SRP Diabetes Postdoc Fellowships - Project 3

Project title: TRAIN, a novel target in non-alcoholic fatty liver disease.
Principal Investigator: Jorge Ruas
Department of Physiology and Pharmacology

Jorge Ruas

C3 Department of Physiology and Pharmacology

Research Project

TRAIN, a novel target in non-alcoholic fatty liver disease (NAFLD).

We have identified a gene and protein with previously unknown function and discovered that it operates as a major regulator of inflammation, extracellular matrix remodeling, and fibrogenesis. Based on its function, we have named it Tissue Remodeler and Activator of INflammation (TRAIN). Increasing mouse liver TRAIN expression, within pathophysiological levels, is sufficient to elicit many of the metabolic, morphological, histological, and transcriptional abnormalities characteristic of non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH).

In this project, the postdoctoral fellow will perform molecular studies using primary hepatocyte cultures, a hepatocyte-specific TRAIN knockout mouse model (already generated and available in the lab), and liver biopsies and blood samples from patients with different degrees of NAFLD/NASH. The overall aim of the project is to understand how TRAIN regulates NAFLD and to identify potential biomarkers of disease progression.

You can find out more about our research group and our different projects at

Project description

Read the complete project description.

How to apply

The closing date for applications was midnight CEST on Sunday 6th June, 2021.