Aleksander Mathe

Publications
CV
Public outreach and news

Articles

Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2024;27(12):pyae062
Exploring the Anxiolytic Potential of NPY by a Dipeptidyl Peptidase-IV Inhibitor in an Animal Model of PTSD
Dahan M; Zohar J; Todder D; Mathe AA; Cohen H
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;57:1-14
Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours
Carboni L; El Khoury A; Beiderbeck DI; Neumann ID; Mathe AA
Article: ACTA NEUROPSYCHIATRICA. 2022;34(2):86-92
Sirtuins and neuropeptide y downregulation in Flinders Sensitive Line rat model of depression
Stiernborg M; Efstathopoulos P; Lennartsson A; Lavebratt C; Mathe AA
Article: MOLECULAR PSYCHIATRY. 2021;26(9):5140-5149
Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance
Nasca C; Dobbin J; Bigio B; Watson K; de Angelis P; Kautz M; Cochran A; Mathe AA; Kocsis JH; Lee FS; Murrough JW; McEwen BS; Rasgon N
Article: SCIENTIFIC REPORTS. 2021;11(1):11856
The monoamine stabilizer OSU6162 has anxiolytic-like properties and reduces voluntary alcohol intake in a genetic rat model of depression
Melas PA; Wirf M; Andre H; Jayaram-Lindstrom N; Mathe AA; Steensland P
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2020;23(12):783-790
A Randomized Controlled Trial of Intranasal Neuropeptide Y in Patients With Major Depressive Disorder
Mathe AA; Michaneck M; Berg E; Charney DS; Murrough JW
Article: CELLS. 2020;9(8):E1818-1818
Depression-Associated GeneNegr1-Fgfr2Pathway Is Altered by Antidepressant Treatment
Carboni L; Pischedda F; Piccoli G; Lauria M; Musazzi L; Popoli M; Mathe AA; Domenici E
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:304
Non-dopaminergic Alterations in Depression-Like FSL Rats in Experimental Parkinsonism and L-DOPA Responses
Schintu N; Zhang X; Stroth N; Mathe AA; Andren PE; Svenningsson P
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2020;32:94-103
Rapid effects of S-ketamine on the morphology of hippocampal astrocytes and BDNF serum levels in a sex-dependent manner
Ardalan M; Elfving B; Rafati AH; Mansouri M; Zarate CAJ; Mathe AA; Wegener G
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2020;31:69-85
Gene expression signature of antidepressant treatment response/non-response in Flinders Sensitive Line rats subjected to maternal separation
Marchetti L; Lauria M; Caberlotto L; Musazzi L; Popoli M; Mathe AA; Domenici E; Carboni L
Article: BEHAVIOURAL BRAIN RESEARCH. 2019;367:28-34
Sustained overexpression of neuropeptide S in the amygdala reduces anxiety-like behavior in rats
Tillmann S; Skibdal HE; Christiansen SH; Gotzsche CR; Hassan M; Mathe AA; Wegener G; Woldbye DPD
Article: ACTA NEUROPSYCHIATRICA. 2019;31(2):93-99
CGRP in a gene-environment interaction model for depression: effects of antidepressant treatment
Angelucci F; Ellenbroek BA; El Khoury A; Mathe AA
Article: BEHAVIOURAL BRAIN RESEARCH. 2018;351:93-103
Sex-dependent behavior, neuropeptide profile and antidepressant response in rat model of depression
Sanchez C; El Khoury A; Hassan M; Wegener G; Mathe AA
Article: NEUROPSYCHOPHARMACOLOGY. 2018;43(10):2134-2145
Cross-species evidence from human and rat brain transcriptome for growth factor signaling pathway dysregulation in major depression
Carboni L; Marchetti L; Lauria M; Gass P; Vollmayr B; Redfern A; Jones L; Razzoli M; Malki K; Begni V; Riva MA; Domenici E; Caberlotto L; Mathe AA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(34):8627-8632
Acetyl-L-carnitine deficiency in patients with major depressive disorder
Nasca C; Bigio B; Lee FS; Young SP; Kautz MM; Albright A; Beasley J; Millington DS; Mathe AA; Kocsis JH; Murrough JW; McEwen BS; Rasgon N
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2018;21(1):3-11
A Randomized Dose-Ranging Study of Neuropeptide Y in Patients with Posttraumatic Stress Disorder
Sayed S; Van Dam NT; Horn SR; Kautz MM; Parides M; Costi S; Collins KA; Iacoviello B; Iosifescu DV; Mathe AA; Southwick SM; Feder A; Charney DS; Murrough JW
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2018;28(1):159-170
Neuropeptide S in the basolateral amygdala mediates an adaptive behavioral stress response in a rat model of posttraumatic stress disorder by increasing the expression of BDNF and the neuropeptide YY1 receptor.
Cohen H; Vainer E; Zeev K; Zohar J; Mathé AA
Article: FRONTIERS IN PSYCHIATRY. 2017;8:102
Neuropeptide Y and Calcitonin Gene-Related Peptide in Cerebrospinal Fluid in Parkinson's Disease with Comorbid Depression versus Patients with Major Depressive Disorder
Svenningsson P; Palhagen S; Mathe AA
Article: ACTA NEUROPSYCHIATRICA. 2017;29(1):54-58
Decreased levels of kynurenic acid in prefrontal cortex in a genetic animal model of depression
Liu X-C; Erhardt S; Goiny M; Engberg G; Mathe AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2016;19(12):pyw069
MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro
Bin Wei Y; Melas PA; Villaescusa JC; Liu JJ; Xu N; Christiansen SH; Elbrond-Bek H; Woldbye DPD; Wegener G; Mathe AA; Lavebratt C
Article: TRANSLATIONAL PSYCHIATRY. 2016;6(10):e917
The wake-promoting drug modafinil stimulates specific hypothalamic circuits to promote adaptive stress responses in an animal model of PTSD
Cohen S; Ifergane G; Vainer E; Matar MA; Kaplan Z; Zohar J; Mathe AA; Cohen H
Article: NEUROPEPTIDES. 2016;59:83-88
Gene-environment interactions in a rat model of depression. Maternal separation affects neurotensin in selected brain regions
Ellenbroek BA; Angelucci F; Husum H; Mathe AA
Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2016;81:36-45
Testing different paradigms to optimize antidepressant deep brain stimulation in different rat models of depression
Rummel J; Voget M; Hadar R; Ewing S; Sohr R; Klein J; Sartorius A; Heinz A; Mathe AA; Vollmayr B; Winter C
Article: BRAIN STRUCTURE & FUNCTION. 2016;221(7):3521-3546
Exploring the role of neuropeptide S in the regulation of arousal: a functional anatomical study
Adori C; Barde S; Vas S; Ebner K; Su J; Svensson C; Mathe AA; Singewald N; Reinscheid RR; Uhlen M; Kultima K; Bagdy G; Hokfelt T
Article: TRANSLATIONAL PSYCHIATRY. 2016;6(8):e869
Elevation of Il6 is associated with disturbed let-7 biogenesis in a genetic model of depression
Wei YB; Liu JJ; Villaescusa JC; Aberg E; Brene S; Wegener G; Mathe AA; Lavebratt C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(28):7906-7911
Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance
