2019 KI Symposium “CNS Injuries and Repair”
This symposium gathered some of the leading scientists working on critical aspects regarding neuron intrinsic axon growth inhibitors, extrinsic inhibition associated with myelin components and glial and fibrotic scar elements and remyelination as well as neurotechnology development, which has led to the development of therapeutic strategies to promote recovery following CNS injuries.
Damage to the adult central nervous system most often leads to persistent deficits due to limited tissue regeneration and the inability of mature axons to regenerate after injury. Reduced inherent axonal growth capacity and local inhibition at the lesion site are the two main obstacles for axons to regenerate. At the lesion, inhibitory molecules associated with myelin, inflammatory cells and different scar components have been identified as impediment for regrowing axons. Secondary damage and limited remyelination further exacerbates injury. These barriers collectively present a great challenge in restoring the original circuitry. Despite the number of obstacles, our understanding of the complex injury mechanisms is growing and promising therapeutic approaches are emerging.
Date: 3 April 2019
Venue: The Nobel Forum, Karolinska Institutet, Sweden
Quentin Barraud (EPFL Geneva, Switzerland)
Catherina Becker (The University of Edinburgh, UK)
Frank Bradke (DZNE Bonn, Germany)
Jonas Frisén (Karolinska Institutet, Sweden)
Christian Göritz (Karolinska Institutet, Sweden)
Kai Liu (Hong Kong University of Science and Technology, Hong Kong)
Martin Schwab (University and ETH Zurich, Switzerland)
Jerry Silver (Case Western Reserve University, USA)
This symposium was supported by the Ming Wai Lau Centre for Reparative Medicine.