Anastasios Damdimopoulos

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Articles

Article: ENVIRONMENT INTERNATIONAL. 2024;187:108710
Persistent organic pollutants dysregulate energy homeostasis in human ovaries in vitro
Li T; Bjorvang RD; Hao J; Di Nisio V; Damdimopoulos A; Lindskog C; Papaikonomou K; Damdimopoulou P
Article: REPRODUCTIVE TOXICOLOGY. 2023;119:108393
Identification of phthalate mixture exposure targets in the human and mouse ovary in vitro
Tarvainen I; Soto DA; Laws MJ; Bjorvang RD; Damdimopoulos A; Roos K; Li T; Kramer S; Li Z; Lavogina D; Visser N; Kallak TK; Lager S; Gidlof S; Edlund E; Papaikonomou K; Oberg M; Olovsson M; Salumets A; Velthut-Meikas A; Flaws JA; Damdimopoulou P
Article: CANCERS. 2023;15(4):1298
Sex- and Female Age-Dependent Differences in Gene Expression in Diffuse Large B-Cell Lymphoma-Possible Estrogen Effects
Huang D; Berglund M; Damdimopoulos A; Antonson P; Lindskog C; Enblad G; Amini R-M; Okret S
Article: TOXICOLOGY. 2023;485:153425
Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models
Li T; Vazakidou P; Leonards PEG; Damdimopoulos A; Panagiotou EM; Arnelo C; Jansson K; Pettersson K; Papaikonomou K; van Duursen M; Damdimopoulou P
Article: ISCIENCE. 2022;25(12):105526
Survivin promotes a glycolytic switch in CD4⁺ T cells by suppressing the transcription of PFKFB3 in rheumatoid arthritis
Erlandsson MC; Andersson KME; Oparina NY; Chandrasekaran V; Saghy T; Damdimopoulos A; Garcia-Bonete M-J; Einbeigi Z; Silfversward ST; Pekna M; Katona G; Bokarewa MI
Article: MOLECULAR PSYCHIATRY. 2022;27(8):3247-3261
Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia
Matlik K; Garton DR; Montano-Rodriguez AR; Olfat S; Eren F; Casserly L; Damdimopoulos A; Panhelainen A; Porokuokka LL; Kopra JJ; Turconi G; Schweizer N; Bereczki E; Piehl F; Engberg G; Cervenka S; Piepponen TP; Zhang F-P; Sipila P; Jakobsson J; Sellgren CM; Erhardt S; Andressoo J-O
Article: CANCERS. 2022;14(13):3098
Estrogen Receptor β (ESR2) Transcriptome and Chromatin Binding in a Mantle Cell Lymphoma Tumor Model Reveal the Tumor-Suppressing Mechanisms of Estrogens
Huang D; Huang Z; Indukuri R; Revanna CB; Berglund M; Guan J; Yakimchuk K; Damdimopoulos A; Williams C; Okret S
Article: PLOS PATHOGENS. 2022;18(5):e1010494
Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate
Bradley F; Boger MF; Kaldhusdal V; Ahlberg A; Edfeldt G; Lajoie J; Bergstrom S; Omollo K; Damdimopoulos A; Czarnewski P; Manberg A; Oyugi J; Kimani J; Nilsson P; Fowke K; Tjernlund A; Broliden K
Article: ISCIENCE. 2022;25(4):104137
DUX4 is a multifunctional factor priming human embryonic genome activation
Vuoristo S; Bhagat S; Hyden-Granskog C; Yoshihara M; Gawriyski L; Jouhilahti E-M; Ranga V; Tamirat M; Huhtala M; Kirjanov I; Nykanen S; Krjutskov K; Damdimopoulos A; Weltner J; Hashimoto K; Recher G; Ezer S; Paluoja P; Paloviita P; Takegami Y; Kanemaru A; Lundin K; Airenne TT; Otonkoski T; Tapanainen JS; Kawaji H; Murakawa Y; Burglin TR; Varjosalo M; Johnson MS; Tuuri T; Katayama S; Kere J
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:203-221
An Optimized ChIP-Seq Protocol to Determine Chromatin Binding of Estrogen Receptor Beta.
Indukuri R; Damdimopoulos A; Williams C
Article: ACTA PHYSIOLOGICA. 2021;233(1):e13668
Pharmacological HIF-PHD inhibition reduces renovascular resistance and increases glomerular filtration by stimulating nitric oxide generation
Burmakin M; Fasching A; Kobayashi H; Urrutia AA; Damdimopoulos A; Palm F; Haase VH
Article: INTERNATIONAL JOURNAL OF CANCER. 2021;149(3):692-706
Genome-wide estrogen receptor β chromatin binding in human colon cancer cells reveals its tumor suppressor activity
Indukuri R; Jafferali MH; Song D; Damdimopoulos A; Hases L; Zhao C; Archer A; Williams C
Article: MOLECULAR CELL. 2021;81(5):953-968.e9
The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages
Huang Z; Liang N; Goni S; Damdimopoulos A; Wang C; Ballaire R; Jager J; Niskanen H; Han H; Jakobsson T; Bracken AP; Aouadi M; Venteclef N; Kaikkonen MU; Fan R; Treuter E