Bigio B; Mathe AA; Sousa VC; Zelli D; Svenningsson P; McEwen BS; Nasca C
Article: BEHAVIOURAL BRAIN RESEARCH. 2015;291:299-305
Altered local field potential activity and serotonergic neurotransmission are further characteristics of the Flinders sensitive line rat model of depression
Voget M; Rummel J; Avchalumov Y; Sohr R; Haumesser JK; Rea E; Mathe AA; Hadar R; van Riesen C; Winter C
Article: BRAIN STIMULATION. 2015;8(4):714-723
Medial Forebrain Bundle Deep Brain Stimulation has Symptom-specific Anti-depressant Effects in Rats and as Opposed to Ventromedial Prefrontal Cortex Stimulation Interacts With the Reward System
Edemann-Callesen H; Voget M; Empl L; Vogel M; Wieske F; Rummel J; Heinz A; Mathe AA; Hadar R; Winter C
Article: JOURNAL OF NEUROSCIENCE. 2015;35(11):4599-4613
Selective Breeding for High Anxiety Introduces a Synonymous SNP That Increases Neuropeptide S Receptor Activity
Slattery DA; Naik RR; Grund T; Yen Y-C; Sartori SB; Fuechsl A; Finger BC; Elfving B; Nordemann U; Guerrini R; Calo G; Wegener G; Mathe AA; Singewald N; Czibere L; Landgraf R; Neumann ID
Article: BEHAVIOURAL BRAIN RESEARCH. 2015;281:348-357
Expression of inflammatory markers in a genetic rodent model of depression
Strenn N; Suchankova P; Nilsson S; Fischer C; Wegener G; Mathe AA; Ekman A
Article: NEUROPSYCHOPHARMACOLOGY. 2015;40(3):774-790
Diurnal Fluctuations in HPA and Neuropeptide Y-ergic Systems Underlie Differences in Vulnerability to Traumatic Stress Responses at Different Zeitgeber Times
Cohen S; Vainer E; Matar MA; Kozlovsky N; Kaplan Z; Zohar J; Mathe AA; Cohen H
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2015;18(7):pyv002
Telomerase Dysregulation in the Hippocampus of a Rat Model of Depression: Normalization by Lithium
Bin Wei Y; Backlund L; Wegener G; Mathe AA; Lavebratt C
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2014;24(12):1907-1915
Low neuropeptide Y in cerebrospinal fluid in bipolar patients is associated with previous and prospective suicide attempts
Sandberg JV; Jakobsson J; Palsson E; Landen M; Mathe AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;18(1):pyu023
Cerebrospinal Fluid Neuropeptide Y Levels in Major Depression and Reported Childhood Trauma
Soleimani L; Oquendo MA; Sullivan GM; Mathe AA; Mann JJ
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;18(2):pyu032
Antidepressant-Like Effect of Sodium Butyrate is Associated with an Increase in TET1 and in 5-Hydroxymethylation Levels in the Bdnf Gene
Bin Wei Y; Melas PA; Wegener G; Mathe AA; Lavebratt C
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;18(3):pyu067
Synaptoproteomic Analysis of a Rat Gene-Environment Model of Depression Reveals Involvement of Energy Metabolism and Cellular Remodeling Pathways
Mallei A; Failler M; Corna S; Racagni G; Mathe AA; Popoli M
Article: JOURNAL OF PSYCHOPHARMACOLOGY. 2014;28(10):964-972
Effects of lithium and valproic acid on BDNF protein and gene expression in an in vitro human neuron-like model of degeneration
Croce N; Mathe AA; Gelfo F; Caltagirone C; Bernardini S; Angelucci F
Article: NEUROSCIENCE LETTERS. 2014;559:163-168
Antidepressant effects on serotonin 1A/1B receptors in the rat brain using a gene x environment model
Shrestha SS; Pine DS; Luckenbaugh DA; Varnas K; Henter ID; Innis RB; Mathe AA; Svenningsson P
Article: BRAIN STIMULATION. 2014;7(1):21-28
Anti-Anhedonic Effect of Deep Brain Stimulation of the Prefrontal Cortex and the Dopaminergic Reward System in a Genetic Rat Model of Depression: An Intracranial Self-Stimulation Paradigm Study
Rea E; Rummel J; Schmidt TT; Hadar R; Heinz A; Mathe AA; Winter C
Article: FRONTIERS IN PSYCHOLOGY. 2013;4:597
Maternal status regulates cortical responses to the body odor of newborns
Lundstrom JN; Mathe A; Schaal B; Frasnelli J; Nitzsche K; Gerber J; Hummel T
Article: TRANSLATIONAL PSYCHIATRY. 2013;3(5):e261
Long-term lithium treatment in bipolar disorder is associated with longer leukocyte telomeres
Martinsson L; Wei Y; Xu D; Melas PA; Mathe AA; Schalling M; Lavebratt C; Backlund L
Article: TRANSLATIONAL PSYCHIATRY. 2013;3(5):e255
Allele-specific programming of Npy and epigenetic effects of physical activity in a genetic model of depression
Melas PA; Lennartsson A; Vakifahmetoglu-Norberg H; Wei Y; Aberg E; Werme M; Rogdaki M; Mannervik M; Wegener G; Brene S; Mathe AA; Lavebratt C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(12):4804-4809
L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors
Nasca C; Xenos D; Barone Y; Caruso A; Scaccianoce S; Matrisciano F; Battaglia G; Mathe AA; Pittaluga A; Lionetto L; Simmaco M; Nicoletti F
Article: BIOLOGICAL PSYCHIATRY. 2012;72(12):997-1003
Cerebrospinal Fluid Neuropeptide Y-like Immunoreactivity Correlates with Impulsive Aggression in Human Subjects
Coccaro EF; Lee R; Liu T; Mathe AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15(8):1051-1061
Quetiapine affects neuropeptide Y and corticotropin-releasing hormone in cerebrospinal fluid from schizophrenia patients: relationship to depression and anxiety symptoms and to treatment response
Nikisch G; Baumann P; Liu T; Mathe AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15(5):669-679
Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression
Melas PA; Rogdaki M; Lennartsson A; Bjork K; Qi H; Witasp A; Werme M; Wegener G; Mathe AA; Svenningsson P; Lavebratt C
Article: PEPTIDES. 2012;35(1):49-55
Neuropeptide Y: Identification of a novel rat mRNA splice-variant that is downregulated in the hippocampus and the prefrontal cortex of a depression-like model
Melas PA; Mannervik M; Mathe AA; Lavebratt C
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15(3):375-387
Neuropeptide S alters anxiety, but not depression-like behaviour in Flinders Sensitive Line rats: a genetic animal model of depression
Wegener G; Finger BC; Elfving B; Keller K; Liebenberg N; Fischer CW; Singewald N; Slattery DA; Neumann ID; Mathe AA
Article: MOLECULAR PSYCHIATRY. 2012;17(2):173-184
Emotional memory impairments in a genetic rat model of depression: involvement of 5-HT/MEK/Arc signaling in restoration
Eriksson TM; Delagrange P; Spedding M; Popoli M; Mathe AA; Oegren SO; Svenningsson P
Article: NEUROPSYCHOPHARMACOLOGY. 2012;37(2):350-363
The Neuropeptide Y (NPY)-ergic System is Associated with Behavioral Resilience to Stress Exposure in an Animal Model of Post-Traumatic Stress Disorder
Cohen H; Liu T; Kozlovsky N; Kaplan Z; Zohar J; Mathe AA
