Alejandra Machado

About me
Publications
Grants
Public outreach and news

Research

My previous research work focused on cognition in the context of normal aging and neurodegenerative disorders such as Alzheimer’s Disease (AD), with a focus on a multidimensional and integrative approach, combining cognitive assessments, biomarkers, and neuroimaging data.

Since 2020, I have extended my research into the field of insurance medicine, with a particular emphasis on neurological disorders. My work has primarily focused on identyfing risk factos for, and the consequences of, sickness absence in individuals with multiple sclerosis (MS).

Articles

Article: MULTIPLE SCLEROSIS JOURNAL - EXPERIMENTAL, TRANSLATIONAL AND CLINICAL. 2025;11(1):20552173241304324
Factors associated with self-reported work ability among people with multiple sclerosis in Sweden
Teni FS; Machado A; Dervish J; Fink K; Gyllensten H; Friberg E
Article: BMJ OPEN. 2024;14(12):e087563
Workplace and social support, treatment satisfaction, and their impact on quality of life in Swedish women with multiple sclerosis: a cross-sectional survey study
Machado A; Wredendal E; Fink K; Friberg E
Journal article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2024;34:ckae144.1301
Impact of Multiple Sclerosis on different life dimensions among working women in Sweden
Machado A; Teni FS; Friberg E
Article: MULTIPLE SCLEROSIS JOURNAL - EXPERIMENTAL, TRANSLATIONAL AND CLINICAL. 2024;10(4):20552173241305982
Sick leave in the prodromal phase of multiple sclerosis and its association with diagnostic delay: A short report
Machado A; Pettersson E; Alexanderson K; Hillert J; Friberg E
Journal article: OCCUPATIONAL MEDICINE-OXFORD. 2024;74(Supplement_1):0
P-309 NON-PHARMACOLOGICAL INTERVENTIONS FOR WORK PARTICIPATION IN PEOPLE WITH MULTIPLE SCLEROSIS
Saddal S; Van der Hiele K; Machado A; De Perez BD; Friberg E; Nair RD; Benedict R; Radford K; Daams J; Hulst H; De Groot V; Schaafsma F
Journal article: OCCUPATIONAL MEDICINE-OXFORD. 2024;74(Supplement_1):0
P-625 NON-STANDARD FORMS OF EMPLOYMENT AMONG PEOPLE WITH MULTIPLE SCLEROSIS IN SWEDEN: A SURVEY PERSPECTIVE
Machado A; Friberg E
Article: JOURNAL OF OCCUPATIONAL REHABILITATION. 2024;34(2):461-471
Work Adjustments by Types of Occupations Amongst People with Multiple Sclerosis: A Survey Study
Machado A; Murley C; Dervish J; Teni FS; Friberg E
Article: BMC PUBLIC HEALTH. 2024;24(1):1389
Exploring the working life of people with multiple sclerosis during the COVID-19 pandemic in Sweden
Murley C; Dervish J; Machado A; Svard V; Wennman-Larsen A; Hillert J; Friberg E
Article: MULTIPLE SCLEROSIS JOURNAL - EXPERIMENTAL, TRANSLATIONAL AND CLINICAL. 2024;10(2):20552173241248293
Coronavirus disease 2019 infection among working-aged people with multiple sclerosis and the impact of disease-modifying therapies
Murley C; Pettersson E; Hillert J; Machado A; Friberg E
Article: MULTIPLE SCLEROSIS JOURNAL. 2024;30(3):419-431
Recent trends in disease-modifying therapy use and associated sickness absence and disability pension among people with multiple sclerosis in Sweden
Teni FS; Machado A; Fink K; Gyllensten H; Hillert J; Friberg E
Article: FRONTIERS IN PUBLIC HEALTH. 2024;12:1331746
Disclosing or concealing multiple sclerosis in the workplace: two sides of the same coin-insights from a Swedish population-based survey
Dervish J; Arfuch VM; Murley C; Mckay KA; Machado A; Wennman-Larsen A; Friberg E
Article: EUROPEAN JOURNAL OF HEALTH ECONOMICS. 2023;24(8):1357-1371
Excess costs of multiple sclerosis: a register-based study in Sweden
Murley C; Tinghog P; Teni FS; Machado A; Alexanderson K; Hillert J; Karampampa K; Friberg E
Article: NEUROLOGY. 2023;101(3):e277-e288
Association of Chronic Kidney Disease With Plasma NfL and Other Biomarkers of Neurodegeneration The H70 Birth Cohort Study in Gothenburg
Dittrich A; Ashton NJJ; Zetterberg H; Blennow K; Zettergren A; Simren J; Skillback T; Shams S; Machado A; Westman E; Scholl M; Skoog I; Kern S
Article: EUROPEAN JOURNAL OF NEUROLOGY. 2023;30(7):1843-1853
