Yenan Bryceson

Publications
CV
Public outreach and news

Articles

Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2024;221(7):e20221122
Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect
Koegl T; Chang H-F; Staniek J; Chiang SCC; Thoulass G; Lao J; Weissert K; Dettmer-Monaco V; Geiger K; Manna PT; Beziat V; Momenilandi M; Tu S-M; Keppler SJ; Pattu V; Wolf P; Kupferschmid L; Tholen S; Covill LE; Ebert K; Straub T; Gross M; Gather R; Engel H; Salzer U; Schell C; Maier S; Lehmberg K; Cornu TI; Pircher H; Shahrooei M; Parvaneh N; Elling R; Rizzi M; Bryceson YT; Ehl S; Aichele P; Ammann S
Article: JOURNAL OF IMMUNOLOGY. 2024;212(5):868-880
KIR2DS1 and KIR2DL1-C245 Dominantly Repress NK Cell Degranulation Triggered by Monoclonal or Bispecific Antibodies, whereas Education by Uptuning Inhibitory Killer Ig-related Receptors Exerts No Advantage in Ab-dependent Cellular Cytotoxicity
Leijonhufvud C; Sanz-Ortega L; Schlums H; Gaballa A; Andersson A; Eriksson C; Segerberg F; Uhlin M; Bryceson YT; Carlsten M
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2024;44(2):50
Evaluation of Genetic or Cellular Impairments in Type I IFN Immunity in a Cohort of Young Adults with Critical COVID-19
Covill LE; Sendel A; Campbell TM; Piiroinen I; Enoksson SL; Borgstrom EW; Hansen S; Ma K; Marits P; Norlin AC; Smith CIE; Kahlin J; Eriksson LI; Bergman P; Bryceson YT
Article: NATURE. 2023;623(7988):803-813
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency
Le Voyer T; Parent AV; Liu X; Cederholm A; Gervais A; Rosain J; Nguyen T; Lorenzo MP; Rackaityte E; Rinchai D; Zhang P; Bizien L; Hancioglu G; Ghillani-Dalbin P; Charuel J-L; Philippot Q; Gueye MS; Renkilaraj MRLM; Ogishi M; Soudee C; Migaud M; Rozenberg F; Momenilandi M; Riller Q; Imberti L; Delmonte OM; Mueller G; Keller B; Orrego J; Gallego WAF; Rubin T; Emiroglu M; Parvaneh N; Eriksson D; Aranda-Guillen M; Berrios DI; Vong L; Katelaris CH; Mustillo P; Raedler J; Bohlen J; Celik JB; Astudillo C; Winter S; McLean C; Guffroy A; DeRisi JL; Yu D; Miller C; Feng Y; Guichard A; Beziat V; Bustamante J; Pan-Hammarstrom Q; Zhang Y; Rosen LB; Holland SM; Bosticardo M; Kenney H; Castagnoli R; Slade CA; Boztug K; Mahlaoui N; Latour S; Abraham RS; Lougaris V; Hauck F; Sediva A; Atschekzei F; Sogkas G; Poli MC; Slatter MA; Palterer B; Keller MD; Pinzon-Charry A; Sullivan A; Droney L; Suan D; Wong M; Kane A; Hu H; Ma C; Grombirikova H; Ciznar P; Dalal I; Aladjidi N; Hie M; Lazaro E; Franco J; Keles S; Malphettes M; Pasquet M; Maccari ME; Meinhardt A; Ikinciogullari A; Shahrooei M; Celmeli F; Frosk P; Goodnow CC; Gray PE; Belot A; Kuehn HS; Rosenzweig SD; Miyara M; Licciardi F; Servettaz A; Barlogis V; Le Guenno G; Herrmann V-M; Kuijpers T; Ducoux G; Sarrot-Reynauld F; Schuetz C; Cunningham-Rundles C; Rieux-Laucat F; Tangye SG; Sobacchi C; Doffinger R; Warnatz K; Grimbacher B; Fieschi C; Berteloot L; Bryant VL; Assant ST; Su H; Neven B; Abel L; Zhang Q; Boisson B; Cobat A; Jouanguy E; Kampe O; Bastard P; Roifman CM; Landegren N; Notarangelo LD; Anderson MS; Casanova J-L; Puel A
Article: IMMUNITY. 2023;56(6):1285-1302.e7
Human skin-resident CD8+T cells require RUNX2 and RUNX3 for induction of cytotoxicity and expression of the integrin CD49a
Zitti B; Hoffer E; Zheng W; Pandey RV; Schlums H; Casoni GP; Fusi I; Nguyen L; Karner J; Kokkinou E; Carrasco A; Gahm J; Ehrstrom M; Happaniemi S; Keita AV; Hedin CRH; Mjosberg J; Eidsmo L; Bryceson YT
Article: CELL REPORTS MEDICINE. 2023;4(5):101038
The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis
Kokkinou E; Soini T; Pandey RV; van Acker A; Theorell J; Czarnewski P; Kvedaraite E; Vandamme N; Lourda M; Sorini C; Weigel W; Carrasco A; Tibbitt CA; Schlums H; Lindforss U; Nordenvall C; Ljunggren M; Idestrom M; Svensson M; Henter J-I; Villablanca EJ; Bryceson YT; Rolandsdotter H; Mjosberg J
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2023;220(5):e20220170
Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia
Garcia-Garcia A; de Diego RP; Flores C; Rinchai D; Sole-Violan J; Deya-Martinez A; Garcia-Solis B; Lorenzo-Salazar JM; Hernandez-Brito E; Lanz A-L; Moens L; Bucciol G; Almuqamam M; Domachowske J; Colino E; Santos-Perez JL; Marco F; Pignata C; Bousfiha A; Turvey S; Bauer S; Haerynck F; Ocejo-Vinyals JG; Lendinez F; Prader S; Naumann-Bartsch N; Pachlopnik Schmid J; Biggs C; Hildebrand K; Dreesman A; Cardenes MA; Ailal F; Benhsaien I; Giardino G; Molina-Fuentes A; Fortuny C; Madhavarapu S; Conway D; Prando C; Schidlowski L; Alvarez MTMDS; Alfaro R; de Castro FR; Meyts I; Hauck F; Puel A; Bastard P; Boisson B; Jouanguy E; Abel L; Cobat A; Zhang Q; Casanova J-L; Alsina L; Rodriguez-Gallego C
Article: SCIENCE IMMUNOLOGY. 2023;8(82):eabn0484
Bcl11b sustains multipotency and restricts effector programs of intestinal-resident memory CD8+T cells
Helm EY; Zelenka T; Cismasiu VB; Islam S; Silvane L; Zitti B; Holmes TD; Drashansky TT; Kwiatkowski AJ; Tao C; Dean J; Obermayer AN; Chen X; Keselowsky BG; Zhang W; Huo Z; Zhou L; Sheridan BS; Conejo-Garcia JR; Shaw TI; Bryceson YT; Avram D
Article: EXPERIMENTAL CELL RESEARCH. 2023;425(2):113541
Viral host range factors antagonize pathogenic SAMD9 and SAMD9L variants
Gahr S; Casoni GP; Falk-Paulsen M; Maschkowitz G; Bryceson YT; Voss M
Article: SCIENCE SIGNALING. 2023;16(780):eabq0752
SHP-1 localization to the activating immune synapse promotes NK cell tolerance in MHC class I deficiency
Schmied L; Luu TT; Sondergaard JN; Hald SH; Meinke S; Mohammad DK; Singh SB; Mayer C; Casoni GP; Chrobok M; Schlums H; Rota G; Truong HM; Westerberg LS; Guarda G; Alici E; Wagner AK; Kadri N; Bryceson YT; Saeed MB; Hoglund P
Article: GENOME MEDICINE. 2023;15(1):22
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
Matuozzo D; Talouarn E; Marchal A; Zhang P; Manry J; Seeleuthner Y; Zhang Y; Bolze A; Chaldebas M; Milisavljevic B; Gervais A; Bastard P; Asano T; Bizien L; Barzaghi F; Abolhassani H; Abou Tayoun A; Aiuti A; Alavi Darazam I; Allende LM; Alonso-Arias R; Arias AA; Aytekin G; Bergman P; Bondesan S; Bryceson YT; Bustos IG; Cabrera-Marante O; Carcel S; Carrera P; Casari G; Chaibi K; Colobran R; Condino-Neto A; Covill LE; Delmonte OM; El Zein L; Flores C; Gregersen PK; Gut M; Haerynck F; Halwani R; Hancerli S; Hammarstroem L; Hatipoglu N; Karbuz A; Keles S; Kyheng C; Leon-Lopez R; Franco JL; Mansouri D; Martinez-Picado J; Metin Akcan O; Migeotte I; Morange P-E; Morelle G; Martin-Nalda A; Novelli G; Novelli A; Ozcelik T; Palabiyik F; Pan-Hammarstroem Q; de Diego RP; Planas-Serra L; Pleguezuelo DE; Prando C; Pujol A; Reyes LF; Riviere JG; Rodriguez-Gallego C; Rojas J; Rovere-Querini P; Schlueter A; Shahrooei M; Sobh A; Soler-Palacin P; Tandjaoui-Lambiotte Y; Tipu I; Tresoldi C; Troya J; van de Beek D; Zatz M; Zawadzki P; Al-Muhsen SZ; Alosaimi MF; Alsohime FM; Baris-Feldman H; Butte MJ; Constantinescu SN; Cooper MA; Dalgard CL; Fellay J; Heath JR; Lau Y-L; Lifton RP; Maniatis T; Mogensen TH; von Bernuth H; Lermine A; Vidaud M; Boland A; Deleuze J-F; Nussbaum R; Kahn-Kirby A; Mentre F; Tubiana S; Gorochov G; Tubach F; Hausfater P; Effort COVIDHG; Meyts I; Zhang S-Y; Puel A; Notarangelo LD; Boisson-Dupuis S; Su HC; Boisson B; Jouanguy E; Casanova J-L; Zhang Q; Abel L; Cobat A
Article: SCIENCE. 2023;379(6632):eabo3627-20
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children
