Adrian Gonon

Publications
CV
Public outreach and news

Articles

Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 2025;45(1):e12918
Impact of experience on visual and Simpson's biplane echocardiographic assessment of left ventricular ejection fraction
Akil S; Castaings J; Thind P; Ahlfeldt T; Akhtar M; Gonon AT; Quintana M; Bouma K
Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 2024;44(4):340-348
Pulmonary volumes and signs of chronic airflow limitation in quantitative computed tomography
Backlin E; Gonon A; Skold M; Smedby O; Breznik E; Janerot-Sjoberg B
Article: CLINICAL RESEARCH IN CARDIOLOGY. 2020;109(6):655-672
Circulatory factors associated with function and prognosis in patients with severe heart failure
Rullman E; Melin M; Mandic M; Gonon A; Fernandez-Gonzalo R; Gustafsson T
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2019;63(4):515-522
Effects of thoracic epidural analgesia on exercise-induced myocardial ischaemia in refractory angina pectoris
Gonon A; Richter A; Cederholm I; Khan J; Novak J; Milovanovic M; Janerot-Sjoberg B
Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 2018;38(1):118-127
Effects of enhanced external counterpulsation on skeletal muscle gene expression in patients with severe heart failure
Melin M; Montelius A; Ryden L; Gonon A; Hagerman I; Rullman E
Article: ACTA PHYSIOLOGICA. 2017;221(3):174-181
Vagal nerve stimulation reduces infarct size via a mechanism involving the alpha-7 nicotinic acetylcholine receptor and downregulation of cardiac and vascular arginase
Kiss A; Tratsiakovich Y; Mahdi A; Yang J; Gonon AT; Podesser BK; Pernow J
Article: DIABETES & VASCULAR DISEASE RESEARCH. 2017;14(3):236-245
Inhibition of Rho kinase protects from ischaemia-reperfusion injury via regulation of arginase activity and nitric oxide synthase in type 1 diabetes
Tratsiakovich Y; Kiss A; Gonon AT; Yang J; Sjoquist P-O; Pernow J
Article: PLOS ONE. 2016;11(4):e0153036
Variability in Physical Activity Assessed with Accelerometer Is an Independent Predictor of Mortality in CHF Patients
Melin M; Hagerman I; Gonon A; Gustafsson T; Rullman E
Article: JOURNAL OF ULTRASOUND IN MEDICINE. 2015;34(9):1599-1605
In Search of the Optimal Heart Perfusion Ultrasound Imaging Platform
Grishenkov D; Gonon A; Janerot-Sjoberg B
Article: DRUG DESIGN DEVELOPMENT AND THERAPY. 2015;9:2409-2419
Ultrasound contrast agent loaded with nitric oxide as a theranostic microdevice
Grishenkov D; Gonon A; Weitzberg E; Lundberg JO; Harmark J; Cerroni B; Paradossi G; Janerot-Sjoberg B
Article: PLOS ONE. 2014;9(8):e104731
The Role of Arginase and Rho Kinase in Cardioprotection from Remote Ischemic Perconditioning in Non-Diabetic and Diabetic Rat In Vivo
Kiss A; Tratsiakovich Y; Gonon AT; Fedotovskaya O; Lanner JT; Andersson DC; Yang J; Pernow J
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2013;720(1-3):121-123
Arginase as a target for treatment of myocardial ischemia-reperfusion injury
Tratsiakovich Y; Yang J; Gonon AT; Sjoquist P-O; Pernow J
Article: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2013;169(1):83-88
Myocardial protection by co-administration of L-arginine and tetrahydrobiopterin during ischemia and reperfusion
Tratsiakovich Y; Gonon AT; Kiss A; Yang J; Bohm F; Tornvall P; Settergren M; Channon KM; Sjoquist P-O; Pernow J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(37):15049-15054
Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity
Yang J; Gonon AT; Sjoquist P-O; Lundberg JO; Pernow J
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2013;712(1-3):16-21
Arginase inhibition reduces infarct size via nitric oxide, protein kinase C epsilon and mitochondrial ATP-dependent K⁺ channels
Tratsiakovich Y; Gonon AT; Krook A; Yang J; Shemyakin A; Sjoquist P-O; Pernow J
Article: PLOS ONE. 2012;7(7):e42038
Local Arginase Inhibition during Early Reperfusion Mediates Cardioprotection via Increased Nitric Oxide Production
Gonon AT; Jung C; Katz A; Westerblad H; Shemyakin A; Sjoquist P-O; Lundberg JO; Pernow J
