Vilija Oke
About me
I am associated professor and specialist in Rheumatology. Currently I have a position as a senior consultant and head of research at Academic Specialist Center, Center for Rheumatology.
I am a researcher affiliated to assoc. prof. Aleksandra Antovic/prof. Elisabet Svenungssons group.
I did my specialization in Rheumatology at Karolinska University Hospital.
I defended my PhD thesis in 2011 at the Department of Medicine, Solna, Karolinska Institutet.
The title of my thesis is “Studies on molecular regulation of inflammation in Cutaneous lupus Erythematosus”.
I am a researcher and affiliated to assoc. prof. Aleksandra Antovic/prof. Elisabet Svenungssons group.
Research
My research focus is skin inflammation in autoimmune disease. I believe that
investigation of autoimmune skin inflammation can provide us with better
insight in systemic autoimmunity.Major lines of research:
1) Molecular pathogenesis of skin inflammation in cutaneous lupus
erythematosus and other systemic rheumatic diseases (HUD-SS study).
2) Co-morbidity in psoriatic arthritis (COMPASs study)
Teaching
I am an expert in teaching on autoimmune rheumatic diseases and skin manifestations of rheumatic diseases.
Articles
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2025;84(9):1549-1560Alabbasi S; Tacconelli S; de Vries M; Gunnarsson I; Oke V; Kvarnstrom M; De Michele A; Di Gregorio P; Patrignani P; Idborg H; Jakobsson P-J
- Article: RHEUMATOLOGY. 2025;64(3):1170-1178Elbagir S; Mohammed NA; Oke V; Larsson A; Nilsson J; Elshafie A; Elagib EM; Nur MAM; Gunnarsson I; Svenungsson E; Ronnelid J
- Article: QJM-AN INTERNATIONAL JOURNAL OF MEDICINE. 2024;117(8):581-588Nln I; Shum J; Ghodke-Puranik Y; Tipon R; Triese D; Amin S; Makol A; Osborn T; Chowdhary V; Thanarajasingam U; Muskardin TLW; Oke V; Gunnarsson I; Zickert A; Zervou MI; Boumpas DT; Svenungsson E; Goulielmos GN; Niewold TB
- Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2024;83:1456Sharaf M; Gossec L; Baraliakos X; Galloway J; Kristensen LE; Oke V; Sfikakis PP; Rampakakis E; Lavie F; Innes IBM
- Journal article: REVUE DU RHUMATISME (EDITION FRANCAISE). 2023;90:a170-a171Gossec L; Baraliakos X; Galloway J; Kristensen LE; Oke V; Sfikakis P; Rampakakis E; Sharaf M; Lavie F; Mcinnes IB
- Article: LUPUS SCIENCE & MEDICINE. 2022;9(1):e000744Hayry A; Faustini F; Zickert A; Larsson A; Niewold TB; Svenungsson E; Oke V; Gunnarsson I
- Article: ACR OPEN RHEUMATOLOGY. 2022;4(1):27-39Diaz-Gallo L-M; Oke V; Lundstrom E; Elvin K; Wu YL; Eketjall S; Zickert A; Gustafsson JT; Jonsen A; Leonard D; Birmingham DJ; Nordmark G; Bengtsson AA; Ronnblom L; Gunnarsson I; Yu C-Y; Padyukov L; Svenungsson E
- Article: ARTHRITIS RESEARCH & THERAPY. 2021;23(1):132Niewold TB; Meves A; Lehman JS; Popovic-Silwerfeldt K; Hayry A; Soderlund-Matell T; Charlesworth CM; Madden B; Lundberg IE; Wahren-Herlenius M; Svenungsson E; Oke V
- Journal article: RHEUMATOLOGY. 2021;60(3):1575Bjork A; Rodrigues RDS; Andersson ER; Sepulveda JIR; Mofors J; Kvarnstrom M; Oke V; Svenungsson E; Gunnarsson I; Wahren-Herlenius M
- Article: RHEUMATOLOGY. 2021;60(3):1445-1455Bjork A; Rodrigues RDS; Andersson ER; Sepulveda JIR; Mofors J; Kvarnstrom M; Oke V; Svenungsson E; Gunnarsson I; Wahren-Herlenius M
- Article: JOURNAL OF RHEUMATOLOGY. 2020;47(6):865-875Ruacho G; Kvarnstrom M; Zickert A; Oke V; Ronnelid J; Eketjall S; Elvin K; Gunnarsson I; Svenungsson E
- Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1029Idborg H; Zandian A; Ossipova E; Wigren E; Preger C; Mobarrez F; Checa A; Sohrabian A; Pucholt P; Sandling JK; Fernandes-Cerqueira C; Ronnelid J; Oke V; Grosso G; Kvarnstrom M; Larsson A; Wheelock CE; Syvanen A-C; Ronnblom L; Kultima K; Persson H; Graslund S; Gunnarsson I; Nilsson P; Svenungsson E; Jakobsson P-J
- Article: ARTHRITIS RESEARCH & THERAPY. 2019;21(1):107Oke V; Gunnarsson I; Dorschner J; Eketjaell S; Zickert A; Niewold TB; Svenungsson E
- Article: LUPUS SCIENCE & MEDICINE. 2018;5(1):e000260Idborg H; Eketjall S; Pettersson S; Gustafsson JT; Zickert A; Kvarnstrom M; Oke V; Jakobsson P-J; Gunnarsson I; Svenungsson E
- Article: ARTHRITIS RESEARCH & THERAPY. 2017;19(1):139Oke V; Brauner S; Larsson A; Gustafsson J; Zickert A; Gunnarsson I; Svenungsson E
- Article: LUPUS SCIENCE & MEDICINE. 2016;3(1):e000170Zickert A; Oke V; Parodis L; Svenungsson E; Sundstrom Y; Gunnarsson I
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2011;131(8):1622-1630Kuhn A; Wozniacka A; Szepietowski JC; Glaeser R; Lehmann P; Haust M; Sysa-Jedrzejowska A; Reich A; Oke V; Huegel R; Calderon C; de Vries DE; Nyberg F
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2009;129(8):2000-2010Oke V; Vassilaki I; Espinosa A; Strandberg L; Kuchroo VK; Nyberg F; Wahren-Herlenius M
- Article: EXPERIMENTAL CELL RESEARCH. 2008;314(20):3605-3613Espinosa A; Oke V; Elfving A; Nyberg F; Covacu R; Wahren-Herlenius M
- Article: LUPUS. 2007;16(10):794-802Barkauskaite V; Ek M; Popovic K; Harris HE; Wahren-Herlenius M; Nyberg F
All other publications
- Conference publication: 2024;:36.2-3637Juto A; Faustini F; Häyry A; Larsson A; Malmström V; Bruchfeld A; Antovic A; Oke V; Gunnarsson I
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2024;83:1134-1135Hayry A; Oke V; Larsson A; Svenungsson E; Gunnarsson I; Faustini F
- Conference publication: 2024;:a49.2-a4a50Häyry A; Oke V; Svenungsson E; Faustini F; Gunnarsson I
- Conference publication: 2024;:a55-a56Niewold TB; Meves A; Lehman J; Dasari S; Popovic-Silwerfeldt K; Charlesworth C; Madden B; Svenungsson E; Oke V
- Conference publication: 2024;:a29.2-a2a30Elbagir S; Mohammed NA; Oke V; Larsson A; Nilsson J; Elshafie A; Elagib EM; Nur MA; Gunnarsson I; Svenungsson E; Rönnelid J
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2023;75:2807-2809Gossec L; Baraliakos X; Galloway J; Erik L; Oke V; Sfikakis P; Rampakakis E; Sharaf M; Lavie F; McInnes I
- Conference publication: 2023;:a101.1-a1a101Elbagir S; Mohammed NA; Oke V; Zickert A; Svanqvist A; Westerberg CM; Larsson A; Nilsson J; Elshafie A; Elagib EM; Nur MA; Gunnarsson I; Svenungsson E; Rönnelid J
- Conference publication: 2023;:a59.1-a5a59Häyry A; Niewold TB; Meves A; Lehman JS; Popovic-Silwerfeldt K; Charlesworth CM; Madden B; Svenungsson E; Oke V
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:1806Avik A; Waldheim E; Geschwind S; Antovic A; Oke V
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:1058-1059Hayry A; Niewold T; Meves A; Lehman J; Popovic-Silwerfeldt K; Charlesworth C; Madden B; Svenungsson E; Oke V
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:1240Elbagir S; Mohammed NA; Oke V; Zickert A; Larsson A; Nilsson J; Elshafie A; Svanqvist A; Westerberg C; Elagib EM; Nur MAM; Gunnarsson I; Svenungsson E; Ronnelid J
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:1596.1-151596Juto A; Faustini F; Hayry A; Larsson A; Malmstrom V; Bruchfeld A; Antovic A; Oke V; Gunnarsson I
- Conference publication: 2022;:a17.1-a1a17Häyry A; Faustini F; Zickert A; Larsson A; Sundelin B; Svenungsson E; Oke V; Gunnarsson I
- Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(21):11327Idborg H; Oke V