Article: PSYCHONEUROENDOCRINOLOGY. 2012;37(1):78-86
The neuroendocrinology of childhood trauma in personality disorder
Lee RJ; Hempel J; TenHarmsel A; Liu T; Mathe AA; Klock A
Article: PHARMACOGENETICS AND GENOMICS. 2011;21(12):779-789
Antidepressants and the resilience to early-life stress in inbred mouse strains
Binder E; Malki K; Paya-Cano JL; Fernandes C; Aitchison KJ; Mathe AA; Sluyter F; Schalkwyk LC
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2011;21(12):918-927
Effects of olanzapine on extracellular concentrations and tissue content of neurotensin in rat brain regions
Gruber SHM; Angelucci F; Nomikos GG; Mathe AA
Article: NEUROPEPTIDES. 2011;45(6):401-406
Increased numbers of orexin/hypocretin neurons in a genetic rat depression model
Mikrouli E; Wortwein G; Soylu R; Mathe AA; Petersen A
Article: JOURNAL OF PSYCHOPHARMACOLOGY. 2011;25(10):1378-1387
Dissociation of antidepressant-like activity of escitalopram and nortriptyline on behaviour and hippocampal BDNF expression in female rats
Hansson AC; Rimondini R; Heilig M; Mathe AA; Sommer WH
Article: BEHAVIOURAL BRAIN RESEARCH. 2011;221(1):43-49
Impact of early life stress on alcohol consumption and on the short- and long-term responses to alcohol in adolescent female rats
Van Waes V; Darnaudery M; Marrocco J; Gruber SH; Talavera E; Mairesse J; Van Cama G; Casolla B; Nicoletti F; Mathe AA; Maccari S; Morley-Fletcher S
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2011;21(7):545-562
Nortriptyline influences protein pathways involved in carbohydrate metabolism and actin-related processes in a rat gene-environment model of depression
Piubelli C; Gruber S; El Khoury A; Mathe AA; Domenici E; Carboni L
Article: JOURNAL OF PSYCHOPHARMACOLOGY. 2011;25(7):896-907
Cytochrome P450 and ABCB1 genetics: association with quetiapine and norquetiapine plasma and cerebrospinal fluid concentrations and with clinical response in patients suffering from schizophrenia. A pilot study
Nikisch G; Baumann P; Oneda B; Kiessling B; Weisser H; Mathe AA; Yoshitake T; Kehr J; Wiedemann G; Eap CB
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2011;14(6):796-833
Escitalopram modulates neuron-remodelling proteins in a rat gene-environment interaction model of depression as revealed by proteomics. Part I: genetic background
Piubelli C; Vighini M; Mathe AA; Domenici E; Carboni L
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2011;14(6):834-855
Escitalopram affects cytoskeleton and synaptic plasticity pathways in a rat gene-environment interaction model of depression as revealed by proteomics. Part II: environmental challenge
Piubelli C; Vighini M; Mathe AA; Domenici E; Carboni L
Article: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. 2011;99(1):104-111
Prolonged chronic ethanol exposure alters neuropeptide Y and corticotropin-releasing factor levels in the brain of adult Wistar rats
Criado JR; Liu T; Ehlers CL; Mathe AA
Article: NEUROPSYCHOPHARMACOLOGY. 2011;36(8):1769-1777
Resting Glutamate Levels and Rapid Glutamate Transients in the Prefrontal Cortex of the Flinders Sensitive Line Rat: A Genetic Rodent Model of Depression
Hascup KN; Hascup ER; Stephens ML; Glaser PEA; Yoshitake T; Mathe AA; Gerhardt GA; Kehr J
Article: NEUROPHARMACOLOGY. 2011;60(7-8):1243-1253
Synaptoproteomics of learned helpless rats involve energy metabolism and cellular remodeling pathways in depressive-like behavior and antidepressant response
Mallei A; Giambelli R; Gass P; Racagni G; Mathe AA; Vollmayr B; Popoli M
Article: NEUROSCIENCE. 2011;176:349-380
REGULATION OF CYTOSKELETON MACHINERY, NEUROGENESIS AND ENERGY METABOLISM PATHWAYS IN A RAT GENE-ENVIRONMENT MODEL OF DEPRESSION REVEALED BY PROTEOMIC ANALYSIS
Piubelli C; Carboni L; Becchi S; Mathe AA; Domenici E
Article: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY. 2010;30(5):496-503
Quetiapine and Norquetiapine in Plasma and Cerebrospinal Fluid of Schizophrenic Patients Treated With Quetiapine Correlations to Clinical Outcome and HVA, 5-HIAA, and MHPG in CSF
Nikisch G; Baumann P; Wiedemann G; Kiessling B; Weisser H; Hertel A; Yoshitake T; Kehr J; Mathe AA
Article: PLOS ONE. 2010;5(9):e12596
Expression Profiling of a Genetic Animal Model of Depression Reveals Novel Molecular Pathways Underlying Depressive-Like Behaviours
Blaveri E; Kelly F; Mallei A; Harris K; Taylor A; Reid J; Razzoli M; Carboni L; Piubelli C; Musazzi L; Racagni G; Mathe A; Popoli M; Domenici E; Bates S
Article: ALCOHOL. 2010;44(6):487-493
Effects of prolonged ethanol vapor exposure on forced swim behavior, and neuropeptide Y and corticotropin-releasing factor levels in rat brains
Walker BM; Drimmer DA; Walker JL; Liu T; Mathe AA; Ehlers CL
Article: HIPPOCAMPUS. 2010;20(7):820-828
The Antidepressant Effects of Running and Escitalopram Are Associated With Levels of Hippocampal NPY and Y1 Receptor But Not Cell Proliferation in a Rat Model of Depression
Bjornebekk A; Mathe AA; Brene S
Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2010;44(8):511-520
Early-life stress and antidepressant treatment involve synaptic signaling and Erk kinases in a gene-environment model of depression
Musazzi L; Mallei A; Tardito D; Gruber SHM; El Khoury A; Racagni G; Mathe AA; Popoli M
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2010;13(5):563-572
Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression
Elfving B; Plougmann PH; Muller HK; Mathe AA; Rosenberg R; Wegener G
Article: BRAIN RESEARCH. 2010;1325:112-120
Enhanced expression of the neuronal K⁺/Cl^- cotransporter, KCC2, in spontaneously depressed Flinders Sensitive Line rats
Matrisciano F; Nasca C; Molinaro G; Riozzi B; Scaccianoce S; Raggi MA; Mercolini L; Biagioni F; Mathe AA; Sanna E; Maciocco E; Pignatelli M; Biggio G; Nicoletti F
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2010;20(1):18-24
CSF neurochemicals during tryptophan depletion in individuals with remitted depression and healthy controls
Moreno FA; Parkinson D; Palmer C; Castro WL; Misiaszek J; El Khoury A; Mathe AA; Wright R; Delgado PL
Article: NEUROBIOLOGY OF DISEASE. 2009;34(2):375-380
Increased levels of cocaine and amphetamine regulated transcript in two animal models of depression and anxiety
Wiehager S; Beiderbeck DI; Gruber SHM; El-Khoury A; Wamsteeker J; Neumann ID; Petersen A; Mathe AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2009;12(4):553-559
Remodelling by early-life stress of NMDA receptor-dependent synaptic plasticity in a gene-environment rat model of depression
