SRP Diabetes Postdoc Fellowships - Project 5

Project title: Circadian control of mitochondrial metabolism in type 2 diabetes.

Prinicipal Investigator: Juleen Zierath

Department of Molecular Medicine and Surgery

Juleen Zierath

Integrative Physiology
K1 Department of Molecular Medicine and Surgery

Research Project

Circadian control of mitochondrial metabolism in type 2 diabetes.

Mitochondria are a central node for the integration of nutrient and energy homeostasis and are highly dynamic organelles that cope with oscillations in energy demand imposed by energetic stressors throughout the day. Preliminary results from our group indicate that mitochondrial rhythmicity of respiration is lost in skeletal muscle from type 2 diabetic patients. The mechanisms underlying disrupted circadian rhythmicity of the intrinsic molecular clock in type 2 diabetes are currently unknown. The main objective of this project is to determine whether there is bidirectional signaling between the core clock and pathways coordinating mitochondrial metabolism, and the extent to which the circadian transcriptional machinery is disrupted in type 2 diabetes. These questions are clinically relevant given the dynamic diurnal changes in a plethora of hormones, metabolites and substrates. The postdoctoral fellow will adopt multi-disciplinary approaches, integrating animal models and cell-based systems with clinical material from type 2 diabetic patients to identify and functionally validate candidate transcription factors and transcriptional pathways for intervention to restore circadian rhythmicity in type 2 diabetes. This project will also include usage of RNA-seq, ChIP-seq and interaction proteomics as well as respirometry and microscopy. The successful candidate will receive necessary basic training within these technologies.

Project description

Read the complete project description.

How to apply

The closing date for applications was midnight CEST on Sunday 6th June, 2021.