Vivianne Malmström

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Articles

Article: SCIENTIFIC REPORTS. 2024;14(1):15511
Evidence of membranolytic targeting and intracellular citrullination in neutrophils isolated from patients with rheumatoid arthritis
Moadab F; Wang X; Le E; Gazitt T; Najjar R; Nelson JL; Joshua V; Malmstrom V; Elkon K; Groenwall C; Mustelin T
Article: ARTHRITIS & RHEUMATOLOGY. 2023;75(11):1910-1922
Rheumatoid Arthritis-Specific Autoimmunity in the Lung Before and at the Onset of Disease
Joshua V; Loberg Haarhaus M; Hensvold A; Wahamaa H; Gerstner C; Hansson M; Israelsson L; Stalesen R; Skoeld M; Grunewald J; Klareskog L; Groenwall C; Rethi B; Catrina A; Malmstrom V
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2023;299(11):105320
Autoreactive B cells against malondialdehyde-induced protein cross-links are present in the joint, lung, and bone marrow of rheumatoid arthritis patients
Sahlstrom P; Joshua V; Valkovskaia V; Biese C; Stalesen R; Israelsson L; Vegvari A; Scheel-Toellner D; Klareskog L; Hansson M; Hensvold A; Malmstrom V; Gronwall C
Article: CLINICAL RHEUMATOLOGY. 2023;42(10):2889-2895
Occurrence and localization of FOXP3+cells in kidney biopsies in lupus nephritis and ANCA-associated vasculitis
Zickert A; Jankovic MR; Malmstrom V; Chemin K; Gunnarsson I
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2023;52(3):293-301
Pentraxin-3-a potential biomarker in ANCA-associated vasculitis
Jonasdottir AD; Antovic A; Qureshi AR; Nordin A; Malmstrom V; Gunnarsson I; Bruchfeld A
Article: KIDNEY INTERNATIONAL. 2023;103(5):973-985
Identification of proteinase 3 autoreactive CD4+T cells and their T-cell receptor repertoires in antineutrophil cytoplasmic antibody-associated vasculitis
Sharma RK; Yoosuf N; Afonso M; Scheffschick A; Avik A; Bartoletti A; Horuluoglu B; Boada JSD; Boddul SK; Jonasdottir AD; Lovstrom B; Brauner H; Raposo B; Chemin K; Bruchfeld A; Gunnarsson I; Malmstrom V
Article: ARTHRITIS & RHEUMATOLOGY. 2023;75(5):673-684
Diversity and Clonality of T Cell Receptor Repertoire and Antigen Specificities in Small Joints of Early Rheumatoid Arthritis
Turcinov S; af Klint E; Van Schoubroeck B; Kouwenhoven A; Mia S; Chemin K; Wils H; Van Hove C; De Bondt A; Keustermans K; Van Houdt J; Reumers J; Felix N; Rao NL; Peeters P; Stevenaert F; Klareskog L; McKinnon M; Baker D; Suri A; Malmstroem V
Article: JOURNAL OF AUTOIMMUNITY. 2023;136:103022
The human bone marrow plasma cell compartment in rheumatoid arthritis-Clonal relationships and anti-citrulline autoantibody producing cells
Hensvold A; Horuluoglu B; Sahlstrom P; Thyagarajan R; Boada JSD; Hansson M; Mathsson-Alm L; Gerstner C; Sippl N; Israelsson L; Wedin R; Steen J; Klareskog L; Rethi B; Catrina AI; Diaz-Gallo L-M; Malmstrom V; Gronwall C
Article: BIOMOLECULES. 2023;13(4):630
Anti-Citrullinated Protein Antibody Reactivity towards Neutrophil-Derived Antigens: Clonal Diversity and Inter-Individual Variation
Circiumaru A; Afonso MG; Wahamaa H; Krishnamurthy A; Hansson M; Mathsson-Alm L; Keszei M; Stalesen R; Ottosson L; de Vries C; Shelef MA; Malmstrom V; Klareskog L; Catrina AI; Gronwall C; Hensvold A; Rethi B
Article: NATURE COMMUNICATIONS. 2023;14(1):691
A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis
He Y; Ge C; Moreno-Giro A; Xu B; Beusch CM; Sandor K; Su J; Cheng L; Lonnblom E; Lundqvist C; Slot LM; Tong D; Urbonaviciute V; Liang B; Li T; Lahore GF; Aoun M; Malmstrom V; Rispens T; Ernfors P; Svensson CI; Scherer HU; Toes REM; Gjertsson I; Ekwall O; Zubarev RA; Holmdahl R
Article: ARTHRITIS & RHEUMATOLOGY. 2023;75(2):164-170
Combination of Two Monoclonal Anti-Citrullinated Protein Antibodies Induced Tenosynovitis, Pain, and Bone Loss in Mice in a Peptidyl Arginine Deiminase-4-Dependent Manner
Krishnamurthy A; Circiumaru A; Sun J; Kisten Y; Damberg P; Sakuraba K; Sandor K; Jarvoll P; Zhou T; Malmstrom V; Svensson CI; Hensvold A; Catrina AI; Klareskog L; Rethi B
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1073414
Analysis of IGH allele content in a sample group of rheumatoid arthritis patients demonstrates unrevealed population heterogeneity
Hardt U; Corcoran MM; Narang S; Malmstrom V; Padyukov L; Hedestam GBK
Article: MOLECULAR IMMUNOLOGY. 2022;152:106-110
Five commercially-available antibodies react differentially with allelic forms of human HLA-DR beta chain
Houtman M; Dzebisashvili A; Dubnovitsky A; Kozhukh G; Ronnblom L; Klareskog L; Malmstrom V; Padyukov L
Article: PAIN. 2022;163(8):1542-1559
Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity, and acid-sensing ion channel 3-dependent sensitization
Jurczak A; Delay L; Barbier J; Simon N; Krock E; Sandor K; Agalave NM; Rudjito R; Wigerblad G; Rogoz K; Briat A; Miot-Noirault E; Martinez-Martinez A; Bromme D; Gronwall C; Malmstrom V; Klareskog L; Khoury S; Ferreira T; Labrum B; Deval E; Miguel Jimenez-Andrade J; Marchand F; Svensson CI
Article: SCIENTIFIC REPORTS. 2022;12(1):11876
Integrated single cell and spatial transcriptomics reveal autoreactive differentiated B cells in joints of early rheumatoid arthritis
Hardt U; Carlberg K; af Klint E; Sahlstrom P; Larsson L; van Vollenhoven A; Machado SH; Israelsson L; Amara K; Chemin K; Korotkova M; Hedestam GBK; Catrina AI; Teichmann SA; Stahl PL; Malmstrom V
Article: NATURE COMMUNICATIONS. 2022;13(1):4046
Single cell sequencing identifies clonally expanded synovial CD4⁺ T_PH cells expressing GPR56 in rheumatoid arthritis
Argyriou A; Wadsworth MH; Lendvai A; Christensen SM; Hensvold AH; Gerstner C; van Vollenhoven A; Kravarik K; Winkler A; Malmstrom V; Chemin K
Article: JOURNAL OF AUTOIMMUNITY. 2022;131:102857
Modulating T-cell activation with antisense oligonucleotides targeting lymphocyte cytosolic protein 2
Iyer VS; Boddul SV; Johnsson A-K; Raposo B; Sharma RK; Shen Y; Kasza Z; Lim KW; Chemin K; Nilsson G; Malmstrom V; Phan AT; Wermeling F
Article: ARTHRITIS & RHEUMATOLOGY. 2022;74(6):984-991
Rheumatoid Factor and Anti-Modified Protein Antibody Reactivities Converge on IgG Epitopes