Ryan B; Musazzi L; Mallei A; Tardito D; Gruber SHM; El Khoury A; Anwyl R; Racagni G; Mathe AA; Rowan MJ; Popoli M
Article: NEUROSCIENCE LETTERS. 2009;451(2):148-151
Nortriptyline mediates behavioral effects without affecting hippocampal cytogenesis in a genetic rat depression model
Petersen A; Woertwein G; Gruber SHM; El-Khoury A; Mathe AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2008;11(8):1135-1147
Housing conditions modulate escitalopram effects on antidepressive-like behaviour and brain neurochemistry
Bjornebekk A; Mathe AA; Gruber SHM; Brene S
Article: NEUROPEPTIDES. 2008;42(5-6):535-541
Differential effects of olanzapine, haloperidol and risperidone on calcitonin gene-related peptide in the rat brain
Angelucci F; Gruber SHM; Caltagirone C; Mathe AA
Article: NEUROPHARMACOLOGY. 2008;55(4):525-531
Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats
Matrisciano F; Caruso A; Orlando R; Marchiafava M; Bruno V; Battaglia G; Gruber SHM; Melchiorri D; Tatarelli R; Girardi P; Mathe AA; Nicoletti F
Article: EUROPEAN PSYCHIATRY. 2008;23(5):356-359
CSF monoamine metabolites and neuropeptides in depressed patients before and after electroconvulsive therapy
Nikisch G; Mathe AA
Article: NEUROSCIENCE LETTERS. 2008;436(3):305-308
Escitalopram reduces increased hippocampal cytogenesis in a genetic rat depression model
Petersen A; Wortwein G; Gruber SHM; Mathe AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2008;11(1):93-101
Gene-environment interaction affects substance P and neurokinin A in the entorhinal cortex and periaqueductal grey in a genetic animal model of depression:: implications for the pathophysiology of depression
Husum H; Wortwein G; Andersson W; Bolwig TG; Mathe AA
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17(12):756-762
Chronic amphetamine treatment reduces NGF and BDNF in the rat brain
Angelucci F; Gruber SHM; El Khoury A; Tonali PA; Mathe AA
Article: JOURNAL OF PSYCHOPHARMACOLOGY. 2007;21(8):820-825
Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor
Angelucci F; Ricci V; Pomponi M; Conte G; Mathe AA; Tonali PA; Bria P
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2007;10(5):609-619
Restraint stress influences AP-1 and CREB DNA-binding activity induced by chronic lithium treatment in the rat frontal cortex and hippocampus
Miller JC; Jimenez P; Mathe AA
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):226-231
Search for biological correlates of depression and mechanisms of action of antidepressant treatment modalities.: Do neuropeptides play a role?
Mathe AA; Husum H; El Khoury A; Jimenez-Vasquez P; Gruber SHM; Woertwein G; Nikisch G; Baumann P; Agren H; Andersson W; Soedergren A; Angelucci F
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):136-140
Running is rewarding and antidepressive
Brene S; Bjornebekk A; Aberg E; Mathe AA; Olson L; Werme M
Article: NEUROREPORT. 2007;18(10):1039-1043
Isolated Flinders Sensitive Line rats have decreased dopamine D2 receptor mRNA
Bjornebekk A; Mathe AA; Brene S
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17(4):298-308
Electroconvulsive stimuli selectively affect behavior and neuropeptide Y (NPY) and NPYY₁ receptor gene expressions in hippocampus and hypothalamus of Flinders Sensitive Line rat model of depression
Jimenez-Vasquez PA; Diaz-Cabiale Z; Caberlotto L; Bellido I; Overstreet D; Fuxe K; Mathe AA
Article: BRAIN RESEARCH. 2007;1131(1):181-186
Impact of an intense stress on ethanol consumption in female rats characterized by their pre-stress preference:: Modulation by prenatal stress
Darnaudery M; Louvart H; Defrance L; Leonhardt M; Morley-Fletcher S; Gruber SH; Galietta G; Mathe AA; Maccari S
Article: HIPPOCAMPUS. 2007;17(12):1193-1200
Social isolation increases number of newly proliferated cells in hippocampus in female Flinders Sensitive Line rats
Bjornebekk A; Mathe AA; Gruber SHM; Brene S
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16(8):592-600
Effects of acute and subchronic d-amphetamine on ventral striatal concentrations of neurotensin and neuropeptide Y in rats treated with antipsychotic drugs
Gruber SHM; Nomikos GG; Mathe AA
Article: PEPTIDES. 2006;27(12):3202-3207
Anxiolytic-like effect of the selective Neuropeptide YY2 receptor antagonist BIIE0246 in the elevated plus-maze
Bacchi F; Mathe AA; Jimenez P; Stasi L; Arban R; Gerrard P; Caberlotto L
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2006;84(6):1292-1302
Exacerbated loss of cell survival, neuropeptide Y-immunoreactive (IR) cells, and serotonin-IR fiber lengths in the dorsal hippocampus of the aged flinders sensitive line "depressed" rat:: Implications for the pathophysiology of depression?
Husum H; Aznar S; Hoyer-Hansen S; Larsen MH; Mikkelsen JD; Moller A; Mathe AA; Woertwein G
Article: NEUROPSYCHOPHARMACOLOGY. 2006;31(2):256-264
Running has differential effects on NPY, opiates, and cell proliferation in an animal model of depression and controls
Bjornebekk A; Mathé AA; Brené S
Article: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. 2006;83(1):28-34
The effects of social isolation on neuropeptide Y levels, exploratory and anxiety-related behaviors in rats
Thorsell A; Slawecki CJ; El Khoury A; Mathe AA; Ehlers CL
Article: PSYCHOPHARMACOLOGY. 2005;181(4):751-760
Long-term citalopram administration reduces responsiveness of HPA axis in patients with major depression: relationship with S-citalopram concentrations in plasma and cerebrospinal fluid (CSF) and clinical response
Nikisch G; Mathé AA; Czernik A; Thiele J; Bohner J; Eap CB; Ågren H; Baumann P
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2005;8(3):357-368
The antidepressant effect of running is associated with increased hippocampal cell proliferation
Bjornebekk A; Mathé AA; Brené S
Article: NEUROPEPTIDES. 2005;39(4):369-377
Increased CRF-like and NPY-like immunoreactivity in adult rats exposed to nicotine during adolescence: Relation to anxiety-like and depressive-like behavior
Slawecki CJ; Thorsell AK; El Khoury A; Mathé AA; Ehlers CL
Article: ALCOHOL. 2005;36(2):91-97
Effect of social isolation on ethanol consumption and substance P/neurokinin expression in Wistar rats.
Thorsell A; Slawecki CJ; Khoury A; Mathe AA; Ehlers CL
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2005;15(3):311-317
Effect of chronic olanzapine treatment on nerve growth factor and brain-derived neurotrophic factor in the rat brain.