Lee D; Le Pen J; Yatim A; Dong B; Aquino Y; Ogishi M; Pescarmona R; Talouarn E; Rinchai D; Zhang P; Perret M; Liu Z; Jordan I; Bozdemir SE; Bayhan GI; Beaufils C; Bizien L; Bisiaux A; Lei W; Hasan M; Chen J; Gaughan C; Asthana A; Libri V; Luna JM; Jaffre F; Hoffmann HH; Michailidis E; Moreews M; Seeleuthner Y; Bilguvar K; Mane S; Flores C; Zhang Y; Arias AA; Bailey R; Schluter A; Milisavljevic B; Bigio B; Le Voyer T; Materna M; Gervais A; Moncada-Velez M; Pala F; Lazarov T; Levy R; Neehus A-L; Rosain J; Peel J; Chan Y-H; Morin M-P; Pino-Ramirez RM; Belkaya S; Lorenzo L; Anton J; Delafontaine S; Toubiana J; Bajolle F; Fumado V; DeDiego ML; Fidouh N; Rozenberg F; Perez-Tur J; Chen S; Evans T; Geissmann F; Lebon P; Weiss SR; Bonnet D; Duval X; Pan-Hammarstrom Q; Planas AM; Meyts I; Haerynck F; Pujol A; Sancho-Shimizu V; Dalgard CL; Bustamante J; Puel A; Boisson-Dupuis S; Boisson B; Maniatis T; Zhang Q; Bastard P; Notarangelo L; Beziat V; de Diego RP; Rodriguez-Gallego C; Su HC; Lifton RP; Jouanguy E; Cobat A; Alsina L; Keles S; Haddad E; Abel L; Belot A; Quintana-Murci L; Rice CM; Silverman RH; Zhang S-Y; Casanova J-L
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2022;219(11):e20220514
Autoantibodies against type I IFNs in patients with critical influenza pneumonia
Zhang Q; Pizzorno A; Miorin L; Bastard P; Gervais A; Le Voyer T; Bizien L; Manry J; Rosain J; Philippot Q; Goavec K; Padey B; Cupic A; Laurent E; Saker K; Vanker M; Saerekannu K; Garcia-Salum T; Ferres M; Le Corre N; Sanchez-Cespedes J; Balsera-Manzanero M; Carratala J; Retamar-Gentil P; Abelenda-Alonso G; Valiente A; Tiberghien P; Zins M; Debette S; Meyts I; Haerynck F; Castagnoli R; Notarangelo LD; Gonzalez-Granado LI; Dominguez-Pinilla N; Andreakos E; Triantafyllia V; Rodriguez-Gallego C; Sole-Violan J; Ruiz-Hernandez JJ; Rodriguez de Castro F; Ferreres J; Briones M; Wauters J; Vanderbeke L; Feys S; Kuo C-Y; Lei W-T; Ku C-L; Tal G; Etzioni A; Hanna S; Fournet T; Casalegno J-S; Queromes G; Argaud L; Javouhey E; Rosa-Calatrava M; Cordero E; Aydillo T; Medina RA; Kisand K; Puel A; Jouanguy E; Abel L; Cobat A; Trouillet-Assant S; Garcia-Sastre A; Casanova J-L
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2022;42(8):1685-1695
Novel RAB27A Variant Associated with Late-Onset Hemophagocytic Lymphohistiocytosis Alters Effector Protein Binding
Zondag TCE; Torralba-Raga L; Van Laar JAM; Hermans MAW; Bouman A; Hollink IHIM; Van Hagen PM; Briggs DA; Hume AN; Bryceson YT
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2022;219(8):e20220131
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia
Zhang Q; Matuozzo D; Le Pen J; Lee D; Moens L; Asano T; Bohlen J; Liu Z; Moncada-Velez M; Kendir-Demirkol Y; Jing H; Bizien L; Marchal A; Abolhassani H; Delafontaine S; Bucciol G; Bayhan GI; Keles S; Kiykim A; Hancerli S; Haerynck F; Florkin B; Hatipoglu N; Ozcelik T; Morelle G; Zatz M; Ng LFP; Lye DC; Young BE; Leo Y-S; Dalgard CL; Lifton RP; Renia L; Meyts I; Jouanguy E; Hammarstrom L; Pan-Hammarstrom Q; Boisson B; Bastard P; Su HC; Boisson-Dupuis S; Abel L; Rice CM; Zhang S-Y; Cobat A; Casanova J-L
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2022;219(7):e20220202
Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency
Campbell TM; Liu Z; Zhang Q; Moncada-Velez M; Covill LE; Zhang P; Darazam IA; Bastard P; Bizien L; Bucciol G; Enoksson SL; Jouanguy E; Karabela SN; Khan T; Kendir-Demirkol Y; Augusto Arias A; Mansouri D; Marits P; Marr N; Migeotte I; Moens L; Ozcelik T; Pellier I; Sendel A; Senoglu S; Shahrooei M; Smith CIE; Vandernoot I; Willekens K; Yasar KK; Bergman P; Abel L; Cobat A; Casanova J-L; Meyts I; Bryceson YT
Article: SCIENCE IMMUNOLOGY. 2022;7(70):eabj8301
CD45RA⁺CD62L^- ILCs in human tissues represent a quiescent local reservoir for the generation of differentiated ILCs
Kokkinou E; Pandey RV; Mazzurana L; Gutierrez-Perez I; Tibbitt CA; Weigel W; Soini T; Carrasco A; Rao A; Nagasawa M; Bal SM; Jangard M; Friberg D; Lindforss U; Nordenvall C; Ljunggren M; Haapaniemi S; Keita AV; Soderholm J; Hedin C; Spits H; Bryceson YT; Mjosberg J
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;149(1):388-399.e4
Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity
Gross M; Speckmann C; May A; Gajardo-Carrasco T; Wustrau K; Maier SL; Panning M; Huzly D; Agaimy A; Bryceson YT; Choo S; Chow CW; Dueckers G; Fasth A; Fraitag S; Graewe K; Haxelmans S; Holzinger D; Hudowenz O; Huebschen JM; Khurana C; Kienle K; Klifa R; Korn K; Kutzner H; Laemmermann T; Ledig S; Lipsker D; Meeths M; Naumann-Bartsch N; Rascon J; Schaenzer A; Seidl M; Tesi B; Vauloup-Fellous C; Vollmer-Kary B; Warnatz K; Wehr C; Neven B; Vargas P; Sepulveda FE; Lehmberg K; Schmitt-Graeff A; Ehl S
Article: CELL STEM CELL. 2021;28(12):2062-2075.e5
Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy
Woan KV; Kim H; Bjordahl R; Davis ZB; Gaidarova S; Goulding J; Hancock B; Mahmood S; Abujarour R; Wang H; Tuininga K; Zhang B; Wu C-Y; Kodal B; Khaw M; Bendzick L; Rogers P; Ge MQ; Bonello G; Meza M; Felices M; Huffman J; Dailey T; Lee TT; Walcheck B; Malmberg KJ; Blazar BR; Bryceson YT; Valamehr B; Miller JS; Cichocki F
Article: SCIENCE IMMUNOLOGY. 2021;6(65):eabe3454
Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells
Hetemaki I; Kaustio M; Kinnunen M; Heikkila N; Keskitalo S; Nowlan K; Miettinen S; Sarkkinen J; Glumoff V; Andersson N; Kettunen K; Vanhanen R; Nurmi K; Eklund KK; Dunkel J; Mayranpaa MI; Schlums H; Arstila TP; Kisand K; Bryceson YT; Peterson P; Otava U; Syrjanen J; Saarela J; Varjosalo M; Kekalainen E
Article: ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS. 2021;69(1):31
Molecular Genetics Diversity of Primary Hemophagocytic Lymphohistiocytosis among Polish Pediatric Patients
Babol-Pokora K; Wolowiec M; Popko K; Jaworowska A; Bryceson YT; Tesi B; Henter J-I; Mlynarski W; Badowska W; Balwierz W; Drabko K; Kalwak K; Maciejka-Kemblowska L; Pieczonka A; Sobol-Milejska G; Koltan S; Malinowska I
Article: JOURNAL OF RHEUMATOLOGY. 2021;48(10):1596-1602
Efficacy of Moderately Dosed Etoposide in Macrophage Activation Syndrome-Hemophagocytic Lymphohistiocytosis
Horne A; Greenwood TVB; Chiang SCC; Meeths M; Bjorklund C; Ekelund M; Erensjo P; Berg S; Hagelberg S; Bryceson YT; Andersson U; Henter J-I
Article: SCIENCE IMMUNOLOGY. 2021;6(62):eabg3533
Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes
Parga-Vidal L; Behr FM; Kragten NAM; Nota B; Wesselink TH; Kavazovic I; Covill LE; Schuller MBP; Bryceson YT; Wensveen FM; van Lier RAW; van Dam TJP; Stark R; van Gisbergen KPJM
Article: SCIENCE IMMUNOLOGY. 2021;6(62):eabl4348
X-linked recessive TLR7 deficiency in ∼1% of men under 60 years old with life-threatening COVID-19
Asano T; Boisson B; Onodi F; Matuozzo D; Moncada-Velez M; Renkilaraj MRLM; Zhang P; Meertens L; Bolze A; Materna M; Korniotis S; Gervais A; Talouarn E; Bigio B; Seeleuthner Y; Bilguvar K; Zhang Y; Neehus A-L; Ogishi M; Pelham SJ; Le Voyer T; Rosain J; Philippot Q; Soler-Palacin P; Colobran R; Martin-Nalda A; Riviere JG; Tandjaoui-Lambiotte Y; Chaibi K; Shahrooei M; Darazam IA; Olyaei NA; Mansouri D; Palabiyik F; Ozcelik T; Novelli G; Novelli A; Casari G; Aiuti A; Carrera P; Bondesan S; Barzaghi F; Rovere-Querini P; Tresoldi C; Franco JL; Rojas J; Reyes LF; Bustos IG; Arias AA; Morelle G; Kyheng C; Troya J; Planas-Serra L; Schluter A; Gut M; Pujol A; Allende LM; Rodriguez-Gallego C; Flores C; Cabrera-Marante O; Pleguezuelo DE; de Diego RP; Keles S; Aytekin G; Akcan OM; Bryceson YT; Bergman P; Brodin P; Smole D; Smith CIE; Norlin A-C; Campbell TM; Covill LE; Hammarstrom L; Pan-Hammarstrom Q; Abolhassani H; Mane S; Marr N; Ata M; Al Ali F; Khan T; Spaan AN; Dalgard CL; Bonfanti P; Biondi A; Tubiana S; Burdet C; Nussbaum R; Kahn-Kirby A; Snow AL; Bustamante J; Puel A; Boisson-Dupuis S; Zhang S-Y; Beziat V; Lifton RP; Bastard P; Notarangelo LD; Abel L; Su HC; Jouanguy E; Amara A; Soumelis V; Cobat A; Zhang Q; Casanova J-L