Mergaert AM; Zheng Z; Denny MF; Amjadi MF; Bashar SJ; Newton MA; Malmstrom V; Gronwall C; McCoy SS; Shelef MA
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2022;207(2):199-204
Kidney infiltrating NK cells and NK-like T-cells in lupus nephritis: presence, localization, and the effect of immunosuppressive treatment
Scheffschick A; Fuchs S; Malmstrom V; Gunnarsson I; Brauner H
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):129
Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium
Vickovic S; Schapiro D; Carlberg K; Lotstedt B; Larsson L; Hildebrandt F; Korotkova M; Hensvold AH; Catrina AI; Sorger PK; Malmstrom V; Regev A; Stahl PL
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:826152
Rituximab in Systemic Lupus Erythematosus: Transient Effects on Autoimmunity Associated Lymphocyte Phenotypes and Implications for Immunogenicity
Faustini F; Sippl N; Stalesen R; Chemin K; Dunn N; Fogdell-Hahn A; Gunnarsson I; Malmstroem V
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:804822
Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells: Implications for a Bacterial Origin in RA Etiology
Sherina N; de Vries C; Kharlamova N; Sippl N; Jiang X; Brynedal B; Kindstedt E; Hansson M; Mathsson-Alm L; Israelsson L; Stalesen R; Saevarsdottir S; Holmdahl R; Hensvold A; Johannsen G; Eriksson K; Sallusto F; Catrina AI; Roennelid J; Groenwall C; Yucel-Lindberg T; Alfredsson L; Klareskog L; Piccoli L; Malmstroem V; Amara K; Lundberg K
Article: SCIENTIFIC REPORTS. 2021;11(1):24512
Biased TCR gene usage in citrullinated Tenascin C specific T-cells in rheumatoid arthritis
Sharma RK; Boddul SV; Yoosuf N; Turcinov S; Dubnovitsky A; Kozhukh G; Wermeling F; Kwok WW; Klareskog L; Malmstrom V
Article: ARTHRITIS RESEARCH & THERAPY. 2021;23(1):211
First exposure to rituximab is associated to high rate of anti-drug antibodies in systemic lupus erythematosus but not in ANCA-associated vasculitis
Faustini F; Dunn N; Kharlamova N; Ryner M; Bruchfeld A; Malmstrom V; Fogdell-Hahn A; Gunnarsson I
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2021;205(1):44-52
Arthritis in systemic lupus erythematosus is characterized by local IL-17A and IL-6 expression in synovial fluid
Sippl N; Faustini F; Ronnelid J; Turcinov S; Chemin K; Gunnarsson I; Malmstrom V
Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2021;39(3):578-586
Atherosclerosis in rheumatoid arthritis: associations between anti-cytomegalovirus IgG antibodies, CD4+CD28null T-cells, CD8+CD28null T-cells and intima-media thickness
Wahlin B; Fasth AER; Karp K; Lejon K; Malmstrom V; Rahbar A; Wallberg-Jonsson S; Sodergren A
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2021;50(3):183-188
Detection of human cytomegalovirus in synovial neutrophils obtained from patients with rheumatoid arthritis
Xu X; Estekizadeh A; Davoudi B; Varani S; Malmstrom V; Rahbar A; Soderberg-Naucler C
Article: SCIENCE IMMUNOLOGY. 2021;6(58):eabe0896
The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR
Lim JJ; Jones CM; Loh TJ; Ting YT; Zareie P; Loh KL; Felix NJ; Suri A; McKinnon M; Stevenaert F; Sharma RK; Klareskog L; Malmstrom V; Baker DG; Purcell AW; Reid HH; La Gruta NL; Rossjohn J
Article: JCI INSIGHT. 2021;6(5):145217
Shared recognition of citrullinated tenascin-C peptides by T and B cells in rheumatoid arthritis
Song J; Schwenzer A; Wong A; Turcinov S; Rims C; Martinez LR; Arribas-Layton D; Gerstner C; Muir VS; Midwood KS; Malmstrom V; James EA; Buckner JH
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:707217
Haplotype-Specific Expression Analysis of MHC Class II Genes in Healthy Individuals and Rheumatoid Arthritis Patients
Houtman M; Hesselberg E; Ronnblom L; Klareskog L; Malmstrom V; Padyukov L
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:627986
A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis
Gronwall C; Liljefors L; Bang H; Hensvold AH; Hansson M; Mathsson-Alm L; Israelsson L; Joshua V; Svard A; Stalesen R; Titcombe PJ; Steen J; Piccoli L; Sherina N; Clavel C; Svenungsson E; Gunnarsson I; Saevarsdottir S; Kastbom A; Serre G; Alfredsson L; Malmstrom V; Ronnelid J; Catrina AI; Lundberg K; Klareskog L
Article: JOURNAL OF TRANSLATIONAL AUTOIMMUNITY. 2021;4:100087
In vitro and ex vivo functional characterization of human HLA-DRB1*04 restricted T cell receptors
Boddul SV; Sharma RK; Dubnovitsky A; Raposo B; Gerstner C; Shen Y; Iyer VS; Kasza Z; Kwok WW; Winkler AR; Klareskog L; Malmstrom V; Bettini M; Wermeling F
Article: ARTHRITIS & RHEUMATOLOGY. 2020;72(10):1643-1657
Different Hierarchies of Anti-Modified Protein Autoantibody Reactivities in Rheumatoid Arthritis
Sahlstroem P; Hansson M; Steen J; Amara K; Titcombe PJ; Forsstrom B; Stalesen R; Israelsson L; Piccoli L; Lundberg K; Klareskog L; Mueller DL; Catrina AI; Skriner K; Malmstrom V; Gronwall C
Article: BMC IMMUNOLOGY. 2020;21(1):27
Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis
Gerstner C; Turcinov S; Hensvold AH; Chemin K; Uchtenhagen H; Ramwadhdoebe TH; Dubnovitsky A; Kozhukh G; Ronnblom L; Kwok WW; Achour A; Catrina A; van Baarsen LGM; Malmstrom V
Article: ARTHRITIS & RHEUMATOLOGY. 2020;72(1):179-191
Proinflammatory Histidyl-Transfer RNA Synthetase-Specific CD4+T Cells in the Blood and Lungs of Patients With Idiopathic Inflammatory Myopathies
Galindo-Feria AS; Albrecht I; Fernandes-Cerqueira C; Notarnicola A; James EA; Herrath J; Dastmalchi M; Sandalova T; Ronnblom L; Jakobsson P-J; Fathi M; Achour A; Grunewald J; Malmstrom V; Lundberg IE
Article: SCIENTIFIC REPORTS. 2019;9(1):19995
Rheumatoid arthritis patients display B-cell dysregulation already in the naive repertoire consistent with defects in B-cell tolerance
Wang Y; Lloyd KA; Melas I; Zhou D; Thyagarajan R; Lindqvist J; Hansson M; Svard A; Mathsson-Alm L; Kastbom A; Lundberg K; Klareskog L; Catrina AI; Rapecki S; Malmstrom V; Gronwall C
Article: SCIENTIFIC REPORTS. 2019;9(1):18975
Exploring inflammatory signatures in arthritic joint biopsies with Spatial Transcriptomics
Carlberg K; Korotkova M; Larsson L; Catrina AI; Stahl PL; Malmstrom V
Article: ANNALS OF THE RHEUMATIC DISEASES. 2019;78(12):1621-1631