Angelucci F; Aloe L; Iannitelli A; Gruber SHM; Mathé AA
Article: PSYCHOPHARMACOLOGY. 2005;178(2-3):115-124
Neuropeptide expression in rats exposed to chronic mild stresses
Sergeyev V; Fetissov S; Mathé A; Jimenez P; Bartfal T; Mortas P; Gaudet L; Moreau JL; Hökfelt T
Article: PSYCHOPHARMAKOTHERAPIE. 2005;12(4):130-134
Citalopram plasma and cerebrospinal fluid (CSF) concentrations monitoring: Relationship with CSF monoamine metabolites and clinical outcomes
Nikisch G; Mathé AA; Baumann P
Article: JOURNAL OF STUDIES ON ALCOHOL AND DRUGS. 2005;66(1):46-52
Effect of ethanol on brain neuropeptides in adolescent and adult rats.
Slawecki CJ; Jiménez-Vasquez P; Mathé AA; Ehlers CL
Article: EPILEPSY & BEHAVIOR. 2004;5(2):204-215
Levetiracetam prevents changes in levels of brain-derived neurotrophic factor and neuropeptide Y mRNA and of Y1- and Y5-like receptors in the hippocampus of rats undergoing amygdala kindling: implications for antiepileptogenic and mood-stabilizing properties
Husum H; Bolwig TG; Sánchez C; Mathé AA; Hansen SL
Article: NEUROPSYCHOBIOLOGY. 2004;50(3):239-243
Neuropeptide Y in euthymic lithium-treated women with bipolar disorder
El Khoury A; Mathé AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2003;6(3):225-231
Lithium treatment alters brain concentrations of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a rat model of depression.
Angelucci F; Aloe L; Jiménez-Vasquez P; Mathé AA
Article: NEUROPSYCHOPHARMACOLOGY. 2003;28(7):1292-1299
Topiramate normalizes hippocampal NPY-LI in flinders sensitive line 'depressed' rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: implications for mood-stabilizing and weight loss-inducing effects.
Husum H; Van Kammen D; Termeer E; Bolwig G; Mathé A
Article: BIPOLAR DISORDERS. 2003;5(2):129-137
Social support in bipolar disorder: its relevance to remission and relapse.
Johnson L; Lundström O; Aberg-Wistedt A; Mathé AA
Article: JOURNAL OF NEUROCHEMISTRY. 2003;85(2):462-468
Differential expression and regulation of myristoylated alanine-rich C kinase substrate (MARCKS) in the hippocampus of C57/BL6J and DBA/2J mice.
McNamara RK; Vasquez PA; Mathe AA; Lenox RH
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2003;60(2):378-381
Identification of the bioactive peptide PEC-60 in brain
Norberg Å; Gruber S; Angelucci F; Renlund S; Wadensten H; Efendic S; Östenson CG; Jörnvall H; Sillard R; Mathé AA
Article: NEUROPEPTIDES. 2003;37(1):51-56
Electroconvulsive stimuli alter nerve growth factor but not brain-derived neurotrophic factor concentrations in brains of a rat model of depression.
Angelucci F; Aloe L; Jiménez-Vasquez P; Mathé AA
Article: NEUROPSYCHOBIOLOGY. 2003;48(1):14-18
Decreased plasma prolactin release in euthymic lithium-treated women with bipolar disorder
El Khoury A; Tham A; Mathé AA; Åberg-Wistedt A; Stein-Malmgren R
Article: NEUROPSYCHOPHARMACOLOGY. 2002;27(5):756-764
Early life stress changes concentrations of neuropeptide Y and corticotropin-releasing hormone in adult rat brain. Lithium treatment modifies these changes.
Husum H; Mathé AA
Article: NEUROPEPTIDES. 2002;36(5):363-369
Extracellular levels of NPY in the dorsal hippocampus of freely moving rats are markedly elevated following a single electroconvulsive stimulation, irrespective of anticonvulsive Y1 receptor blockade.
Husum H; Gruber SHM; Bolwig TG; Mathé AA
Article: JOURNAL OF ECT. 2002;18(3):138-143
Electroconvulsive stimuli alter the regional concentrations of nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in adult rat brain.
Angelucci F; Aloe L; Jiménez-Vasquez P; Mathé AA
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2002;69(1):133-139
d-Amphetamine-induced increase in neurotensin and neuropeptide Y outflow in the ventral striatum is mediated via stimulation of dopamine D1 and D2/3 receptors.
Gruber SHM; Nomikos GG; Mathé AA
Article: NEUROPHARMACOLOGY. 2002;42(6):798-806
Early maternal deprivation alters hippocampal levels of neuropeptide Y and calcitonin-gene related peptide in adult rats.
Husum H; Termeer E; Mathé AA; Bolwig TG; Ellenbroek BA
Article: NEUROPSYCHOPHARMACOLOGY. 2002;26(5):595-604
Effects of haloperidol and risperidone on neurotensin levels in brain regions and neurotensin efflux in the ventral striatum of the rat.
Gruber SHM; Nomikos GG; Mathé AA
Article: NEUROSCIENCE LETTERS. 2002;317(2):101-105
Increased density of galanin binding sites in the dorsal raphe in a genetic rat model of depression
Bellido I; Díaz-Cabiale Z; Jiménez-Vasquez PA; Andbjer B; Mathé AA; Fuxe K
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2001;4(4):329-336
Tryptophan depletion in lithium-stabilized patients with affective disorder
Johnson L; El-Khoury A; Åberg-Wistedt A; Stain-Malmgren R; Mathé AA
Article: DEVELOPMENTAL BRAIN RESEARCH. 2001;131(1-2):149-152
Early maternal separation alters neuropeptide Y concentrations in selected brain regions in adult rats.
Jiménez-Vasquez PA; Mathé AA; Thomas JD; Riley EP; Ehlers CL
Article: JOURNAL OF STUDIES ON ALCOHOL AND DRUGS. 2001;62(6):736-740
Substance P and neurokinin levels are decreased in the cortex and hypothalamus of alcohol-preferring (P) rats.
Slawecki CJ; Jimenéz-Vasquez P; Mathé AA; Ehlers CL
Article: NEUROPEPTIDES. 2001;35(5-6):285-291
A pilot study of rat brain regional distribution of calcitonin, katacalcin and calcitonin gene-related peptide before and after antipsychotic treatment.
Angelucci F; Gruber SH; Mathé AA
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2001;64(6):606-611
Dopamine receptor antagonists prevent the d-amphetamine-induced increase in calcitonin gene-related peptide levels in ventral striatum.
Gruber SH; Nomikos GG; Mathé AA
Article: NEUROPEPTIDES. 2001;35(3-4):168-173
Neuropeptide Y (NPY) mRNA in rat brain tissue: effects of decapitation and high-energy microwave irradiation on post mortem stability.
Thorsell A; Gruber SH; Mathé AA; Heilig M
Article: NEUROPSYCHOPHARMACOLOGY. 2001;24(2):183-191
Changed concentrations of tachykinins and neuropeptide Y in brain of a rat model of depression: lithium treatment normalizes tachykinins.
Husum H; Vasquez PA; Mathé AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2000;3(4):277-283
Tryptophan depletion selectively reduces CSF 5-HT metabolites in healthy young men: results from single lumbar puncture sampling technique.
Moreno FA; McGavin C; Malan TP; Gelenberg AJ; Heninger GR; Mathé AA; Delgado PL
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2000;10(6):495-500
Effects of acute and chronic electroconvulsive stimuli on cAMP and cGMP efflux in the rat striatum and hippocampus
Nomikos GG; Gruber S; Svensson TH; Mathé AA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(23):12852-12857
Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression.
