SRP Diabetes Postdoc Fellowships - Project 2
Project title: Identification of reno-protective molecular signatures in diabetic nephropathy using single cell transcriptomics.
Principal Investigator: Jaakko Patrakka
Department of Laboratory Medicine
Identification of reno-protective molecular signatures in diabetic nephropathy using single cell transcriptomics
Therapeutical options for diabetic nephropathy are limited and often of poor efficacy. The overarching goal of this translational project is to define the molecular fingerprints of reno-protective drugs at the single cell level in kidney tissue, with the purpose of identifying underlying cellular mechanisms that slow the progression of nephropathy. We use single cell RNA sequencing to extensively profile mouse/human kidney tissue and urine samples in healthy and diabetic conditions. Studies will be complemented with experiments in kidney organoids. Key molecular mechanisms identified will be validated and investigated further using transgenic mouse models.
Read the complete project description.
How to apply
The closing date for applications was midnight CEST on Sunday 6th June, 2021.