G; Bountra C; Bowness P; Burgess-Brown N; Carpenter L; Chen L; Damerell D; Egner U; Fujii R; Howe T; Jakobsson P-J; Katopodis A; Knight JC; Marsden BD; De Martino J; Matthias G; McVean G; Mueller-Fahrnow A; Malarstig A; O'Callaghan CA; Ostermann N; Paez-cortez JR; Peeters PJ; Prinz F; Soulard P; Sundstrom M; Yabuki C; Vlach J; De Wolf H; Knezevic B; Burnham KL; Osgood J; Sanniti A; Lara AL; Kasela S; De Cesco S; Wegner JK; Handunnetthi L; McCann FE; Sekine T; Brennan PE; Sundstrom Y; Milani L; Berg L; Gohlmann HW; Fairfax BP
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2018;38(10):2505-2518
Associations of Circulating Protein Levels With Lipid Fractions in the General Population
Figarska SM; Gustafsson S; Sundstrom J; Arnlov J; Malarstig A; Elmstahl S; Fall T; Lind L; Ingelsson E
Article: WELLCOME OPEN RESEARCH. 2018;3:13
Human CCL3L1 copy number variation, gene expression, and the role of the CCL3L1-CCR5 axis in lung function.
Adewoye AB; Shrine N; Odenthal-Hesse L; Welsh S; Malarstig A; Jelinsky S; Kilty I; Tobin MD; Hollox EJ; Wain LV
Article: NATURE GENETICS. 2017;49(12):1758-1766
Exome-wide association study of plasma lipids in >300,000 individuals
Liu DJ; Peloso GM; Yu H; Butterworth AS; Wang X; Mahajan A; Saleheen D; Emdin C; Alam D; Alves AC; Amouyel P; Di Angelantonio E; Arveiler D; Assimes TL; Auer PL; Baber U; Ballantyne CM; Bang LE; Benn M; Bis JC; Boehnke M; Boerwinkle E; Bork-Jensen J; Bottinger EP; Brandslund I; Brown M; Busonero F; Caulfield MJ; Chambers JC; Chasman DI; Chen YE; Chen Y-DI; Chowdhury R; Christensen C; Chu AY; Connell JM; Cucca F; Cupples LA; Damrauer SM; Davies G; Deary IJ; Dedoussis G; Denny JC; Dominiczak A; Dube M-P; Ebeling T; Eiriksdottir G; Esko T; Farmaki A-E; Feitosa MF; Ferrario M; Ferrieres J; Ford I; Fornage M; Franks PW; Frayling TM; Frikke-Schmidt R; Fritsche LG; Frossard P; Fuster V; Ganesh SK; Gao W; Garcia ME; Gieger C; Giulianini F; Goodarzi MO; Grallert H; Grarup N; Groop L; Grove ML; Gudnason V; Hansen T; Harris TB; Hayward C; Hirschhorn JN; Holmen OL; Huffman J; Huo Y; Hveem K; Jabeen S; Jackson AU; Jakobsdottir J; Jarvelin M-R; Jensen GB; Jorgensen ME; Jukema JW; Justesen JM; Kamstrup PR; Kanoni S; Karpe F; Kee F; Khera AV; Klarin D; Koistinen HA; Kooner JS; Kooperberg C; Kuulasmaa K; Kuusisto J; Laakso M; Lakka T; Langenberg C; Langsted A; Launer LJ; Lauritzen T; Liewald DCM; Lin LA; Linneberg A; Loos RJF; Lu Y; Lu X; Magi R; Malarstig A; Manichaikul A; Manning AK; Mantyselka P; Marouli E; Masca NGD; Maschio A; Meigs JB; Melander O; Metspalu A; Morris AP; Morrison AC; Mulas A; Mueller-Nurasyid M; Munroe PB; Neville MJ; Nielsen JB; Nielsen SF; Nordestgaard BG; Ordovas JM; Mehran R; O'Donnell CJ; Orho-Melander M; Molony CM; Muntendam P; Padmanabhan S; Palmer CNA; Pasko D; Patel AP; Pedersen O; Perola M; Peters A; Pisinger C; Pistis G; Polasek O; Poulter N; Psaty BM; Rader DJ; Rasheed A; Rauramaa R; Reilly DF; Reiner AP; Renstrom F; Rich SS; Ridker PM; Rioux JD; Robertson NR; Roden DM; Rotter JI; Rudan I; Salomaa V; Samani NJ; Sanna S; Sattar N; Schmidt EM; Scott RA; Sever P; Sevilla RS; Shaffer CM; Sim X; Sivapalaratnam S; Small KS; Smith AV; Smith BH; Somayajula S; Southam L; Spector TD; Speliotes EK; Starr JM; Stirrups KE; Stitziel N; Strauch K; Stringham HM; Surendran P; Tada H; Tall AR; Tang H; Tardif J-C; Taylor KD; Trompet S; Tsao PS; Tuomilehto J; Tybjaerg-Hansen A; van Zuydam NR; Varbo A; Varga TV; Virtamo J; Waldenberger M; Wang N; Wareham NJ; Warren HR; Weeke PE; Weinstock J; Wessel J; Wilson JG; Wilson PWF; Xu M; Yaghootkar H; Young R; Zeggini E; Zhang H; Zheng NS; Zhang W; Zhang Y; Zhou W; Zhou Y; Zoledziewska M; Howson JMM; Danesh J; McCarthy MI; Cowan CA; Abecasis G; Deloukas P; Musunuru K; Willer CJ; Kathiresan S
