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  • Doctorate in Technical Sciences, Technical University, Vienna; 2000
  • Diplom-Ingenieur (B.S. and M.S.) in Mathematics, Technical University, Vienna; 1995

Research description

The current focus of my applied work is on molecular data and its use in clinical and epidemiological applications. This includes working with gene expression microarrays as well as SELDI-TOF mass spectrometry, mostly in the context of cancer. My theoretical work is generally motivated by the high-dimensional nature of these molecular data sets and attempts to address the problem of multiple testing through variants of the false discovery rate.

I also feel strongly about making theoretical ideas available as software tools. Consequently, I maintain several packages for the statistical program R available at the Bioconductor repository.



Cervical screening and risk of adenosquamous and rare histological types of invasive cervical carcinoma: population based nested case-control study
Lei J, Andrae B, Ploner A, Lagheden C, Eklund C, Nordqvist Kleppe S, et al
BMJ (Clinical research ed.) 2019;365():l1207-

Joint Contributions of Rare Copy Number Variants and Common SNPs to Risk for Schizophrenia
Cnv Analysis Group And The Schizophrenia Working Group Of The Psychiatric Genomics Consortium, Bergen Se, Ploner A, Howrigan D, O'donovan Mc, Smoller Jw, et al
The American journal of psychiatry 2019;176(1):29-35

Mode of HPV vaccination delivery and equity in vaccine uptake: A nationwide cohort study
Wang J, Ploner A, Sparén P, Lepp T, Roth A, Arnheim-dahlström L, et al
Preventive medicine 2019;120():26-33

The frailty index is a predictor of cause-specific mortality independent of familial effects from midlife onwards: a large cohort study
Li X, Ploner A, Karlsson Ik, Liu X, Magnusson Pke, Pedersen Nl, et al
BMC medicine 2019;17(1):94-

Apolipoprotein E DNA methylation and late-life disease
Karlsson Ik, Ploner A, Wang Y, Gatz M, Pedersen Nl, Hägg S
International journal of epidemiology 2018;():-

Association between poor oral health and gastric cancer: A prospective cohort study
Ndegwa N, Ploner A, Liu Z, Roosaar A, Axéll T, Ye W
International journal of cancer 2018;143(9):2281-2288

Effectiveness of varying number of doses and timing between doses of quadrivalent HPV vaccine against severe cervical lesions
Dehlendorff C, Sparén P, Baldur-felskov B, Herweijer E, Arnheim-dahlström L, Ploner A, et al
Vaccine 2018;36(43):6373-6378

Family history of gastric mucosal abnormality and the risk of gastric cancer: a population-based observational study
Song H, Ekheden Ig, Ploner A, Ericsson J, Nyren O, Ye W
International journal of epidemiology 2018;47(2):440-449

High-risk human papillomavirus status and prognosis in invasive cervical cancer: A nationwide cohort study
Lei J, Ploner A, Lagheden C, Eklund C, Nordqvist Kleppe S, Andrae B, et al
PLoS medicine 2018;15(10):e1002666-

PPD ACT: an app-based genetic study of postpartum depression
Guintivano J, Krohn H, Lewis C, Byrne Em, Henders Ak, Ploner A, et al
Translational psychiatry 2018;8(1):260-

Substantially reduced incidence of genital warts in women and men six years after HPV vaccine availability in Sweden
Herweijer E, Ploner A, Sparén P
Vaccine 2018;36(15):1917-1920

Assessment of Breast Cancer Risk Factors Reveals Subtype Heterogeneity
Holm J, Eriksson L, Ploner A, Eriksson M, Rantalainen M, Li J, et al
Cancer research 2017;77(13):3708-3717

Effectiveness of cervical screening after age 60 years according to screening history: Nationwide cohort study in Sweden
Wang J, Andrae B, Sundström K, Ploner A, Ström P, Elfström Km, et al
PLoS medicine 2017;14(10):e1002414-

Genetic susceptibility to cardiovascular disease and risk of dementia
Karlsson Ik, Ploner A, Song C, Gatz M, Pedersen Nl, Hägg S
Translational psychiatry 2017;7(5):e1142-

Short telomere length is associated with impaired cognitive performance in European ancestry cohorts
Neurocharge Cognitive Working Group, Hägg S, Zhan Y, Karlsson R, Gerritsen L, Ploner A, et al
Translational psychiatry 2017;7(4):e1100-

Timing of two versus three doses of quadrivalent HPV vaccine and associated effectiveness against condyloma in Sweden: a nationwide cohort study
Lamb F, Herweijer E, Ploner A, Uhnoo I, Sundstrom K, Sparen P, et al
BMJ OPEN 2017;7(6):e015021-

