Leonard Girnita's group
Cross-talk between the receptor tyrosine kinases (RTKs) and G protein-coupled receptors (GPCRs). Functional, diagnostic and therapeutic implications for cancer.
General description: "Receptor pathology" lab, performing translational research by investigating the molecular properties and regulatory mechanisms that control the function of plasma membrane receptors under normal and pathological circumstances. The final goal is to determine potential utility of the signalling complexes involved in the RTKs/GPCRs cross talk as biomarkers or molecular targets in cancer.
Hypothesis underlying research: Signalling complexes coordinated by beta-arrestins, kinases and (de)ubiqitine ligases contribute to tumourigenesis and the progression of cancer and could be targeted in therapies.