Self-reported restrictions in different life domains and associated factors among people with multiple sclerosis in Sweden
Teni FS; Machado A; Murley C; Fink K; Gyllensten H; Dervish J; Hillert J; Friberg E
Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S2)
Biomarker evidence of neurodegeneration in chronic kidney disease, in a general population
Dittrich A; Ashton NJ; Zetterberg H; Blennow K; Zettergren A; Simrén J; Shams S; Machado A; Westman E; Schöll M; Skoog I; Kern S
Article: MULTIPLE SCLEROSIS AND RELATED DISORDERS. 2023;69:104456
Trajectories of disease-modifying therapies and associated sickness absence and disability pension among 1923 people with multiple sclerosis in Sweden
Teni FS; Machado A; Murley C; He A; Fink K; Gyllensten H; Glaser A; Alexanderson K; Hillert J; Friberg E
Article: PLOS ONE. 2023;18(8):e0288998
Gender differences in earnings among people with multiple sclerosis and associations with type of occupation and family composition: A population-based study with matched references
Machado A; Azad A; Pettersson E; Hillert JV; Alexanderson KV; Friberg EV
Journal article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2022;32(Supplement_3):ckac129.097
Excess costs of multiple sclerosis: A register-based study in Sweden
Murley C; Tinghög P; Teni FS; Machado A; Alexanderson K; Hillert J; Karampampa K; Friberg E
Article: NEUROLOGY. 2022;99(15):e1619-e1629
Association of Cerebrovascular and Alzheimer Disease Biomarkers With Cholinergic White Matter Degeneration in Cognitively Unimpaired Individuals
Cedres N; Ferreira D; Nemy M; Machado A; Pereira JB; Shams S; Wahlund L-O; Zettergren A; Stepankova O; Vyslouzilova L; Eriksdotter M; Teipel S; Grothe MJ; Blennow K; Zetterberg H; Scholl M; Kern S; Skoog I; Westman E
Article: ACTA NEUROLOGICA SCANDINAVICA. 2022;146(3):283-294
Self-employment, sickness absence, and disability pension in multiple sclerosis
Machado A; Murley C; Hillert J; Alexanderson K; Friberg E
Article: MULTIPLE SCLEROSIS JOURNAL. 2022;28(9):1402-1413
Trajectories of sickness absence and disability pension days among people with multiple sclerosis by type of occupation
Bosma AR; Murley C; Aspling J; Hillert J; Schaafsma FG; Anema JR; Boot CRL; Alexanderson K; Machado A; Friberg E
Article: JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY. 2022;28(2):188-202
Swedish Normative Data for Mindmore: A Comprehensive Cognitive Screening Battery, Both Digital and Self-Administrated
van den Hurk W; Bergman I; Machado A; Bjermo J; Gustavsson A
Article: ALZHEIMER'S AND DEMENTIA: DIAGNOSIS, ASSESSMENT AND DISEASE MONITORING. 2022;14(1):e12295
Plasma and CSF NfL are differentially associated with biomarker evidence of neurodegeneration in a community-based sample of 70-year-olds
Dittrich A; Ashton NJ; Zetterberg H; Blennow K; Simren J; Geiger F; Zettergren A; Shams S; Machado A; Westman E; Scholl M; Skoog I; Kern S
Journal article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2022;32
Excess costs of multiple sclerosis: A register-based study in Sweden
Murley C; Tinghog P; Teni FSS; Machado A; Alexanderson K; Hillert J; Karampampa K; Friberg E
Journal article: ALZHEIMERS & DEMENTIA. 2021;17(S5)
The association of Alzheimer’s disease and cerebrovascular disease biomarkers towards the neurodegeneration of the cholinergic pathways
Cedres N; Ferreira D; Nemy M; Machado A; Pereira JB; Wahlund L; Zettergren A; Teipel SJ; Grothe MJ; Eriksdotter M; Stepankova O; Vyslouzilova L; Blennow K; Zetterberg H; Kern S; Skoog I; Westman E
Article: NEUROBIOLOGY OF AGING. 2021;101:1-12
Effects of amyloid pathology and the APOE ε4 allele on the association between cerebrospinal fluid Aβ38 and Aβ40 and brain morphology in cognitively normal 70-years-olds
Lindberg O; Kern S; Skoog J; Machado A; Pereira JB; Sacuiu SF; Wahlund L-O; Blennow K; Zetterberg H; Zettergren A; Westman E; Skoog I
Article: ALZHEIMER'S AND DEMENTIA: DIAGNOSIS, ASSESSMENT AND DISEASE MONITORING. 2021;13(1):e12141
Sex differences in CSF biomarkers for neurodegeneration and blood-brain barrier integrity
