Yitian Zhou
Affiliated to Research
E-mail: yitian.zhou@ki.se
Visiting address: Solnavägen 9, Biomedicum, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Individanpassad medicin och läkemedelsutveckling, 171 77 Stockholm
Research
My research focuses on characterizing the variation on human pharmacogenome, with particular interest in CYP genes, drug transporters and HLA genes. I studied distribution of clinically relevant variant alleles across different populations and ethnicities to infer their consequence on drug response phenotype. By leveraging AI/ML-based computational tools, I developed methods to interpret functional impact of pharmacogenetic variants, including rare variants as the majority identified from next-generation sequencing projects.
Teaching
Pharmacogenomics sessions for the Master's Programme in Translational Physiology and Pharmacology, KI
Articles
- Review: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2025;91(2):252-263Tremmel R; Pirmann S; Zhou Y; Lauschke VM
- Article: JOURNAL OF GENETICS AND GENOMICS. 2024;51(11):1228-1236Gonzalez-Padilla D; Camara MD; Lauschke VM; Zhou Y
- Article: PHARMACOGENOMICS JOURNAL. 2024;24(3):17Zhou Y; Pirmann S; Lauschke VM
- Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2024;68(5):e01390-e01323Camara MD; Zhou Y; Dara A; Tekete MM; de Sousa TN; Sissoko S; Dembele L; Ouologuem N; Togo AH; Alhousseini ML; Fofana B; Sagara I; Djimde AA; Gil PJ; Lauschke VM
- Article: HUMAN GENOMICS. 2024;18(1):40Camara MD; Zhou Y; De Sousa TN; Gil JP; Djimde AA; Lauschke VM
- Review: EXPERT REVIEW OF CLINICAL PHARMACOLOGY. 2024;17(3):213-223Zhou Y; Lauschke VM
- Review: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2024;64:33-51Lauschke VM; Zhou Y; Ingelman-Sundberg M
- Article: NPJ GENOMIC MEDICINE. 2023;8(1):24Tremmel R; Zhou Y; Schwab M; Lauschke VM
- Article: CLINICAL PHARMACOLOGY & THERAPEUTICS. 2023;113(3):712-723Khor CC; Winter S; Sutiman N; Muerdter TE; Chen S; Lim JSL; Li Z; Li J; Sim KS; Ganchev B; Eccles D; Eccles B; Tapper W; Zgheib NKK; Tfayli A; Ng RCH; Yap YS; Lim E; Wong M; Wong NS; Ang PCS; Dent R; Tremmel R; Klein K; Schaeffeler E; Zhou Y; Lauschke VMM; Eichelbaum M; Schwab M; Brauch HBB; Chowbay B; Schroth W
- Article: HUMAN GENOMICS. 2023;17(1):15Zhou Y; Nevosadova L; Eliasson E; Lauschke VMM
- Article: LANCET. 2023;401(10374):347-356Swen JJ; van der Wouden CH; Manson LEN; Abdullah-Koolmees H; Blagec K; Blagus T; Boehringer S; Cambon-Thomsen A; Cecchin E; Cheung K-C; Deneer VHM; Dupui M; Ingelman-Sundberg M; Jonsson S; Joefield-Roka C; Just KS; Karlsson MO; Konta L; Koopmann R; Kriek M; Lehr T; Mitropoulou C; Rial-Sebbag E; Rollinson V; Roncato R; Samwald M; Schaeffeler E; Skokou M; Schwab M; Steinberger D; Stingl JC; Tremmel R; Turner RM; van Rhenen MH; Fajardo CLD; Dolzan V; Patrinos GP; Pirmohamed M; Sunder-Plassmann G; Toffoli G; Guchelaar H-J
- Article: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2023;280:237-260Zhou Y; Lauschke VM
- Article: ISCIENCE. 2022;25(12):105506Xun D; Chen D; Zhou Y; Lauschke VM; Wang R; Wang Y
- Article: PHARMACOGENOMICS JOURNAL. 2022;22(5-6):284-293Zhou Y; Lauschke VM
- Review: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2022;131(6):452-464Zhou Y; Koutsilieri S; Eliasson E; Lauschke VM