Article: EUROPEAN JOURNAL OF ANAESTHESIOLOGY. 2021;38(7):692-701
Clinical and laboratory signs of haemophagocytic lymphohistiocytosis associated with pandemic influenza A (H1N1) infection in patients needing extracorporeal membrane oxygenation A retrospective observational study
Greenwood TVB; Holzgraefe B; Chiang SCC; Wang Y; Tesi B; Bryceson YT; Henter J-I
Article: BLOOD. 2021;137(15):2033-2045
RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis
Kalinichenko A; Casoni GP; Dupre L; Trotta L; Huemer J; Galgano D; German Y; Haladik B; Pazmandi J; Thian M; Petronczki OY; Chiang SC; Taskinen M; Hekkala A; Kauppila S; Lindgren O; Tapiainen T; Kraakman MJ; Vettenranta K; Lomakin AJ; Saarela J; Seppanen MRJ; Bryceson YT; Boztug K
Article: ACTA PAEDIATRICA, INTERNATIONAL JOURNAL OF PAEDIATRICS. 2021;110(4):1315-1321
Patients with both Langerhans cell histiocytosis and Crohn's disease highlight a common role of interleukin-23
Kvedaraite E; Lourda M; Han H; Tesi B; Mitchell J; Idestrom M; Mouratidou N; Rassidakis G; Greenwood TVB; Cohen-Aubart F; Jadersten M; Akefeldt SO; Svensson M; Kannourakis G; Bryceson YT; Haroche J; Henter J-I
Article: SCIENCE IMMUNOLOGY. 2021;6(57):eabc9801
The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation
Holmes TD; Pandey RV; Helm EY; Schlums H; Han H; Campbell TM; Drashansky TT; Chiang S; Wu C-Y; Tao C; Shoukier M; Tolosa E; Von Hardenberg S; Sun M; Klemann C; Marsh RA; Lau CM; Lin Y; Sun JC; Mansson R; Cichocki F; Avram D; Bryceson YT
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51(3):694-702
Mass cytometry analysis of blood immune cells from psoriasis patients on biological therapy
Solberg SM; Aarebrot AK; Sarkar I; Petrovic A; Sandvik LF; Bergum B; Jonsson R; Bryceson YT; Appel S
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(10):e1346
LIR-1 educates expanded human NK cells and defines a unique antitumor NK cell subset with potent antibody-dependent cellular cytotoxicity
Leijonhufvud C; Reger R; Segerberg F; Theorell J; Schlums H; Bryceson YT; Childs RW; Carlsten M
Article: CELL. 2020;183(4):968-981.e7
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19
Consiglio CR; Cotugno N; Sardh F; Pou C; Amodio D; Rodriguez L; Tan Z; Zicari S; Ruggiero A; Pascucci GR; Santilli V; Campbell T; Bryceson Y; Eriksson D; Wang J; Marchesi A; Lakshmikanth T; Campana A; Villani A; Rossi P; Landegren N; Palma P; Brodin P
Article: SCIENCE. 2020;370(6515):eabd4585
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Bastard P; Rosen LB; Zhang Q; Michailidis E; Hoffmann H-H; Zhang Y; Dorgham K; Philippot Q; Rosain J; Beziat V; Manry J; Shaw E; Haljasmagi L; Peterson P; Lorenzo L; Bizien L; Trouillet-Assant S; Dobbs K; de Jesus AA; Belot A; Kallaste A; Catherinot E; Tandjaoui-Lambiotte Y; Le Pen J; Kerner G; Bigio B; Seeleuthner Y; Yang R; Bolze A; Spaan AN; Delmonte OM; Abers MS; Aiuti A; Casari G; Lampasona V; Piemonti L; Ciceri F; Bilguvar K; Lifton RP; Vasse M; Smadja DM; Migaud M; Hadjadj J; Terrier B; Duffy D; Quintana-Murci L; van de Beek D; Roussel L; Vinh DC; Tangye SG; Haerynck F; Dalmau D; Martinez-Picado J; Brodin P; Nussenzweig MC; Boisson-Dupuis S; Rodriguez-Gallego C; Vogt G; Mogensen TH; Oler AJ; Gu J; Burbelo PD; Cohen JI; Biondi A; Bettini LR; D'Angio M; Bonfanti P; Rossignol P; Mayaux J; Rieux-Laucat F; Husebye ES; Fusco F; Ursini MV; Imberti L; Sottini A; Paghera S; Quiros-Roldan E; Rossi C; Castagnoli R; Montagna D; Licari A; Marseglia GL; Duval X; Ghosn J; Tsang JS; Goldbach-Mansky R; Kisand K; Lionakis MS; Puel A; Zhang S-Y; Holland SM; Gorochov G; Jouanguy E; Rice CM; Cobat A; Notarangelo LD; Abel L; Su HC; Casanova J-L
Article: SCIENCE. 2020;370(6515):eabd4570
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Zhang Q; Bastard P; Liu Z; Le Pen J; Moncada-Velez M; Chen J; Ogishi M; Sabli IKD; Hodeib S; Korol C; Rosain J; Bilguvar K; Ye J; Bolze A; Bigio B; Yang R; Arias AA; Zhou Q; Zhang Y; Onodi F; Korniotis S; Karpf L; Philippot Q; Chbihi M; Bonnet-Madin L; Dorgham K; Smith N; Schneider WM; Razooky BS; Hoffmann H-H; Michailidis E; Moens L; Han JE; Lorenzo L; Bizien L; Meade P; Neehus A-L; Ugurbil AC; Corneau A; Kerner G; Zhang P; Rapaport F; Seeleuthner Y; Manry J; Masson C; Schmitt Y; Schlueter A; Le Voyer T; Khan T; Li J; Fellay J; Roussel L; Shahrooei M; Alosaimi MF; Mansouri D; Al-Saud H; Al-Mulla F; Almourfi F; Al-Muhsen SZ; Alsohime F; Al Turki S; Hasanato R; van de Beek D; Biondi A; Bettini LR; D'Angio M; Bonfanti P; Imberti L; Sottini A; Paghera S; Quiros-Roldan E; Rossi C; Oler AJ; Tompkins MF; Alba C; Vandernoot I; Goffard J-C; Smits G; Migeotte I; Haerynck F; Soler-Palacin P; Martin-Nalda A; Colobran R; Morange P-E; Keles S; Colkesen F; Ozcelik T; Yasar KK; Senoglu S; Karabela SN; Rodriguez-Gallego C; Novelli G; Hraiech S; Tandjaoui-Lambiotte Y; Duval X; Laouenan C; Snow AL; Dalgard CL; Milner JD; Vinh DC; Mogensen TH; Marr N; Spaan AN; Boisson B; Boisson-Dupuis S; Bustamante J; Puel A; Ciancanelli MJ; Meyts I; Maniatis T; Soumelis V; Amara A; Nussenzweig M; Garcia-Sastre A; Krammer F; Pujol A; Duffy D; Lifton RP; Zhang S-Y; Gorochov G; Beziat V; Jouanguy E; Sancho-Shimizu V; Rice CM; Abel L; Notarangelo LD; Cobat A; Su HC; Casanova J-L
Article: JOURNAL OF PEDIATRIC HEMATOLOGY/ONCOLOGY. 2020;42(7):e627-e629
Different Clinical Presentation of 3 Children With Familial Hemophagocytic Lymphohistiocytosis With 2 Novel Mutations
Akyol S; Ozcan A; Sekine T; Chiang SCC; Yilmaz E; Karakurkcu M; Patiroglu T; Bryceson Y; Unal E
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2020;40(6):901-916
Neuroinflammatory Disease as an Isolated Manifestation of Hemophagocytic Lymphohistiocytosis
Blincoe A; Heeg M; Campbell PK; Hines M; Khojah A; Klein-Gitelman M; Talano J-A; Speckmann C; Touzot F; Lankester A; Legger GE; Riviere JG; Garcia-Prat M; Alonso L; Putti MC; Lehmberg K; Maier S; El Chazli Y; Elmaksoud MA; Astigarraga I; Kurjane N; Bulina I; Kenina V; Bryceson Y; Rascon J; Lortie A; Goldstein G; Booth C; Worth A; Wassmer E; Schmitt EG; Warren JT; Bednarski JJ; Ali S; Chiang K-Y; Krueger J; Henry MM; Holland SM; Marsh RA; Ehl S; Haddad E
Article: PEDIATRIC BLOOD AND CANCER. 2020;67(4):e28184
Diagnostic challenges for a novel SH2D1A mutation associated with X-linked lymphoproliferative disease
Torralba-Raga L; Tesi B; Chiang SCC; Schlums H; Nordenskjoeld M; Horne A; Henter J-I; Meeths M; Abdelhaleem M; Weitzman S; Bryceson Y
Article: PLOS BIOLOGY. 2020;18(3):e3000648
Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity
Kavazovic I; Han H; Balzaretti G; Slinger E; Lemmermann NAW; ten Brinke A; Merkler D; Koster J; Bryceson YT; de Vries N; Jonjic S; Klarenbeek PL; Polic B; Eldering E; Wensveen FM
Article: JOURNAL OF PEDIATRIC HEMATOLOGY/ONCOLOGY. 2020;42(2):156-159
A Rare Case of Activated Phosphoinositide 3-Kinase Delta Syndrome (APDS) Presenting With Hemophagocytosis Complicated With Hodgkin Lymphoma