Article: DIABETOLOGIA. 2012;55(3):600-607
The endothelin receptor antagonist bosentan improves peripheral endothelial function in patients with type 2 diabetes mellitus and microalbuminuria: a randomised trial
Rafnsson A; Bohm F; Settergren M; Gonon A; Brismar K; Pernow J
Article: CELLULAR SIGNALLING. 2011;23(5):820-826
Hypoxia followed by re-oxygenation induces oxidation of tyrosine phosphatases
Sandin A; Dagnell M; Gonon A; Pernow J; Stangl V; Aspenstrom P; Kappert K; Ostman A
Article: ACTA PHYSIOLOGICA. 2011;201(2):219-226
The combination of l-arginine and ischaemic post-conditioning at the onset of reperfusion limits myocardial injury in the pig
Gonon AT; Jung C; Yang J; Sjoquist P-O; Pernow J
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2011;651(1-3):146-151
Opioid receptor agonist Eribis peptide 94 reduces infarct size in different porcine models for myocardial ischaemia and reperfusion
Karlsson LO; Grip L; Bissessar E; Bobrova I; Gustafsson T; Kavianipour M; Odenstedt J; Wikstrom G; Gonon AT
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2010;95(5):2359-2366
Regulation of Glucose Uptake by Endothelin-1 in Human Skeletal Muscle in Vivo and in Vitro
Shemyakin A; Salehzadeh F; Boehm F; Al-Khalili L; Gonon A; Wagner H; Efendic S; Krook A; Pernow J
Article: CARDIOVASCULAR RESEARCH. 2010;85(1):147-154
Arginase inhibition mediates cardioprotection during ischaemia-reperfusion
Jung C; Gonon AT; Sjoquist P-O; Lundberg JO; Pernow J
Article: CARDIOVASCULAR RESEARCH. 2008;78(1):116-122
Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide
Gonon AT; Widegren U; Bulhak A; Salehzadeh F; Persson J; Sjoquist P-O; Pernow J
Article: DIABETES CARE. 2007;30(3):591-596
Dual endothelin receptor blockade acutely improves insulin sensitivity in obese patients with insulin resistance and coronary artery disease
Ahlborg G; Shemyakin A; Bohm F; Gonon A; Pernow J
Article: BASIC RESEARCH IN CARDIOLOGY. 2007;102(1):80-89
Cardioprotection mediated by rosiglitazone, a peroxisome proliferatoractivated receptor gamma ligand, in relation to nitric oxide
Gonon AT; Bulhak A; Labruto F; Sjoquist P-O; Pernow J
Article: PEPTIDES. 2005;26(9):1661-1666
The effects of arg-vasopressin on osteoblast-like cells in endothelial nitric oxide synthase-knockout mice and their wild type counterparts
Lagumdzija A; Pernow Y; Bucht E; Gonon A; Petersson M
Article: CLINICAL SCIENCE. 2005;108(4):357-363
The endothelin-I receptor antagonist bosentan protects against ischaemia/reperfusion-induced endothelial dysfunction in humans
Böhm F; Settergren M; Gonon AT; Pernow J
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2005;144(6):860-866
Cardioprotective effect of an endothelin receptor antagonist during ischaemia/reperfusion in the severely atherosclerotic mouse heart
Gonon AT; Bulhak A; Bröijersén A; Pernow J
Article: REGULATORY PEPTIDES. 2005;125(1-3):173-177
Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism
Nyström T; Gonon AT; Sjöholm Å; Pernow J
Article: ACTA PHYSIOLOGICA. 2005;183(2):151-159
Oral pre-treatment with rosuvastatin protects porcine myocardium from ischaemia/reperfusion injury via a mechanism related to nitric oxide but not to serum cholesterol level
Bulhak AA; Gourine AV; Gonon AT; Sjöquist PO; Valen G; Pernow J
Article: ACTA PHYSIOLOGICA. 2004;182(1):29-35
Inhibited anabolic effect of insulin-like growth factor-I on stromal bone marrow cells in endothelial nitric oxide synthase-knockout mice
Lagumdzija A; Ou G; Petersson M; Bucht E; Gonon A; Pernow Y
Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2004;286(5):H1767-H1774
Nitric oxide mediates protective effect of endothelin receptor antagonism during myocardial ischemia and reperfusion
Gonon AT; Erbas D; Bröijersén A; Valen G; Pernow J
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2003;95(6):2218-2222
L-arginine protects from ischemia-reperfusion-induced endothelial dysfunction in humans in vivo
Pernow J; Böhm F; Beltran E; Gonon A