Article: DEVELOPMENTAL DYNAMICS. 2020;249(12):1500-1513
Transcriptome analysis of the epididymis fromPlag1deficient mice suggests dysregulation of sperm maturation and extracellular matrix genes
Wong J; Damdimopoulos A; Damdimopoulou P; Gasperoni JG; Tran SC; Grommen SVH; De Groef B; Dworkin S
Article: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 2020;37(9):2137-2150
Culture of human ovarian tissue in xeno-free conditions using laminin components of the human ovarian extracellular matrix
Hao J; Tuck AR; Prakash CR; Damdimopoulos A; Sjodin MOD; Lindberg J; Niklasson B; Pettersson K; Hovatta O; Damdimopoulou P
Article: NATURE COMMUNICATIONS. 2020;11(1):1147
Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells
Wagner M; Yoshihara M; Douagi I; Damdimopoulos A; Panula S; Petropoulos S; Lu H; Pettersson K; Palm K; Katayama S; Hovatta O; Kere J; Lanner F; Damdimopoulou P
Article: SCIENTIFIC REPORTS. 2019;9(1):8411
Pleomorphic Adenoma Gene 1 Is Needed For Timely Zygotic Genome Activation and Early Embryo Development
Madissoon E; Damdimopoulos A; Katayama S; Krjutskov K; Einarsdottir E; Mamia K; De Groef B; Hovatta O; Kere J; Damdimopoulou P
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2019;137:59-73
Implications of the mitochondrial interactome of mammalian thioredoxin 2 for normal cellular function and disease
Chasapis CT; Makridakis M; Damdimopoulos AE; Zoidakis J; Lygirou V; Mavroidis M; Vlahou A; Miranda-Vizuete A; Spyrou G; Vlamis-Gardikas A
Article: NATURE COMMUNICATIONS. 2019;10(1):1684
Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα
Liang N; Damdimopoulos A; Goni S; Huang Z; Vedin L-L; Jakobsson T; Giudici M; Ahmed O; Pedrelli M; Barilla S; Alzaid F; Mendoza A; Schroder T; Kuiper R; Parini P; Hollenberg A; Lefebvre P; Francque S; Van Gaal L; Staels B; Venteclef N; Treuter E; Fan R
Article: FASEB JOURNAL. 2019;33(2):1631-1643
G protein pathway suppressor 2 (GPS2) links inflammation and cholesterol efflux by controlling lipopolysaccharide-induced ATP-binding cassette transporter A1 expression in macrophages
Huang Z; Liang N; Damdimopoulos A; Fan R; Treuter E
Article: ENDOCRINOLOGY. 2016;157(10):3719-3730
The Hydroxysteroid (17β) Dehydrogenase Family Gene HSD17B12 Is Involved in the Prostaglandin Synthesis Pathway, the Ovarian Function, and Regulation of Fertility
Kemilainen H; Adam M; Maki-Jouppila J; Damdimopoulou P; Damdimopoulos AE; Kere J; Hovatta O; Laajala TD; Aittokallio T; Adamski J; Ryberg H; Ohlsson C; Strauss L; Poutanen M
Article: NATURE MEDICINE. 2016;22(7):780-791
Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes
Fan R; Toubal A; Goni S; Drareni K; Huang Z; Alzaid F; Ballaire R; Ancel P; Liang N; Damdimopoulos A; Hainault I; Soprani A; Aron-Wisnewsky J; Foufelle F; Lawrence T; Gautier J-F; Venteclef N; Treuter E
Article: BIOSCIENCE REPORTS. 2015;35(6):e00269
The expression and activity of thioredoxin reductase 1 splice variants v1 and v2 regulate the expression of genes associated with differentiation and adhesion
Nalvarte I; Damdimopoulos AE; Ruegg J; Spyrou G
Article: REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY. 2011;9(1):128
Members of the murine Pate family are predominantly expressed in the epididymis in a segment-specific fashion and regulated by androgens and other testicular factors
Turunen HT; Sipila P; Pujianto DA; Damdimopoulos AE; Bjorkgren I; Huhtaniemi I; Poutanen M
Article: JOURNAL OF NUTRITION. 2011;141(9):1583-1589
A Single Dose of Enterolactone Activates Estrogen Signaling and Regulates Expression of Circadian Clock Genes in Mice
Damdimopoulou P; Nurmi T; Salminen A; Damdimopoulos AE; Kotka M; van der Saag P; Strauss L; Poutanen M; Pongratz I; Makela S
Article: GENES & DEVELOPMENT. 2010;24(4):381-395
GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRβ in the hepatic acute phase response
Venteclef N; Jakobsson T; Ehrlund A; Damdimopoulos A; Mikkonen L; Ellis E; Nilsson L-M; Parini P; Janne OA; Gustafsson J-A; Steffensen KR; Treuter E
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1793(10):1588-1596