Cansever M; Zietara N; Chiang SCC; Ozcan A; Yilmaz E; Karakukcu M; Rohlfs M; Somekh I; Canoz O; Abdulrezzak U; Bryceson Y; Klein C; Unal E; Patiroglu T
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:1154
Alternative UNC13D Promoter Encodes a Functional Munc13-4 Isoform Predominantly Expressed in Lymphocytes and Platelets
Galgano D; Soheili T; Voss M; Torralba-Raga L; Tesi B; Cichocki F; Andre I; Rettig J; Cavazzana M; Bryceson Y
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2019;216(12):2778-2799
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function
Lam MT; Coppola S; Krumbach OHF; Prencipe G; Insalaco A; Cifaldi C; Brigida I; Zara E; Scala S; Di Cesare S; Martinelli S; Di Rocco M; Pascarella A; Niceta M; Pantaleoni F; Ciolfi A; Netter P; Carisey AF; Diehl M; Akbarzadeh M; Conti F; Merli P; Pastore A; Mortera SL; Camerini S; Farina L; Buchholzer M; Pannone L; Cao TN; Coban-Akdemir ZH; Jhangiani SN; Muzny DM; Gibbs RA; Basso-Ricci L; Chiriaco M; Dvorsky R; Putignani L; Carsetti R; Janning P; Stray-Pedersen A; Erichsen HC; Horne A; Bryceson YT; Torralba-Raga L; Ramme K; Rosti V; Bracaglia C; Messia V; Palma P; Finocchi A; Locatelli F; Chinn IK; Lupski JR; Mace EM; Cancrini C; Aiuti A; Ahmadian MR; Orange JS; De Benedetti F; Tartaglia M
Article: MINERVA ANESTESIOLOGICA. 2019;85(12):1289-1298
Elevated ferritin and soluble CD25 in critically ill patients are associated with parameters of (hyper) inflammation and lymphocyte cytotoxicity
von Bahr Greenwood T; Palmkvist-Kaijser K; Chiang SC; Tesi B; Bryceson YT; Hjelmqvist H; Henter J-I
Article: NATURE COMMUNICATIONS. 2019;10(1):3106
Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis
Serwas NK; Hoeger B; Ardy RC; Stulz SV; Sui Z; Memaran N; Meeths M; Krolo A; Petronczki OY; Pfajfer L; Hou TZ; Halliday N; Santos-Valente E; Kalinichenko A; Kennedy A; Mace EM; Mukherjee M; Tesi B; Schrempf A; Loizou JI; Kain R; Bidmon-Fliegenschnee B; Schickel J-N; Glauzy S; Huemer J; Garncarz W; Salzer E; Pierides I; Bilic I; Thiel J; Priftakis P; Banerjee PP; Foerster-Waldl E; Medgyesi D; Huber W-D; Orange JS; Meffre E; Sansom DM; Bryceson YT; Altman A; Boztug K
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2019;216(6):1280-1290
Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria
Hart GT; Tran TM; Theorell J; Schlums H; Arora G; Rajagopalan S; Sangala ADJ; Welsh KJ; Traore B; Pierce SK; Crompton PD; Bryceson YT; Long EO
Article: CANCER. 2019;125(11):1848-1854
Haploinsufficiency of UNC13D increases the risk of lymphoma
Lofstedt A; Ahlm C; Tesi B; Bergdahl IA; Nordenskjold M; Bryceson YT; Henter J-I; Meeths M
Article: PEDIATRIC INFECTIOUS DISEASE JOURNAL. 2019;38(2):e29-e31
Fatal Central Nervous System Lymphocytic Vasculitis after Treatment for Burkitt Lymphoma in a Patient with a SH2D1A Mutation
Neves JF; Raga LT; Chiang SCC; Tesi B; Vieira JP; Cordeiro AI; Borrego L; Bryceson YT
Article: PLOS ONE. 2019;14(3):e0203247
Determination of essential phenotypic elements of clusters in high-dimensional entities-DEPECHE
Theorell A; Bryceson YT; Theorell J
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1354
Progressive Impairment of NK Cell Cytotoxic Degranulation Is Associated With TGF-β1 Deregulation and Disease Progression in Pancreatic Cancer
Jun E; Song AY; Choi J-W; Lee HH; Kim M-Y; Ko D-H; Kang HJ; Kim SW; Bryceson Y; Kim SC; Kim HS
Article: NPJ GENOMIC MEDICINE. 2019;4:14
Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease
Keskitalo S; Haapaniemi EM; Glumoff V; Liu X; Lehtinen V; Fogarty C; Rajala H; Chiang SC; Mustjoki S; Kovanen P; Lohi J; Bryceson YT; Seppanen M; Kere J; Heiskanen K; Varjosalo M
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1855
Cytotoxic Granule Exocytosis From Human Cytotoxic T Lymphocytes Is Mediated by VAMP7
Chitirala P; Ravichandran K; Galgano D; Sleiman M; Krause E; Bryceson YT; Rettig J
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2728
Dynamic Changes in Natural Killer Cell Subset Frequencies in the Absence of Cytomegalovirus Infection
Gyurova IE; Schlums H; Sucharew H; Ambroggio L; Ochayon DE; Win HT; Bryceson YT; Bernsteins DI; Waggoner SN
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2018;88(6):e12725
Serum cytokine measurements and biological therapy of psoriasis - Prospects for personalized treatment?
Solberg SM; Sandvik LF; Eidsheim M; Jonsson R; Bryceson YT; Appel S
Article: SCIENCE IMMUNOLOGY. 2018;3(29):eaat9781
Clonal expansion and compartmentalized maintenance of rhesus macaque NK cell subsets
Wu C; Espinoza DA; Koelle SJ; Yang D; Truitt L; Schlums H; Lafont BA; Davidson-Moncada JK; Lu R; Kaur A; Hammer Q; Li B; Panch S; Allan DA; Donahue RE; Childs RW; Romagnani C; Bryceson YT; Dunbar CE
Article: NATURE IMMUNOLOGY. 2018;19(10):1083-1092
NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development
Jelencic V; Sestan M; Kavazovic I; Lenartic M; Marinovic S; Holmes TD; Prchal-Murphy M; Lisnic B; Sexl V; Bryceson YT; Wensveen FM; Polic B
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2018;215(9):2379-2395
ARID5B regulates metabolic programming in human adaptive NK cells
Cichocki F; Wu C-Y; Zhang B; Felices M; Tesi B; Tuininga K; Dougherty P; Taras E; Hinderlie P; Blazar BR; Bryceson YT; Miller JS
Article: BRITISH JOURNAL OF DERMATOLOGY. 2018;179(2):371-380
Phosphorylation of intracellular signalling molecules in peripheral blood cells from patients with psoriasis on originator or biosimilar infliximab
Aarebrot AK; Solberg SM; Davies R; Bader LI; Holmes TD; Gavasso S; Bryceson YT; Jonsson R; Sandvik LF; Appel S
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;142(1):333-335.e8
Screening for Wiskott-Aldrich syndrome by flow cytometry
Chiang SCC; Vergamini SM; Husami A; Neumeier L; Quinn K; Ellerhorst T; Sheppard L; Gifford C; Buchbinder D; Joshi A; Ifversen M; Kleiner GI; Bussel JB; Chandrakasan S; Pesek RD; Pozos TC; Rose MJ; Scurlock AM; Zhang K; Bryceson YT; Bleesing J; Marsh RA
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;142(1):317-321.e8
A RAB27A 5′ untranslated region structural variant associated with late-onset hemophagocytic lympho-histiocytosis and normal pigmentation
Tesi B; Rascon J; Chiang SCC; Burnyte B; Lofstedt A; Fasth A; Heizmann M; Juozapaite S; Kiudeliene R; Kvedaraite E; Miseviciene V; Muleviciene A; Mueller M-L; Nordenskjold M; Matuzeviciene R; Samaitiene R; Speckmann C; Stankeviciene S; Zekas V; Voss M; Ehl S; Vaiciene-Magistris N; Henter J-I; Meeths M; Bryceson YT
Article: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(7):1070-1077
The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE
Hagberg N; Joelsson M; Leonard D; Reid S; Eloranta M-L; Mo J; Nilsson MK; Syvanen A-C; Bryceson YT; Ronnblom L
Article: HAEMATOLOGICA. 2018;103(3):427-437
Constitutional SAMD9L mutations cause familial myelodysplastic syndrome and transient monosomy 7
Pastor VB; Sahoo SS; Boklan J; Schwabe GC; Saribeyoglu E; Strahm B; Lebrecht D; Voss M; Bryceson YT; Erlacher M; Ehninger G; Niewisch M; Schlegelberger B; Baumann I; Achermann JC; Shimamura A; Hochrein J; Tedgard U; Nilsson L; Hasle H; Boerries M; Busch H; Niemeyer CM; Wlodarski MW
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:3146
Comprehensive Genetic Results for Primary Immunodeficiency Disorders in a Highly Consanguineous Population
Al-Herz W; Chou J; Delmonte OM; Massaad MJ; Bainter W; Castagnoli R; Klein C; Bryceson YT; Geha RS; Notarangelo LD
