Susanne Schlisio Group

Oxygen-sensing and Cancer

Our research concerns the mechanisms of how disruption of oxygen-sensing pathways can lead to cancer. Oxygen sensors enable the cell to adapt to low-oxygen environments and are critical for normal development and apoptosis. These events are often disrupted in the development of tumors. Oxygen sensing is mediated partly via prolyl hydroxylases that require molecular oxygen for enzymatic activity. Our work focuses on how prolyl hydroxylases execute apoptosis in neural precursors during development and how disruption of this process can lead to certain forms of nervous-system tumors.

The Susanne Schlisio group is currently recruiting Post Docs, please apply using the contact details below

Publications

Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression.
Westerlund I, Shi Y, Toskas K, Fell S, Li S, Surova O, et al
Proc. Natl. Acad. Sci. U.S.A. 2017 Jul;114(30):E6137-E6146

Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA.
Fell S, Li S, Wallis K, Kock A, Surova O, Rraklli V, et al
Genes Dev. 2017 May;31(10):1036-1053

The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis.
Li S, Fell S, Surova O, Smedler E, Wallis K, Chen Z, et al
Dev. Cell 2016 Jan;36(2):164-78

The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth.
Koivunen P, Fell S, Lu W, Rabinowitz J, Kung A, Schlisio S
Hypoxia (Auckl) ;4():15-27

XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis.
Choo Z, Koh R, Wallis K, Koh T, Kuick C, Sobrado V, et al
Oncotarget 2016 Jun;7(23):34229-39

RNA helicase A is a downstream mediator of KIF1Bβ tumor-suppressor function in neuroblastoma.
Chen Z, Wallis K, Fell S, Sobrado V, Hemmer M, Ramsköld D, et al
Cancer Discov 2014 Apr;4(4):434-51

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility.
Astuti D, Ricketts C, Chowdhury R, McDonough M, Gentle D, Kirby G, et al
Endocr. Relat. Cancer 2011 Feb;18(1):73-83

Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum.
Schlisio S
J. Cell. Mol. Med. 2009 Oct;13(10):4104-12

The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.
Schlisio S, Kenchappa R, Vredeveld L, George R, Stewart R, Greulich H, et al
Genes Dev. 2008 Apr;22(7):884-93

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.
Young A, Schlisio S, Minamishima Y, Zhang Q, Li L, Grisanzio C, et al
Nat. Cell Biol. 2008 Mar;10(3):361-9

pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2.
Yang H, Minamishima Y, Yan Q, Schlisio S, Ebert B, Zhang X, et al
Mol. Cell 2007 Oct;28(1):15-27

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.
Lee S, Nakamura E, Yang H, Wei W, Linggi M, Sajan M, et al
Cancer Cell 2005 Aug;8(2):155-67

Group Members

Senior researcher

Susanne Schlisio

Organizational unit: Susanne Schlisio
E-mail: susanne.schlisio@ki.se

Postdoc

Shuijie LI

Phone: +46-(0)76-032 80 05
Organizational unit: Susanne Schlisio
E-mail: shuijie.li@ki.se

Postdoc

Stuart Fell

Organizational unit: Susanne Schlisio
E-mail: Stuart.Fell@ki.se

Graduate Student

Wenyu Li

Organizational unit: Susanne Schlisio
E-mail: wenyu.li@ki.se

Laboratory at Ludwig Cancer Research

Susanne Schlisio laboratory at Ludwig Cancer Research

Funding

  • Swedish Research Council (VR)
  • Swedish Childhood Cancer Foundation (BCF)
  • Swedish Cancer Society (CF)
  • Para Difference Foundation
  • Gösta Fraenckels stiftelse för medicinsk forskning

Contact

Senior researcher

Susanne Schlisio

Organizational unit: Susanne Schlisio
E-mail: susanne.schlisio@ki.se

Cell Biology