SRP Diabetes Postdoc Fellowships - Project 1

Project title: Adipocyte heterogeneity - a novel determinant of insulin resistance and type 2 diabetes.

Prinicipal Investigators: Niklas Mejhert and Mikael Rydén

Department of Medicine, Huddinge

Niklas Mejhert

Researcher
H7 Department of Medicine, Huddinge

Mikael Ryden

Professor/senior physician
H7 Department of Medicine, Huddinge

Research Project

Adipocyte heterogeneity - a novel determinant of insulin resistance and type 2 diabetes

Based on spatial transcriptomics, a state-of-the-art approach to combine histological and transcriptional data in tissues, we have in unpublished studies been able to demonstrate that human white adipocytes are heterogenous and display features that can be subdivided into lipid storage (i.e. anabolic), energy sensing (i.e. limiting storage capacity) and pro-inflammatory actions. These results provide an unprecedented view on white adipose tissue (WAT) suggesting that this organ is much more complex than previously anticipated and that the proportion and function of specific adipocyte subpopulations may explain the interindividual differences linking WAT to cardiometabolic phenotypes. In this project, we will study the function of adipocyte subtypes and their causal link to metabolic diseases. The results generated in this project may uncover novel cell autonomous and/or non-autonomous mechanisms controlling fat cell heterogeneity and may lay the foundation for future development of risk markers and therapies targeting WAT.

Project description

Read the complete project description.

How to apply

The closing date for applications was midnight CEST on Sunday 6th June, 2021.