Postdoc Fellowships 2023 - Project 4
Short title: Insulin nanotechnology
Principal Investigator
Research Project
Mapping the biodistribution of multivalent insulin variants in zebrafish and in mice
At the Teixeira lab (https://ki.se/en/mbb/ana-teixeira-group), we have developed DNA nanotechnology-based approaches to map and target membrane protein nanodomains (e.g. Ambrosetti et al, Nat Nanotechnology, 2021; Fang et al, ACS Nano, 2021; Verheyen, Fang et al, Nucleic Acids Research, 2020; Shaw, Lundin, et al, Nat Methods 2014). In this project, the postdoctoral research fellow will investigate the nanoscale spatial organization of insulin receptors in different tissues. This information will be used to develop multivalent insulin variants using DNA- and protein-based self-assembly. The biodistribution and tissue specific effects of different multivalent insulin variants will be mapped in wild type and diabetes models in zebrafish and mice. This work aims to form the basis for the future development of insulin variants with tailored tissue targeting patterns.
Project description
Read the complete project description.
Lab webpage
How to apply
Link to job posting at VARBI application portal
The closing date for applications is midnight CEST on Sunday 30th April, 2023.