Yi Jin

Publications
CV
Public outreach and news

Articles

Article: ANGIOGENESIS. 2024;28(1):6
Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT.
Queiro-Palou A; Jin Y; Jakobsson L
Journal article: LIFE SCIENCE ALLIANCE. 2024;7(3):e202302168
VE-cadherin junction dynamics in initial lymphatic vessels promotes lymph node metastasis.
Sáinz-Jaspeado M; Ring S; Proulx ST; Richards M; Martinsson P; Li X; Claesson-Welsh L; Ulvmar MH; Jin Y
Journal article: NATURE CARDIOVASCULAR RESEARCH. 2022;1(12):1156-1173
Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis.
Jin Y; Ding Y; Richards M; Kaakinen M; Giese W; Baumann E; Szymborska A; Rosa A; Nordling S; Schimmel L; Akmeriç EB; Pena A; Nwadozi E; Jamalpour M; Holstein K; Sáinz-Jaspeado M; Bernabeu MO; Welsh M; Gordon E; Franco CA; Vestweber D; Eklund L; Gerhardt H; Claesson-Welsh L
Article: CIRCULATION. 2021;144(20):1629-1645
Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium
Franco Cereceda A; Bäck M; Plunde O; Pawelzik S-C
Journal article: CIRCULATION. 2021;144(20):1629-1645
Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium
Sainz-Jaspeado M; Smith RO; Plunde O; Pawelzik S-C; Jin Y; Nordling S; Ding Y; Aspenstrom P; Hedlund M; Bastianello G; Ascione F; Li Q; Demir CS; Fernando D; Daniel G; Franco-Cereceda A; Kroon J; Foiani M; Petrova TV; Kilimann MW; Back M; Claesson-Welsh L
Journal article: DEVELOPMENT. 2020;147(7):dev185405
c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly.
Schimmel L; Fukuhara D; Richards M; Jin Y; Essebier P; Frampton E; Hedlund M; Dejana E; Claesson-Welsh L; Gordon E
Article: CIRCULATION RESEARCH. 2020;126(2):243-257
Loss of Endothelial Endoglin Promotes High-Output Heart Failure Through Peripheral Arteriovenous Shunting Driven by VEGF Signaling
Tual-Chalot S; Garcia-Collado M; Redgrave RE; Singh E; Davison B; Park C; Lin H; Luli S; Jin Y; Wang Y; Lawrie A; Jakobsson L; Arthur HM
Journal article: EMBO REPORTS. 2019;20(11):e47845
Myc-dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor-2.
Testini C; Smith RO; Jin Y; Martinsson P; Sun Y; Hedlund M; Sáinz-Jaspeado M; Shibuya M; Hellström M; Claesson-Welsh L
Journal article: EUROPEAN HEART JOURNAL. 2019;40(Supplement_1):ehz746.0128
6089Increased vascular endothelial growth factor signalling following loss of endothelial endoglin leads to peripheral arteriovenous shunting and high output heart failure
Tual-Chalot S; Garcia-Collado M; Redgrave RE; Singh E; Davison B; Luli S; Jin Y; Wang Y; Lawrie A; Jakobsson L; Arthur HM
Article: SCIENTIFIC REPORTS. 2018;8(1):10672
Characterization of multi-cellular dynamics of angiogenesis and vascular remodelling by intravital imaging of the wounded mouse cornea
Wang Y; Jin Y; Lavina B; Jakobsson L
Article: DEVELOPMENT. 2017;144(19):3590-3601
Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity
Wang Y; Jin Y; Mae MA; Zhang Y; Ortsater H; Betsholtz C; Makinen T; Jakobsson L
Article: NATURE CELL BIOLOGY. 2017;19(6):639-652
Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling
Jin Y; Muhl L; Burmakin M; Wang Y; Duchez A-C; Betsholtz C; Arthur HM; Jakobsson L
Article: NATURE CELL BIOLOGY. 2017;19(6):653-665
Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues
Sugden WW; Meissner R; Aegerter-Wilmsen T; Tsaryk R; Leonard EV; Bussmann J; Hamm MJ; Herzog W; Jin Y; Jakobsson L; Denz C; Siekmann AF
Article: ONCOGENE. 2016;35(6):748-760
TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis
Pang M-F; Georgoudaki A-M; Lambut L; Johansson J; Tabor V; Hagikura K; Jin Y; Jansson M; Alexander JS; Nelson CM; Jakobsson L; Betsholtz C; Sunds M; Karlsson MCI; Fuxe J
Article: BIOCHEMICAL SOCIETY TRANSACTIONS. 2014;42(6):1576-1583
VEGF, Notch and TGFβ/BMPs in regulation of sprouting angiogenesis and vascular patterning
Jin Y; Kaluza D; Jakobsson L
Article: DEVELOPMENTAL CELL. 2012;23(3):587-599
The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2
Gaengel K; Niaudet C; Hagikura K; Siemsen BL; Muhl L; Hofmann JJ; Ebarasi L; Nystrom S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstrom M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2012;32(8):1951-1959
Endothelial cells require related transcription enhancer factor-1 for cell-cell connections through the induction of gap junction proteins.
An X; Jin Y; Philbrick MJ; Wu J; Messmer-Blust A; Song X; Cully BL; He P; Xu M; Duffy HS; Li J
Article: CANCERS. 2012;4(2):400-419
The dynamics of developmental and tumor angiogenesis-a comparison.
Jin Y; Jakobsson L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(25):22699-22705
RTEF-1, an upstream gene of hypoxia-inducible factor-1α, accelerates recovery from ischemia.
Jin Y; Wu J; Song X; Song Q; Cully BL; Messmer-Blust A; Xu M; Foo S-Y; Rosenzweig A; Li J
Article: CARDIOVASCULAR RESEARCH (CVR). 2011;90(2):325-334
The endothelium-dependent effect of RTEF-1 in pressure overload cardiac hypertrophy: role of VEGF-B.
Xu M; Jin Y; Song Q; Wu J; Philbrick MJ; Cully BL; An X; Guo L; Gao F; Li J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(35):23436-23443
RGS5, a hypoxia-inducible apoptotic stimulator in endothelial cells.
Jin Y; An X; Ye Z; Cully B; Wu J; Li J
Article: CIRCULATION. 2009;120(7):617-627
Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor.
An X; Jin Y; Guo H; Foo S-Y; Cully BL; Wu J; Zeng H; Rosenzweig A; Li J
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All other publications

