SRP Diabetes Postdoc Fellowships - Project 4

Project title: Mitochondria-encoded circular RNAs in diabetic foot ulcers.

Principal Investigator: Ning Xu Landén

Department of Medicine, Solna

Ning Xu Landén

Researcher
N Xu Landén
K2 Department of Medicine, Solna

Research Project

Mitochondria-encoded circular RNAs in diabetic foot ulcers.

Diabetic foot ulcer (DFU) is a major complication of diabetes mellitus, and increased understanding of its molecular pathogenesis is needed to develop more effective treatments. Circular RNA (circRNA) is a class of RNA with the 3′ and 5′ ends covalently linked, which widespread in eukaryotes has only been recognized lately; however, increasing evidence has demonstrated their important roles in health and diseases. A novel type of mitochondria-encoded circRNAs (mecciRNAs) has been discovered in humans and mice recently. The purpose of this research project is to unravel the role(s) of mecciRNAs in skin wound healing and to explore the therapeutic potential of modulating circRNAs in DFU. The findings of this study will, from a new angle, add to our understanding of the pathogenesis of diabetic ulcers and may uncover novel drug targets for further clinical studies.

The successful candidate will work in the wound healing research group headed by Dr. Ning Xu Landén (www.xulandenlab.com). The group belongs to the Dermatology and Venereology Division, Department of Medicine Solna and the Ming Wai Lau Centre for Reparative Medicine, and is physically located at the Centre of Molecular Medicine (CMM; https://www.cmm.ki.se/).

Project description

Read the complete project description.

How to apply

The closing date for applications was midnight CEST on Sunday 6th June, 2021.