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Important breakthroughs in the history of Alzheimer's research

Bengt Winblad lists important breakthroughs in the history of Alzheimer's research:

1906: German neuropathologist and psychiatrist Alois Alzheimer presents the first ever images of plaque and neurofibrillary tangles in the brain of a former dementia patient.

1910: The disease is first named after its discoverer by Emil Kraepelin in a textbook.

1976: The lack of acetylcholine (ACH), an essential component of neurotransmission, is revealed, paving the way for the drugs in use today.

1984: Glenner and Wong identify the presence of the beta-amyloid protein in plaque.

1986: The tau protein is described in the neurofibrillary tangles.

1992: Mutations of the gene that codes for the protein deposited in plaque are identified in a British and Swedish family.

1993: A mutation of the apolipoprotein E gene is linked to Alzheimer's. The first Alzheimer's drug, an ACH inhibitor, is registered in the USA.

2002: A new form of drug, the NMDA receptor blocker, is registered.