Yana Ruchiy

Yana Ruchiy

Affiliated to Research
Visiting address: BioMedicum A4, Solnavägen 9, 17165 Solna
Postal address: K6 Kvinnors och barns hälsa, K6 Barnonkologi och Barnkirurgi Blomgren, 171 77 Stockholm
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About me

  • I am a former PhD student within the research group of Prof. Klas Blomgren, studying
    the effects of radiotherapy on tumour microenvironment in paediatric brain
    tumours.

Research

  • During my PhD studies, my research is mainly focused on two projects:
    1. The effects of lithium on tumour progression in a mouse model of Group 3
    medulloblastoma.
    In the course of this project, I have created an in vivo model of Group 3
    medulloblastoma through an orthotopic injection of medulloblastoma cells. I
    then used this model to study the effects of lithium and irradiation on
    tumour growth and analysed it through whole-brain immunostaining and volume
    imaging techniques.
    2. Studies of inter- and intra- tumoural heterogeneity and tumour
    microenvironment in medulloblastoma.
    In the course of this project, I analysed single-cell datasets from Swedish
    medulloblastoma patients, comprising all four medulloblastoma subtypes. The
    main goal of this study was to look into the individual genomic landscapes of
    these tumours and the interactions between the tumour cells and their
    microenvironment, to provide a more detailed characterisation of
    different medulloblastoma subtypes and try to identify potential therapeutic
    targets.

Articles

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Grants

Employments

  • Affiliated to Research, Department of Women's and Children's Health, Karolinska Institutet, 2025-2027
  • Affiliated to Research, Department of Women's and Children's Health, Karolinska Institutet, 2025-2027

Degrees and Education

  • PhD, Medical Sciences, Novel therapeutic targets and treatment strategies in paediatric brain tumours, KBH, Karolinska Institutet, 2025
  • Molecular Medicine MSc, Charité - University Medicine Berlin, 2020
  • Biological Sciences BSc, Lancaster University, 2016

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