Vladislav Kuzin

Vladislav Kuzin

Postdoctoral Researcher
Visiting address: Solnavägen 9, 17165 Stockholm
Postal address: C5 Cell- och molekylärbiologi, C5 CMB Baranello, 171 77 Stockholm
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About me

  • I came to Stockholm from the snowy valleys of Siberia, where in 2017 I
    graduated from Novosibirsk State University, specializing in bio-medical
    physics. My previous project consisted of studying main physical and
    chemo-physical properties of latex microspheres and studying cellular
    response to mechanical stress caused by elevated hydrostatic pressure. Now I
    am a PhD student and my focus in the group is studying the regulatory
    interactions of TOP2 and RNAPII. Deciphering the factors and the molecular
    mechanisms of TOP2 regulation may be an effective novel strategy for
    targeting the stimulation of TOP2 activity in different types pf tumors. In
    my current project I will address this question from different sides by
    characterizing structural requirements of RNAPII and TOP2 interactions using
    such techniques as in vitro pull down assays and in vitro relaxation assays,
    studying genomic distributions of TOP2 sites of occupancy and activity with
    variations of ChIP-seq and performing combinatorial drug screening with TOP2
    and transcription inhibitors. I especially enjoy the experimental part of the
    research and I am really enthusiastic about learning bioinformatics analysis
    of sequencing data.

Articles

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Employments

  • Postdoctoral Researcher, Department of Cell and Molecular Biology, Karolinska Institutet, 2023-2025

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Cell and Molecular Biology, Karolinska Institutet, 2023

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