Yizhou Hu

About me
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About me

Molecular system biology, work on molecular biochemistry and translational
medicine since 2005, coding since 2008.
* Ph.D., Pathology (Oncology and Molecular Cell Biology), Translational
Cancer Biology Program, Faculty of Medicine, University of Helsinki,
Finland
* M.Sc., Genetics (Human Genetics and Bioinformatics), Faculty of Biological
and Environmental Sciences, University of Helsinki, Finland
* B.Sc., Biotechnology (Medical Biotechnology), Life Science College of
Soochow University, Suzhou, China

Research

Nervous system tumor, single-cell/spatial technology, developmental
neurobiology, and deep learning.
*Recent Publications: *
* Neogenin suppresses tumor progression and metastasis via inhibiting
Merlin/YAP signaling [1], Cell Death Discov., 2023
* Neural network learning defines glioblastoma features to be of neural
crest perivascular or radial glia lineages [2], Sci Adv., 2022
* Single cell transcriptional zonation of human psoriasis skin identifies an
alternative immunoregulatory axis conducted by skin resident cells
[3], Cell Death Dis., 2021
*Software:*
1) SWAPLINE, Single-cell Weighted Assignment and Projection on developmental
LINEages [4]
2) scCAMEL, learning-based single-cell analysis toolkits,
website: https://sccamel.readthedocs.io/ [5]
*Dataset visualization:*
1. Single cell transcriptional zonation of human psoriasis skin identifies
an alternative immunoregulatory axis conducted by skin resident cells, Cell
Death Dis., 2021
Website: https://yz-studio.shinyapps.io/shinyapph5ad/ [6]
[1] https://pubmed.ncbi.nlm.nih.gov/36746934/
[2] https://pubmed.ncbi.nlm.nih.gov/35675414/
[3] https://pubmed.ncbi.nlm.nih.gov/33958582/
[4] https://github.com/ernforslab/Hu-et-al._GBMlineage2022
[5] https://sccamel.readthedocs.io
[6] https://yz-studio.shinyapps.io/shinyapph5ad/

Selected publications

Journal article: NATURE NEUROSCIENCE. 2024;27(12):2326-2340
Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation
Yu H; Nagi SS; Usoskin D; Hu Y; Kupari J; Bouchatta O; Yan H; Cranfill SL; Gautam M; Su Y; Lu Y; Wymer J; Glanz M; Albrecht P; Song H; Ming G-L; Prouty S; Seykora J; Wu H; Ma M; Marshall A; Rice FL; Li M; Olausson H; Ernfors P; Luo W
Article: SCIENCE. 2024;385(6712):eado6593
Morphine-responsive neurons that regulate mechanical antinociception
Fatt MP; Zhang M-D; Kupari J; Altinkok M; Yang Y; Hu Y; Svenningsson P; Ernfors P
Article: CELL DEATH DISCOVERY. 2023;9(1):47
Neogenin suppresses tumor progression and metastasis via inhibiting Merlin/YAP signaling
Hu X; Li L; Li F; Yang Y; An J; Zhou X; Zhang R; Shi L; Zhao H; Wang J; Hu Y; Xu Y
Article: SCIENCE ADVANCES. 2022;8(23):eabm6340
Neural network learning defines glioblastoma features to be of neural crest perivascular or radial glia lineages
Hu Y; Jiang Y; Behnan J; Ribeiro MM; Kalantzi C; Zhang M-D; Lou D; Haring M; Sharma N; Okawa S; Del Sol A; Adameyko I; Svensson M; Persson O; Ernfors P
Article: CELL DEATH AND DISEASE. 2021;12(5):450
Single cell transcriptional zonation of human psoriasis skin identifies an alternative immunoregulatory axis conducted by skin resident cells
Gao Y; Yao X; Zhai Y; Li L; Li H; Sun X; Yu P; Xue T; Li Y; Hu Y
Article: NATURE COMMUNICATIONS. 2021;12(1):2141
Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes
He B; Chen P; Zambrano S; Dabaghie D; Hu Y; Moller-Hackbarth K; Unnersjoe-Jess D; Korkut GG; Charrin E; Jeansson M; Bintanel-Morcillo M; Witasp A; Wennberg L; Wernerson A; Schermer B; Benzing T; Ernfors P; Betsholtz C; Lal M; Sandberg R; Patrakka J
Article: NATURE COMMUNICATIONS. 2021;12(1):1510
Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain
Kupari J; Usoskin D; Parisien M; Lou D; Hu Y; Fatt M; Lonnerberg P; Spangberg M; Eriksson B; Barkas N; Kharchenko PV; Lore K; Khoury S; Diatchenko L; Ernfors P

