SRP Diabetes Postdoc Fellowships - Project 2

Project title: Identification of reno-protective molecular signatures in diabetic nephropathy using single cell transcriptomics.

Principal Investigator: Jaakko Patrakka

Department of Laboratory Medicine

Jaakko Patrakka

Researcher
H5 Department of Laboratory Medicine

Research Project

Identification of reno-protective molecular signatures in diabetic nephropathy using single cell transcriptomics

Therapeutical options for diabetic nephropathy are limited and often of poor efficacy. The overarching goal of this translational project is to define the molecular fingerprints of reno-protective drugs at the single cell level in kidney tissue, with the purpose of identifying underlying cellular mechanisms that slow the progression of nephropathy. We use single cell RNA sequencing to extensively profile mouse/human kidney tissue and urine samples in healthy and diabetic conditions. Studies will be complemented with experiments in kidney organoids. Key molecular mechanisms identified will be validated and investigated further using transgenic mouse models.

Project description

Read the complete project description.

How to apply

The closing date for applications was midnight CEST on Sunday 6th June, 2021.