Article: JOURNAL OF INTERNAL MEDICINE. 2017;282(5):429-444
Integrative studies implicate matrix metalloproteinase-12 as a culprit gene for large-artery atherosclerotic stroke
Mahdessian H; Matic LP; Lengquist M; Gertow K; Sennblad B; Baldassarre D; Veglia F; Humphries SE; Rauramaa R; de Faire U; Smit AJ; Giral P; Kurl S; Mannarino E; Tremoli E; Hamsten A; Eriksson P; Hedin U; Malarstig A
Article: PLOS GENETICS. 2017;13(4):e1006706
Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease
Folkersen L; Fauman E; Sabater-Lleal M; Strawbridge RJ; Franberg M; Sennblad B; Baldassarre D; Veglia F; Humphries SE; Rauramaa R; de Faire U; Smit AJ; Giral P; Kurl S; Mannarino E; Enroth S; Johansson A; Enroth SB; Gustafsson S; Lind L; Lindgren C; Morris AP; Giedraitis V; Silveira A; Franco-Cereceda A; Tremoli E; Gyllensten U; Ingelsson E; Brunak S; Eriksson P; Ziemek D; Hamsten A; Malarstig A
Article: HUMAN MOLECULAR GENETICS. 2016;25(9):1867-1874
Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis
Hinds DA; Buil A; Ziemek D; Martinez-Perez A; Malik R; Folkersen L; Germain M; Malarstig A; Brown A; Manuel Soria J; Dichgans M; Bing N; Franco-Cereceda A; Carlos Souto J; Dermitzakis ET; Hamsten A; Worrall BB; Tung JY; Sabater-Lleal M
Article: CIRCULATION. 2016;133(13):1230-1239
Circulating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Predicts Future Risk of Cardiovascular Events Independently of Established Risk Factors
Leander K; Malarstig A; van't Hooft FM; Hyde C; Hellenius M-L; Troutt JS; Konrad RJ; Ohrvik J; Hamsten A; de Faire U
Article: PLOS ONE. 2016;11(10):e0164041
The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro
Miller S; Henry AP; Hodge E; Kheirallah AK; Billington CK; Rimington TL; Bhaker SK; Obeidat M; Melen E; Merid SK; Swan C; Gowland C; Nelson CP; Stewart CE; Bolton CE; Kilty I; Malarstig A; Parker SG; Moffatt MF; Wardlaw AJ; Hall IP; Sayers I
Article: JOURNAL OF INTERNAL MEDICINE. 2014;275(6):640-651
The HLA locus contains novel foetal susceptibility alleles for congenital heart block with significant paternal influence
Meisgen S; Ostberg T; Salomonsson S; Ding B; Eliasson H; Malarstig A; Alfredsson L; Klareskog L; Hamsten A; Olsson T; Axelsson T; Gadler F; Jonzon A; Sonesson S-E; Kockum I; Wahren-Herlenius M
Article: PLOS ONE. 2014;9(12):e111156
No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking, Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80,607 Subjects