Article: NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 2002;7(3):210-216
Cardioprotective effect induced by brief exposure to nitric oxide before myocardial ischemia-reperfusion in vivo
Gourine AV; Bulhak AA; Gonon AT; Pernow J; Sjöquist PO
Article: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. 2002;40(3):339-345
Time-dependent cardioprotection with calcium antagonism and experimental studies with clevidipine in ischemic-reperfused pig hearts:: Part II
Segawa D; Sjöquist PO; Wang QD; Gonon A; Rydén L
Article: BASIC RESEARCH IN CARDIOLOGY. 2001;96(5):454-462
Limitation of infarct size and attenuation of myeloperoxidase activity by an endothelin A receptor antagonist following ischaemia and reperfusion
Gonon AT; Gourine AV; Middelveld RJM; Alving K; Pernow J
Article: CARDIOVASCULAR RESEARCH. 2001;51(1):100-107
Short-acting calcium antagonist clevidipine protects against reperfusion injury via local nitric oxide-related mechanisms in the jeopardised myocardium
Gourine A; Gonon A; Sjöquist PO; Pernow J
Article: EUROPEAN HEART JOURNAL SUPPLEMENTS. 2001;3(C):C22-C27
The role of the endothelium for reperfusion injury
Pernow J; Gonon AT; Gourine A
Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2001;280(3):H1105-H1112
Involvement of nitric oxide in cardioprotective effect of endothelin receptor antagonist during ischemia-reperfusion
Gourine AV; Gonon AT; Pernow J
Article: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. 2000;36(3):405-412
Cardioprotection from ischemia and reperfusion injury by an endothelin A-receptor antagonist in relation to nitric oxide production
Gonon AT; Gourine AV; Pernow J
Article: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. 2000;36(3):338-343
Calcium antagonist protects the myocardium from reperfusion injury by interfering with mechanisms directly related to reperfusion:: An experimental study with the ultrashort-acting calcium antagonist clevidipine
Segawa D; Sjöquist PO; Wang QD; Gonen A; Nordlander M; Rydén L
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1999;380(2-3):123-128
Cardiac inotropic vs. chronotropic selectivity of isradipine, nifedipine and clevidipine, a new ultrashort-acting dihydropyridine
Segawa D; Sjöquist PO; Nordlander M; Wang QD; Gonon A; Rydén L
Article: CARDIOVASCULAR RESEARCH. 1998;39(3):674-682
The endothelin A receptor antagonist LU 135252 protects the myocardium from neutrophil injury during ischaemia/reperfusion
Gonon AT; Wang QD; Pernow J
Article: ACTA PHYSIOLOGICA. 1998;163(4):325-330
Contribution of endothelin to the coronary vasoconstriction in the isolated rat heart induced by nitric oxide synthase inhibition
Wang QD; Gonon A; Shimizu M; Sjöquist PO; Pernow J
Article: ACTA PHYSIOLOGICA. 1998;163(2):131-137
The novel non-peptide selective endothelin A receptor antagonist LU 135 252 protects against myocardial ischaemic and reperfusion injury in the pig
Gonon AT; Wang QD; Shimizu M; Pernow J
Article: CARDIOVASCULAR RESEARCH. 1998;38(2):493-499
Calcitonin gene-related peptide in myocardial ischaemia and reperfusion in the pig
Källner G; Gonon A; Franco-Cereceda A
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All other publications

Editorial comment: JOURNAL OF NUCLEAR CARDIOLOGY. 2022;29(6):3599-3603
Myocardial perfusion imaging performed by dedicated cardiac cadmium-zinc-telluride camera in dextrocardia with situs inversus: A case report
Forsberg L; Soares M; Gonon A
Letter: CARDIOLOGY. 2006;105(3):162-164
Deadly myocardial fibrosis of unknown etiology in adolescence
Tornvall P; Lindholm J; Svjatoha V; Gonon A
Doctoral thesis: 2000
The role of endothelin during myocardial ischaemia and reperfusion : pathophysiological mechanisms and interactions with nitric oxide
Gonon AT

Employments

Affiliated to Research, Department of Laboratory Medicine, Karolinska Institutet, 2024-2026

Degrees and Education

Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2000

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