Thorsell A; Michalkiewicz M; Dumont Y; Quirion R; Caberlotto L; Rimondini R; Mathé AA; Heilig M
Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2000;34(6):405-412
Neuropeptide Y in male and female brains of Flinders Sensitive Line, a rat model of depression. Effects of electroconvulsive stimuli.
Jiménez-Vasquez PA; Overstreet DH; Mathé AA
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2000;61(4):458-463
Effects of typical and atypical antipsychotics on neuropeptide Y in rat brain tissue and microdialysates from ventral striatum.
Gruber SH; Mathé AA
Article: JOURNAL OF AFFECTIVE DISORDERS. 2000;59(2):139-148
Age of onset in affective disorder: its correlation with hereditary and psychosocial factors.
Johnson L; Andersson-Lundman G; Aberg-Wistedt A; Mathé AA
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2000;60(6):783-794
Brain-derived neurotrophic factor and tyrosine kinase receptor TrkB in rat brain are significantly altered after haloperidol and risperidone administration.
Angelucci F; Mathé AA; Aloe L
Article: BEHAVIOURAL BRAIN RESEARCH. 2000;111(1-2):115-123
Neuropeptide Y in brains of the Flinders Sensitive Line rat, a model of depression. Effects of electroconvulsive stimuli and d-amphetamine on peptide concentrations and locomotion.
Jiménez Vasquez PA; Salmi P; Ahlenius S; Mathé AA
Article: NEUROPHARMACOLOGY. 2000;39(8):1463-1473
Involvement of hippocampal neuropeptide Y in mediating the chronic actions of lithium, electroconvulsive stimulation and citalopram.
Husum H; Mikkelsen JD; Hogg S; Mathé AA; Mørk A
Article: NEUROREPORT. 2000;11(6):1369-1373
Mapping the differences in the brain concentration of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in an animal model of depression.
Angelucci F; Aloe L; Vasquez PJ; Mathé AA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 1999;2(3):173-179
Calcitonin gene-related peptide (CGRP) levels and alcohol.
Ehlers CL; Somes C; Li T-K; Lumeng L; Hwang BH; Jimenez P; Mathé AA
Article: NEUROSCIENCE LETTERS. 1999;265(3):191-194
Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders Sensitive Line rats, a genetic animal model of depression
Caberlotto L; Jimenez P; Overstreet DH; Hurd YL; Mathé AA; Fuxe K
Article: BIOLOGICAL PSYCHIATRY. 1999;45(3):285-289
Venlafaxine but not bupropion decreases cerebrospinal fluid 5-hydroxyindoleacetic acid in unipolar depression.
Little JT; Ketter TA; Mathé AA; Frye MA; Luckenbaugh D; Post RM
Article: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. 1998;22(8):1778-1782
Neuropeptide Y levels in ethanol-naive alcohol-preferring and nonpreferring rats and in Wistar rats after ethanol exposure.
Ehlers CL; Li TK; Lumeng L; Hwang BH; Somes C; Jimenez P; Mathé AA
Article: ACTA PSYCHIATRICA SCANDINAVICA. 1998;97(5):374-380
Serotonergic 'vulnerability' in affective disorder: a study of the tryptophan depletion test and relationships between peripheral and central serotonin indexes in citalopram-responders.
Aberg-Wistedt A; Hasselmark L; Stain-Malmgren R; Apéria B; Kjellman BF; Mathé AA
Article: NEUROPEPTIDES. 1997;31(4):357-365
A comparison between microwave irradiation and decapitation: basal levels of dynorphin and enkephalin and the effect of chronic morphine treatment on dynorphin peptides
Nylander I; Stenfors C; TanNo K; Mathe AA; Terenius L
Article: NEUROPSYCHOPHARMACOLOGY. 1997;16(6):408-418
Basal and stimulated C-fos mRNA expression in the rat brain: effect of chronic dietary lithium.
Miller JC; Mathé AA
Article: NEUROCHEMICAL RESEARCH. 1997;22(5):629-636
Effects of electroconvulsive stimuli and MK-801 on neuropeptide Y, neurokinin A, and calcitonin gene-related peptide in rat brain
Mathe AA; Gruber S; Jimenez PA; Theodorsson E; Stenfors C
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1997;319(2-3):191-195
Decreased levels of preprotachykinin-A and tachykinin NK1 receptor mRNA in specific regions of the rat striatum after electroconvulsive stimuli
Zachrisson O; Mathe AA; Lindefors N
Article: JOURNAL OF CLINICAL PSYCHIATRY. 1997;58(1):26-29
Impaired neuropsychological performance in euthymic patients with recurring mood disorders
Tham A; Engelbrektson K; Mathe AA; Johnson L; Olsson E; AbergWistedt A
Article: BRAIN RESEARCH. 1996;43(1-2):347-350
Effects of chronic lithium and electroconvulsive stimuli on cholecystokinin mRNA expression in the rat brain
Zachrisson O; Mathe AA; Lindefors N
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 1996;46(3):316-323
The psychotomimetic drugs D-amphetamine and phencyclidine release calcitonin gene-related peptide in the limbic forebrain of the rat
Mathe AA; Hertel P; Nomikos GG; Gruber S; Mathe JM; Svensson TH
Article: BRAIN RESEARCH. 1995;698(1-2):39-45
Concurrent analysis of neuropeptides and biogenic amines in brain tissue of rats treated with electroconvulsive stimuli.
Stenfors C; Bjellerup P; Mathé AA; Theodorsson E
Article: PSYCHOLOGICAL MEDICINE. 1995;25(5):1037-1049
A TWIN STUDY OF GENERALIZED ANXIETY DISORDER AND MAJOR DEPRESSION
ROY MA; NEALE MC; PEDERSEN NL; MATHE AA; KENDLER KS
Article: NEUROSCIENCE LETTERS. 1995;194(1-2):89-92
REGION-SPECIFIC EFFECTS OF CHRONIC LITHIUM ADMINISTRATION ON NEUROPEPTIDE-Y AND SOMATOSTATIN MESSENGER-RNA EXPRESSION IN THE RAT-BRAIN
ZACHRISSON O; MATHE AA; STENFORS C; LINDEFORS N
Article: BRAIN RESEARCH. 1995;31(1-2):71-85
LIMBIC EFFECTS OF REPEATED ELECTROCONVULSIVE STIMULATION ON NEUROPEPTIDE-Y AND SOMATOSTATIN MESSENGER-RNA EXPRESSION IN THE RAT-BRAIN
ZACHRISSON O; MATHE AA; STENFORS C; LINDEFORS N
Article: ACTA PSYCHIATRICA SCANDINAVICA. 1995;92(1):51-55
Seasonal mood variation among Japanese residents of Stockholm.
Murase S; Murase S; Kitabatake M; Yamauchi T; Mathé AA
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 1995;41(2):206-212
Chromatographic and immunochemical characterization of rat brain neuropeptide Y-like immunoreactivity (NPY-LI) following repeated electroconvulsive stimuli.
