Zaher ElBeck
Affiliated to Research
E-mail: zaher.elbeck@ki.se
Visiting address: Novum, Blickagången 6, 14157 Huddinge/Stockholm
Postal address: H7 Medicin, Huddinge, H7 ICCA Betsholtz, 171 77 Stockholm
Part of:
About me
- My interest is in redox biology in the cardiovascular system, but from a
different perspective than the way it has been commonly viewed.
Oxidative species are a divergent group of cellular metabolites, with a wide
variety of functions. Together with reductants, they regulate almost all
cellular functions, from mediating cellular communications, to catalyzing a
variety of biochemical reactions, and post-translationally modifying
proteins.
We demonstrate that in cardiomyocytes mitochondrial isocitrate dehydrogenase
(IDH2) constitutes a major antioxidant defense mechanism. In both male and
female mice and humans, the paradoxical reduction in expression of IDH2
associated with heart failure is compensated for by an increase in the
enzyme’s activity. We describe extensive mutual regulation of the
antioxidant activities of IDH2 and NRF2 by a network involving 2-oxoglutarate
and L2-hydroxyglutarate and mediated in part through unconventional
hydroxy-methylation of cytosine residues present in introns. We highlight a
sex difference in cardiac antioxidative capacity, which even
influences cardiomyocyte morphology
. Conditional targeting of ROS in a murine model of heart failure improves
cardiac function in sex- and phenotype-dependent manners.
To read more about my research, please see our recent manuscript
(Epigenetic modulators link mitochondrial redox homeostasis to cardiac
function) in BioRxiv (https://doi.org/10.1101/2022.03.26.485908).
Articles
- Article: CELL REPORTS. 2024;43(3):113911Vazquez-Liebanas E; Mocci G; Li W; Lavina B; Reddy A; O'Connor C; Hudson N; Elbeck Z; Nikoloudis I; Gaengel K; Vanlandewijck M; Campbell M; Betsholtz C; Mae MA
- Article: NATURE COMMUNICATIONS. 2024;15(1):2358ElBeck Z; Hossain MB; Siga H; Oskolkov N; Karlsson F; Lindgren J; Walentinsson A; Koppenhofer D; Jarvis R; Burli R; Jamier T; Franssen E; Firth M; Degasperi A; Bendtsen C; Menzies RI; Streckfuss-Bomeke K; Kohlhaas M; Nickel AG; Lund LH; Maack C; Vegvari A; Betsholtz C
- Article: JOURNAL OF CELL SCIENCE. 2021;134(18):jcs258684Biquand A; Spinozzi S; Tonino P; Cosette J; Strom J; Elbeck Z; Knoll R; Granzier H; Lostal W; Richard I
- Article: NATURE COMMUNICATIONS. 2021;12(1):5180Grote Beverborg N; Später D; Knöll R; Hidalgo A; Yeh ST; Elbeck Z; Silljé HHW; Eijgenraam TR; Siga H; Zurek M; Palmér M; Pehrsson S; Albery T; Bomer N; Hoes MF; Boogerd CJ; Frisk M; van Rooij E; Damle S; Louch WE; Wang Q-D; Fritsche-Danielson R; Chien KR; Hansson KM; Mullick AE; de Boer RA; van der Meer P
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(24):E9687-9687Rodrigues PG; Miranda-Silva D; Li X; Sousa-Mendes C; Martins-Ferreira R; Elbeck Z; Leite-Moreira AF; Knoll R; Falcao-Pires I
- Article: GENES. 2020;11(12):E1430-1430Sielemann K; Elbeck Z; Gaertner A; Brodehl A; Stanasiuk C; Fox H; Paluszkiewicz L; Tiesmeier J; Wlost S; Gummert J; Albaum SP; Sielemann J; Knoell R; Milting H
- Article: BASIC RESEARCH IN CARDIOLOGY. 2019;115(1):7Esfahani PH; ElBeck Z; Sagasser S; Li X; Hossain MB; Talukdar HA; Sandberg R; Knoll R
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2019;11(520):eaat6072Lostal W; Roudaut C; Faivre M; Charton K; Suel L; Bourg N; Best H; Smith JE; Gohlke J; Corre G; Li X; Elbek Z; Knoell R; Deschamps J-Y; Granzier H; Richard I
All other publications
- Doctoral thesis: 2023Elback Z
- Preprint: BIORXIV. 2022Elbeck Z; Hossain MB; Siga H; Oskolkov N; Karlsson F; Lindgren J; Walentinsson A; Remedios CD; Koppenhöfer D; Jarvis R; Bürli R; Jamier T; Franssen E; Firth M; Degasperi A; Bendtsen C; Dudek J; Kohlhaas M; Nickel A; Lund L; Maack C; Végvári Á; Betsholtz C
- Editorial comment: CARDIOVASCULAR RESEARCH. 2019;115(14):1943-1945Hossain MB; Elbeck Z; Siga H; Knoll R
Employments
- Affiliated to Research, Department of Medicine, Huddinge, Karolinska Institutet, 2023-2025
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Medicine, Huddinge, Karolinska Institutet, 2023