Skillback T; Blennow K; Zetterberg H; Shams S; Machado A; Pereira J; Lindberg O; Mielke MM; Zettergren A; Ryden L; Westman E; Wahlund L-O; Skoog I; Kern S
Journal article: ALZHEIMERS & DEMENTIA. 2020;16(S4)
Sex differences in CSF biomarkers for neurodegeneration and blood‐brain barrier integrity
Skillback T; Blennow K; Zetterberg H; Shams S; Machado A; Pereira JB; Lindberg O; Mielke MM; Zettergren A; Rydén L; Westman E; Wahlund L; Skoog I; Kern S
Article: ALZHEIMERS RESEARCH & THERAPY. 2020;12(1):51
The cholinergic system in subtypes of Alzheimer's disease: an in vivo longitudinal MRI study
Machado A; Ferreira D; Grothe MJ; Eyjolfsdottir H; Almqvist PM; Cavallin L; Lind G; Linderoth B; Seiger A; Teipel S; Wahlberg LU; Wahlund L-O; Westman E; Eriksdotter M
Article: AGING-US. 2020;12(1):894-901
Predicting Fazekas scores from automatic segmentations of white matter signal abnormalities
Cedres N; Ferreira D; Machado A; Shams S; Sacuiu S; Waern M; Wahlund L-O; Zettergren A; Kern S; Skoog I; Westman E
Article: JOURNAL OF ALZHEIMERS DISEASE. 2019;68(1):295-309
Subjective Cognitive Decline Below and Above the Age of 60: A Multivariate Study on Neuroimaging, Cognitive, Clinical, and Demographic Measures
Cedres N; Machado A; Molina Y; Diaz-Galvan P; Andres Hernandez-Cabrera J; Barroso J; Westman E; Ferreira D
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2019;34(2):191-209
The Gothenburg H70 Birth cohort study 2014-16: design, methods and study population
Sterner TR; Ahlner F; Blennow K; Dahlin-Ivanoff S; Falk H; Johansson LH; Hoff M; Holm M; Horder H; Jacobsson T; Johansson B; Johansson L; Kern J; Kern S; Machado A; Fassberg MM; Nilsson J; Ribbe M; Rothenberg E; Ryden L; Sadeghi A; Sacuiu S; Samuelsson J; Sigstrom R; Skoog J; Thorvaldsson V; Waern M; Westman E; Wetterberg H; Zetterberg H; Zetterberg M; Zettergren A; Ostling S; Skoog I
Article: FRONTIERS IN PSYCHOLOGY. 2019;10:2327
Comparing Traditional and Digitized Cognitive Tests Used in Standard Clinical Evaluation - A Study of the Digital Application Minnemera
Bjorngrim S; van den Hurk W; Betancort M; Machado A; Lindau M
Article: NEUROBIOLOGY OF AGING. 2018;71:179-188
Proposal for a hierarchical, multidimensional, and multivariate approach to investigate cognitive aging
Machado A; Barroso J; Molina Y; Nieto A; Diaz-Flores L; Westman E; Ferreira D
Article: HIPPOCAMPUS. 2017;27(6):653-667
The interactive effect of demographic and clinical factors on hippocampal volume: A multicohort study on 1958 cognitively normal individuals
Ferreira D; Hansson O; Barroso J; Molina Y; Machado A; Andres Hernandez-Cabrera J; Muehlboeck J-S; Stomrud E; Nagga K; Lindberg O; Ames D; Kalpouzos G; Fratiglioni L; Backman L; Graff C; Mecocci P; Vellas B; Tsolaki M; Kloszewska I; Soininen H; Lovestone S; Ahlstrom H; Lind L; Larsson E-M; Wahlund L-O; Simmons A; Westman E
Article: FRONTIERS IN AGING NEUROSCIENCE. 2017;9:188
Cognitive Variability during Middle-Age: Possible Association with Neurodegeneration and Cognitive Reserve
Ferreira D; Machado A; Molina Y; Nieto A; Correia R; Westman E; Barroso J
Article: BEHAVIOURAL BRAIN RESEARCH. 2016;311:375-383
Different reserve proxies confer overlapping and unique endurance to cortical thinning in healthy middle-aged adults
Ferreira D; Bartres-Faz D; Nygren L; Rundkvist LJ; Molina Y; Machado A; Junque C; Barroso J; Westman E
Article: PSICOTHEMA. 2015;27(3):216-222
Cognitive decline before the age of 50 can be detected with sensitive cognitive measures
Ferreira D; Correia R; Nieto A; Machado A; Molina Y; Barroso J
Article: NEUROBIOLOGY OF AGING. 2014;35(5):1086-1094
Cognitive decline is mediated by gray matter changes during middle age
Ferreira D; Molina Y; Machado A; Westman E; Wahlund L-O; Nieto A; Correia R; Junque C; Diaz-Flores L; Barroso J
Article: REVISTA DE NEUROLOGIA. 2014;58(9):389-395
Alternate form of the test de aprendizaje verbal Espana-Complutense (TAVEC)
Nieto A; Hernandez-Rodriguez E; Hernandez-Torres A; Velasco Rodriguez-Solis P; Hess-Medler S; Machado-Fernandez A; Molina-Rodriguez Y; Barroso J
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All other publications

Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2024;30(3):1065
Income from work and associated factors following multiple sclerosis diagnosis: a 13-year register-based follow-up study
Teni FS; Machado A; Friberg E
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2023;29:433-434
Risk of diagnostic delay in multiple sclerosis associated with sickness absence during the prodromal phase of the disease
Machado A; Alexanderson K; Hillert J; Friberg E
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2023;29:452-453
Covid-19 susceptibility and disease modifying therapies on working-aged individuals with multiple sclerosis: a survey study
Murley C; Pettersson E; Hillert J; Machado A; Friberg E
Conference publication: INTERNATIONAL JOURNAL OF STROKE. 2023;18(3):11
A PHASE I TRIAL OF DEEP CEREBELLAR ELECTRICAL STIMULATION TO ENHANCE CHRONIC, POST-STROKE MOTOR REHABILITATION: 10-MONTH FOLLOW-UP DATA
Baker K; Rosenfeldt A; Clark C; Nagel S; Machado A
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):672-673
Trajectories of disease-modifying therapies and associated sickness absence and disability pension among people with multiple sclerosis
Teni FS; Machado A; Murley C; He A; Fink K; Gyllensten H; Glaser A; Alexanderson K; Hillert J; Friberg E
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):207-208
Working life of people with multiple sclerosis during the COVID-19 pandemic: a cross-sectional survey of working-aged people with multiple sclerosis in Sweden
Murley C; Machado A; Hillert J; Friberg E
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):200-201
Limitations in different life domains early in the disease course among people with multiple sclerosis in Sweden
Teni FS; Machado A; Murley C; Fink K; Gyllensten H; Dervish J; Hillert J; Friberg E
Conference publication: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2021;31:459
Sickness absence and disability pension within different employment status in multiple sclerosis
Machado A; Murley C; Hillert J; Alexanderson K; Friberg E
Conference publication: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2021;31:ckab164.725
Trajectories of sickness absence and disability pension by type of occupation in multiple sclerosis
Bosma A; Murley C; Aspling J; Hillert J; Schaafsma F; Anema J; Boot CRL; Alexanderson K; Machado A; Friberg E
Conference publication: INTERNATIONAL JOURNAL OF STROKE. 2021;16(2_SUPPL):12
REPETITIVE PERIPHERAL SENSORY STIMULATION AS AN ADD-ON INTERVENTION FOR UPPER LIMB REHABILITATION IN STROKE: A RANDOMIZED TRIAL
Conforto A; Machado A; Ribeiro N; Plow E; Liew S-L; Da Costa Leite C; Zavaliangos-Petropulu A; Menezes I; Dos Anjos S; Luccas R; Peckham P; Cohen L
Preprint: MEDRXIV. 2020
The cholinergic system and treatment response in subtypes of Alzheimer’s disease
Machado A; Ferreira D; Grothe M; Eyjolfsdottir H; Almqvist P; Cavallin L; Lind G; Linderoth B; Seiger Å; Teipel S; Wahlberg L; Wahlund L-O; Westman E; Eriksdotter M; for the Alzheimer’s Disease Neuroimaging Initiativ
Conference publication: EUROPEAN HEART JOURNAL. 2020;41:3298
Pregnancy outcomes in women with mechanical heart valves
Ferreira V; Monteiro AV; Santos MP; Patricio L; Borges A; Machado A; Castelo A; Bras PG; Mano T; Cardoso I; Grazina A; Alves MJ; Ferreira RC
Letter: REVISTA DE NEUROLOGIA. 2014;59(10):480
Parallel version of the Spain-Complutense verbal learning test (TAVEC) Reply
Nieto A; Hernandez-Rodriguez E; Hernandez-Torres A; Velasco Rodriguez-Sols P; Hess-Medler S; Machado-Fernandez A; Molina-Rodriguez Y; Barroso J

Grants

Mild cognitive impairment and dementia diagnosis in the workplace: demographics, risk factors and strategies to withstand the early workforce exit
Swedish Research Council for Health Working Life and Welfare
1 January 2025 - 1 January 2028
Uncovering sustainable work strategies for individuals with Multiple Sclerosis
Swedish Research Council for Health Working Life and Welfare
1 January 2024 - 31 December 2026

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