Stenfors C; Mathé AA; Theodorsson E
Article: BEHAVIOR GENETICS. 1995;25(3):217-232
A PILOT SWEDISH TWIN STUDY OF AFFECTIVE-ILLNESS INCLUDING HOSPITAL-ASCERTAINED AND POPULATION-ASCERTAINED SUBSAMPLES - RESULTS OF MODEL-FITTING
KENDLER KS; PEDERSEN NL; NEALE MC; MATHE AA
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Review: DISCOVER MENTAL HEALTH. 2024;4(1):2
The neuropsychopharmacology of acetyl-L-carnitine (LAC): basic, translational and therapeutic implications
Bigio B; Azam S; Mathe AA; Nasca C
Other: NEUROPSYCHOPHARMACOLOGY. 2020;45(11):1960
Torgny Svensson, MD, Ph.D. (1945-2020) IN MEMORIAM
Aghajanian GK; Mathe AA; Eriksson E; Krystal JH
Review: FRONTIERS IN ENDOCRINOLOGY. 2017;8:178
Neuropeptide Y in Alcohol Addiction and Affective Disorders
Thorsell A; Mathe AA
Review: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. 2014;92(8):621-630
The effect of neuropeptide Y on cell survival and neurotrophin expression in in-vitro models of Alzheimer's disease
Angelucci F; Gelfo F; Fiore M; Croce N; Mathe AA; Bernardini S; Caltagirone C
Review: FRONTIERS IN BEHAVIORAL NEUROSCIENCE. 2013;7:10
Understanding resilience
Wu G; Feder A; Cohen H; Kim JJ; Calderon S; Charney DS; Mathe AA
Corrigendum: JOURNAL OF PSYCHIATRIC RESEARCH. 2012;46(8):1108
Relationship between dopamine D₂ receptor occupancy, clinical response, and drug and monoamine metabolites levels in plasma and cerebrospinal fluid. A pilot study in patients suffering from first-episode schizophrenia treated with quetiapine (Retraction of vol 44, pg 754, 2010)
Nikisch G; Baumann P; Kiessling B; Reinert M; Wiedemann G; Kehr J; Mathe AA; Piel M; Roesch F; Weisser H; Schneider P; Hertel A
Review: EXPERT OPINION ON THERAPEUTIC TARGETS. 2011;15(11):1317-1331
Central functions of neuropeptide Y in mood and anxiety disorders
Wu G; Feder A; Wegener G; Bailey C; Saxena S; Charney D; Mathe AA
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2011;35(6):1357-1375
Animal models of depression and anxiety: What do they tell us about human condition?
Neumann ID; Wegener G; Homberg JR; Cohen H; Slattery DA; Zohar J; Olivier JDA; Mathe AA
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2010;34(6):1037-1048
Early-life stress and antidepressants modulate peripheral biomarkers in a gene-environment rat model of depression
Carboni L; Becchi S; Piubelli C; Mallei A; Giambelli R; Razzoli M; Mathe AA; Popoli M; Domenici E
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2010;20:S186
Potential therapeutic targets from cellular/molecular signalling mechanisms in depression models
Svenningsson P; Eriksson TM; Bjork K; Ogren SO; Mathe A; El Yacoubi M; Vaugeois JM
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S479
Neuropeptide S alters depression- and anxiety-like behaviors in the FSL/FRL rats, a genetic animal model of depression
Wegener G; Finger BC; Slattery DA; Neumann ID; Mathe AA
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S398
Social isolation and "depressed" Flinders Sensitive Line rats: behaviour, steroids, and neuronal plasticity markers
Bianchi M; Ladurelle N; Liere P; Pianos A; Mathe AA; Baulieu EE
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S41-S42
Neuropeptide Y modulation of the glutamatergic system in the Flinders Sensitive Line rat: a rat model of depression
Hascup KN; Hascup ER; Gerhardt GA; Mathe AA; Kehr J
Review: INTERNATIONAL REVIEW OF NEUROBIOLOGY. 2009;88:1-24
EFFECTS OF PSYCHOSTIMULANTS ON NEUROTROPHINS: IMPLICATIONS FOR PSYCHOSTIMULANT-INDUCED NEUROTOXICITY
Angelucci F; Ricci V; Spalletta G; Caltagirone C; Mathe AA; Bria P
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:S355-S356
Proteome changes in rat hippocampus and pre-frontal/frontal cortex in Flinders rats after nortriptyline treatment
Carboni L; Piubelli C; De Luca M; Gruber S; Andersson W; El Khoury A; Mathe AA; Domenici E
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:S355
Proteome changes in rat hippocampus and pre-frontal/frontal cortex in Flinders rats after escitalopram treatment
Piubelli C; Becchi S; El Khoury A; Andersson W; Gruber S; Mathe AA; Domenici E; Carboni L
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:S323
Hippocampal cytogenesis is increased in a genetic rat model of depression. Escitalopram reduces increased cell number
Mathe A; Gruber SHM; Wortwein G; Petersen A
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:S254
Effects of maternal separation and antidepressant treatment on adult brain and behavior in a rat model of depression
El Khoury A; Werme M; Gruber SHM; Mathe AA
Letter: HARVARD REVIEW OF PSYCHIATRY. 2008;16(4):267
Untitled
Isacsson G; Mathe A
Meeting abstract: EUROPEAN PSYCHIATRY. 2008;23:S2
Gene-environment interaction in an animal model of depression
Mathe AA; El Khoury A; Gruber SH
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2008;32(3):651-661
Acute stress differentially affects corticotropin-releasing hormone mRNA expression in the central amygdala of the "depressed" flinders sensitive line and the control flinders, resistant line rats
Zambello E; Jimenez-Vasquez PA; El Khoury A; Mathe AA; Caberlotto L
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:S19-S20
Synaptoproteomic analysis of a rat model of depression with gene-environment interaction
Mallei A; Giambelli R; Barbiero VS; Musazzi L; El Khoury A; Gruber SH; Mathe AA; Racagni G; Popoli M
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S510-S511
Brain biochemistry markers differentiate between animal models of anxiety and depression
Mathe AA; Gruber SHM; El Khoury A; Beiderbeck D; Neumann ID; Landgraf R
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S213
Gene-environment interaction in a genetic rat model of depression
Mathe A; El Khoury A; Gruber SHM; Sodergren A; Jimenez P; Husum H; Wortwein G
Letter: MOLECULAR PSYCHIATRY. 2007;12(8):704-706
Group-II metabotropic glutamate receptor ligands as adjunctive drugs in the treatment of depression:: a new strategy to shorten the latency of antidepressant medication?