- Preprint: RESEARCH SQUARE. 2021Niewold TB; Meves A; Lehman JS; Popovic-Silwerfeldt K; Häyry A; Söderlund-Matell T; Charlesworth CM; Madden B; Lundberg IE; Wahren-Herlenius M; Svenungsson E; Oke V
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2020;79:335Niewold T; Popovic-Silwerfeldt K; Lehman J; Meves A; Charlesworth C; Madden B; Hayry A; Antovic A; Lundberg IE; Wahren-Herlenius M; Svenungsson E; Oke V
- Conference publication: LUPUS SCIENCE & MEDICINE. 2020;7(Suppl 1):a25-A26Niewold TB; Meves A; Lehman J; Popovic-Silwerfeldt K; Antovic A; Dorschner JM; Charlesworth CM; Lundberg I; Wahren-Herlenius M; Svenungsson E; Oke V
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2019;71Shum J; Ghodke-Puranik Y; Tipon R; Dorschner J; Vsetecka D; Amin S; Makol A; Ernste F; Osborn T; Moder K; Chowdhary V; Thanarajasingam U; Oke V; Gunnarsson I; Zickert A; Zervou M; Svenungsson E; Goulielmos G; Niewold T
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2018;70Niewold TB; Meves A; Lehman JS; Popovic-Silwerfeldt K; Charlesworth C; Wahren-Herlenius M; Svenungsson E; Oke V
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2018;77:406Oke V; Gunnarsson I; Dorschner JM; Zickert A; Niewold TB; Svenungsson E
- Conference publication: 2018;:a16.1-a1a16Diaz Gallo L; Lundström E; Oke V; Elvin K; Wu Y; Gustafsson J; Jönsen A; Leonard D; Zickert A; Nordmark G; Bengtsson A; Sandling J; Rönnblom L; Gunnarsson I; Yu C; Padyukov L; Svenungsson E
- Meeting abstract: 2018;:a44.2-a4a45Kvarnström M; Ruacho G; Gustafsson J; Zickert A; Oke V; Rönnelid J; Elvin K; Gunnarsson I; Svenungsson E
- Conference publication: 2018;:a17.1-a1a17Oke V; Gunnarsson I; Dorschner J; Zickert A; Niewold T; Svenungsson E
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2017;69Gallo LMD; Lundstrom E; Oke V; Elvin K; Wu YL; Gustafsson J; Jonsen A; Leonard D; Zickert A; Nordmark G; Bengtsson AA; Sandling JK; Ronnblom L; Gunnarsson I; Yu C-Y; Padyukov L; Svenungsson E
- Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2017;69Patients with Secondary Sjogren's Syndrome to SLE Are Characterized By Typical Autoantibodies and a Pro-Inflammatory StateKvarnstrom M; Ruacho G; Gustafsson J; Zickert A; Oke V; Ronnelid J; Elvin K; Gunnarsson I; Svenungsson E
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2017;76:885Kvarnstrom M; Ruacho G; Gustafsson T; Zickert A; Oke V; Ronnelid J; Elvin K; Gunnarsson I; Svenungsson E
- Conference publication: LUPUS SCIENCE & MEDICINE. 2017;4(Suppl 1):a107Oke V; Brauner S; Larsson A; Gustafsson J; Zickert A; Gunnarsson I; Svenungsson E
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2016;75:128Oke V; Brauner S; Larsson A; Gustafsson J; Zickert A; Gunnarsson I; Svenungsson E
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2016;75:430-431Eketjall S; Idborg H; Gustafsson JT; Zickert A; Kvarnstrom M; Oke V; Susanne P; Jakobsson P-J; Gunnarsson I; Svenungsson E
- Meeting abstract: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2016;45:39-40The TNF-α/p-albumin ratio: a suggested biomarker for disease activity in SLESvenungsson E; Eketjall S; Idborg H; Gustafsson JT; Zickert A; Kvarnstrom M; Oke V; Pettersson S; Jakobsson P-J; Gunnarsson I
- Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2016;34(4):S45Oke V; Brauner S; Larsson A; Gustafsson J; Zickert A; Gunnarsson I; Svenungsson E
- Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2015;67The Ratio Between TNF-a and P-Albumin - a Suggested Measure of Disease Activity in SLEEketjall S; Idborg H; Gustafsson J; Zickert A; Kvarnstrom M; Oke V; Pettersson S; Jakobsson PJ; Gunnarsson I; Svenungsson E