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(6):491-502
Patients with Primary Sjogren's Syndrome Have Alterations in Absolute Quantities of Specific Peripheral Leucocyte Populations
Davies R; Hammenfors D; Bergum B; Jakobsen K; Solheim M; Vogelsang P; Brun JG; Bryceson Y; Jonsson R; Appel S
Article: CANCER RESEARCH. 2017;77(20):5664-5675
GSK3 Inhibition Drives Maturation of NK Cells and Enhances Their Antitumor Activity
Cichocki F; Valamehr B; Bjordahl R; Zhang B; Rezner B; Rogers P; Gaidarova S; Moreno S; Tuininga K; Dougherty P; McCullar V; Howard P; Sarhan D; Taras E; Schlums H; Abbot S; Shoemaker D; Bryceson YT; Blazar BR; Wolchko S; Cooley S; Miller JS
Article: ELIFE. 2017;6:e26423
High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors
Marcais A; Marotel M; Degouve S; Koenig A; Fauteux-Daniel S; Drouillard A; Schlums H; Viel S; Besson L; Allatif O; Blery M; Vivier E; Bryceson Y; Thaunat O; Walzer T
Article: LEUKEMIA. 2017;31(5):1108-1116
Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia
Ilander M; Olsson-Stromberg U; Schlums H; Guilhot J; Bruck O; Lahteenmaki H; Kasanen T; Koskenvesa P; Soderlund S; Hoglund M; Markevarn B; Sjalander A; Lotfi K; Dreimane A; Lubking A; Holm E; Bjoreman M; Lehmann S; Stenke L; Ohm L; Gedde-Dahl T; Majeed W; Ehrencrona H; Koskela S; Saussele S; Mahon F-X; Porkka K; Hjorth-Hansen H; Bryceson YT; Richter J; Mustjoki S
Article: BLOOD. 2017;129(16):2266-2279
Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms
Tesi B; Davidsson J; Voss M; Rahikkala E; Holmes TD; Chiang SCC; Komulainen-Ebrahim J; Gorcenco S; Nilsson AR; Ripperger T; Kokkonen H; Bryder D; Fioretos T; Henter J-I; Mottonen M; Niinimaki R; Nilsson L; Pronk CJ; Puschmann A; Qian H; Uusimaa J; Moilanen J; Tedgard U; Cammenga J; Bryceson YT
Article: BLOOD. 2017;129(14):1940-1946
Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs
Corat MAF; Schlums H; Wu C; Theorell J; Espinoza DA; Sellers SE; Townsley DM; Young NS; Bryceson YT; Dunbar CE; Winkler T
Article: BLOOD. 2017;129(14):1927-1939
Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells
Schlums H; Jung M; Han H; Theorell J; Bigley V; Chiang SCC; Allan DSJ; Davidson-Moncada JK; Dickinson RE; Holmes TD; Hsu AP; Townsley D; Winkler T; Wang W; Aukrust P; Nordoy I; Calvo KR; Holland SM; Collin M; Dunbar CE; Bryceson YT
Article: CLINICAL IMMUNOLOGY. 2017;177:29-42
Natural killer cell biology illuminated by primary immunodeficiency syndromes in humans
Voss M; Bryceson YT
Article: JOURNAL OF MEDICAL GENETICS. 2017;54(3):196-201
Mutations in the phosphatidylinositol glycan C (PIGC) gene are associated with epilepsy and intellectual disability
Edvardson S; Murakami Y; Thi TMN; Shahrour M; St-Denis A; Shaag A; Damseh N; Le Deist F; Bryceson Y; Abu-Libdeh B; Campeau PM; Kinoshita T; Elpeleg O
Article: IMMUNITY. 2017;46(2):287-300
CD49a Expression Defines Tissue-Resident CD8⁺ T Cells Poised for Cytotoxic Function in Human Skin
Cheuk S; Schlums H; Serezal IG; Martini E; Chiang SC; Marquardt N; Gibbs A; Detlofsson E; Introini A; Forkel M; Hoog C; Tjernlund A; Michaelsson J; Folkersen L; Mjosberg J; Blomqvist L; Ehrstrom M; Stahle M; Bryceson YT; Eidsmo L
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:723
Unperturbed cytotoxic lymphocyte Phenotype and Function in Myalgic encephalomyelitis/chronic Fatigue syndrome Patients
Theorell J; Bileviciute-Ljungar I; Tesi B; Schlums H; Johnsgaard MS; Asadi-Azarbaijani B; Strand EB; Bryceson YT
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:426
Differences in Granule Morphology yet Equally Impaired Exocytosis among Cytotoxic T Cells and NK Cells from Chediak-Higashi Syndrome Patients
Chiang SCC; Wood SM; Tesi B; Akar HH; Al-Herz W; Ammann S; Belen FB; Caliskan U; Kaya Z; Lehmberg K; Patiroglu T; Tokgoz H; Unuvar A; Introne WJ; Henter J-I; Nordenskjold M; Ljunggren H-G; Meeths M; Ehl S; Krzewski K; Bryceson YT
Article: GENES. 2016;7(12):E108-108
Novel PIGT Variant in Two Brothers: Expansion of the Multiple Congenital Anomalies-Hypotonia Seizures Syndrome 3 Phenotype
Skauli N; Wallace S; Chiang SCC; Baroy T; Holmgren A; Stray-Pedersen A; Bryceson YT; Stromme P; Frengen E; Misceo D
Article: BIOCONJUGATE CHEMISTRY. 2016;27(9):2095-2102
Site-Specific Photolabeling of the IgG Fab Fragment Using a Small Protein G Derived Domain
Kanje S; von Witting E; Chiang SCC; Bryceson YT; Hobert S
Article: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2016;65(9):1135-1147
Reduced potency of cytotoxic T lymphocytes from patients with high-risk myelodysplastic syndromes
Sand K; Theorell J; Bruserud O; Bryceson YT; Kittang AO
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2016;36(5):480-489
Successful Hematopoietic Stem Cell Transplantation in a Patient with LPS-Responsive Beige-Like Anchor (LRBA) Gene Mutation
Tesi B; Priftakis P; Lindgren F; Chiang SCC; Kartalis N; Lofstedt A; Lorinc E; Henter J-I; Winiarski J; Bryceson YT; Meeths M
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2016;137(4):1165-1177
Chediak-Higashi syndrome: Lysosomal trafficking regulator domains regulate exocytosis of lytic granules but not cytokine secretion by natural killer cells
Gil-Krzewska A; Wood SM; Murakami Y; Victoria N; Chiang SCC; Cullinane AR; Peruzzi G; Gahl WA; Coligan JE; Introne WJ; Bryceson YT; Krzewski K
Article: LEUKEMIA. 2016;30(2):456-463
CD56^dimCD57⁺NKG2C⁺ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT
Cichocki F; Cooley S; Davis Z; DeFor TE; Schlums H; Zhang B; Brunstein CG; Blazar BR; Wagner J; Diamond DJ; Verneris MR; Bryceson YT; Weisdorf DJ; Miller JS
Article: METHODS IN MOLECULAR BIOLOGY. 2016;1441:117-130
Analysis of Intracellular Ca(2+) Mobilization in Human NK Cell Subsets by Flow Cytometry.
Theorell J; Bryceson YT
Article: GENOME MEDICINE. 2015;7:130
Targeted high-throughput sequencing for genetic diagnostics of hemophagocytic lymphohistiocytosis
Tesi B; Lagerstedt-Robinson K; Chiang SCC; Ben Bdira E; Abboud M; Belen B; Devecioglu O; Fadoo Z; Yeoh AEJ; Erichsen HC; Mottonen M; Akar HH; Hastbacka J; Kaya Z; Nunes S; Patiroglu T; Sabel M; Saribeyoglu ET; Tvedt TH; Unal E; Unal S; Unuvar A; Meeths M; Henter J-I; Nordenskjold M; Bryceson YT
Article: THE LANCET HAEMATOLOGY. 2015;2(12):e536-e542
Cancer risk in relatives of patients with a primary disorder of lymphocyte cytotoxicity: a retrospective cohort study
Lofstedt A; Chiang SCC; Oneloev E; Bryceson YT; Meeths M; Henter J-I
Article: PEDIATRIC BLOOD AND CANCER. 2015;62(12):2094-2100
Spectrum of Atypical Clinical Presentations in Patients With Biallelic PRF1 Missense Mutations
Tesi B; Chiang SCC; El-Ghoneimy D; Hussein AA; Langenskiold C; Wali R; Fadoo Z; Silva JP; Lecumberri R; Unal S; Nordenskjold M; Bryceson YT; Henter J-I; Meeths M
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2015;21(9):1653-1662
Adaptive Natural Killer Cell and Killer Cell Immunoglobulin-Like Receptor-Expressing T Cell Responses are Induced by Cytomegalovirus and Are Associated with Protection against Cytomegalovirus Reactivation after Allogeneic Donor Hematopoietic Cell Transplantation
Davis ZB; Cooley SA; Cichocki F; Felices M; Wangen R; Luo X; DeFor TE; Bryceson YT; Diamond DJ; Brunstein C; Blazar BR; Wagner JE; Weisdorf DJ; Horowitz A; Guethlein LA; Parham P; Verneris MR; Miller JS
Article: JOURNAL OF CELL BIOLOGY. 2015;210(1):135-151
VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity.