Anticitrullinated protein antibodies facilitate migration of synovial tissue-derived fibroblasts
Sun M; Rethi B; Krishnamurthy A; Joshua V; Circiumaru A; Hensvold AH; Ossipova E; Gronwall C; Liu Y; Engstrom M; Catrina SB; Steen J; Malmstrom V; Klareskog L; Svensson C; Ospelt C; Wahamaa H; Catrina AI
Article: BIO-PROTOCOL. 2019;9(17):e3347
A Refined Protocol for Identifying Citrulline-specific Monoclonal Antibodies from Single Human B Cells from Rheumatoid Arthritis Patient Material
Amara K; Israelsson L; Stalesen R; Sahlstrom P; Steen J; Malmstrom V; Gronwall C
Article: JOURNAL OF IMMUNOLOGY. 2019;202(11):3143-3150
Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts
Krishnamurthy A; Ytterberg AJ; Sun M; Sakuraba K; Steen J; Joshua V; Tarasova NK; Malmstrom V; Wahamaa H; Rethi B; Catrina AI
Article: ARTHRITIS & RHEUMATOLOGY. 2019;71(3):340-350
Generation and Characterization of Anti-Citrullinated Protein Antibody-Producing B Cell Clones From Rheumatoid Arthritis Patients
Germar K; Fehres CM; Scherer HU; van Uden N; Pollastro S; Yeremenko N; Hansson M; Kerkman PF; van der Voort EIH; Reed E; Maassen H; Kwakkenbos MJ; Bakker AQ; Klareskog L; Malmstrom V; de Vries N; Toes REM; Lundberg K; Spits H; Baeten DL
Article: ARTHRITIS & RHEUMATOLOGY. 2019;71(2):196-209
Recognition of Amino Acid Motifs, Rather Than Specific Proteins, by Human Plasma Cell-Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis
Steen J; Forsstroem B; Sahlstroem P; Odowd V; Israelsson L; Krishnamurthy A; Badreh S; Alm LM; Compson J; Ramskold D; Ndlovu W; Rapecki S; Hansson M; Titcombe PJ; Bang H; Mueller DL; Catrina AI; Gronwall C; Skriner K; Nilsson P; Lightwood D; Klareskog L; Malmstrom V
Article: ARTHRITIS & RHEUMATOLOGY. 2019;71(2):210-221
Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies
Ge C; Xu B; Liang B; Lonnblom E; Lundstrom SL; Zubarev RA; Ayoglu B; Nilsson P; Skogh T; Kastbom A; Malmstrom V; Klareskog L; Toes REM; Rispens T; Dobritzsch D; Holmdahl R
Article: EBIOMEDICINE. 2019;40:517-527
B cell alterations during BAFF inhibition with belimumab in SLE
Ramskold D; Parodis I; Lakshmikanth T; Sippl N; Khademi M; Chen Y; Zickert A; Mikes J; Achour A; Amara K; Piehl F; Brodin P; Gunnarsson I; Malmstrom V
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2019;89(1):e12732
Effect of CTLA4-Ig (abatacept) treatment on T cells and B cells in peripheral blood of patients with polymyositis and dermatomyositis
Tang Q; Ramskold D; Krystufkova O; Mann HF; Wick C; Dastmalchi M; Lakshmikanth T; Chen Y; Mikes J; Alexanderson H; Achour A; Brodin P; Vencovsky J; Lundberg IE; Malmstrom V
Article: ARTHRITIS & RHEUMATOLOGY. 2018;70(12):1933-1945
Pathogenic Citrulline-Multispecific B Cell Receptor Clades in Rheumatoid Arthritis
Titcombe PJ; Wigerblad G; Sippl N; Zhang N; Shmagel AK; Sahlstrom P; Zhang Y; Barsness LO; Ghodke-Puranik Y; Baharpoor A; Hansson M; Israelsson L; Skriner K; Niewold TB; Klareskog L; Svensson CI; Amara K; Malmstrom V; Mueller DL
Article: ARTHRITIS RESEARCH & THERAPY. 2018;20(1):188
T-cell transcriptomics from peripheral blood highlights differences between polymyositis and dermatomyositis patients
Houtman M; Ekholm L; Hesselberg E; Chemin K; Malmstrom V; Reed AM; Lundberg IE; Padyukov L
Article: JOURNAL OF AUTOIMMUNITY. 2018;92:47-56
Memory T cells specific to citrullinated α-enolase are enriched in the rheumatic joint
Pieper J; Dubnovitsky A; Gerstner C; James EA; Rieck M; Kozhukh G; Tandre K; Pellegrino S; Gebe JA; Ronnblom L; Sandalova T; Kwok WW; Klareskog L; Buckner JH; Achour A; Malmstrom V
Article: LUPUS. 2018;27(9):1470-1478
Rituximab-mediated late-onset neutropenia in systemic lupus erythematosus - distinct roles of BAFF and APRIL
Parodis I; Soder F; Faustini F; Kasza Z; Samuelsson I; Zickert A; Svenungsson E; van Vollenhoven RF; Malmstrom V; Wermeling F; Gunnarsson I
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2018;48(6):1030-1045
Variable domain N-linked glycosylation and negative surface charge are key features of monoclonal ACPA: Implications for B-cell selection
Lloyd KA; Steen J; Amara K; Titcombe PJ; Israelsson L; Lundstrom SL; Zhou D; Zubarev RA; Reed E; Piccoli L; Gabay C; Lanzavecchia A; Baeten D; Lundberg K; Mueller DL; Klareskog L; Malmstrom V; Gronwall C
Article: JOURNAL OF AUTOIMMUNITY. 2018;90:28-38
T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus
Houtman M; Shchetynsky K; Chemin K; Hensvold AH; Ramskold D; Tandre K; Eloranta M-L; Ronnblom L; Uebe S; Catrina AI; Malmstrom V; Padyukov L
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2018;48(4):655-669
EOMES-positive CD4⁺ Tcells are increased in PTPN22 (1858T) risk allele carriers
Chemin K; Ramskold D; Diaz-Gallo L-M; Herrath J; Houtman M; Tandre K; Ronnblom L; Catrina A; Malmstrom V
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:3033
Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis
Lloyd KA; Wigerblad G; Sahlstrom P; Garimella MG; Chemin K; Steen J; Titcombe PJ; Marklein B; Zhou D; Stalesen R; Ossipova E; Lundqvist C; Ekwall O; Ronnelid J; Mueller DL; Karlsson MCI; Kaplan MJ; Skriner K; Klareskog L; Wermeling F; Malmstrom V; Gronwall C
Article: JOURNAL OF AUTOIMMUNITY. 2017;84:29-45
Autoreactivity to malondialdehyde-modifications in rheumatoid arthritis is linked to disease activity and synovial pathogenesis
Gronwall C; Amara K; Hardt U; Krishnamurthy A; Steen J; Engstrom M; Sun M; Ytterberg AJ; Zubarev RA; Scheel-Toellner D; Greenberg JD; Klareskog L; Catrina AI; Malmstrom V; Silverman GJ
Article: ANNALS OF THE RHEUMATIC DISEASES. 2017;76(10):1755-1763
H1N1 vaccination in Sjogren's syndrome triggers polyclonal B cell activation and promotes autoantibody production
Brauner S; Folkersen L; Kvarnstrom M; Meisgen S; Petersen S; Franzen-Malmros M; Mofors J; Brokstad KA; Klareskog L; Jonsson R; Westerberg LS; Trollmo C; Malmstrom V; Ambrosi A; Kuchroo VK; Nordmark G; Wahren-Herlenius M
Article: DATA IN BRIEF. 2017;13:356-370
Immunoglobulin characteristics and RNAseq data of FcRL4+ B cells sorted from synovial fluid and tissue of patients with rheumatoid arthritis.
