Postdoc Fellowships 2023 - Project 3
Short title: DNA damage as a driver of adipocyte senescence
Principal Investigator
Kirsty Spalding
ProfessorResearch Project
Investigating DNA damage as a driver of adipocyte senescence and inflammation in obese, hyperinsulinemic individuals
Senescent cells, which can release factors that cause inflammation and dysfunction, increase in adipose tissue and associate with obesity and hyperinsulinemia. The proposed project will determine whether oxidative stress and DNA damage in human adipocytes drives adipocyte senescence, and the associated pro-inflammatory secretory profile. A small molecule approach to attenuate adipocyte DNA damage and reverse adipocyte senescence will be investigated.
Project description
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Lab webpage
How to apply
The recruitment process has finished.