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4D Type 2 Diabetes project

Project 4D (four diagnoses)

One important strategy, set by Karolinska Institutet (KI) and the Stockholm County Council (SCC), concerns a joint program, the “4D programme” (“D” as in diagnoses: Arthritis, Breast cancer, Diabetes Type 2, and Heart failure). Programme 4D includes five main projects, consisting of the four diagnoses as well as a fifth enabling project focusing on informatics. The projects in turn consist of 23 sub-projects, at various phases and stages of development.

The overall goal of Programme 4D is to improve the health of people by investigating ways in which clinical research results can be converted systematically and more rapidly into new and improved treatments through the use of real-world data and informatics. The individual plays a central role in this process, either being a well-informed patient participating actively in treatment and research findings or by understanding the impact of personalized prevention. Simply put, this collaboration programme makes healthcare more accessible to patients and to clinical research, as well as making clinical research more accessible to patients and healthcare. The four diagnoses included are currently among the most prevalent in Europe, and progress in these areas has the potential to benefit many patients. Work within the four diagnoses will lay the foundations for building generic models of collaboration between the university and the healthcare system for other chronic disorders as well, as well as for promoting translational research and implementation of research into practice.

4D Type 2 Diabetes Project

SRP Diabetes has helped developed the project 4D (four diagnoses) type 2 diabetes project. This is a joint project between
Karolinska Institutet and Stockholm County Council with the aim of strengthening the interaction between clinical research and health care.
This collaboration has resulted in the launch of a pilot study during 2014 to identify people at high risk for developing diabetes at two different academic primary health care units. At the same time, this collaboration will lead to the establishment of a biobank. The project will lay the foundation for efforts to build a cohort of both pre-diabetic and diabetic people. This collaboration between research and primary health care has also resulted in the development of several new grant applications to the EU framework program Horizon 2020. See separate webpage for more information.

Leaders for 4D type 2 diabetes project:

There is a project group with representatives from both KI and SCC in the area.

Claes-Göran Östenson, (SRP Diabetes PI) Senior consultantof Endocrinology at Karolinska University Hospital and Professor of Endocrinology, Karolinska Institutet.


Eva Toft, Senior consultant and Senior advisor in Endocrinology at Stockholm County Council and Associate professor at Karolinska Institutet.

Lisa-Juntti Berggren, (SRP Diabetes PI) Senior Consultant of Endocrinology at Karolinska University Hospital and Associate Professor, Karolinska Institutet

Anna Krook, (head of SRP Diabetes metabolic phenotyping facility) Professor of Integrative Physiology, Karolinska Institutet