Amara K; Clay E; Yeo L; Ramsköld D; Spengler J; Sippl N; Cameron J; Israelsson L; Titcombe PJ; Grönwall C; Sahbudin I; Filer A; Raza K; Malmström V; Scheel-Toellner D
Article: JOURNAL OF AUTOIMMUNITY. 2017;81:34-43
B cells expressing the IgA receptor FcRL4 participate in the autoimmune response in patients with rheumatoid arthritis
Amara K; Clay E; Yeo L; Ramskold D; Spengler J; Sippl N; Cameron JA; Israelsson L; Titcombe PJ; Gronwall C; Sahbudin I; Filer A; Raza K; Malmstrom V; Scheel-Toeliner D
Article: ARTHRITIS RESEARCH & THERAPY. 2016;18(1):284
Antibody responses to de novo identified citrullinated fibrinogen peptides in rheumatoid arthritis and visualization of the corresponding B cells
Joshua V; Schobers L; Titcombe PJ; Israelsson L; Ronnelid J; Hansson M; Catrina AI; Pruijn GJM; Malmstrom V
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2016;45(5):404-407
Late-onset neutropenia after rituximab in ANCA-associated vasculitis
Knight A; Sundstrom Y; Borjesson O; Brochfeld A; Malinstrom V; Gunnarsson I
Article: MOLECULAR MEDICINE. 2016;22:322-328
Integration of Known DNA, RNA and Protein Biomarkers Provides Prediction of Anti-TNF Response in Rheumatoid Arthritis: Results from the COMBINE Study
Folkersen L; Brynedal B; Diaz-Gallo LM; Ramskold D; Shchetynsky K; Westerlind H; Sundstrom Y; Schepis D; Hensvold A; Vivar N; Eloranta M-L; Ronnblom L; Brunak S; Malmstrom V; Catrina A; Moerch UGW; Klareskog L; Padyukov L; Berg L
Article: MOLECULAR & CELLULAR PROTEOMICS. 2016;15(9):3017-3029
Approach for Identifying Human Leukocyte Antigen (HLA)-DR Bound Peptides from Scarce Clinical Samples
Heyder T; Kohler M; Tarasova NK; Haag S; Rutishauser D; Rivera NV; Sandin C; Mia S; Malmstrom V; Wheelock AM; Wahlstrom J; Holmdahl R; Eklund A; Zubarev RA; Grunewald J; Ytterberg AJ
Article: ARTHRITIS & RHEUMATOLOGY. 2016;68(8):2016-2026
CD4+and CD8+CD28^null T Cells Are Cytotoxic to Autologous Muscle Cells in Patients With Polymyositis
Pandya JM; Venalis P; Al-Khalili L; Hossain MS; Stache V; Lundberg IE; Malmstrom V; Fasth AER
Article: ARTHRITIS & RHEUMATOLOGY. 2016;68(5):1124-1135
A Novel HLA-DRB1*10:01-Restricted T Cell Epitope From Citrullinated Type II Collagen Relevant to Rheumatoid Arthritis
Chemin K; Pollastro S; James E; Ge C; Albrecht I; Herrath J; Gerstner C; Tandre K; Rizzi TS; Ronnblom L; Catrina A; Holmdahl R; Klareskog L; de Vries N; Malmstrom V
Article: ANNALS OF THE RHEUMATIC DISEASES. 2016;75(4):730-738
Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism
Wigerblad G; Bas DB; Fernades-Cerqueira C; Krishnamurthy A; Nandakumar KS; Rogoz K; Kato J; Sandor K; Su J; Miguel Jimenez-Andrade J; Finn A; Farinotti AB; Amara K; Lundberg K; Holmdahl R; Jakobsson P-J; Malmstrom V; Catrina AI; Klareskog L; Svensson CI
Article: ANNALS OF THE RHEUMATIC DISEASES. 2016;75(4):721-729
Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss
Krishnamurthy A; Joshua V; Hensvold AH; Jin T; Sun M; Vivar N; Ytterberg AJ; Engstrom M; Fernandes-Cerqueira C; Amara K; Magnusson M; Wigerblad G; Kato J; Jimenez-Andrade JM; Tyson K; Rapecki S; Lundberg K; Catrina S-B; Jakobsson P-J; Svensson C; Malmstrom V; Klareskog L; Wahamaa H; Catrina AI
Article: ARTHRITIS RESEARCH & THERAPY. 2016;18:80
Effects of conventional immunosuppressive treatment on CD244+(CD28null) and FOXP3+T cells in the inflamed muscle of patients with polymyositis and dermatomyositis
Pandya JM; Loell I; Hossain MS; Zong M; Alexanderson H; Raghavan S; Lundberg IE; Malmstrom V
Article: FRONTIERS IN IMMUNOLOGY. 2016;7:494
Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis
Gerstner C; Dubnovitsky A; Sandin C; Kozhukh G; Uchtenhagen H; James EA; Ronnelid J; Ytterberg AJ; Pieper J; Reed E; Tandre C; Rieck M; Zubarev RA; Ronnblom L; Sandalova T; Buckner JH; Achour A; Malmstrom V
Article: PLOS ONE. 2016;11(6):e0158076
Antiphospholipid Antibodies in Lupus Nephritis
Parodis I; Arnaud L; Gerhardsson J; Zickert A; Sundelin B; Malmstrom V; Svenungsson E; Gunnarsson I
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2015;182(1):90-100
IL-1R1 is expressed on both Helios⁺ and Helios^-FoxP3⁺CD4⁺ T cells in the rheumatic joint
Muller M; Herrath J; Malmstrom V
Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(9):1772-1777
Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validation
Ytterberg AJ; Joshua V; Reynisdottir G; Tarasova NK; Rutishauser D; Ossipova E; Hensvold AH; Eklund A; Skold CM; Grunewald J; Malmstrom V; Jakobsson PJ; Ronnelid J; Padyukov L; Zubarev RA; Klareskog L; Catrina AI
Article: NATURE COMMUNICATIONS. 2015;6:6651
Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss
Harre U; Lang SC; Pfeifle R; Rombouts Y; Fruhbeisser S; Amara K; Bang H; Lux A; Koeleman CA; Baum W; Dietel K; Groehn F; Malmstroem V; Klareskog L; Kroenke G; Kocijan R; Nimmerjahn F; Toes REM; Herrmann M; Scherer HU; Schett G
Article: BMC IMMUNOLOGY. 2015;16(1):7
IL-17 and IL-23 in lupus nephritis - association to histopathology and response to treatment
Zickert A; Amoudruz P; Sundstrom Y; Ronnelid J; Malmstrom V; Gunnarsson I
Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(2):375-380
Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins
Hensvold AH; Magnusson PKE; Joshua V; Hansson M; Israelsson L; Ferreira R; Jakobsson P-J; Holmdahl R; Hammarstrom L; Malmstrom V; Askling J; Klareskog L; Catrina AI
Article: LUPUS SCIENCE AND MEDICINE. 2015;2(1):e000061
Evaluation of B lymphocyte stimulator and a proliferation inducing ligand as candidate biomarkers in lupus nephritis based on clinical and histopathological outcome following induction therapy.
