Zaher ElBeck
Cardiovascular molecular biologist studying stress-adaptive signaling, microvascular regulation, and myocardial infarction through translational experimental and human models.
About me
My research aims to uncover new molecular mechanisms that protect the heart during ischemic stress. I focus on how stress-adaptive signaling, microvascular regulation, and cardiomyocyte responses interact in myocardial infarction. I am currently establishing an independent translational research line in ischemic heart disease, integrating experimental models with human cohort studies and human cardiac organoids to identify pathways with future clinical relevance.
Research
My research interests lie in myocardial infarction, coronary microvascular biology, cardiomyocyte stress adaptation, and translational cardiovascular medicine. I am particularly interested in how stress-responsive signaling pathways regulate communication between the heart muscle and the coronary microvasculature during ischemic injury. To address these questions, I combine molecular biology, functional genomics, experimental cardiovascular models, human cohort material, and human cardiac organoids. The aim is to define clinically relevant mechanisms that can be translated into targeted gene- or RNA-based therapies and biomarkers for ischemic heart disease.
Teaching
I am interested in supervising motivated master’s and exchange students who are passionate about cardiovascular research and interested in carrying out a project in the field. Students with an interest in experimental or translational cardiac biology are very welcome to contact me by email.
Articles
- Article: CELL REPORTS. 2024;43(3):113911Vazquez-Liebanas E; Mocci G; Li W; Lavina B; Reddy A; O'Connor C; Hudson N; Elbeck Z; Nikoloudis I; Gaengel K; Vanlandewijck M; Campbell M; Betsholtz C; Mae MA
- Article: NATURE COMMUNICATIONS. 2024;15(1):2358ElBeck Z; Hossain MB; Siga H; Oskolkov N; Karlsson F; Lindgren J; Walentinsson A; Koppenhofer D; Jarvis R; Burli R; Jamier T; Franssen E; Firth M; Degasperi A; Bendtsen C; Menzies RI; Streckfuss-Bomeke K; Kohlhaas M; Nickel AG; Lund LH; Maack C; Vegvari A; Betsholtz C
- Article: JOURNAL OF CELL SCIENCE. 2021;134(18):jcs258684Biquand A; Spinozzi S; Tonino P; Cosette J; Strom J; Elbeck Z; Knoll R; Granzier H; Lostal W; Richard I
- Article: NATURE COMMUNICATIONS. 2021;12(1):5180Grote Beverborg N; Später D; Knöll R; Hidalgo A; Yeh ST; Elbeck Z; Silljé HHW; Eijgenraam TR; Siga H; Zurek M; Palmér M; Pehrsson S; Albery T; Bomer N; Hoes MF; Boogerd CJ; Frisk M; van Rooij E; Damle S; Louch WE; Wang Q-D; Fritsche-Danielson R; Chien KR; Hansson KM; Mullick AE; de Boer RA; van der Meer P
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(24):E9687-9687Rodrigues PG; Miranda-Silva D; Li X; Sousa-Mendes C; Martins-Ferreira R; Elbeck Z; Leite-Moreira AF; Knoll R; Falcao-Pires I
- Article: GENES. 2020;11(12):E1430-1430Sielemann K; Elbeck Z; Gaertner A; Brodehl A; Stanasiuk C; Fox H; Paluszkiewicz L; Tiesmeier J; Wlost S; Gummert J; Albaum SP; Sielemann J; Knoell R; Milting H
- Article: BASIC RESEARCH IN CARDIOLOGY. 2019;115(1):7Esfahani PH; ElBeck Z; Sagasser S; Li X; Hossain MB; Talukdar HA; Sandberg R; Knoll R
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2019;11(520):eaat6072Lostal W; Roudaut C; Faivre M; Charton K; Suel L; Bourg N; Best H; Smith JE; Gohlke J; Corre G; Li X; Elbek Z; Knoell R; Deschamps J-Y; Granzier H; Richard I
All other publications
- Doctoral thesis: 2023Elback Z
- Preprint: BIORXIV. 2022Elbeck Z; Hossain MB; Siga H; Oskolkov N; Karlsson F; Lindgren J; Walentinsson A; Remedios CD; Koppenhöfer D; Jarvis R; Bürli R; Jamier T; Franssen E; Firth M; Degasperi A; Bendtsen C; Dudek J; Kohlhaas M; Nickel A; Lund L; Maack C; Végvári Á; Betsholtz C
- Editorial: CARDIOVASCULAR RESEARCH. 2019;115(14):1943-1945Hossain MB; Elbeck Z; Siga H; Knoll R
Employments
- Affiliated to Research, Department of Medicine, Huddinge, Karolinska Institutet, 2026-2029
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Medicine, Huddinge, Karolinska Institutet, 2023
