KERIC offers a fully equipped facility for experimental surgery with four full size operation units equipped with ventilators and monitors for physiological functions, and two laboratories for small animal surgery. We provide tools for angiography (Philips XD20), MRI (Varian 9.4T), two PET-CT and one PET-MR (Mediso nanoScan), and offer our resources to both academic research, training courses and for external clients to develop and test new equipment.
KERIC is a core facility offering different imaging analyses in experimental systems in combination with experimental surgery in large animals like swine as well as in rodents. The unit belongs to the department of comparative medicine (AKM) and is situated at Karolinska University Hospital, Solna. KERIC is financed by core facility support from Karolinska Institutet and Karolinska University Hospital, and by user fees.
We offer a fully equipped facility for Experimental surgery with four full size operation units equipped with ventilators and monitors for physiological functions, and two laboratories for small animal surgery. We provide tools for Angiography (Philips XD20), MRI (Varian 9.4T), PET-MRI/CT (Mediso nanoScan), and offer our resources to both academic research, training courses and for external clients to develop and test new equipment.
When you run project with KERIC we offer support by our specialised Application Scientists and Animal Technicians with expertise in the modalities we have. We will run the equipment and can help you with designing the experiments and project workflow. We can also offer support with the Ethical Approval application process.
We can Host animals direct or indirect with collaboration within KU (AKM).
The unit for angiography provides a monoplane Philips XD20 including 3D angiography and XperCT. It is a joint project with Philips Healthcare offering possibilities for advanced endovascular research, device development and courses in endovascular treatment. The equipment is continuously upgraded and used in activities like:
- Research in endovascular devices
- Experimental stroke research, combined
- Radiation reduction in angiography
- Development of direct puncture devices
- Superselective stem cell installation
- Courses in endovascular stroke treatment
- 4 fully equiped operation units for large animal (swine):
- Operation Table Trusystem 7000
- Anaesthesia equipment, Draeger Primus Infinitiv
- Monitor equipment, Datex (Philips MX800, coming)
- Surgical diathermy. Valleylab, ForceTriad
- Operation light
- Surgical suction
- Standard surgical instruments
The MRI platform has a 9.4 T Varian scanner (30 cm bore size) of which the effective inner bore is 20cm in diameter. It is a well equipped state-of-the-art system, which is ideal for characterizing different animal models such as rat, mouse and rabbit for various diseases and translational research. The 9.4T MRI can be combined with CT and PET to give more complete imaging analysis. We can offer support to research groups from academia and industry with different applications such as:
- Anatomical imaging of brain (2 and 3-D)
- Whole body (2 and 3-D)
- Functional imaging (fMRI, pharmacological MRI)
- Cardiac imaging with synchronised triggering
- Magnetic Resonance Spectroscopy (1H MRS)
KERIC have to three PET systems. One nanoScan PET-MRI and two nanoScan PET-CT multimodal small animal imaging systems. The PET modules (spatial resolution 0.8mm) a 1T static MRI module (spatial resolution <100 µm), and a CT module (min. voxel size: 10-34 µm)
We collaborate with Radio pharmacy Core Facility at KI that can produce radio ligands. Short half time as well as long half time and more advanced ligand systems that can be activated in-vivo. There are also in house cyclotrons that can ensure fast delivery which is especially important for effective short half time ligands, such as FTG.