The human thioredoxin reductase-1 splice variant TXNRD1_v3 is an atypical inducer of cytoplasmic filaments and cell membrane filopodia
Damdimopoulou PE; Miranda-Vizuete A; Arner ESJ; Gustafsson J-A; Damdimopoulos AE
Article: MOLECULAR CELL. 2009;34(4):510-518
GPS2 Is Required for Cholesterol Efflux by Triggering Histone Demethylation, LXR Recruitment, and Coregulator Assembly at the ABCG1 Locus
Jakobsson T; Venteclef N; Toresson G; Damdimopoulos AE; Ehrlund A; Lou X; Sanyal S; Steffensen KR; Gustafsson J-A; Treuter E
Article: MOLECULAR AND CELLULAR BIOLOGY. 2009;29(8):2230-2242
E3 Ubiquitin Ligase RNF31 Cooperates with DAX-1 in Transcriptional Repression of Steroidogenesis
Ehrlund A; Anthonisen EH; Gustafsson N; Venteclef N; Remen KR; Damdimopoulos AE; Galeeva A; Pelto-Huikko M; Lalli E; Steffensen KR; Gustafsson J-A; Treuter E
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(5):2814-2821
Induction of cell membrane protrusions by the N-terminal glutaredoxin domain of a rare splice variant of human thioredoxin reductase 1
Dammeyer P; Damdimopoulos AE; Nordman T; Jimenez A; Miranda-Vizuete A; Arner ESJ
Article: ENDOCRINOLOGY. 2008;149(1):339-345
Ligands differentially modify the nuclear mobility of estrogen receptors α and β
Damdimopoulos AE; Spyrou G; Gustafsson J-A
Article: ENDOCRINOLOGY. 2007;148(10):4875-4886
Diet-derived polyphenol metabolite enterolactone is a tissue-specific estrogen receptor activator
Penttinen P; Jaehrling J; Damdimopoulos AE; Inzunza J; Lemmen JG; van der Saag P; Pettersson K; Gauglitz G; Makela S; Pongratz I
Article: ENDOCRINOLOGY. 2007;148(7):3196-3204
Bfk, a novel member of the Bcl2 gene family, is highly expressed in principal cells of the mouse epididymis and demonstrates a predominant nuclear localization
Pujianto DA; Damdimopoulos AE; Sipilae P; Jalkanen J; Huhtaniemi I; Poutanen M
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2007;1773(6):687-690
Nuclear immobilization of DsRed1 tagged proteins: A novel tool for studying DNA-protein interactions?
Damdimopoulos AE; Gustafsson J-A; Spyrou G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(10):7482-7490
Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia-inducible factor-1α
Zhou J; Damdimopoulos AE; Spyrou G; Bruene B
Article: BIOCHEMICAL PHARMACOLOGY. 2005;69(12):1765-1772
The role of thioredoxin reductase activity in selenium-induced cytotoxicity
Madeja Z; Sroka J; Nyström C; Björkhem-Bergman L; Nordman T; Damdimopoulos A; Nalvarte I; Eriksson LC; Spyrou G; Olsson JM; Björnstedt M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(52):54510-54517
Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells -: Effect on cell growth and differentiation
Nalvarte I; Damdimopoulos AE; Nystöm C; Nordman T; Miranda-Vizuete A; Olsson JM; Eriksson L; Björnstedt M; Arnér ESJ; Spyrou G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(37):38721-38729
An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling
Damdimopoulos AE; Miranda-Vizuete A; Treuter E; Gustafsson J; Spyrou G
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2004;36(10):1270-1278
Human mitochondrial thioredoxin reductase reduces cytochrome c and confers resistance to complex III inhibition
Nalvarte I; Damdimopoulos AE; Spyrou G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(15):13133-13142
Characterization of human thioredoxin-like 2 -: A novel microtubule-binding thioredoxin expressed predominantly in the cilia of lung airway epithelium and spermatid manchette and axoneme
Sadek CM; Jiménez A; Damdimopoulos AE; Kieselbach T; Nord M; Gustafsson JA; Spyrou I; Davis EC; Oko R; van der Hoorn FA; Miranda-Vizuete A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(4):2141-2146
The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone -: A novel mechanism for defense against oxidative stress
Xia L; Nordman T; Olsson JM; Damdimopoulos A; Björkhem-Bergman L; Nalvarte I; Eriksson LC; Arnér ESJ; Spyrou G; Björnstedt M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(2):1059-1066