Marshall MR; Pattu V; Halimani M; Maier-Peuschel M; Müller M-L; Becherer U; Hong W; Hoth M; Tschernig T; Bryceson YT; Rettig J
Article: HAEMATOLOGICA. 2015;100(7):978-988
The syndrome of hemophagocytic lymphohistiocytosis in primary immunodeficiencies: implications for differential diagnosis and pathogenesis
Bode SFN; Ammann S; Al-Herz W; Bataneant M; Dvorak CC; Gehring S; Gennery A; Gilmour KC; Gonzalez-Granado LI; Gross-Wieltsch U; Ifversen M; Lingman-Framme J; Matthes-Martin S; Mesters R; Meyts I; van Montfrans JM; Schmid JP; Pai S-Y; Soler-Palacin P; Schuermann U; Schuster V; Seidel MG; Speckmann C; Stepensky P; Sykora K-W; Tesi B; Vraetz T; Waruiru C; Bryceson YT; Moshous D; Lehmberg K; Jordan MB; Ehl S
Article: JOURNAL OF IMMUNOLOGY. 2015;194(9):4518-4527
Coordinated Expression of DNAM-1 and LFA-1 in Educated NK Cells
Enqvist M; Ask EH; Forslund E; Carlsten M; Abrahamsen G; Beziat V; Andersson SA; Schaffer M; Spurkland A; Bryceson Y; Onfelt B; Malmberg K-J
Article: ARTHRITIS & RHEUMATOLOGY. 2015;67(4):1000-1011
Functional Anti-CD94/NKG2A and Anti-CD94/NKG2C Autoantibodies in Patients With Systemic Lupus Erythematosus
Hagberg N; Theorell J; Hjorton K; Spee P; Eloranta M-L; Bryceson YT; Roennblom L
Article: IMMUNITY. 2015;42(3):443-456
Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function
Schlums H; Cichocki F; Tesi B; Theorell J; Beziat V; Holmes TD; Han H; Chiang SCC; Foley B; Mattsson K; Larsson S; Schaffer M; Malmberg K-J; Ljunggren H-G; Miller JS; Bryceson YT
Article: PEDIATRIC BLOOD AND CANCER. 2015;62(2):346-352
Incidence and Clinical Presentation of Primary Hemophagocytic Lymphohistiocytosis in Sweden
Meeths M; Horne A; Sabel M; Bryceson YT; Henter J-I
Article: BLOOD. 2015;125(4):639-648
Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3
Haapaniemi EM; Kaustio M; Rajala HLM; van Adrichem AJ; Kainulainen L; Glumoff V; Doffinger R; Kuusanmaki H; Heiskanen-Kosma T; Trotta L; Chiang S; Kulmala P; Eldfors S; Katainen R; Siitonen S; Karjalainen-Lindsberg M-L; Kovanen PE; Otonkoski T; Porkka K; Heiskanen K; Hanninen A; Bryceson YT; Uusitalo-Seppala R; Saarela J; Seppanen M; Mustjoki S; Kere J
Article: PEDIATRIC BLOOD AND CANCER. 2014;61(12):2313-2315
Hematopoietic Stem Cell Transplantation of an Adolescent With Neurological Manifestations of Homozygous Missense PRF1 Mutation
Hussein AA; Hamadah T; Qandeel M; Sughayer M; Amarin R; Mansour A; Chiang SC; Al-Zaben A; Meeths M; Bryceson YT
Article: PEDIATRIC BLOOD AND CANCER. 2014;61(7):1329-1335
Updates on Histiocytic Disorders
Vaiselbuh SR; Bryceson YT; Allen CE; Whitlock JA; Abla O
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2014;211(6):1079-1091
Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency
Cichocki F; Schlums H; Li H; Stache V; Holmes T; Lenvik TR; Chiang SCC; Miller JS; Meeths M; Anderson SK; Bryceson YT
Article: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2014;63(6):627-641
Immunomodulatory activity of commonly used drugs on Fc-receptor-mediated human natural killer cell activation
Theorell J; Gustavsson A-L; Tesi B; Sigmundsson K; Ljunggren H-G; Lundbaeck T; Bryceson YT
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2014;34(4):469-477
Novel STAT3 Mutation Causing Hyper-IgE Syndrome: Studies of the Clinical Course and Immunopathology
Sundin M; Tesi B; Bohme MS; Bryceson YT; Putsep K; Chiang SC; Thunberg S; Winiarski J; Wikstorm A-C
Article: BLOOD. 2014;123(6):863-874
The evolution of cellular deficiency in GATA2 mutation
Dickinson RE; Milne P; Jardine L; Zandi S; Swierczek SI; McGovern N; Cookson S; Ferozepurwalla Z; Langridge A; Pagan S; Gennery A; Heiskanen-Kosma T; Hamalainen S; Seppanen M; Helbert M; Tholouli E; Gambineri E; Reykdal S; Gottfredsson M; Thaventhiran JE; Morris E; Hirschfield G; Richter AG; Jolles S; Bacon CM; Hambleton S; Haniffa M; Bryceson Y; Allen C; Prchal JT; Dick JE; Bigley V; Collin M
Article: FRONTIERS IN IMMUNOLOGY. 2014;4:515
An N-terminal missense mutation in STX11 causative of FHLA abrogates syntaxin-11 binding to Munc18-2
Muller M-L; Chiang SCC; Meeths M; Tesi B; Entesarian M; Nilsson D; Wood SM; Nordenskjold M; Henter J-I; Naqvi A; Bryceson YT
Article: JOURNAL OF VIROLOGY. 2013;87(24):13446-13455
Epstein-Barr Virus Coinfection in Children Boosts Cytomegalovirus-Induced Differentiation of Natural Killer Cells
Saghafian-Hedengren S; Sohlberg E; Theorell J; Carvalho-Queiroz C; Nagy N; Persson J-O; Nilsson C; Bryceson YT; Sverremark-Ekstrom E
Article: RHEUMATOLOGY. 2013;52(10):1818-1823
Anti-NKG2A autoantibodies in a patient with systemic lupus erythematosus
Hagberg N; Theorell J; Eloranta M-L; Pascal V; Bryceson YT; Ronnblom L
Article: JOURNAL OF IMMUNOLOGY. 2013;191(6):2989-2998
Systemic Lupus Erythematosus Immune Complexes Increase the Expression of SLAM Family Members CD319 (CRACC) and CD229 (LY-9) on Plasmacytoid Dendritic Cells and CD319 on CD56^dim NK Cells
Hagberg N; Theorell J; Schlums H; Eloranta M-L; Bryceson YT; Ronnblom L
Article: BLOOD. 2013;122(8):1411-1418
Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage
Cohnen A; Chiang SC; Stojanovic A; Schmidt H; Claus M; Saftig P; Janssen O; Cerwenka A; Bryceson YT; Watzl C
Article: JOURNAL OF MEDICAL GENETICS. 2013;50(8):521-528
A novel intellectual disability syndrome caused by GPI anchor deficiency due to homozygous mutations in PIGT
Kvarnung M; Nilsson D; Lindstrand A; Korenke GC; Chiang SCC; Blennow E; Bergmann M; Stodberg T; Makitie O; Anderlid B-M; Bryceson YT; Nordenskjold M; Nordgren A
Article: HAEMATOLOGICA. 2013;98(5):760-764
Development of classical Hodgkin's lymphoma in an adult with biallelic STXBP2 mutations.
Machaczka M; Klimkowska M; Chiang SCC; Meeths M; Müller M-L; Gustafsson B; Henter J-I; Bryceson YT
Article: BLOOD. 2013;121(8):1345-1356
Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production
Chiang SCC; Theorell J; Entesarian M; Meeths M; Mastafa M; Al-Herz W; Frisk P; Gilmour KC; Ifversen M; Langenskiold C; Machaczka M; Naqvi A; Payne J; Perez-Martinez A; Sabel M; Unal E; Unal S; Winiarski J; Nordenskjold M; Ljunggren H-G; Henter J-I; Bryceson YT
Article: STEM CELLS AND DEVELOPMENT. 2012;21(17):3147-3151
Treatment of Familial Hemophagocytic Lymphohistiocytosis with Third-Party Mesenchymal Stromal Cells
Mougiakakos D; Machaczka M; Jitschin R; Klimkowska M; Entesarian M; Bryceson YT; Henter J-I; Sander B; Le Blanc K
Article: PEDIATRIC BLOOD AND CANCER. 2012;59(1):191-193
Hemophagocytic syndrome in a 4-month-old infant with biotinidase deficiency
Kardas F; Patiroglu T; Unal E; Chiang SCC; Bryceson YT; Kendirci M
Article: BLOOD. 2012;119(12):2754-2763
A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes
Bryceson YT; Pende D; Maul-Pavicic A; Gilmour KC; Ufheil H; Vraetz T; Chiang SC; Marcenaro S; Meazza R; Bondzio I; Walshe D; Janka G; Lehmberg K; Beutel K; zur Stadt U; Binder N; Arico M; Moretta L; Henter J-I; Ehl S
Article: PLOS ONE. 2012;7(1):e29672
Kinome Analysis of Receptor-Induced Phosphorylation in Human Natural Killer Cells
Koenig S; Nimtz M; Scheiter M; Ljunggren H-G; Bryceson YT; Jaensch L
Article: BLOOD. 2011;118(22):5783-5793
Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D
Meeths M; Chiang SCC; Wood SM; Entesarian M; Schlums H; Bang B; Nordenskjold E; Bjorklund C; Jakovljevic G; Jazbec J; Hasle H; Holmqvist B-M; Rajic L; Pfeifer S; Rosthoj S; Sabel M; Salmi TT; Stokland T; Winiarski J; Ljunggren H-G; Fadeel B; Nordenskjold M; Henter J-I; Bryceson YT
Article: BLOOD. 2011;118(17):4620-4629
Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome
Jessen B; Maul-Pavicic A; Ufheil H; Vraetz T; Enders A; Lehmberg K; Laengler A; Gross-Wieltsch U; Bay A; Kaya Z; Bryceson YT; Koscielniak E; Badawy S; Davies G; Hufnagel M; Schmitt-Graeff A; Aichele P; zur Stadt U; Schwarz K; Ehl S
Article: JOURNAL OF IMMUNOLOGY. 2011;186(9):5085-5094
IFN-α Production by Plasmacytoid Dendritic Cells Stimulated with RNA-Containing Immune Complexes Is Promoted by NK Cells via MIP-1β and LFA-1
Hagberg N; Berggren O; Leonard D; Weber G; Bryceson YT; Alm GV; Eloranta M-L; Ronnblom L
Article: PEDIATRIC BLOOD AND CANCER. 2011;56(4):654-657
Unusual Functional Manifestations of a Novel STX11 Frameshift Mutation in Two Infants With Familial Hemophagocytic Lymphohistiocytosis Type 4 (FHL4)
Macartney CA; Weitzman S; Wood SM; Bansal D; Steele M; Meeths M; Abdelhaleem M; Bryceson YT
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2011;366(1-2):106-118
Sensitive and viable quantification of inside-out signals for LFA-1 activation in human cytotoxic lymphocytes by flow cytometry
Theorell J; Schlums H; Chiang SCC; Huang TY; Tattermusch A; Wood SM; Bryceson YT
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(8):3324-3329
ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis
Maul-Pavicic A; Chiang SCC; Rensing-Ehl A; Jessen B; Fauriat C; Wood SM; Sjoqvist S; Hufnagel M; Schulze I; Bass T; Schamel WW; Fuchs S; Pircher H; McCarl C-A; Mikoshiba K; Schwarz K; Feske S; Bryceson YT; Ehl S
Article: BLOOD. 2010;116(15):2635-2643
Spectrum of clinical presentations in familial hemophagocytic lymphohistiocytosis type 5 patients with mutations in STXBP2
Meeths M; Entesarian M; Al-Herz W; Chiang SCC; Wood SM; Al-Ateeqi W; Almazan F; Boelens JJ; Hasle H; Ifversen M; Lund B; van den Berg JM; Gustafsson B; Hjelmqvist H; Nordenskjold M; Bryceson YT; Henter J-I
Article: LEUKEMIA. 2010;24(9):1607-1616
Reduced DNAM-1 expression on bone marrow NK cells associated with impaired killing of CD34⁺ blasts in myelodysplastic syndrome
Carlsten M; Baumann BC; Simonsson M; Jadersten M; Forsblom A-M; Hammarstedt C; Bryceson YT; Ljunggren H-G; Hellstrom-Lindberg E; Malmberg K-J
Article: PEDIATRIC BLOOD AND CANCER. 2010;54(4):563-572
Clinical Presentation of Griscelli Syndrome Type 2 and Spectrum of RAB27A Mutations
Meeths M; Bryceson YT; Rudd E; Zheng C; Wood SM; Ramme K; Beutel K; Hasle H; Heilmann C; Hultenby K; Ljunggren H-G; Fadeel B; Nordenskjold M; Henter J-I
Article: BLOOD. 2010;115(11):2167-2176
Regulation of human NK-cell cytokine and chemokine production by target cell recognition
Fauriat C; Long EO; Ljunggren H-G; Bryceson YT
Article: IMMUNITY. 2010;32(2):175-186
Synergistic Signals for Natural Cytotoxicity Are Required to Overcome Inhibition by c-Cbl Ubiquitin Ligase
Kim HS; Das A; Gross CC; Bryceson YT; Long EO
Article: METHODS IN MOLECULAR BIOLOGY. 2010;612:353-364
Analysis of the KIR repertoire in human NK cells by flow cytometry.
