Research Division of Biochemistry

The Division of Biochemistry has a long history of research in redox biology. Several projects in the division center around the role of thioredoxin and glutaredoxin systems in health and disease. Another focus is on the synthesis, function and biomedical applications of selenoproteins, i.e. proteins containing a reactive selenocysteine (Sec) residue.

Research interests

Chemical reactions that selenocysteine (left) and cysteine (right) are involved in.Enzymatic redox control systems, i.e. regulated reduction and oxidation processes that in turn regulate cellular functions, are crucial for life. Many, if not most, cell functions are linked either directly or indirectly to redox processes. The research carried out in our division is aimed at better understanding basic characteristics of redox biology in health and disease, from structure and function of redox active enzymes to regulation of redox signaling in living cells or organisms. Our special focus areas of redox biology involve in-depth studies of the thioredoxin and glutaredoxin systems, selenoproteins, redox signaling cascades, cancer therapeutics and antimicrobial therapy. Our methodologies span from all aspects of enzyme and protein characterizations, biochemical assays of redox protein function, techniques of molecular biology and cell biology to animal experiments.

Research groups

Elias Arnér Group
Areas of interest include novel methods of selenoprotein production and their studies, thioredoxin reductases, thioredoxin related protein of 14 kDa, transcription factor regulation, anticancer therapy, redox signaling.

Arne Holmgren Group
Areas of interest include thioredoxin and glutaredoxin systems, new antibiotic principles, DNA synthesis, anticancer mechanisms, glutathione, redox signaling.

Aristi Fernandes Group
Areas of interest include mechanistic investigations of redox modulation by selenium compounds and other redox modulating entities for development of novel anticancer therapeutics.

Alfredo Gimenez-Cassina Group
Areas of interest include nutrient sensing, signaling mechanisms that modulate energy metabolism and therapeutic strategies based on modulating mitochondrial metabolism.

Contact

Head of Division, Professor

Elias Arnér

Phone: +46-(0)8-524 869 83
Organizational unit: Elias Arnérs group
E-mail: Elias.Arner@ki.se

Administrator

Lena Ringden

Phone: +46-(0)8-524 877 28
Organizational unit: Elias Arnérs group
E-mail: Lena.Ringden@ki.se

Address

Division of Biochemistry
Department of Medical Biochemistry and Biophysics
Karolinska Institutet
Scheeles väg 2
171 77 Stockholm

Visiting address

Scheele laboratory
Scheeles väg 2
House B1, 5th floor.

Map