I am a biologist trained at the Universtiy of Uppsala during the 1990's. My research focus on understanding genetic susceptibility and predisposition. Things like:
- Fundamental aspects of the twin model
- Heritability, variance partitioning
- Large scale gene mapping for complex disease and other traits
- Genetic susceptibility and predisposition
Leading the Swedish Twin Registry (STR)
I am in charge of the Swedish Twin Registry with responsibility for data/sample collection, handling of research applications, data withdrawals and research collaborations. I am also chair of the STR Steering Committee. The epidemiologic and genetic data available in the STR are utilized in studies of a large number of diseases and health related traits by various groups in Sweden and abroad.
- MSc, Natural Sciences, Uppsala University (1995)
- PhD, Medical Genetics, Uppsala University (2000)
- Postdoc, Columbia University, New York (2002)
Mutagenesis. Smoking is associated with mosaic loss of chromosome Y.
Science 2015 Jan;347(6217):81-3
The risk of switch to mania in patients with bipolar disorder during treatment with an antidepressant alone and in combination with a mood stabilizer.
Am J Psychiatry 2014 Oct;171(10):1067-73
IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L.
Hum. Mol. Genet. 2014 Aug;23(15):4177-84
Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults.
JAMA Psychiatry 2014 Mar;71(3):255-64
Utilizing twins as controls for non-twin case-materials in genome wide association studies.
PLoS ONE 2013 ;8(12):e83101
Multifactorial analysis of changes in body mass index across the adult life course: a study with 65 years of follow-up.
Int J Obes (Lond) 2014 Aug;38(8):1133-41
Germline genetic contributions to risk for esophageal adenocarcinoma, Barrett's esophagus, and gastroesophageal reflux.
J. Natl. Cancer Inst. 2013 Nov;105(22):1711-8
Heritability and the equal environments assumption: evidence from multiple samples of misclassified twins.
Behav. Genet. 2013 Sep;43(5):415-26
Clinical depression, antidepressant use and risk of future cardiovascular disease.
Eur. J. Epidemiol. 2013 Jul;28(7):589-95
Multilocus genetic risk scores for coronary heart disease prediction.
Arterioscler. Thromb. Vasc. Biol. 2013 Sep;33(9):2267-72
Genome-wide association study of susceptibility loci for cervical cancer.
J. Natl. Cancer Inst. 2013 May;105(9):624-33
Genetic determinants of mortality. Can findings from genome-wide association studies explain variation in human mortality?
Hum. Genet. 2013 May;132(5):553-61
The Swedish Twin Registry: establishment of a biobank and other recent developments.
Twin Res Hum Genet 2013 Feb;16(1):317-29
The genetic structure of the Swedish population.
PLoS ONE 2011 ;6(8):e22547
Genetic and environmental regulation of inflammatory CVD biomarkers Lp-PLA2 and IgM anti-PC.
Atherosclerosis 2011 Sep;218(1):117-22
Current supervision of PhD students
- Vilhelmina Ullemar
- German Dario Carrasquilla Lopezhttp://bibliometrics.ki.se/public/publicProfile/310
I am docent since 2011 and gives regular lectures in the Medical program and Psychology program at KI and also teach occasionally in Stockholm University and Uppsala university. Pedagogically I am most proud about my contribution to the KI graduate course "Genetic Epidmiology" for which I have been resposible since 2009.