Preprint: RESEARCH SQUARE PLATFORM LLC. 2022
YES kinase controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis
Jin Y; Ding Y; Richards M; Kaakinen M; Szymborska A; Rosa A; Baumann E; Giese W; Pena A; Nwadozi E; Jamalpour M; Holstein K; Sáinz-Jaspeado M; Vestweber D; Welsh M; Bernabeu M; Franco C; Eklund L; Gerhardt H; Claesson-Welsh L
Conference publication: CARDIOVASCULAR DRUGS AND THERAPY. 2020;34(2):277
LOSS OF ENDOTHELIAL ENDOGLIN IN ADULT LIFE LEADS TO PERIPHERAL ARTERIOVENOUS SHUNTING AND HIGH OUTPUT HEART FAILURE.
Tual-Chalot S; Garcia-Collado M; Redgrave RE; Singh E; Davison B; Luli S; Jin Y; Wang Y; Lawrie A; Jakobsson L; Arthur HM
Conference publication: ANGIOGENESIS. 2019;22(4):600
Amplified responses to VEGF signaling following loss of endothelial Endoglin leads to peripheral arteriovenous shunting and high-output heart failure
Tual-Chalot S; Garcia-Collado M; Redgrave RE; Singh E; Davison B; Luli S; Jin Y; Wang Y; Lawrie A; Jakobsson L; Arthur H
Conference publication: EUROPEAN HEART JOURNAL. 2019;40:3716
Increased vascular endothelial growth factor signalling following loss of endothelial endoglin leads to peripheral arteriovenous shunting and high output heart failure
Tual-Chalot S; Garcia-Collado M; Redgrave RE; Singh E; Davison B; Luli S; Jin Y; Wang Y; Lawrie A; Jakobsson L; Arthur HM
Conference publication: EUROPEAN HEART JOURNAL. 2015;36:497-498
Endoglin is required to maintain normal cardiac function in adult life
Tual-Chalot S; Davison BJ; Jin Y; Redgrave RE; Jakobsson L; Taggart MJ; Arthur HM
Conference publication: ANGIOGENESIS. 2013;16(1):246-247
The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2
Gaengel K; Niaudet C; Hagikura K; Siemsen LB; Muhl L; Hofmann JJ; Ebarasi L; Nystrom S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstrom M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
Corrigendum: DEVELOPMENTAL CELL. 2012;23(6):1264
The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2 (vol 23, pg 587, 2012)
Gaengel K; Niaudet C; Hagikura K; Lavina B; Muhl L; Hofmann JJ; Ebarasi L; Nystroem S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstroem M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
Review: TRENDS IN CARDIOVASCULAR MEDICINE. 2011;21(1):1-5
The role of transcription enhancer factors in cardiovascular biology.
Jin Y; Messmer-Blust AF; Li J

Employments

Research Specialist, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2024-2025
Assistant Professor, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2015-2017
Postdoctoral Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2013-2015

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