Baumert J; Huang J; McKnight B; Sabater-Lleal M; Steri M; Chu AY; Trompet S; Lopez LM; Fornage M; Teumer A; Tang W; Rudnicka AR; Maelarstig A; Hottenga J-J; Kavousi M; Lahti J; Tanaka T; Hayward C; Huffman JE; Morange P-E; Rose LM; Basu S; Rumley A; Stott DJ; Buckley BM; de Craen AJM; Sanna S; Masala M; Biffar R; Homuth G; Silveira A; Sennblad B; Goel A; Watkins H; Mueller-Nurasyid M; Rueckerl R; Taylor K; Chen M-H; de Geus EJC; Hofman A; Witteman JCM; de Maat MPM; Palotie A; Davies G; Siscovick DS; Kolcic I; Wild SH; Song J; McArdle WL; Ford I; Sattar N; Schlessinger D; Grotevendt A; Franzosi MG; Illig T; Waldenberger M; Lumley T; Tofler GH; Willemsen G; Uitterlinden AG; Rivadeneira F; Raeikkonen K; Chasman DI; Folsom AR; Lowe GD; Westendorp RGJ; Slagboom PE; Cucca F; Wallaschofski H; Strawbridge RJ; Seedorf U; Koenig W; Bis JC; Mukamal KJ; van Dongen J; Widen E; Franco OH; Starr JM; Liu K; Ferrucci L; Polasek O; Wilson JF; Oudot-Mellakh T; Campbell H; Navarro P; Bandinelli S; Eriksson J; Boomsma DI; Dehghan A; Clarke R; Hamsten A; Boerwinkle E; Jukema JW; Naitza S; Ridker PM; Voezke H; Deary IJ; Reiner AP; Tregoueet D-A; O'Donnell CJ; Strachan DP; Peters A; Smith NL
Article: PLOS ONE. 2014;9(8):e104082
Common Genetic Determinants of Lung Function, Subclinical Atherosclerosis and Risk of Coronary Artery Disease
Sabater-Lleal M; Maelarstig A; Folkersen L; Artigas MS; Baldassarre D; Kavousi M; Almgren P; Veglia F; Brusselle G; Hofman A; Engstrom G; Franco OH; Melander O; Paulsson-Berne G; Watkins H; Eriksson P; Humphries SE; Tremoli E; de Faire U; Tobin MD; Hamsten A
Article: CIRCULATION. 2013;128(12):1310-1324
Multiethnic Meta-Analysis of Genome-Wide Association Studies in > 100 000 Subjects Identifies 23 FibrinogenAssociated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease
Sabater-Lleal M; Huang J; Chasman D; Naitza S; Dehghan A; Johnson AD; Teumer A; Reiner AP; Folkersen L; Basu S; Rudnicka AR; Trompet S; Malarstig A; Baumert J; Bis JC; Guo X; Hottenga JJ; Shin S-Y; Lopez LM; Lahti J; Tanaka T; Yanek LR; Oudot-Mellakh T; Wilson JF; Navarro P; Huffman JE; Zemunik T; Redline S; Mehra R; Pulanic D; Rudan I; Wright AF; Kolcic I; Polasek O; Wild SH; Campbell H; Curb JD; Wallace R; Liu S; Eaton CB; Becker DM; Becker LC; Bandinelli S; Raikkonen K; Widen E; Palotie A; Fornage M; Green D; Gross M; Davies G; Harris SE; Liewald DC; Starr JM; Williams FMK; Grant PJ; Spector TD; Strawbridge RJ; Silveira A; Sennblad B; Rivadeneira F; Uitterlinden AG; Franco OH; Hofman A; van Dongen J; Willemsen G; Boomsma DI; Yao J; Jenny NS; Haritunians T; McKnight B; Lumley T; Taylor KD; Rotter JI; Psaty BM; Peters A; Gieger C; Illig T; Grotevendt A; Homuth G; Voelzke H; Kocher T; Goel A; Franzosi MG; Seedorf U; Clarke R; Steri M; Tarasov KV; Sanna S; Schlessinger D; Stott DJ; Sattar N; Buckley BM; Rumley A; Lowe GD; McArdle WL; Chen M-H; Tofler GH; Song J; Boerwinkle E; Folsom AR; Rose LM; Franco-Cereceda A; Teichert M; Ikram MA; Mosley TH; Bevan S; Dichgans M; Rothwell PM; Sudlow CLM; Hopewell JC; Chambers JC; Saleheen D; Kooner JS; Danesh J; Nelson CP; Erdmann J; Reilly MP; Kathiresan S; Schunkert H; Morange P-E; Ferrucci L; Eriksson JG; Jacobs D; Deary IJ; Soranzo N; Witteman JCM; de Geus EJC; Tracy RP; Hayward C; Koenig W; Cucca F; Jukema JW; Eriksson P; Seshadri S; Markus HS; Watkins H; Samani NJ; Wallaschofski H; Smith NL; Tregouet D; Ridker PM; Tang W; Strachan DP; Hamsten A; O'Donnell CJ
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2013;98(3):668-676
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease
van Meurs JBJ; Pare G; Schwartz SM; Hazra A; Tanaka T; Vermeulen SH; Cotlarciuc I; Yuan X; Malarstig A; Bandinelli S; Bis JC; Morn H; Brown MJ; Chen C; Chen Y-D; Clarke RJ; Dehghan A; Erdmann J; Ferrucci L; Hamsten A; Hofman A; Hunten DJ; Goel A; Johnson AD; Kathiresan S; Kampman E; Kiel DP; Kiemeney LA; Chambers JC; Kraft P; Lindemans J; McKnight B; Nelson CP; O'Donnell CJ; Psaty BM; Ridken PM; Rivadeneira F; Rose LM; Seedoif U; Siscovick DS; Schunkert H; Selhub J; Ueland PM; Vollenweiden P; Waeben G; Waterworth DM; Watkins H; Witteman JCM; den Heijen M; Jacques P; Uitterlinden AG; Koonet JS; Rader DJ; Reilly MP; Moose V; Chasman DI; Samani NJ; Ahmadi KR
Article: RESPIRATORY RESEARCH. 2013;14(1):77
HTR4 gene structure and altered expression in the developing lung
Hodge E; Nelson CP; Miller S; Billington CK; Stewart CE; Swan C; Malarstig A; Henry AP; Gowland C; Melen E; Hall IP; Sayers I
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2012;32(6):1526-1534
Common and Low-Frequency Genetic Variants in the PCSK9 Locus Influence Circulating PCSK9 Levels
Chernogubova E; Strawbridge R; Mahdessian H; Malarstig A; Krapivner S; Gigante B; Hellenius M-L; de Faire U; Franco-Cereceda A; Syvaenen A-C; Troutt JS; Konrad RJ; Eriksson P; Hamsten A; van 't Hooft FM
Article: PLOS ONE. 2012;7(2):e32306
Combined Chromatin and Expression Analysis Reveals Specific Regulatory Mechanisms within Cytokine Genes in the Macrophage Early Immune Response
Iglesias MJ; Reilly S-J; Emanuelsson O; Sennblad B; Najafabadi MP; Folkersen L; Malarstig A; Lagergren J; Eriksson P; Hamsten A; Odeberg J
Article: DIABETES. 2011;60(10):2624-2634
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
Strawbridge RJ; Dupuis J; Prokopenko I; Barker A; Ahlqvist E; Rybin D; Petrie JR; Travers ME; Bouatia-Naji N; Dimas AS; Nica A; Wheeler E; Chen H; Voight BF; Taneera J; Kanoni S; Peden JF; Turrini F; Gustafsson S; Zabena C; Almgren P; Barker DJP; Barnes D; Dennison EM; Eriksson JG; Eriksson P; Eury E; Folkersen L; Fox CS; Frayling TM; Goel A; Gu HF; Horikoshi M; Isomaa B; Jackson AU; Jameson KA; Kajantie E; Kerr-Conte J; Kuulasmaa T; Kuusisto J; Loos RJF; Luan J; Makrilakis K; Manning AK; Teresa Martinez-Larrad M; Narisu N; Mannila MN; Ohrvik J; Osmond C; Pascoe L; Payne F; Sayer AA; Sennblad B; Silveira A; Stancakova A; Stirrups K; Swift AJ; Syvanen A-C; Tuomi T; van 't Hooft FM; Walker M; Weedon MN; Xie W; Zethelius B; Ongen H; Malarstig A; Hopewell JC; Saleheen D; Chambers J; Parish S; Danesh J; Kooner J; Ostenson C-G; Lind L; Cooper CC; Serrano-Rios M; Ferrannini E; Forsen TJ; Clarke R; Franzosi MG; Seedorf U; Watkins H; Froguel P; Johnson P; Deloukas P; Collins FS; Laakso M; Dermitzakis ET; Boehnke M; McCarthy MI; Wareham NJ; Groop L; Pattou F; Gloyn AL; Dedoussis GV; Lyssenko V; Meigs JB; Barroso I; Watanabe RM; Ingelsson E; Langenberg C; Hamsten A; Florez JC
Article: JOURNAL OF INTERNAL MEDICINE. 2011;270(3):229-236
Plasma CD93 concentration is a potential novel biomarker for coronary artery disease
Malarstig A; Silveira A; Wagsater D; Ohrvik J; Backlund A; Samnegard A; Khademi M; Hellenius M-L; Leander K; Olsson T; Uhlen M; de Faire U; Eriksson P; Hamsten A
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2011;19(4):479-484
A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE
Sandling JK; Garnier S; Sigurdsson S; Wang C; Nordmark G; Gunnarsson I; Svenungsson E; Padyukov L; Sturfelt G; Jonsen A; Bengtsson AA; Truedsson L; Eriksson C; Rantapaa-Dahlqvist S; Malarstig A; Strawbridge RJ; Hamsten A; Criswell LA; Graham RR; Behrens TW; Eloranta M-L; Alm G; Ronnblom L; Syvanen A-C
Article: NATURE GENETICS. 2011;43(4):339-U89
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
Peden JF; Hopewell JC; Saleheen D; Chambers JC; Hager J; Soranzo N; Collins R; Danesh J; Elliott P; Farrall M; Stirrups K; Zhang W; Hamsten A; Parish S; Lathrop M; Watkins H; Clarke R; Deloukas P; Kooner JS; Goel A; Ongen H; Strawbridge RJ; Heath S; Malarstig A; Helgadottir A; Ohrvik J; Murtaza M; Potter S; Hunt SE; Delepine M; Jalilzadeh S; Axelsson T; Syvanen A-C; Gwilliam R; Bumpstead S; Gray E; Edkins S; Folkersen L; Kyriakou T; Franco-Cereceda A; Gabrielsen A; Seedorf U; Eriksson P; Offer A; Bowman L; Sleight P; Armitage J; Peto R; Abecasis G; Ahmed N; Caulfield M; Donnelly P; Froguel P; Kooner AS; McCarthy MI; Samani NJ; Scott J; Sehmi J; Silveira A; Hellenius M-L; van't Hooft FM; Olsson G; Rust S; Assmann G; Barlera S; Tognoni G; Franzosi MG; Linksted P; Green FR; Rasheed A; Zaidi M; Shah N; Samuel M; Mallick NH; Azhar M; Zaman KS; Samad A; Ishaq M; Gardezi AR; Memon F-U; Frossard PM; Spector T; Peltonen L; Nieminen MS; Sinisalo J; Salomaa V; Ripatti S; Bennett D; Leander K; Gigante B; de Faire U; Pietri S; Gori F; Marchioli R; Sivapalaratnam S; Kastelein JJP; Trip MD; Theodoraki EV; Dedoussis GV; Engert JC; Yusuf S; Anand SS
Article: CURRENT ATHEROSCLEROSIS REPORTS. 2010;12(3):159-166
Genetics of Atherothrombosis and Thrombophilia
Malarstig A; Hamsten A
Article: CIRCULATION. 2010;121(12):1382-1392
Novel Associations of Multiple Genetic Loci With Plasma Levels of Factor VII, Factor VIII, and von Willebrand Factor The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium
Smith NL; Chen M-H; Dehghan A; Strachan DP; Basu S; Soranzo N; Hayward C; Rudan I; Sabater-Lleal M; Bis JC; de Maat MPM; Rumley A; Kong X; Yang Q; Williams FMK; Vitart V; Campbell H; Maelarstig A; Wiggins KL; Van Duijn CM; McArdle WL; Pankow JS; Johnson AD; Silveira A; McKnight B; Uitterlinden AG; Aleksic N; Meigs JB; Peters A; Koenig W; Cushman M; Kathiresan S; Rotter JI; Bovill EG; Hofman A; Boerwinkle E; Tofler GH; Peden JF; Psaty BM; Leebeek F; Folsom AR; Larson MG; Spector TD; Wright AF; Wilson JF; Hamsten A; Lumley T; Witteman JCM; Tang W; O'Donnell CJ
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2009;361(26):2518-2528
Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease
Clarke R; Peden JF; Hopewell JC; Kyriakou T; Goel A; Heath SC; Parish S; Barlera S; Franzosi MG; Rust S; Bennett D; Silveira A; Malarstig A; Green FR; Lathrop M; Gigante B; Leander K; de Faire U; Seedorf U; Hamsten A; Collins R; Watkins H; Farrall M
Article: PLOS ONE. 2009;4(11):e7677
Relationship between CAD Risk Genotype in the Chromosome 9p21 Locus and Gene Expression. Identification of Eight New ANRIL Splice Variants
Folkersen L; Kyriakou T; Goel A; Peden J; Malarstig A; Paulsson-Berne G; Hamsten A; Franco-Cereceda A; Gabrielsen A; Eriksson P; Watkins H
Article: PLOS GENETICS. 2009;5(11):e1000730
Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis
Chasman DI; Pare G; Mora S; Hopewell JC; Peloso G; Clarke R; Cupples LA; Hamsten A; Kathiresan S; Maelarstig A; Ordovas JM; Ripatti S; Parker AN; Miletich JP; Ridker PM
Article: MOLECULAR MEDICINE REPORTS. 2009;2(6):971-976
Tumour-derived adhesion factor in colorectal cancer
Malarstig A; Wagsater D; Lofgren S; Hugander A; Zar N; Dimberg J
Article: BLOOD. 2009;114(7):1417-1422
Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study
Malarstig A; Buil A; Carolos Souto J; Clarke R; Blanco-Vaca F; Fontcuberta J; Peden J; Andersen M; Silveira A; Barlera S; Seedorf U; Watkins H; Almasy L; Hamsten A; Manuel Soria J
Article: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2009;2(2):142-150
Novel Associations of CPS1, MUT, NOX4, and DPEP1 With Plasma Homocysteine in a Healthy Population A Genome-Wide Evaluation of 13 974 Participants in the Women's Genome Health Study
Pare G; Chasman DI; Parker AN; Zee RRY; Malarstig A; Seedorf U; Collins R; Watkins H; Hamsten A; Miletich JP; Ridker PM
Article: CLINICAL SCIENCE. 2009;116(5-6):507-512
IGF-I/IGFBP-3 ratio: a mechanistic insight into the metabolic syndrome
Sierra-Johnson J; Romero-Corral A; Somers VK; Lopez-Jimenez F; Malarstig A; Brismar K; Hamsten A; Fisher RM; Hellenius M-L
Article: HEART. 2008;94(6):724-729
Raised interleukin-10 is an indicator of poor outcome and enhanced systemic inflammation in patients with acute coronary syndrome
Malarstig A; Eriksson P; Hamsten A; Lindahl B; Wallentin L; Siegbahn A
Article: CLINICAL CHEMISTRY. 2008;54(5):833-840
Genetic variants of tumor necrosis factor superfamily, member 4 (TNFSF4), and risk of incident atherothrombosis and venous thromboembolism
Maelarstig A; Eriksson P; Rose L; Diehl KA; Hamsten A; Ridker PM; Zee RYL
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2008;28(5):975-982
Variants of the interferon regulatory factor 5 gene regulate expression of IRF5 mRNA in atherosclerotic tissue but are not associated with myocardial infarction
Malarstig A; Sigurdsson S; Eriksson P; Paulsson-Berne G; Hedin U; Wallentin L; Siegbahn A; Hamsten A; Syvanen A-C
Article: THROMBOSIS RESEARCH. 2007;120(3):407-413
The intersubject variability of tissue factor mRNA production in human monocytes--relation with the toll-like receptor 4.
Mälarstig A; Siegbahn A
Article: THROMBOSIS RESEARCH. 2007;119(4):467-473
Genetic variation in the interleukin-6 gene in relation to risk and outcomes in acute coronary syndrome.
Mälarstig A; Wallentin L; Siegbahn A
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2006;26(7):1667-1673
Soluble CD40L levels are regulated by the -3459 A>G polymorphism and predict myocardial infarction and the efficacy of antithrombotic treatment in non-ST elevation acute coronary syndrome.
Mälarstig A; Lindahl B; Wallentin L; Siegbahn A
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2005;25(12):2667-2672
Genetic variations in the tissue factor gene are associated with clinical outcome in acute coronary syndrome and expression levels in human monocytes.
Mälarstig A; Tenno T; Johnston N; Lagerqvist B; Axelsson T; Syvänen A-C; Wallentin L; Siegbahn A
Article: THROMBOSIS RESEARCH. 2003;112(3):175-183
A quantitative real-time PCR method for tissue factor mRNA.
Mälarstig A; Tenno T; Jossan S; Aberg M; Siegbahn A
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