Parodis I; Zickert A; Sundelin B; Axelsson M; Gerhardsson J; Svenungsson E; Malmström V; Gunnarsson I
Article: ARTHRITIS RESEARCH & THERAPY. 2014;16(5):454
Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies
Krystufkova O; Helmers SB; Venalis P; Malmstrom V; Lindroos E; Vencovsky J; Lundberg IE
Article: ANNALS OF THE RHEUMATIC DISEASES. 2014;73(10):1761-1768
Anti-CarP antibodies in two large cohorts of patients with rheumatoid arthritis and their relationship to genetic risk factors, cigarette smoking and other autoantibodies
Jiang X; Trouw LA; van Wesemael TJ; Shi J; Bengtsson C; Kallberg H; Malmstrom V; Israelsson L; Hreggvidsdottir H; Verduijn W; Klareskog L; Alfredsson L; Huizinga TWJ; Toes REM; Lundberg K; van der Woude D
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2014;44(10):2979-2989
Surface expression of CD39 identifies an enriched Treg-cell subset in the rheumatic joint, which does not suppress IL-17A secretion
Herrath J; Chemin K; Albrecht I; Catrina AI; Malmstrom V
Article: ARTHRITIS RESEARCH & THERAPY. 2014;16(4):414
Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis
Snir O; Gomez-Cabrero D; Montes A; Perez-Pampin E; Gomez-Reino JJ; Seddighzadeh M; Klich KU; Israelsson L; Ding B; Catrina AI; Holmdahl R; Alfredsson L; Klareskog L; Tegner J; Gonzalez A; Malmstrom V; Padyukov L
Article: ARTHRITIS RESEARCH & THERAPY. 2014;16(4):R167
Affinity purified anti-citrullinated protein/peptide antibodies target antigens expressed in the rheumatoid joint
Ossipova E; Cerqueira CF; Reed E; Kharlamova N; Israelsson L; Holmdahl R; Nandakumar KS; Engstrom M; Harre U; Schett G; Catrina AI; Malmstrom V; Sommarin Y; Klareskog L; Jakobsson P-J; Lundberg K
Article: IMMUNOLOGY. 2014;142(4):581-593
Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts
Nielsen N; Pascal V; Fasth AER; Sundstrom Y; Galsgaard ED; Ahern D; Andersen M; Baslund B; Bartels EM; Bliddal H; Feldmann M; Malmstrom V; Berg L; Spee P; Soderstrom K
Article: ARTHRITIS RESEARCH & THERAPY. 2014;16(4):R143
Type II collagen antibody response is enriched in the synovial fluid of rheumatoid joints and directed to the same major epitopes as in collagen induced arthritis in primates and mice
Lindh I; Snir O; Lonnblom E; Uysal H; Andersson I; Nandakumar KS; Vierboom M; Hart B; Malmstrom V; Holmdahl R
Article: ARTHRITIS & RHEUMATOLOGY. 2014;66(7):1712-1722
Citrulline-Specific Th1 Cells Are Increased in Rheumatoid Arthritis and Their Frequency Is Influenced by Disease Duration and Therapy
James EA; Rieck M; Pieper J; Gebe JA; Yue BB; Tatum M; Peda M; Sandin C; Klareskog L; Malmstrom V; Buckner JH
Article: JOURNAL OF IMMUNOLOGY. 2014;192(10):4551-4559
Naturally Occurring Human Phosphorylcholine Antibodies Are Predominantly Products of Affinity-Matured B Cells in the Adult
Fiskesund R; Steen J; Amara K; Murray F; Szwajda A; Liu A; Douagi I; Malmstrom V; Frostegard J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2014;73(5):913-920
Anakinra treatment in patients with refractory inflammatory myopathies and possible predictive response biomarkers: a mechanistic study with 12 months follow-up
Zong M; Dorph C; Dastmalchi M; Alexanderson H; Pieper J; Amoudruz P; Helmers SB; Nennesmo I; Malmstrom V; Lundberg IE
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(5):305-314
An optimized Protocol for Human M2 Macrophages using M-CSF and IL-4/IL-10/TGF-β Yields a Dominant Immunosuppressive Phenotype
Mia S; Warnecke A; Zhang X-M; Malmstrom V; Harris RA
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(2):149-155
Peripheral and Site-Specific CD4⁺CD28^null T Cells from Rheumatoid Arthritis Patients Show Distinct Characteristics
Pieper J; Johansson S; Snir O; Linton L; Rieck M; Buckner JH; Winqvist O; van Vollenhoven R; Malmstrom V
Article: PLOS ONE. 2014;9(9):e104382
Accelerating Translational Research by Clinically Driven Development of an Informatics Platform-A Case Study
Abugessaisa I; Saevarsdottir S; Tsipras G; Lindblad S; Sandin C; Nikamo P; Stahle M; Malmstrom V; Klareskog L; Tegner J
Article: PLOS ONE. 2014;9(11):e113924
IgG Antibodies to Cyclic Citrullinated Peptides Exhibit Profiles Specific in Terms of IgG Subclasses, Fc-Glycans and a Fab-Peptide Sequence
Lundstrom SL; Fernandes-Cerqueira C; Ytterberg AJ; Ossipova E; Hensvold AH; Jakobsson P-J; Malmstrom V; Catrina AI; Klareskog L; Lundberg K; Zubarev RA
Article: BMC IMMUNOLOGY. 2013;14:34
CTLA4-Ig (abatacept) therapy modulates T cell effector functions in autoantibody-positive rheumatoid arthritis patients
Pieper J; Herrath J; Raghavan S; Muhammad K; van Vollenhoven R; Malmstrm V
Article: ARTHRITIS & RHEUMATOLOGY. 2013;65(7):1702-1712
Autoantibodies to Posttranslationally Modified Type II Collagen as Potential Biomarkers for Rheumatoid Arthritis
Strollo R; Ponchel F; Malmstrom V; Rizzo P; Bombardieri M; Wenham CY; Landy R; Perret D; Watt F; Corrigall VM; Winyard PG; Pozzilli P; Conaghan PG; Panayi GS; Klareskog L; Emery P; Nissim A
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2013;11:85
Implementation of the CDC translational informatics platform - from genetic variants to the national Swedish Rheumatology Quality Register
Abugessaisa I; Gomez-Cabrero D; Snir O; Lindblad S; Klareskog L; Malmstrom V; Tegner J
Article: GENES AND IMMUNITY. 2013;14(2):83-89
Genetic variation in the serotonin receptor gene affects immune responses in rheumatoid arthritis
Snir O; Hesselberg E; Amoudruz P; Klareskog L; Zarea-Ganji I; Catrina A; Padyukov L; Malmstrom V; Seddighzadeh M
Article: ARTHRITIS RESEARCH & THERAPY. 2012;14(5):R201
Validation of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides
Hansson M; Mathsson L; Schlederer T; Israelsson L; Matsson P; Nogueira L; Jakobsson P-J; Lundberg K; Malmstrom V; Serre G; Holmdahl R; Nystrand M; Klareskog L; Ronnelid J
Article: ARTHRITIS & RHEUMATOLOGY. 2012;64(8):2482-2488
Multifunctional T cell reactivity with native and glycosylated type II collagen in rheumatoid arthritis
Snir O; Backlund J; Bostrom J; Andersson I; Kihlberg J; Buckner JH; Klareskog L; Holmdahl R; Malmstrom V
Article: ARTHRITIS & RHEUMATOLOGY. 2011;63(10):2873-2883
Identification and Functional Characterization of T Cells Reactive to Citrullinated Vimentin in HLA-DRB1*0401-Positive Humanized Mice and Rheumatoid Arthritis Patients
Snir O; Rieck M; Gebe JA; Yue BB; Rawlings CA; Nepom G; Malmstrom V; Buckner JH
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2011;41(8):2279-2290
The inflammatory milieu in the rheumatic joint reduces regulatory T-cell function