Björkström NK; Fauriat C; Bryceson YT; Sandberg JK; Ljunggren H-G; Malmberg K-J
Article: METHODS IN MOLECULAR BIOLOGY. 2010;612:335-352
Functional analysis of human NK cells by flow cytometry.
Bryceson YT; Fauriat C; Nunes JM; Wood SM; Björkström NK; Long EO; Ljunggren H-G
Article: BLOOD. 2009;114(19):4117-4127
Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity
Wood SM; Meeths M; Chiang SCC; Bechensteen AG; Boelens JJ; Heilmann C; Horiuchi H; Rosthoj S; Rutynowska O; Winiarski J; Stow JL; Nordenskjold M; Henter J-I; Ljunggren H-G; Bryceson YT
Article: JOURNAL OF IMMUNOLOGY. 2009;183(8):4921-4930
Primary Human Tumor Cells Expressing CD155 Impair Tumor Targeting by Down-Regulating DNAM-1 on NK Cells
Carlsten M; Norell H; Bryceson YT; Poschke I; Schedvins K; Liunggren H-G; Kiessling R; Malmberg K-J
Article: BLOOD. 2009;114(13):2657-2666
Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors
Bryceson YT; Ljunggren H-G; Long EO
Article: IMMUNITY. 2009;31(1):99-109
Integrin-Dependent Organization and Bidirectional Vesicular Traffic at Cytotoxic Immune Synapses
Liu D; Bryceson YT; Meckel T; Vasiliver-Shamis G; Dustin ML; Long EO
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2008;38(11):2957-2961
Tumor cell recognition by the NK cell activating receptor NKG2D
Bryceson YT; Ljunggren H-G
Article: JOURNAL OF MEDICAL GENETICS. 2008;45(3):134-141
Spectrum, and clinical and functional implications of UNC13D mutations in familial haemophagocytic lymphohistiocytosis
Rudd E; Bryceson YT; Zheng C; Edner J; Wood SM; Ramme K; Gavhed S; Gurgey A; Hellebostad M; Bechensteen AG; Ljunggren H-G; Fadeel B; Nordenskjold M; Henter J-I
Article: BLOOD. 2007;110(6):1906-1915
Defective cytotoxic lymphocyte degranulation in syntaxin-11-deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients
Bryceson YT; Rudd E; Zheng C; Edner J; Ma D; Wood SM; Bechensteen AG; Boelens JJ; Celkan T; Farah RA; Hultenby K; Winiarski J; Roche PA; Nordenskjold M; Henter J-I; Long EO; Ljunggren H-G
Article: CANCER RESEARCH. 2007;67(3):1317-1325
DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells
Carlsten M; Bjorkstrom NK; Norell H; Bryceson Y; van Hall T; Baumann BC; Hanson M; Schedvins K; Kiessling R; Ljunggren H-G; Malmberg KJ
Article: PLOS BIOLOGY. 2006;4(1):e9
Activation of NK cells by an endocytosed receptor for soluble HLA-G.
Rajagopalan S; Bryceson YT; Kuppusamy SP; Geraghty DE; van der Meer A; Joosten I; Long EO
Article: BLOOD. 2006;107(1):159-166
Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion
Bryceson YT; March ME; Ljunggren HG; Long EO
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2005;202(7):1001-1012
Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells
Bryceson YT; March ME; Barber DF; Ljunggren HG; Long EO
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2005;35(4):1230-1239
The rat orthologue to the inhibitory receptor gp49B is expressed by neutrophils and monocytes, but not by NK cells or mast cells.
Bryceson YT; Torgersen KM; Inngjerdingen M; Berg SF; Hoelsbrekken SE; Fossum S; Dissen E
Article: JOURNAL OF NEUROIMMUNOLOGY. 2005;161(1-2):177-182
Expression of a killer cell receptor-like gene in plastic regions of the central nervous system.
Bryceson YT; Foster JA; Kuppusamy SP; Herkenham M; Long EO
Article: IMMUNOGENETICS. 2004;56(7):506-517
Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex
Flornes LM; Bryceson YT; Spurkland A; Lorentzen JC; Dissen E; Fossum S
Article: IMMUNOGENETICS. 2004;56(5):338-342
cDNA cloning of a rat orthologue of SH2D2A encoding T-cell-specific adaptor protein (TSAd):: expression in T and NK cells
Nejad S; Bryceson Y; Dissen E; Sundvold-Gjerstad V; Naper C; Rolstad B; Spurkland A; Vaage JT
Article: BLOOD. 2003;101(12):4909-4915
Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation.
Jin Y; Knudsen E; Wang L; Bryceson Y; Damaj B; Gessani S; Maghazachi AA
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2002;32(7):1856-1864
Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases.
Kveberg L; Bryceson Y; Inngjerdingen M; Rolstad B; Maghazachi AA
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Corrigendum: GENOME MEDICINE. 2024;16(1):6
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 (vol 15, 22, 2023)
Matuozzo D; Talouarn E; Marchal A; Zhang P; Manry J; Seeleuthner Y; Zhang Y; Bolze A; Chaldebas M; Milisavljevic B; Gervais A; Bastard P; Asano T; Bizien L; Barzaghi F; Abolhassani H; Tayoun AA; Aiuti A; Darazam IA; Allende LM; Alonso-Arias R; Arias AA; Aytekin G; Bergman P; Bondesan S; Bryceson YT; Bustos IG; Cabrera-Marante O; Carcel S; Carrera P; Casari G; Chaibi K; Colobran R; Condino-Neto A; Covill LE; Delmonte OM; Zein LE; Flores C; Gregersen PK; Gut M; Haerynck F; Halwani R; Hancerli S; Hammarstroem L; Hatipoglu N; Karbuz A; Keles S; Kyheng C; Leon-Lopez R; Franco JL; Mansouri D; Martinez-Picado J; Akcan OM; Migeotte I; Morange P-E; Morelle G; Martin-Nalda A; Novelli G; Novelli A; Ozcelik T; Palabiyik F; Pan-Hammarstroem Q; de Diego RP; Planas-Serra L; Pleguezuelo DE; Prando C; Pujol A; Reyes LF; Riviere JG; Rodriguez-Gallego C; Rojas J; Rovere-Querini P; Schlueter A; Shahrooei M; Sobh A; Soler-Palacin P; Tandjaoui-Lambiotte Y; Tipu I; Tresoldi C; Troya J; van de Beek D; Zatz M; Zawadzki P; Al-Muhsen SZ; Alosaimi MF; Alsohime FM; Baris-Feldman H; Butte MJ; Constantinescu SN; Cooper MA; Dalgard CL; Fellay J; Heath JR; Lau Y-L; Lifton RP; Maniatis T; Mogensen TH; von Bernuth H; Lermine A; Vidaud M; Boland A; Deleuze J-F; Nussbaum R; Kahn-Kirby A; Mentre F; Tubiana S; Gorochov G; Tubach F; Hausfater P; Meyts I; Zhang S-Y; Puel A; Notarangelo LD; Boisson-Dupuis S; Su HC; Boisson B; Jouanguy E; Casanova J-L; Zhang Q; Abel L; Cobat A
Editorial comment: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2023;8(1):316
Rough operators: sphingomyelinase inhibitors spike NK cells to kill cancer
Carlsten M; Bryceson YT
Letter: NATURE MEDICINE. 2022;28(5):879-882
Studying severe long COVID to understand post-infectious disorders beyond COVID-19
Brodin P; Casari G; Townsend L; O'Farrelly C; Tancevski I; Loeffler-Ragg J; Mogensen TH; Casanova JL
Letter: PEDIATRIC BLOOD AND CANCER. 2022;69(5):e29487
Childhood Kaposi sarcoma related to hypomorphic severe combined immunodeficiency caused by a novel CORO1A mutation
Muleviciene A; Sekine T; Zondag T; Bryceson YT; Tesi B; Rascon J
Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;95(4):e13153
Do reduced numbers of plasmacytoid dendritic cells contribute to the aggressive clinical course of COVID-19 in chronic lymphocytic leukaemia?