Matrisciano F; Panaccione I; Zusso M; Giusti P; Tatarelli R; Iacovelli L; Mathe AA; Gruber SHM; Nicoletti F; Girardi P
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S24
Functional and molecular correlates of synaptic plasticity in a gene -: environment combination rat model of depression
Musazzi L; Barbiero V; Mallei A; Mathe A; El Khoury A; Gruber SH; Racagni G; Ryan BK; Rowan MJ; Popoli M
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16:S336-S337
Proteomic analysis of hippocampus and frontal cortex in a rat model of depression with gene-environment interaction and antidepressant treatment
Carboni L; Piubelli C; Vighini M; El Khoury A; Gruber S; Anderssen W; Mathe AA; Aitchison KJ; Mallei A; Giambelli R; Popoli M; Domenici E
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16:S308-S309
Neuropeptides in human cerebrospinal fluid and in brains of animal models of depression -: effects of treatment
Mathe AA; Nikisch G; Agren H; Baumann P; El Khoury A; Gruber SHM; Husum H; Jimenez-Vasquez P; Wortwein G; Andersson W; Aitchison KJ; McGuffin P
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16:S169-S170
Functional proteomic analysis of an animal model of depression combining genetic vulnerability and environmental stress
Mallei A; Giambelli R; Barbiero VS; Mathe AA; El Khoury A; Carboni L; Domenici E; Aitchison KJ; Racagni G; Popoli M
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2006;30(4):684-693
Effects of maternal separation on neuropetide Y and calcitonin gene-related peptide in "depressed" Flinders Sensitive Line rats:: A study of gene-environment interactions
Wortwein G; Husum H; Andersson W; Bolwig TG; Mathe AA
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2006;30(3):535-540
Adult life behavioral consequences of early maternal separation are alleviated by escitalopram treatment in a rat model of depression
El Khoury A; Gruber SHM; Mork A; Mathé AA
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16:S20-S21
Functional proteomic analysis of an animal model of depression combining genetic vulnerability and environmental stress
Mallei A; Giambelli R; Barbiero VS; Maglione M; Mathé AA; El Khoury A; Carboni L; Domenici E; Racagni G; Popoli M
Published conference paper: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2005;8(3):403-410
Neuropeptide Y and corticotropin-releasing hormone in CSF mark response to antidepressive treatment with citalopram
Nikisch G; Ågren H; Eap CB; Czernik A; Baumann P; Mathé AA
Review: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2005;29(4-5):739-759
The Flinders Sensitive Line rat: a selectively bred putative animal model of depression.
Overstreet DH; Friedman E; Mathé AA; Yadid G
Review: MOLECULAR PSYCHIATRY. 2005;10(4):345-352
BDNF in schizophrenia, depression and corresponding animal models
Angelucci F; Brenè S; Mathé AA
Published conference paper: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY. 2004;24(3):283-290
Stereoselective metabolism of citalopram in plasma and cerebrospinal fluid of depressive patients - Relationship with S-HIAA in CSF and clinical response
Nikisch G; Mathé AA; Czernik A; Eap CB; Jiménez-Vasquez P; Brawand-Amey M; Baumann P
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2004;14:S3
The role of neurogenesis in addiction and depression
Brené S; Åberg E; Bjornebekk A; Hofstetter C; Mathè AA; Olson L
Review: NEUROSCIENCE FOR ADDICTION MEDICINE: FROM PREVENTION TO REHABILITATION - CONSTRUCTS AND DRUGS. 2004;146:151-165
Neurotrophic factors and CNS disorders: findings in rodent models of depression and schizophrenia.
Angelucci F; Mathé AA; Aloe L
Letter: BIOLOGICAL PSYCHIATRY. 2003;53(3):268-270
Comment on "preclinical models: status of basic research in depression".
Overstreet DH; Daws LC; Yadid G; Friedman E; Mathé AA; Janowsky DS
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2002;26(1):41-48
Calcitonin gene-related peptide and calcitonin in the CSF of patients with dementia and depression -: Possible disease markers
Mathé AA; Ågren H; Wallin A; Blennow K
Review: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2000;3(1):13-25
Chronic antipsychotic treatment selectively alters nerve growth factor and neuropeptide Y immunoreactivity and the distribution of choline acetyl transferase in rat brain regions.
Angelucci F; Aloe L; Gruber SHM; Fiore M; Mathé AA
Review: JOURNAL OF ECT. 1999;15(1):60-75
Neuropeptides and electroconvulsive treatment.
Mathé AA
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 1998;22(6):1007-1021
Changes in dietary fatty acids alter phospholipid fatty acid composition in selected regions of rat brain.
Marteinsdottir I; Horrobin DF; Stenfors C; Theodorsson E; Mathé AA
Meeting abstract: BIOLOGICAL PSYCHIATRY. 1998;43:S102
CSF neuropeptide Y correlates with anxiety in patients with affective disorders
Osuch EA; Frye MA; Little JT; Kimbrell TA; Huggins T; Dunn R; Speer A; Cora-Locatelli G; Vanderham L; Post RM; Mathe AA
Meeting abstract: BIOLOGICAL PSYCHIATRY. 1998;43:42S
Deficits in neuropeptide Y in a genetic animal model of depression are normalized by chronic fluoxetine treatment
Caberlotto L; Hurd Y; Fuxe K; Mathe AA; Overstreet DH
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 1998;22(3):529-546
Neuropeptide Y, neurokinin A and neurotensin in brain regions of Fawn Hooded "depressed", Wistar, and Sprague Dawley rats. Effects of electroconvulsive stimuli.
Mathé AA; Jimenez PA; Theodorsson E; Stenfors C
Published conference paper: BEHAVIOURAL BRAIN RESEARCH. 1995;72(1-2):103-114
Effects of D-amphetamine and phencyclidine on behavior and extracellular concentrations of neurotensin and dopamine in the ventral striatum and the medial prefrontal cortex of the rat.
Hertel P; Mathé JM; Nomikos GG; Iurlo M; Mathé AA; Svensson TH
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 1995;19(7):1177-1187
Chronic dietary lithium inhibits basal c-fos mRNA expression in rat brain.
Mathé AA; Miller JC; Stenfors C
Meeting abstract: BIOLOGICAL PSYCHIATRY. 1995;37(9):654
ELEVATED CONCENTRATIONS OF CSF CGRP MIGHT BE A TRAIT MARKER FOR AFFECTIVE-ILLNESS
MATHE AA; GEORGE MS; FRYE MA; POST RM
Meeting abstract: BIOLOGICAL PSYCHIATRY. 1995;37(9):610
CSF CGRP CORRELATES WITH NEUROPEPTIDES IN CONTROLS BUT NOT AFFECTIVE-ILLNESS
GEORGE MS; MATHE AA; FRYE MA; DAVIS CL; PAZZAGLIA PJ; RUBINOW DL; JERRELS S; POST RM
Meeting abstract: BIOLOGICAL PSYCHIATRY. 1995;37(9):609-610
CSF NEUROPEPTIDE-Y IN MOOD DISORDERS AND TREATMENT WITH CARBAMAZEPINE
FRYE MA; MATHE AA; GEORGE MS; PAZZAGLIA PJ; JERRELS S; POST RM
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 1995;19(2):323-332
EFFECTS OF ACUTE AND CHRONIC ELECTROCONVULSIVE TREATMENT ON INTERSTITIAL CONCENTRATIONS OF SOMATOSTATIN IN THE RAT HIPPOCAMPUS AND STRIATUM
MATHE AA; NOMIKOS GG; SVENSSON TH
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Professor Emeritus/Emerita, Department of Clinical Neuroscience, Karolinska Institutet, 2025-2026
Professor, Department of Clinical Neuroscience, Karolinska Institutet, 2021-2024
Professor, Senior, Department of Clinical Neuroscience, Karolinska Institutet, 2018-2021
Professor, Senior, Department of Clinical Neuroscience, Karolinska Institutet, 2011-2017
Professor, Department of Clinical Neuroscience, Karolinska Institutet, 2001-2002
Professor/Senior Physician, Department of Clinical Neuroscience, Karolinska Institutet, 1999-2000
Professor, Assistant/Senior Doctor, Department of Clinical Neuroscience, Karolinska Institutet, 1996-1998

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Docent, Karolinska Institutet, 1984

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