Traditionally, neutrophils, the most abundant white blood cells in humans, have been acknowledged to be the first immune cells that are recruited to sites of infection. However, work during the last years has revealed the necessity of neutrophils also in sterile inflammation. Our group has contributed to this understanding by revealing the importance of neutrophils and their secretory products in atherosclerosis and its complications such as myocardial infarction and intimal hyperplasia. Based on our work we are developing interference strategies aimed at alleviating sterile inflammation.
|Oliver Söhnlein||Professor, gäst|
Neutrophil discharge in acute inflammation
Acute inflammation leads to neutrophilia, the expansion of neutrophil blood cell counts. In many clinical conditions the degree of neutrophil expansion is associated with the clinical outcome. Thus, we here aim at understanding mechanisms of neutrophil release from the bone marrow to ultimately fine tune this response during inflammation. This study is supported by the Swedish Research Council.
Neutrophils talk to cells in their vicinity by release of reactive oxygen species, granule proteins, microparticles, or NETs. By these means, neutrophils can educate macrophages and lymphocyte subsets and thus shape the immune response. It is our aim to understand the relevance of these interactions in physiological settings to identify important neutrophil-centered regulatory mechanisms. Cooperation with proteomics biomedicum.
Swedish Research Council
- Ulf Hedin, KS, Stockholm, Sweden
- Andres Hidalgo, CNIC, Madrid, Spain
- Lars Maegdefessel, KS, Stockholm, Sweden
- Alexander Zarbock, Münster University, Germany