Smith CIE; Zain R; osterborg A; Palma M; Buggert M; Bergman P; Bryceson Y
Review: NATURE. 2022;603(7902):587-598
Human genetic and immunological determinants of critical COVID-19 pneumonia
Zhang Q; Bastard P; Cobat A; Casanova J-L
Editorial comment: NEUROLOGY: GENETICS. 2021;7(6):e628
Adult-Onset Ataxia With Neuropathy and White Matter Abnormalities Due to a Novel SAMD9L Variant
Paucar M; Tesi B; Eshtad S; Eriksson C; Hashim F; Nilsson D; Pourhamidi K; Hellstrom-Lindberg E; Bryceson YT; Svenningsson P
Review: ACTA PAEDIATRICA, INTERNATIONAL JOURNAL OF PAEDIATRICS. 2021;110(11):2903-2911
Genetics and pathophysiology of haemophagocytic lymphohistiocytosis
Meeths M; Bryceson YT
Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;148(1):96-98
Severe COVID-19 in an APS1 patient with interferon autoantibodies treated with plasmapheresis
Lemarquis A; Campbell T; Aranda-Guillen M; Hennings V; Brodin P; Kampe O; Blennow K; Zetterberg H; Wenneras C; Eriksson K; Landegren N; Bryceson Y; Berg S; Ekwall O
Editorial comment: FRONTIERS IN IMMUNOLOGY. 2021;12:769815
Editorial: Membrane Trafficking in Immunology-How Membrane Transport and Exocytosis Defects Underlie Immunodeficiencies
Manna PT; Chiang SCC; Bryceson YT; Orange JS; Ammann S
Review: FRONTIERS IN IMMUNOLOGY. 2021;12:827815
Neuroinflammation Associated With Inborn Errors of Immunity
Lindahl H; Bryceson YT
Editorial comment: FRONTIERS IN IMMUNOLOGY. 2020;11:1448
Editorial: Molecular and Cellular Pathways in NK Cell Development
Sitnicka E; Bryceson Y; Freud AG; Mace EM
Corrigendum: NATURE COMMUNICATIONS. 2019;10(1):4555
Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis (vol 10, pg 3106, 2019)
Serwas NK; Hoeger B; Ardy RC; Stulz SV; Sui Z; Memaran N; Meeths M; Krolo A; Petronczki OY; Pfajfer L; Hou TZ; Halliday N; Santos-Valente E; Kalinichenko A; Kennedy A; Mace EM; Mukherjee M; Tesi B; Schrempf A; Pickl WF; Loizou JI; Kain R; Bidmon-Fliegenschnee B; Schickel J-N; Glauzy S; Huemer J; Garncarz W; Salzer E; Pierides I; Bilic I; Thiel J; Priftakis P; Banerjee PP; Foerster-Waldl E; Medgyesi D; Huber W-D; Orange JS; Meffre E; Sansom DM; Bryceson YT; Altman A; Boztug K
Editorial comment: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2019;216(6):1231-1233
IL2RB maintains immune harmony
Campbell TM; Bryceson YT
Letter: BRITISH JOURNAL OF HAEMATOLOGY. 2019;185(2):354-357
Microdeletion of 7p12.1p13, including IKZF1, causes intellectual impairment, overgrowth, and susceptibility to leukaemia
Jarviaho T; Zachariadis V; Tesi B; Chiang S; Bryceson YT; Mottonen M; Niinimaki R; Bang B; Rahikkala E; Taylan F; Uusimaa J; Harila-Saari A; Nordgren A
Letter: TURKISH JOURNAL OF HAEMATOLOGY. 2018;35(3):200-202
First Report of an SH2D1A Mutation Associated with X-Linked Lymphoproliferative Disease in Turkey
Kesici S; Keskin EY; Chiang SCC; Kasapkara CS; Sekine T; Akcaboy M; Fettah A; Bryceson YT
Review: CYTOKINE AND GROWTH FACTOR REVIEWS. 2018;42:37-46
Natural killer cells in inflammation and autoimmunity
Zitti B; Bryceson YT
Editorial comment: BLOOD. 2018;132(1):5-7
HLH: genomics illuminates pathophysiological diversity
Tesi B; Bryceson YT
Editorial comment: BLOOD. 2017;130(25):2693-2695
Single-cell dissection of monosomy 7 syndromes
Gutierrez-Perez I; Bryceson YT
Review: SEMINARS IN IMMUNOLOGY. 2017;31:20-29
Natural killer cell-mediated immunosurveillance of human cancer
Malmberg K-J; Carlsten M; Bjorklund A; Sohlberg E; Bryceson YT; Ljunggren H-G
Review: SEMINARS IN IMMUNOLOGY. 2016;28(4):368-376
Natural killer cell memory in context
Holmes TD; Bryceson YT
Review: TRENDS IN IMMUNOLOGY. 2016;37(7):451-461
Epigenetic Regulation of Adaptive NK Cell Diversification
Tesi B; Schlums H; Cichocki F; Bryceson YT
Editorial comment: BLOOD. 2016;127(17):2051-2052
HLH susceptibility: genetic lesions add up
Meeths M; Bryceson YT
Review: CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY. 2016;395:63-94
Diversification and Functional Specialization of Human NK Cell Subsets
Cichocki F; Schlums H; Theorell J; Tesi B; Miller JS; Ljunggren H-G; Bryceson YT
Review: CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY. 2016;395:225-243
The Past, Present, and Future of NK Cells in Hematopoietic Cell Transplantation and Adoptive Transfer
Cichocki F; Verneris MR; Cooley S; Bachanova V; Brunstein CG; Blazar BR; Wagner J; Schlums H; Bryceson YT; Weisdorf DJ; Miller JS
Letter: CLINICAL IMMUNOLOGY. 2015;159(1):58-62
A case of XMEN syndrome presented with severe auto-immune disorders mimicking autoimmune lymphoproliferative disease
Patiroglu T; Akar HH; Gilmour K; Unal E; Ozdemir MA; Bibi S; Burns S; Chiang SC; Schlums H; Bryceson YT; Karakukcu M
Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2015;135(6):1638-1641
Hemophagocytic lymphohistiocytosis in 2 patients with underlying IFN-γ receptor deficiency
Tesi B; Sieni E; Neves C; Romano F; Cetica V; Cordeiro AI; Chiang S; Schlums H; Galli L; Avenali S; Tondo A; Canessa C; Henter J-I; Nordenskjold M; Hsu AP; Holland SM; Neves JE; Azzari C; Bryceson YT
Review: EXPERIMENTAL CELL RESEARCH. 2014;325(1):10-17
Pathophysiology and spectrum of diseases caused by defects in lymphocyte cytotoxicity
Meeths M; Chiang SCC; Lofstedt A; Muller M-L; Tesi B; Henter J-I; Bryceson YT
Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2014;134(1):226-228
Combined newborn screening for familial hemophagocytic lymphohistiocytosis and severe T- and B-cell immunodeficiencies
Borte S; Meeths M; Liebscher I; Krist K; Nordenskjold M; Hammarstrom L; von Dobeln U; Henter J-I; Bryceson YT
Review: SEMINARS IN IMMUNOLOGY. 2014;26(2):114-126
NK cell development and function - Plasticity and redundancy unleashed
Cichocki F; Sitnicka E; Bryceson YT
Editorial comment: FRONTIERS IN IMMUNOLOGY. 2014;5:279
Molecular mechanisms regulating cytotoxic lymphocyte development and function, and their associations to human diseases
Krzewski K; Bryceson YT
Letter: BRITISH JOURNAL OF HAEMATOLOGY. 2013;162(3):415-418
Novel deep intronic and missense UNC13D mutations in familial haemophagocytic lymphohistiocytosis type 3
Entesarian M; Chiang SCC; Schlums H; Meeths M; Chan M-Y; Mya S-N; Soh S-Y; Nordenskjold M; Henter J-I; Bryceson YT
Review: FRONTIERS IN IMMUNOLOGY. 2013;4:55
Epigenetic regulation of NK cell differentiation and effector functions
Cichocki F; Miller JS; Anderson SK; Bryceson YT
Editorial comment: BLOOD. 2012;119(17):3873-3875
Lymphocyte cytotoxicity: tug-of-war on microtubules
Wood SM; Bryceson YT
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2011;68(21):3479-3493
Insights into NK cell biology from human genetics and disease associations
Wood SM; Ljunggren H-G; Bryceson YT
Editorial comment: JOURNAL OF INNATE IMMUNITY. 2011;3(3):213-215
Natural Killer Cells: Biology, Physiology and Medicine - Part 1
Bryceson YT; Ljunggren H-G
Review: JOURNAL OF INNATE IMMUNITY. 2011;3(3):216-226
Molecular Mechanisms of Natural Killer Cell Activation
Bryceson YT; Chiang SCC; Darmanin S; Fauriat C; Schlums H; Theorell J; Wood SM
Editorial comment: JOURNAL OF INNATE IMMUNITY. 2011;3(4):327-328
Natural Killer Cells: Biology, Physiology and Medicine - Part 2
Bryceson YT; Ljunggren H-G
Editorial comment: THE LANCET. 2010;376(9758):2116
Cytotoxic therapy for severe swine flu A/H1N1
Henter J-I; Palmkvist-Kaijser K; Holzgraefe B; Bryceson YT; Palmer K
Letter: NATURE REVIEWS CLINICAL ONCOLOGY. 2010;7(10):1
Alemtuzumab treatment for hemophagocytic lymphohistiocytosis
Machaczka M; Vaktnas J; Chiang SCC; Bryceson YT
Review: CURRENT OPINION IN IMMUNOLOGY. 2009;21(6):634-640
Natural killer cells in human autoimmunity
Flodstrom-Tullberg M; Bryceson YT; Shi F-D; Hoglund P; Ljunggren H-G
Published conference paper: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2008;57(10):1541-1552
NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy
Malmberg K-J; Bryceson YT; Carlsten M; Andersson S; Bjorklund A; Bjorkstrom NK; Baumann BC; Fauriat C; Alici E; Dilber MS; Ljunggren H-G
Thesis / dissertation: 2008
Triggering and mechanisms of natural killer cell mediated cytotoxicity
Bryceson, Yenan
Editorial comment: NATURE IMMUNOLOGY. 2008;9(8):835-836
Arrestin NK cell cytotoxicity
Bryceson YT; Ljunggren H-G
Review: CURRENT OPINION IN IMMUNOLOGY. 2008;20(3):344-352
Line of attack: NK cell specificity and integration of signals
Bryceson YT; Long EO
Editorial comment: CURRENT OPINION IN IMMUNOLOGY. 2007;19(3):337-338
Lymphocyte effector functions: armed for destruction?
Bryceson YT; Ljunggren H-G
Review: IMMUNOLOGICAL REVIEWS. 2006;214:73-91
Activation, coactivation, and costimulation of resting human natural killer cells
Bryceson YT; March ME; Ljunggren H-G; Long EO
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Professor/Clinical Chemist, Department of Medicine, Huddinge, Karolinska Institutet, 2020-

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Degree Of Doctor Of Philosophy, Department of Medicine, Huddinge, Karolinska Institutet, 2008

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