Cigarette- and snus-modified association between unprotected exposure to noise from hunting rifle caliber weapons and high frequency hearing loss. A cross-sectional study among swedish hunters
Honeth L, Ström P, Ploner A, Bagger-sjöbäck D, Rosenhall U, Nyrén O
Noise & health 2016;18(85):382-390

Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study
Smelov V, Gheit T, Sundström K, Ploner A, Mckay-chopin S, Eklund C, et al
PloS one 2016;11(5):e0156215-

Longitudinal decline of leukocyte telomere length in old age and the association with sex and genetic risk
Berglund K, Reynolds Ca, Ploner A, Gerritsen L, Hovatta I, Pedersen Nl, et al
Aging 2016;8(7):1398-415

No Evidence for Disease History as a Risk Factor for Narcolepsy after A(H1N1)pdm09 Vaccination
Lamb F, Ploner A, Fink K, Maeurer M, Bergman P, Piehl F, et al
PloS one 2016;11(4):e0154296-

Quadrivalent HPV vaccine effectiveness against high-grade cervical lesions by age at vaccination: A population-based study
Herweijer E, Sundström K, Ploner A, Uhnoo I, Sparén P, Arnheim-dahlström L
International journal of cancer 2016;138(12):2867-74

Risk of invasive cervical cancer after atypical glandular cells in cervical screening: nationwide cohort study
Wang J, Andrae B, Sundström K, Ström P, Ploner A, Elfström Km, et al
BMJ (Clinical research ed.) 2016;352():i276-

Sexual and testing behaviour associated with Chlamydia trachomatis infection: a cohort study in an STI clinic in Sweden
Veličko I, Ploner A, Sparén P, Marions L, Herrmann B, Kühlmann-berenzon S
BMJ open 2016;6(8):e011312-

Adiposity as a cause of cardiovascular disease: a Mendelian randomization study
European Network For Genetic And Genomic Epidemiology Consortium, Hägg S, Fall T, Ploner A, Mägi R, Fischer K, et al
International journal of epidemiology 2015;44(2):578-86

Age- and sex-specific causal effects of adiposity on cardiovascular risk factors
Engage Consortium, Fall T, Hägg S, Ploner A, Mägi R, Fischer K, et al
Diabetes 2015;64(5):1841-52

Apolipoprotein E ε4 genotype and the temporal relationship between depression and dementia
Karlsson Ik, Bennet Am, Ploner A, Andersson Tm, Reynolds Ca, Gatz M, et al
Neurobiology of aging 2015;36(4):1751-1756

Interactions Between High- and Low-Risk HPV Types Reduce the Risk of Squamous Cervical Cancer
Sundström K, Ploner A, Arnheim-dahlström L, Eloranta S, Palmgren J, Adami Ho, et al
Journal of the National Cancer Institute 2015;107(10):-

Risk factors and tumor characteristics of interval cancers by mammographic density
Holm J, Humphreys K, Li J, Ploner A, Cheddad A, Eriksson M, et al
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2015;33(9):1030-7

Self-sampling for analysis of respiratory viruses in a large-scale epidemiological study in Sweden
Plymoth A, Rotzen-ostlund M, Zweygberg-wirgart B, Sundin Cg, Ploner A, Nyren O, et al
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2015;20(11):-

Shooting history and presence of high-frequency hearing impairment in swedish hunters: A cross-sectional internet-based observational study
Honeth L, Ström P, Ploner A, Bagger-sjöbäck D, Rosenhall U, Nyrén O
Noise & health 2015;17(78):273-81

The Participation of HPV-Vaccinated Women in a National Cervical Screening Program: Population-Based Cohort Study
Herweijer E, Feldman Al, Ploner A, Arnheim-dahlström L, Uhnoo I, Netterlid E, et al
PloS one 2015;10(7):e0134185-

Variations of gastric corpus microbiota are associated with early esophageal squamous cell carcinoma and squamous dysplasia
Nasrollahzadeh D, Malekzadeh R, Ploner A, Shakeri R, Sotoudeh M, Fahimi S, et al

Association of varying number of doses of quadrivalent human papillomavirus vaccine with incidence of condyloma
Herweijer E, Leval A, Ploner A, Eloranta S, Simard Jf, Dillner J, et al
JAMA 2014;311(6):597-603

Relative validity of micronutrient and fiber intake assessed with two new interactive meal- and Web-based food frequency questionnaires
Christensen Se, Möller E, Bonn Se, Ploner A, Bälter O, Lissner L, et al
Journal of medical Internet research 2014;16(2):e59-