Herrath J; Muller M; Amoudruz P; Janson P; Michaelsson J; Larsson PT; Trollmo C; Raghavan S; Malmstrom V
Article: PLOS ONE. 2011;6(5):e19138
The Expression of VEGF-A Is Down Regulated in Peripheral Blood Mononuclear Cells of Patients with Secondary Progressive Multiple Sclerosis
Iacobaeus E; Amoudruz P; Strom M; Khademi M; Brundin L; Hillert J; Kockum I; Malmstrom V; Olsson T; Tham E; Piehl F
Article: PLOS ONE. 2011;6(1):e16378
Prostaglandin E₂ Synthesizing Enzymes in Rheumatoid Arthritis B Cells and the Effects of B Cell Depleting Therapy on Enzyme Expression
Gheorghe KR; Thurlings RM; Westman M; Boumans MJ; Malmstrom V; Trollmo C; Korotkova M; Jakobsson P-J; Tak P-P
Article: JOURNAL OF IMMUNOLOGY. 2011;186(1):92-102
Profiling of CD4⁺ T Cells with Epigenetic Immune Lineage Analysis
Janson PCJ; Linton LB; Bergman EA; Marits P; Eberhardson M; Piehl F; Malmstrom V; Winqvist O
Article: ARTHRITIS & RHEUMATOLOGY. 2010;62(11):3457-3466
Expanded T Cell Receptor V_β-Restricted T Cells From Patients With Sporadic Inclusion Body Myositis Are Proinflammatory and Cytotoxic CD28^null T Cells
Pandya JM; Fasth AER; Zong M; Arnardottir S; Dani L; Lindroos E; Malmstrom V; Lundberg IE
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2010;65(7):822-830
Maternal allergic disease does not affect the phenotype of T and B cells or the immune response to allergens in neonates
Rindsjo E; Joerink M; Johansson C; Bremme K; Malmstrom V; Scheynius A
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(2):378-387
Activating NK-cell receptors co-stimulate CD4⁺CD28^- T cells in patients with rheumatoid arthritis
Fasth AER; Bjorkstrom NK; Anthoni M; Malmberg K-J; Malmstrom V
Article: ARTHRITIS & RHEUMATOLOGY. 2010;62(1):44-52
Antibodies to Several Citrullinated Antigens Are Enriched in the Joints of Rheumatoid Arthritis Patients
Snir O; Widhe M; Hermansson M; von Spee C; Lindberg J; Hensen S; Lundberg K; Engstrom A; Venables PJW; Toes REM; Holmdahl R; Klareskog L; Malmstrom V
Article: ANNALS OF THE RHEUMATIC DISEASES. 2009;68(12):1908-1915
FOXP3 expression in blood, synovial fluid and synovial tissue during inflammatory arthritis and intra-articular corticosteroid treatment
Raghavan S; Cao D; Widhe M; Roth K; Herrath J; Engstrom M; Roncador G; Banham AH; Trollmo C; Catrina AI; Malmstrom V
Article: NATURE GENETICS. 2009;41(12):1319-1324
Specific interaction between genotype, smoking and autoimmunity to citrullinated α-enolase in the etiology of rheumatoid arthritis
Mahdi H; Fisher BA; Kallberg H; Plant D; Malmstrom V; Ronnelid J; Charles P; Ding B; Alfredsson L; Padyukov L; Symmons DPM; Venables PJ; Klareskog L; Lundberg K
Article: JOURNAL OF IMMUNOLOGY. 2009;183(7):4792-4799
T Cell Infiltrates in the Muscles of Patients with Dermatomyositis and Polymyositis Are Dominated by CD28^null T Cells
Fasth AER; Dastmalchi M; Rahbar A; Salomonsson S; Pandya JM; Lindroos E; Nennesmo I; Malmberg K-J; Soderberg-Naucler C; Trollmo C; Lundberg IE; Malmstrom V
Article: ANNALS OF THE RHEUMATIC DISEASES. 2009;68(6):836-843
Increased serum levels of B cell activating factor (BAFF) in subsets of patients with idiopathic inflammatory myopathies
Krystufkova O; Vallerskog T; Helmers SB; Mann H; Putova I; Belacek J; Malmstrom V; Trollmo C; Vencovsky J; Lundberg IE
Article: ANNALS OF THE RHEUMATIC DISEASES. 2009;68(5):736-743
Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles
Snir O; Widhe M; von Spee C; Lindberg J; Padyukov L; Lundberg K; Engstrom A; Venables PJ; Lundeberg J; Holmdahl R; Klareskog L; Malmstrom V
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2008;339(2):165-174
Serial re-challenge with influenza vaccine as a tool to study individual immune responses
Vallerskog T; Gaines H; Feldman A; Culbert E; Klareskog L; Malmstrom V; Trollmo C
Article: ANNALS OF THE RHEUMATIC DISEASES. 2008;67(12):1742-1749
Cellular distribution of the C-type II lectin dendritic cell immunoreceptor (DCIR) and its expression in the rheumatic joint: identification of a subpopulation of DCIR plus T cells
Eklow C; Makrygiannakis D; Backdahl L; Padyukov L; Ulfgren A-K; Lorentzen JC; Malmstrom V
Article: ARTHRITIS & RHEUMATOLOGY. 2008;58(8):2287-2295
Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis
Kinloch A; Lundberg K; Wait R; Wegner N; Lim NH; Zendman AJW; Saxne T; Malmstrom V; Venables PJ
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2007;37(8):1127-1136
Immune regulation by CD4⁺CD25⁺ T cells and interleukin-10 in birch pollen-allergic patients and non-allergic controls
Thunberg S; Akdis M; Akdis CA; Gronneberg R; Malmstrom V; Trollmo C; van Hage M; Gafvelin G
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2007;103(3):368-375
Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184-198 of bovine type II collagen (CII) expressing a dominant T cell epitope
Staines NA; Harper N; Ward FJ; Malmstrom V; Holmdahl R; Bansal S
Article: CLINICAL IMMUNOLOGY. 2007;122(1):62-74
Treatment with rituximab affects both the cellular and the humoral arm of the immune system in patients with SLE
Vallerskog T; Gunnarsson I; Widhe M; Risselada A; Klareskog L; van Vollenhoven R; Malmstrom V; Trollmo C
Article: ARTHRITIS RESEARCH & THERAPY. 2007;9(5):r87
Skewed distribution of proinflammatory CD4⁺CD28^null T cells in rheumatoid arthritis
Fasth AE; Snir O; Johansson AA; Nordmark B; Rahbar A; af Klint E; Bjorkstrom NK; Ulfgren A-K; van Vollenhoven RF; Malmstrom V; Trollmo C
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2006;63(6):444-452
FOXP3 identifies regulatory CD25^brigntCD4⁺ T cells in rheumatic joints
Cao D; Borjesson O; Larsson P; Rudin A; Gunnarsson I; Klareskog L; Malmstrom V; Trollmo C
Article: ARTHRITIS RESEARCH & THERAPY. 2006;8(6):R167
Differential effects on BAFF and APRIL levels in rituximab-treated patients with systemic lupus erythematosus and rheumatoid arthritis
Vallerskog T; Heimburger M; Gunnarsson I; Zhou W; Wahren-Herlenius M; Trollmo C; Malmstrom V
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2005;143(1):110-116
Expression of OX40 (CD134) on CD4+T-cells from patients with myasthenia gravis
Zhao XY; Pirskanen R; Malmstrom V; Lefvert AK
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2005;202(8):1051-1061
Essential role for CD103 in the T cell-mediated regulation of experimental colitis
Annacker O; Coombes JL; Malmstrom V; Uhlig HH; Bourne T; Johansson-Lindbom B; Agace WW; Parker CM; Powrie F
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2005;115(6):1304-1310
Neonatal immune responses to microbial stimuli:: Is there an influence of maternal allergy?