- Article: BIOMEDICINE & PHARMACOTHERAPY. 2022;154:113644De Mattia E; Silvestri M; Polesel J; Ecca F; Mezzalira S; Scarabel L; Zhou Y; Roncato R; Lauschke VM; Calza S; Spina M; Puglisi F; Toffoli G; Cecchin E
- Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2022;43(10):852-865Zhou Y; Tremmel R; Schaeffeler E; Schwab M; Lauschke VM
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2022;109(6):1077-1091Trpchevska N; Freidin MB; Broer L; Oosterloo BC; Yao S; Zhou Y; Vona B; Bishop C; Bizaki-Vallaskangas A; Canlon B; Castellana F; Chasman DI; Cherny S; Christensen K; Concas MP; Correa A; Elkon R; Mengel-From J; Gao Y; Giersch ABS; Girotto G; Gudjonsson A; Gudnason V; Heard-Costa NL; Hertzano R; v.B. Hjelmborg J; Hjerling-Leffler J; Hoffman HJ; Kaprio J; Kettunen J; Krebs K; Kahler AK; Lallemend F; Launer LJ; Lee I-M; Leonard H; Li C-M; Lowenheim H; Magnusson PKE; van Meurs J; Milani L; Morton CC; Makitie A; Nalls MA; Nardone GG; Nygaard M; Palviainen T; Pratt S; Quaranta N; Ramo J; Saarentaus E; Sardone R; Satizabal CL; Schweinfurth JM; Seshadri S; Shiroma E; Shulman E; Simonsick E; Spankovich C; Tropitzsch A; Lauschke VM; Sullivan PF; Goedegebure A; Cederroth CR; Williams FMK; Nagtegaal AP
- Review: HUMAN GENETICS. 2022;141(6):1113-1136Zhou Y; Lauschke VM
- Article: PHARMACEUTICS. 2022;14(5):944Dagli-Hernandez C; Borges JB; Rodrigues Marcal EDS; Costa de Freitas RC; Mori AA; Goncalves RM; Faludi AA; de Oliveira VF; Ferreira GM; Bastos GM; Zhou Y; Lauschke VM; Cerda A; Hirata MH; Crespo Hirata RD
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All other publications
- Conference publication: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2023;396:S52Tremmel R; Zhou Y; Nevosadova L; Laarif S; Eliasson E; Lauschke VM
- Conference publication: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2023;396:S52Klein K; Nies AT; Haag M; Hofmann U; Artursson P; Handin N; Burk O; Tremmel R; Winter S; Zhou Y; Schaeffeler E; Zanger UM; Lauschke VM; Schwab M
- Editorial: ANNALS OF TRANSLATIONAL MEDICINE. 2022;10(23):1293-0Zhou Y; Lauschke VM
- Conference publication: 2022;:30-35Sun Y; Zhou Y
- Book chapter: COMPREHENSIVE PHARMACOLOGY. 2022;p. 53-83Zhou Y; Lauschke VM
- Preprint: BIORXIV. 2021Xun D; Chen D; Zhou Y; Lauschke V; Wang R; Wang Y
- Editorial: FRONTIERS IN GENETICS. 2021;12:736626Editorial: Population Pharmacogenomics (PGx): From Variant Identification to Clinical ImplementationHiratsuka M; Zhou Y; Lauschke VM
- Conference publication: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2018;123:5Zhou Y; Mkrtchian S; Kumondai M; Hiratsuka M; Lauschke V
Grants
- Precision Medicine by personalized dosing of capecitabine and tamoxifen in breast cancer – advanced pharmacogene sequencing, phenotype markers and modeling of patient-unique genetic variantsCancerfonden
Employments
- Affiliated to Research, Department of Physiology and Pharmacology, Karolinska Institutet, 2026-2028
- Postdoctoral Researcher, Department of Physiology and Pharmacology, Karolinska Institutet, 2023-2026
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Physiology and Pharmacology, Karolinska Institutet, 2021
- Degree Of Master Of Medical Science 120 Credits, Karolinska Institutet, 2017