ERdJ5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress
Cunnea PM; Miranda-Vizuete A; Bertoli G; Simmen T; Damdimopoulos AE; Hermann S; Leinonen S; Huikko MP; Gustafsson J; Sitia R; Spyrou G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(36):33249-33257
Human mitochondrial thioredoxin -: Involvement in mitochondrial membrane potential and cell death
Damdimopoulos AE; Miranda-Vizuete A; Pelto-Huikko M; Gustafsson J; Spyrou G
Article: GENES TO CELLS. 2001;6(12):1077-1090
Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells
Sadek CM; Damdimopoulos AE; Pelto-Huikko M; Gustafsson J; Spyrou G; Miranda-Vizuete A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(34):31567-31574
Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa
Miranda-Vizuete A; Ljung J; Damdimopoulos AE; Gustafsson J; Oko R; Pelto-Huikko M; Spyrou G
Article: MECHANISMS OF DEVELOPMENT. 2000;97(1-2):13-26
Isolation and characterization of AINT:: a novel ARNT interacting protein expressed during murine embryonic development
Sadek CM; Jalaguier S; Feeney EP; Aitola M; Damdimopoulos AE; Pelto-Huikko M; Gustafsson J
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2000;12(5):1669-1678
Expression of novel antioxidant thioredoxin-2 in the rat brain
Rybnikova E; Damdimopoulos AE; Gustafsson J; Spyrou G; Pelto-Huikko M
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1999;1447(1):113-118
cDNA cloning, expression and chromosomal localization of the mouse mitochondrial thioredoxin reductase gene
Miranda-Vizuete A; Damdimopoulos AE; Spyrou G
Article: FEBS JOURNAL. 1999;261(2):405-412
Human mitochondrial thioredoxin reductase -: cDNA cloning, expression and genomic organization
Miranda-Vizuete A; Damdimopoulos AE; Pedrajas JR; Gustafsson J; Spyrou G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(1):345-353
The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERα and ERβ
Johansson L; Thomsen JS; Damdimopoulos AE; Spyrou G; Gustafsson J; Treuter E
Article: MITOCHONDRIAL DNA. 1999;10(3):179-182
Cloning and sequencing of mouse glutaredoxin (grx) cDNA
Miranda-Vizuete A; Pedrajas JR; Damdimopoulos AE; Spyrou G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(49):30841-30847
Cloning, expression, and characterization of a novel Escherichia coli thioredoxin
Miranda-Vizuete A; Damdimopoulos AE; Gustafsson JA; Spyrou G
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Editorial comment: STEM CELLS. 2023;41(2):105-110
The Continued Absence of Functional Germline Stem Cells in Adult Ovaries
Yoshihara M; Wagner M; Damdimopoulos A; Zhao C; Petropoulos S; Katayama S; Kere J; Lanner F; Damdimopoulou P
Letter: STEM CELLS. 2023;41(2):205-206
Reply: Revisiting Claims of the Continued Absence of Functional Germline Stem Cells in Adult Ovaries
Yoshihara M; Wagner M; Damdimopoulos A; Zhao C; Petropoulos S; Katayama S; Kere J; Lanner F; Damdimopoulou P
Editorial comment: OBSTETRICAL & GYNECOLOGICAL SURVEY. 2020;75(6):354-355
Single-Cell Analysis of Human Ovarian Cortex Identifies Distinct Cell Populations But No Oogonial Stem Cells
Wagner M; Yoshihara M; Douagi I; Damdimopoulos A; Panula S; Petropoulos S; Lu H; Pettersson K; Palm K; Katayama S; Hovatta O; Kere J; Lanner F; Damdimopoulou P
Thesis / dissertation: 2003
Identification and functional characterization of novel thioredoxin systems
Damdimopoulos, Anastasios E
Published conference paper: BIOFACTORS. 2003;18(1-4):45-50
Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase
Nordman T; Xia L; Björkhem-Bergman L; Damdimopoulos A; Nalvarte I; Arnér ESJ; Spyrou G; Eriksson LC; Björnstedt M; Olsson JM
Review: ANTIOXIDANTS & REDOX SIGNALING. 2000;2(4):801-810
The Mitochondrial Thioredoxin System
Miranda-Vizuete A; Damdimopoulos AE; Spyrou G

Employments

Research Infrastructure Specialist, Department of Medicine, Huddinge, Karolinska Institutet, 2024-

Degrees and Education

Doctor Of Philosophy, Department of Biosciences and Nutrition, Karolinska Institutet, 2003

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