Amoudruz P; Holmlund U; Malmström V; Trollmo C; Bremme K; Scheynius A; Sverremark-Ekström E
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2004;60(1-2):199-208
CD28^nullCD4⁺ T cells -: Characterization of an effector memory T-cell population in patients with rheumatoid arthritis
Fasth AER; Cao D; van Vollenhoven R; Trollmo C; Malmström V
Article: AMERICAN JOURNAL OF THE MEDICAL SCIENCES. 2004;327(4):196-201
The additive role of innate and adaptive immunity in the development of arthritis
Malmström V; Trollmo C; Klareskog L
Article: ARTHRITIS RESEARCH & THERAPY. 2004;6(4):R335-R346
CD25^brightCD4⁺ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease
Cao DJ; van Vollenhoven R; Klareskog L; Trollmo C; Malmström V
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2003;33(1):215-223
Isolation and functional characterization of regulatory CD25^brightCD4⁺ T cells from the target organ of patients with rheumatoid arthritis
Cao D; Malmström V; Baecher-Allan C; Hafler D; Klareskog L; Trollmo C
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2002;32(6):1773-1783
Reversal of tolerance induced by transplantation of skin expressing the immunodominant T cell epitope of rat type II collagen entitles development of collagen-induced arthritis but not graft rejection
Bäcklund J; Treschow A; Firan M; Malmström V; Issazadeh-Navikas S; Ward ES; Holmdahl R
Article: JOURNAL OF IMMUNOLOGY. 2001;166(11):6972-6981
CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice
Malmström V; Shipton D; Singh B; Al-Shamkhani A; Puklavec MJ; Barclay AN; Powrie F
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2000;192(2):295-302
Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25⁺CD4⁺ regulatory cells that control intestinal inflammation
Read S; Malmström V; Powrie F
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(13):7574-7579
Definition of MHC and T cell receptor contacts in the HLA-DR4-restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice
Andersson EC; Hansen BE; Jacobsen H; Madsen LS; Andersen CB; Engberg J; Rothbard JB; McDevitt GS; Malmström V; Holmdahl R; Svejgaard A; Fugger L
Article: JOURNAL OF AUTOIMMUNITY. 1998;11(3):213-221
Type II collagen in cartilage evokes peptide-specific tolerance and skews the immune response
Malmstrom V; Kjellen P; Holmdahl R
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1997;45(6):670-677
Arthritis susceptibility in mice expressing human type II collagen in cartilage
Malmstrom V; Ho KKY; Lun J; Tam PPL; Cheah KSE; Holmdahl R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(9):4480-4485
Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis
Malmstrom V; Michaelsson E; Burkhardt H; Mattsson R; Vuorio E; Holmdahl R
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Review: NATURE REVIEWS. RHEUMATOLOGY. 2024;20(7):399-416
The peculiar features, diversity and impact of citrulline-reactive autoantibodies
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Letter: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(5):724-726
Divergent and dominant anti-inflammatory effects of patient-derived anticitrullinated protein antibodies (ACPA) in arthritis development
Raposo B; Afonso M; Israelsson L; Waehaemaa H; Stalesen R; Wermeling F; Hensvold AH; Groenwall C; Rethi B; Klareskog L; Malmstrom V
Editorial comment: NATURE REVIEWS. RHEUMATOLOGY. 2023;19(5):259-260
Citrulline immunity in RA: CD8⁺ T cells enter the scene
Chemin K; Malmstrom V
Corrigendum: NATURE REVIEWS IMMUNOLOGY. 2022;22(7):459
The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting (vol 17, pg 60, 2017)
Malmstrom V; Catrina AI; Klareskog L
Editorial comment: EBIOMEDICINE. 2021;72:103585
New technologies laying a foundation for next generation clinical serology
Gronwall C; Malmstrom V
Letter: ANNALS OF THE RHEUMATIC DISEASES. 2020;79(12):e164
How to communicate in science
Klareskog L; Catrina AI; Svensson C; Malmstrom V
Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2020;92(5):e12958
Proteinase 3 Autoreactivity in Anti-Neutrophil Cytoplasmic Antibody-associated vasculitis-Immunological versus clinical features
Sharma RK; Lovstrom B; Gunnarsson I; Malmstrom V
Review: THE LANCET RHEUMATOLOGY. 2020;2(11):E712-E723
Autoantigens in rheumatoid arthritis and the potential for antigen-specific tolerising immunotherapy
Nel HJ; Malmstrom V; Wraith DC; Thomas R
Letter: ARTHRITIS & RHEUMATOLOGY. 2019;71(2):325-327
The specificity of monoclonal anti-citrullinated protein antibodies: comment on the article by Steen et al Reply
Malmstrom V; Steen J; Klareskog L
Review: FRONTIERS IN IMMUNOLOGY. 2019;10:353
Effector Functions of CD4+T Cells at the Site of Local Autoimmune Inflammation-Lessons From Rheumatoid Arthritis
Chemin K; Gerstner C; Malmstrom V
Editorial comment: NATURE REVIEWS. RHEUMATOLOGY. 2018;14(11):626-628
RHEUMATOID ARTHRITIS The parallel worlds of ACPA-positive and RF-positive B cells
Malmstrom V; Gronwall C
Review: AUTOIMMUNITY REVIEWS. 2017;16(4):343-351
Smoking and pre-existing organ damage reduce the efficacy of belimumab in systemic lupus erythematosus
Parodis I; Sjowall C; Jonsen A; Ramskold D; Zickert A; Frodlund M; Sohrabian A; Arnaud L; Ronnelid J; Malmstrom V; Bengtsson AA; Gunnarsson I
Review: NATURE REVIEWS. RHEUMATOLOGY. 2017;13(2):79-86
Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis
Catrina AI; Svensson CI; Malmstrom V; Schett G; Klareskog L
Corrigendum: FRONTIERS IN IMMUNOLOGY. 2017;8:1236
Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis (vol 7, 494, 2016)
Gerstner C; Dubnovitsky A; Sandin C; Kozhukh G; Uchtenhagen H; James EA; Ronnelid J; Ytterberg AJ; Pieper J; Reed E; Tandre K; Rieck M; Zubarev RA; Ronnblom L; Sandalova T; Buckner JH; Achour A; Malmstrom V
Letter: ARTHRITIS & RHEUMATOLOGY. 2017;69(1):243-244
Circulating CD8+CD28^null T cytotoxic cells in polymyositis-a possible biomarker? Comment on the article by Pandya et al Reply
Malmstrom V; Pandya JM; Lundberg IE; Fasth AER
Review: NATURE REVIEWS IMMUNOLOGY. 2017;17(1):60-75
The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting
Malmstrom V; Catrina AI; Klareskog L
Letter: ARTHRITIS & RHEUMATOLOGY. 2016;68(8):2053-2054
Is citrullination required for the presence of restricted clonotypes reacting with type II collagen? Comment on the article by Chemin et al Reply
Chemin K; Albrecht I; Pollastro S; de Vries N; Holmdahl R; Malmstrom V
Review: CURRENT OPINION IN RHEUMATOLOGY. 2016;28(2):181-188
Is rheumatoid arthritis an autoimmune disease?