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2014;73:363Zickert A; Oke V; Parodis I; Svenungsson E; Gunnarsson I
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2014;73:188Oke V; Gustafsson J; Zickert A; Gunnarsson I; Svenungsson E
- Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2014;43:86-87Oke V; Gustafsson J; Brauner S; Zickert A; Gunnarsson I; Svenungsson E
- Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2014;43:10Zickert A; Oke V; Parodis I; Svenungsson E; Gunnarsson I
- Review: JOURNAL OF INTERNAL MEDICINE. 2013;273(6):544-554Oke V; Wahren-Herlenius M
- Review: JOURNAL OF AUTOIMMUNITY. 2012;39(1-2):77-82Oke V; Wahren-Herlenius M
- Doctoral thesis: 2011Oke V
- Conference publication: ARCHIVES OF DERMATOLOGICAL RESEARCH. 2009;301(1):47Oke V; Strandberg L; Nyberg F; Wahren-Herlenius M
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Grants
- Swedish Research Council1 January 2024 - 31 December 2024
- Increased risk for thrombotic complications in patients with rheumatic diseases -from register data to individual patient and biomarkersStockholm County Council and Karolinska Institutet (ALF)1 January 2024 - 31 December 2025Venous thromboembolism (VTE) is a common thrombotic vascular condition, comprising deep venous thrombosis-DVT and pulmonary embolism-PE. PE has a mortality rate of >15% in the first 3 months after diagnosis. Many studies show that patients with rheumatic diseases have an increased risk for cardiovascular disease. Comparatively little is known about the VTE-risk in rheumatic disorders. Despite the suggestive mechanistic links between systemic autoimmune diseases and VTEs, these highly inflammatory conditions are under-recognized as risk factors for hypercoagulability, and the underlying mechanisms explaining the increased risk for VTEs have not been clarified. We aim to identify, understand and eventually treat the underlying causes for VTE in consecutive cohorts of patients with ANCA-associated vasculitis (AAV), antiphospholipid syndrome (APS), systemic sclerosis (SSc), rheumatoid arthritis (RA) and psoriatic arthritis (PsA). The cross-talk between the coagulation, fibrinolysis and inflammation will be studied by investigating endothelial activation, the levels and activity of extracellular vesicles, thrombin generation, fibrin formation, fibrinolyisis and fibrin clot structure in relation to complement activation and inflammatory markers. In this way we would be able to link different steps of hemostatic process with inflammatory response and clinical characteristics of patients with AAV, APS, SSc, RA and PsA. Performing all analysis simultaneously in a single plasma sample comprises the investigation of virtually all components of hemostais without the need to analyse the whole blood. Identifying clinical- and laboratory characteristics of patients at VTE-risk among patients with AAV, APS, SSc, RA and PsA has important consequences in terms of management and treatmentone might speculate that an addition of anticoagulant treatment to the aggressive anti-inflammatory treatment during flares could remodel vascular involvement especially in early stages of these diseases. The knowledge and clinical experience from this project should lead to favorable prognosis for individual patients.
Employments
- Affiliated to Research, Department of Medicine, Karolinska Institutet, 2023-2026
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2011
Leadership and responsibility assignments
- Responsible for a section, Research and medical student education, Center for Rheumatology, Academic Specialist Center, , 2023-