Influence of radiotherapy for the first tumor on aggressiveness of contralateral breast cancer
Sandberg Me, Alkner S, Hartman M, Eloranta S, Rydén L, Ploner A, et al
International journal of cancer 2013;132(10):2388-94

Partial least squares and logistic regression random-effects estimates for gene selection in supervised classification of gene expression data
Gusnanto A, Ploner A, Shuweihdi F, Pawitan Y
Journal of biomedical informatics 2013;46(4):697-709

Prospective study of HPV16 viral load and risk of in situ and invasive squamous cervical cancer
Sundström K, Ploner A, Dahlström La, Palmgren J, Dillner J, Adami Ho, et al
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2013;22(1):150-8

Quadrivalent human papillomavirus vaccine effectiveness: a Swedish national cohort study
Leval A, Herweijer E, Ploner A, Eloranta S, Fridman Simard J, Dillner J, et al
Journal of the National Cancer Institute 2013;105(7):469-74

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis
European Network For Genetic And Genomic Epidemiology (engage) Consortium, Fall T, Hägg S, Mägi R, Ploner A, Fischer K, et al
PLoS medicine 2013;10(6):e1001474-

Two new meal- and web-based interactive food frequency questionnaires: validation of energy and macronutrient intake
Christensen Se, Möller E, Bonn Se, Ploner A, Wright A, Sjölander A, et al
Journal of medical Internet research 2013;15(6):e109-

Estrogen Receptor Status in Relation to Risk of Contralateral Breast Cancer-A Population-Based Cohort Study
Sandberg Mec, Hall P, Hartman M, Johansson Alv, Eloranta S, Ploner A, et al
PLOS ONE 2012;7(10):e46535-

Familial effects on survival after myocardial infarction: a registry-based sib-pair study
Ekberg S, Ploner A, De Faire U, Pedersen Nl, Bennet Am
European journal of epidemiology 2012;27(12):911-4

Mammographic density and molecular subtypes of breast cancer
Eriksson L, Hall P, Czene K, Silva Id, Mccormack V, Bergh J, et al

Prognostic implications of estrogen receptor pattern of both tumors in contralateral breast cancer
Sandberg Mec, Hartman M, Klevebring D, Eloranta S, Ploner A, Hall P, et al

Assessing Perceived Risk and STI Prevention Behavior: A National Population-Based Study with Special Reference to HPV
Leval A, Sundstrom K, Ploner A, Dahlstrom La, Widmark C, Sparen P
PLOS ONE 2011;6(6):e20624-

Constructing a Population-Based Research Database from Routine Maternal Screening Records: A Resource for Studying Alloimmunization in Pregnant Women
Lee Bk, Ploner A, Zhang Zx, Gryfelt G, Wikman A, Reilly M
PLOS ONE 2011;6(11):e27619-

LifeGene-a large prospective population-based study of global relevance
Almqvist C, Adami Ho, Franks Pw, Groop L, Ingelsson E, Kere J, et al

Short natural sleep is associated with higher T cell and lower NK cell activities
Fondell E, Axelsson J, Franck K, Ploner A, Lekander M, Balter K, et al

Blood Biomarker Levels to Aid Discovery of Cancer-Related Single-Nucleotide Polymorphisms: Kallikreins and Prostate Cancer
Klein Rj, Hallden C, Cronin Am, Ploner A, Wiklund F, Bjartell As, et al

Diagnostic work-up of contralateral breast cancers has not improved over calendar period
Sandberg Mec, Hartman M, Edgren G, Eloranta S, Ploner A, Hall P, et al

Prospective study of human papillomavirus and risk of cervical adenocarcinoma
Dahlstrom La, Ylitalo N, Sundstrom K, Palmgren J, Ploner A, Eloranta S, et al

Prospective Study of Human Papillomavirus (HPV) Types, HPV Persistence, and Risk of Squamous Cell Carcinoma of the Cervix
Sundstrom K, Eloranta S, Sparen P, Dahlstrom La, Gunnell A, Lindgren A, et al

Correlating gene and protein expression data using Correlated Factor Analysis
Tan Cs, Salim A, Ploner A, Lehtio J, Chia Ks, Pawitan Y

GENESTAT: an information portal for design and analysis of genetic association studies
Ripatti S, Becker T, Bickeboller H, Dominicus A, Fischer C, Humphreys K, et al

Increasing stringency in symptom cluster research: a methodological exploration of symptom clusters in patients with inoperable lung cancer
Henoch I, Ploner A, Tishelman C
Oncology nursing forum 2009;36(6):E282-92

Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms
Hult M, Ortsater H, Schuster G, Graedler F, Beckers J, Adamski J, et al

Mapping patterns of complementary and alternative medicine use in cancer: An explorative cross-sectional study of individuals with reported positive "exceptional" experiences
Hok J, Tishelman C, Ploner A, Forss A, Falkenberg T

Detecting differential expression in microarray data: comparison of optimal procedures
Perelman E, Ploner A, Calza S, Pawitan Y

Filtering genes to improve sensitivity in oligonucleotide microarray data analysis
Calza S, Raffelsberger W, Ploner A, Sahel J, Leveillard T, Pawitan Y
NUCLEIC ACIDS RESEARCH 2007;35(16):e102-

Gene expression in 16q is associated with survival and differs between Sorlie breast cancer subtypes
Wennmalm K, Calza S, Ploner A, Hall P, Bjohle J, Klaar S, et al

Annotated regions of significance of SELDI-TOF-MS spectra for detecting protein biornarkers
Tan Cs, Ploner A, Quandt A, Lehtio J, Pernemalm M, Lewensohn R, et al
PROTEOMICS 2006;6(23):6124-33

Estimation of false discovery proportion under general dependence
Pawitan Y, Calza S, Ploner A
BIOINFORMATICS 2006;22(24):3025-31

Finding regions of significance in SELDI measurements for identifying protein biomarkers
Tan Cs, Ploner A, Quandt A, Lehtio J, Pawitan Y
BIOINFORMATICS 2006;22(12):1515-23

Genomic instability and prognosis in breast carcinomas
Kronenwett U, Ploner A, Zetterberg A, Bergh J, Hall P, Auer G, et al

Hormone-replacement therapy influences gene expression profiles and is associated with breast-cancer prognosis: a cohort study
Hall P, Ploner A, Bjohle J, Huang F, Lin Cy, Liu Et, et al
BMC MEDICINE 2006;:16-

Intrinsic molecular signature of breast cancer in a population-based cohort of 412 patients
Calza S, Hall P, Auer G, Bjohle J, Klaar S, Kronenwett U, et al

Multidimensional local false discovery rate for microarray studies
Ploner A, Calza S, Gusnanto A, Pawitan Y
BIOINFORMATICS 2006;22(5):556-65

An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival
Miller Ld, Smeds J, George J, Vega Vb, Vergara L, Ploner A, et al

Bias in the estimation of false discovery rate in microarray studies
Pawitan Y, Murthy Krk, Michiels S, Ploner A
BIOINFORMATICS 2005;21(20):3865-72

Correlation test to assess low-level processing of high-density oligonucleotide microarray data
Ploner A, Miller Ld, Hall P, Bergh J, Pawitan Y

False discovery rate, sensitivity and sample size for microarray studies
Pawitan Y, Michiels S, Koscielny S, Gusnanto A, Ploner A
BIOINFORMATICS 2005;21(13):3017-24

Fold-change estimation of differentially expressed genes using mixture mixed-model
Gusnanto A, Ploner A, Pawitan Y

Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts
Pawitan Y, Bjohle J, Amler L, Borg Al, Egyhazi S, Hall P, et al

Gene profile and response to treatment
Smeds J, Miller Ld, Bjohle J, Hall P, Klaar S, Liu Et, et al
ANNALS OF ONCOLOGY 2005;:ii195-202

ProSpect: An R package for analyzing SELDI measurements identifying protein biomarkers
Quandt A, Ploner A, Tan Cs, Lehtio J, Pawitan Y, Berthold Mr, et al

Fish drift in a Danube sidearm-system: II. Seasonal and diurnal patterns
Zitek A, Schmutz S, Ploner A
JOURNAL OF FISH BIOLOGY 2004;65(5):1339-1357

Fish drift in a Danube sidearm-system: I. Site-, inter- and intraspecific patterns
Zitek A, Schmutz S, Unfer G, Ploner A
JOURNAL OF FISH BIOLOGY 2004;65(5):1319-1338

Moberg picking-up test in patients with inflammatory joint diseases: A survey of suitability in comparison with button test and measures of disease activity
Stamm Ta, Ploner A, Machold Kp, Smolen J

Results of three long-term P-field experiments in Austria 1(st) Report: Effects of different types and quantities of P-fertiliser on yields and P-CAL/DL-contents in soils
Spiegel H, Lindenthal T, Mazorek M, Ploner A, Freyer B, Kochl A
BODENKULTUR 2001;52(1):3-17

New directions in geostatistics
Ploner A, Dutter R

The use of the variogram cloud in geostatistical modelling
Ploner A
ENVIRONMETRICS 1999;10(4):413-437

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