Articles

Journal article: JOURNAL OF DERMATOLOGICAL TREATMENT. 2024;35(1):2337264
Characterization of psoriasis patients in special body areas: real-world evidence from the Chinese Psoriasis Standardized Diagnosis and Treatment Center
Gao Y; Li C; Tong M; Hu Y; Li Y
Journal article: NEURO-ONCOLOGY. 2024;26(10):1878-1894
Super-enhancer-driven IRF2BP2 enhances ALK activity and promotes neuroblastoma cell proliferation
Chen Y; Zhuo R; Sun L; Tao Y; Li G; Zhu F; Xu Y; Wang J; Li Z; Yu J; Yin H; Wu D; Li X; Fang F; Xie Y; Hu Y; Wang H; Yang C; Shi L; Wang X; Zhang Z; Pan J
Article: BMC CANCER. 2024;24(1):89
EMP3 as a prognostic biomarker correlates with EMT in GBM
Li L; Xia S; Zhao Z; Deng L; Wang H; Yang D; Hu Y; Ji J; Huang D; Xin T
Article: NATURE METABOLISM. 2023;5(7):1188-1203
Human resident liver myeloid cells protect against metabolic stress in obesity
Barreby E; Strunz B; Nock S; Naudet L; Shen JX; Johansson H; Soennerborg I; Ma J; Urgard E; Pallett LJ; Hu Y; Fardellas A; Azzimato V; Vankova A; Levi L; Morgantini C; Maini MK; Stal P; Rosshart SP; Coquet JM; Nowak G; Naeslund E; Lauschke VM; Ellis E; Bjoerkstroem NK; Chen P; Aouadi M
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1265517
Integrative single-cell transcriptomic investigation unveils long non-coding RNAs associated with localized cellular inflammation in psoriasis
Gao Y; Na M; Yao X; Li C; Li L; Yang G; Li Y; Hu Y
Article: STEM CELL REPORTS. 2022;17(5):1089-1104
The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research
Muhl L; He L; Sun Y; Mae MA; Pietila R; Liu J; Genove G; Zhang L; Xie Y; Leptidis S; Mocci G; Stritt S; Osman A; Anisimov A; Hemanthakumar KA; Rasanen M; Hansson EM; Bjorkegren J; Vanlandewijck M; Blomgren K; Makinen T; Peng X-R; Hu Y; Ernfors P; Arnold TD; Alitalo K; Lendahl U; Betsholtz C
Article: BMC CANCER. 2018;18(1):1215
EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence
Li L; Huang Y; Gao Y; Shi T; Xu Y; Li H; Hyytiainen M; Keski-Oja J; Jiang Q; Hu Y; Du Z

All other publications

Preprint: BIORXIV. 2023;BIORXIV
Single-Soma Deep RNA sequencing of Human DRG Neurons Reveals Novel Molecular and Cellular Mechanisms Underlying Somatosensation.
Yu H; Usoskin D; Nagi SS; Hu Y; Kupari J; Bouchatta O; Cranfill SL; Gautam M; Su Y; Lu Y; Wymer J; Glanz M; Albrecht P; Song H; Ming G-L; Prouty S; Seykora J; Wu H; Ma M; Rice FL; Olausson H; Ernfors P; Luo W
Preprint: BIORXIV. 2020
Single cell transcriptomics of primate sensory neurons identifies cell types associated with human chronic pain
Kupari J; Usoskin D; Lou D; Parisien M; Hu Y; Fatt M; Lönnerberg P; Spångberg M; Eriksson B; Barkas N; Kharchenko PV; Loré K; Khoury S; Diatchenko L; Ernfors P

Grants

Decoding the molecular and cellular regulatory logic in malignant brain cancer
Åke Wibergs Foundation
1 January 2025 - 31 December 2026
Decoding the molecular and cellular regulatory logic in glioblastoma
Åke Wibergs Foundation
1 January 2024 - 31 December 2025
Decoding the gene regulatory programme in glioblastoma
Åke Wibergs Foundation
1 January 2023 - 31 December 2024
Identifying the perivascular propagating cells of Glioblastoma
SSMF
1 March 2021 - 28 February 2023

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