Important breakthroughs in the history of Alzheimer's research
Bengt Winblad lists important breakthroughs in the history of Alzheimer's research:
1906: German neuropathologist and psychiatrist Alois Alzheimer presents the first ever images of plaque and neurofibrillary tangles in the brain of a former dementia patient.
1910: The disease is first named after its discoverer by Emil Kraepelin in a textbook.
1976: The lack of acetylcholine (ACH), an essential component of neurotransmission, is revealed, paving the way for the drugs in use today.
1984: Glenner and Wong identify the presence of the beta-amyloid protein in plaque.
1986: The tau protein is described in the neurofibrillary tangles.
1992: Mutations of the gene that codes for the protein deposited in plaque are identified in a British and Swedish family.
1993: A mutation of the apolipoprotein E gene is linked to Alzheimer's. The first Alzheimer's drug, an ACH inhibitor, is registered in the USA.
2002: A new form of drug, the NMDA receptor blocker, is registered.