Imaging of thoracic physiology and pathophysiology

We study the lungs and respiration in humans with physiological measurements and imaging techniques in health and disease.

Our research relates to both hypoxia and hyperoxia and our focus varies from strenuous exercise in elite athletes to acute and chronic pulmonary embolism in the clinical setting. Magnetic resonance imaging is our primary method.


  1. Development of new methods using magnetic resonance imaging to diagnose and study pulmonary embolism and related patophysiology.
  2. The effects of hyperoxic exercise regarding performance improvements in elite athletes.
  3. The physiology and pathophysiology of breath-hold diving; studies in human physiology relating to breath-hold diving and drowning.
  4. Hyperbaric physiology and patophysiology related to endogenous nitric oxide.

Financial support


Detection of pulmonary embolism using repeated MRI acquisitions without respiratory gating: a preliminary study.
Nyrén S, Nordgren Rogberg A, Vargas Paris R, Bengtsson B, Westerlund E, Lindholm P
Acta Radiol 2017 Mar;58(3):272-278

Aerobic efficiency is associated with the improvement in maximal power output during acute hyperoxia.
Manselin TA, Södergård O, Larsen FJ, Lindholm P
Physiol Rep 2017 Jan;5(2):

Acute effects of glossopharyngeal insufflation in people with cervical spinal cord injury.
Nygren-Bonnier M, Schiffer TA, Lindholm P
J Spinal Cord Med 2018 Jan;41(1):85-90

A Portable Device for Intermittent Oxygen Supplementation during High-Intensity Exercise.
Lindholm P, Larsson Å, Frånberg O, Gullstrand L
J. Biomedical Science and Engineering, 2017 May, 10, 304-316 2017

Effects of dietary inorganic nitrate on static and dynamic breath-holding in humans.
Schiffer TA, Larsen FJ, Lundberg JO, Weitzberg E, Lindholm P
Respir Physiol Neurobiol 2013 Jan;185(2):339-48

Transient ischemic attacks from arterial gas embolism induced by glossopharyngeal insufflation and a possible method to identify individuals at risk.
Schiffer TA, Lindholm P
Eur. J. Appl. Physiol. 2013 Mar;113(3):803-10

Nitrox permits direct exit for attendants during extended hyperbaric oxygen treatment.
Larsson AC, Uusijärvi J, Frånberg O, Eksborg S, Lindholm P
Undersea Hyperb Med ;39(1):605-12

Investigation of a demand-controlled rebreather in connection with a diving accident.
Frånberg O, Ericsson M, Larsson A, Lindholm P
Undersea Hyperb Med ;38(1):61-72

A fluoroscopic and laryngoscopic study of glossopharyngeal insufflation and exsufflation.
Lindholm P, Norris CM, Braver JM, Jacobson F, Ferrigno M
Respir Physiol Neurobiol 2009 Jun;167(2):189-94 

The physiology and pathophysiology of human breath-hold diving.
Lindholm P, Lundgren CE
J. Appl. Physiol. 2009 Jan;106(1):284-92

Pulmonary edema and hemoptysis after breath-hold diving at residual volume.
Lindholm P, Ekborn A, Oberg D, Gennser M
J. Appl. Physiol. 2008 Apr;104(4):912-7

Aggravated hypoxia during breath-holds after prolonged exercise.
Lindholm P, Gennser M
Eur. J. Appl. Physiol. 2005 Mar;93(5-6):701-7

Oxygen-conserving effects of apnea in exercising men.
Lindholm P, Sundblad P, Linnarsson D
J. Appl. Physiol. 1999 Dec;87(6):2122-7

Group members

Karin Dembrower – Doktorand

Jacob Farnebo – Postdoc

Deepa Gopalan – Doktorand

Anders Kjellberg – Anknuten

Peter Lindholm – Universitetsadjunkt

Koshiar Medson – Doktorand, Forskarstuderande

Anna Nordgren-Rogberg – Doktorand

Johan Uusijärvi – Doktorand

Roberto Vargas – Doktorand


Content reviewer:
Karin Wrangö