I am a vascular surgeon and have worked in Stockholm since 10 years. My PhD thesis, titled "Diabetes and Peripheral Arterial Disease" was presented in 2012 at the Department of Molecular Medicine and Surgery at Karolinska Institute. Since March 2014 I have a 50% post-doc scholarship in combination with clinical work at the Vascular section, the Department of Surgery, Södersjukhuset. I am a member if the SOSVASC research group at the Department of Clinical Science and Education, Södersjukhuset.
My clinical interest for diabetes and peripheral arterial disease coincides with my main line of research. My aim is to work translational based on the clinical problems associated with peripheral arterial disease (PAD) and diabetes.
Medical doctor 1995, University of Linköping
Specialist in General Surgery 2003
Specialist in Vascular Surgery 2005
PhD 2012, Karolinska Institute.
- What is the cause of the rapid progression of arteriosclerosis and intimal hyperplasia in diabetic patients?
In patients with diabetes advanced glycation end products (AGE) are produced. These compounds have several effects on the wall structure as well as the fuction of the arterial vessels. In animal studies it has been well described how the AGE products induces arteriosclerosis and stimulates intimal hyperplasia thru specific receptors in the vessel wall. Intimal hyperplasia is an exaggerated healing process in the arterial wall that incuses stenoses and occlusions after vascular procedures such as by-pass and angioplasty.
We are trying to describe if the mechanisms shown in the animal models also are present in humans. We have described the presence of AGE and RAGE in the veins used in by-pass surgery of the lower extremities.
- Why is the neo-formation of muscle vessels impaired in diabetic patients?
In this project we study the factors that inhibit neo-formation of vessels (angiostatic factors) in muscle. In diabetic patients the compensatory mechanisms for impaired circulation (in PAD) is reduced and neo-formation process is defected. The mechanism behind this is not fully understood. We will compare muscle samples from patients with, and without diabetes (and with, and without PAD ) at a molecular biologic level. The project is a collaboration with Ass prof Thomas Gustafsson at the Research group of Integrative Clinical Physiology and Ass Prof Tara Haas at the York University in Canada.
Other ongoing projects
The role of the intimal wall of the artery in bloodclot formation
- Treatment results of PAD in a 20-year perspective
- Does better perioperative glucose control reduce complications?
- Post traumatic care in blast and gunshot extremity wounds. PhD project for Andres Älgå (I am co-supervisor)
- Trombocyte inhibition in PAD. PhD project for Ove Thott (I am co-supervisor)
- Cellular mechaniwsm in intimal hyperplasia and diabetes. PhD project for Robert Saxelin (I am co-supervisor)