Chemin K; Klareskog L; Malmstrom V
Review: IMMUNOLOGICAL REVIEWS. 2016;269(1):162-174
Mechanisms involved in triggering rheumatoid arthritis
Catrina AI; Joshua V; Klareskog L; Malmstrom V
Review: NATURE REVIEWS. RHEUMATOLOGY. 2014;10(11):645-653
Lungs, joints and immunity against citrullinated proteins in rheumatoid arthritis
Catrina AI; Ytterberg AJ; Reynisdottir G; Malmstrom V; Klareskog L
Review: EUROPEAN JOURNAL OF IMMUNOLOGY. 2014;44(6):1593-1599
Autoimmune priming, tissue attack and chronic inflammation The three stages of rheumatoid arthritis
Holmdahl R; Malmstrom V; Burkhardt H
Review: CURRENT OPINION IN RHEUMATOLOGY. 2014;26(1):72-79
Adaptive immunity in rheumatoid arthritis: anticitrulline and other antibodies in the pathogenesis of rheumatoid arthritis
Klareskog L; Amara K; Malmstrom V
Review: ADVANCES IN IMMUNOLOGY. 2013;118:129-158
Autoimmunity in Rheumatoid Arthritis: Citrulline Immunity and Beyond
Klareskog L; Lundberg K; Malmstrom V
Review: ARTHRITIS RESEARCH & THERAPY. 2012;14(6):230
T cells in myositis
Malmstrom V; Venalis P; Albrecht I
Editorial comment: ARTHRITIS RESEARCH & THERAPY. 2012;14(5):124
Ways forward to identify new ACPA targets in RA
Ytterberg AJ; Malmstrom V
Review: SEMINARS IN IMMUNOLOGY. 2011;23(2):92-98
Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis
Klareskog L; Malmstrom V; Lundberg K; Padyukov L; Alfredsson L
Letter: ARTHRITIS & RHEUMATOLOGY. 2010;62(11):3516-3517
Are antibodies to citrullinated antigens enriched in synovial fluids of patients with rheumatoid arthritis?: comment on the article by Snir et al Reply
Snir O; Klareskog L; Malmstrom V
Letter: NATURE GENETICS. 2010;42(10):816
Gene-environment interaction influences the reactivity of autoantibodies to citrullinated antigens in rheumatoid arthritis Reply
Lundberg K; Alfredsson L; Kallberg H; Mahdi H; Fisher BA; Malmstrom V; Venables PJ; Klareskog L
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2010;69:a73
IDENTIFICATION AND FUNCTION OF T CELLS REACTIVE WITH CITRULLINATED VIMENTIN IN HLA-DRB1*0401 HUMANISED MICE AND RHEUMATOID ARTHRITIS PATIENTS
Snir O; Rieck M; Klich K; Klareskog L; Buckner JH; Malmstrom V
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2010;69:A51
ANTI-TYPE II COLLAGEN-IMMUNE COMPLEX-INDUCED PRODUCTION OF INTERLEUKIN 1β AND TUMOUR NECROSIS FACTOR α STIMULATE PRODUCTION OF MATRIX METALLOPROTEINASES FROM MONOCYTE/RHEUMATOID ARTHRITIS SYNOVIAL FIBROBLAST CO-CULTURES
Mullazehi M; Mathsson L; Feldt O; Schubert K; Korotkova M; Malmstrom V; Ronnelid J
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2010;69:a4-A5
IDENTIFICATION OF SPECIFIC CITRULLINATION SITES ON FIBRINOGEN IN RA
Ossipova E; Malmstrom V; Catrina AI; Klareskog L; Zubarev R; Jakobsson P-J
Review: IMMUNOLOGICAL REVIEWS. 2010;233(1):34-54
Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
Wegner N; Lundberg K; Kinloch A; Fisher B; Malmstrom V; Feldmann M; Venables PJ
Review: ARTHRITIS RESEARCH & THERAPY. 2007;9(2):208
Immune mechanisms in the pathogenesis of idiopathic inflammatory myopathies
Grundtman C; Malmstroem V; Lundberg IE
Meeting abstract: CLINICAL IMMUNOLOGY. 2006;119:S21
Comparative analysis of FOXP3 in target organ and circulation of rheumatic patients.
Cao D; Raghavan S; Widhe M; Ulfgren A-K; Roncador G; Bonham A; Malmstrom V; Trollmo T
Meeting abstract: CLINICAL IMMUNOLOGY. 2006;119:S63
Increased Baff levels after rituximab-induced B-cell depletion in SLE patients.
Wallerskog T; Zhou W; Wohren-Herlenius M; Klareskog L; Malmstrom V; Trollmo C
Review: ARTHRITIS RESEARCH & THERAPY. 2005;7(Suppl 2):S15-S20
Modulating co-stimulation:: a rational strategy in the treatment of rheumatoid arthritis?
Malmström V; Trollmo C; Klareskog L
Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2004;6:S13
CD28nullCD4⁺ T cells:: an effector memory T cell population in patients with rheumatoid arthritis
Fasth AER; Cao D; van Vollenhoven R; Trollmo C; Malmström V
Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2004;6:S14-S15
CD25brightCD4⁺ regulatory T cells accumulate in inflamed joints of patients with chronic rheumatic disease
Cao D; van Vollenhoven R; Klareskog L; Trollmo C; Malmström V
Review: IMMUNOLOGICAL REVIEWS. 2001;182:190-200
Control of intestinal inflammation by regulatory T cells
Singh B; Read S; Asseman C; Malmström V; Mottet C; Stephens LA; Stepankova R; Tlaskalova H; Powrie F
Review: ARTHRITIS RESEARCH & THERAPY. 2000;2(4):315-326
T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis
Malmström V; Bäcklund J; Jansson L; Kihlberg J; Holmdahl R
Review: IMMUNOLOGIST. 1998;6(1):29-34
Interactions between the immune system and tissue matrix - T-cell tolerance to cartilage type II collagen
Malmstrom V; Fugger L; Holmdahl R
Review: IMMUNOLOGICAL REVIEWS. 1995;144:109-135
CHRONICITY OF TISSUE-SPECIFIC EXPERIMENTAL AUTOIMMUNE-DISEASE - A ROLE FOR B-CELLS
HOLMDAHL R; VINGSBO C; MO JA; MICHAELSSON E; MALMSTROM V; JANSSON L; BRUNSBERG U
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Grants

Efficacy and safety of early use of IL-6R blockad versus glucocorticoids for the treatment of arthritis induced by check point inhibitors: a randomized, proof of concept, controlled clinical trial
Swedish Research Council
1 December 2023 - 30 November 2027
Lymphocyte repertoires in autoimmunity - dissecting rheumatic disease
Swedish Research Council
1 January 2023 - 31 December 2025
The lung as a site for break of tolerance and initiation of anti-Jo1 positive interstitial lung disease
Swedish Heart-Lung Foundation
1 January 2021 - 31 December 2022
Lymphocyte function and regulation in rheumatic disease
Swedish Research Council
1 January 2020 - 31 December 2022
The lung as a site for break of tolerance and initiation of anti-Jo1 positive interstitial lung disease
Swedish Heart-Lung Foundation
1 January 2019 - 31 December 2020
Lymphocyte function and regulation in rheumatic disease
Swedish Research Council
1 January 2016 - 31 December 2019
Workshop on the basic science of immune tolerance and its opportunities for drug development in rheumatoid arthritis
Swedish Research Council
1 November 2015 - 30 November 2015
Immune regulation and biomarkers in lupus nephritis
Swedish Research Council
1 January 2015 - 31 December 2017
Lymphocyte function and regulation in rheumatic disease
Swedish Research Council
1 January 2013 - 31 December 2015
Autoimmune Diseases
Knut and Alice Wallenberg Foundation
1 January 2011 - 1 January 2016
Towards immune specific diagnosis and prevention of rheumatoid arthritis
Swedish Research Council
1 January 2011 - 31 December 2013
Lymphocyte function and regulation in inflammatory rheumatic disease
Swedish Research Council
1 January 2010 - 31 December 2012
Towards immune specific diagnosis and prevention of rheumatoid arthritis
Swedish Research Council
1 January 2009 - 31 December 2011
T-cell receptor repertoar studier vid rheumatoid artrit
KID - partial funding of doctoral education at Karolinska Institutet

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