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Publications

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Ladds Mjgw, Van Leeuwen Imm, Drummond Cj, Chu S, Healy Ar, Popova G, et al
Nature communications 2018;9(1):1107-

Multiplexed ChIP-Seq Using Direct Nucleosome Barcoding: A Tool for High-Throughput Chromatin Analysis
Chabbert Cd, Adjalley Sh, Steinmetz Lm, Pelechano V
Methods in molecular biology (Clifton, N.J.) 2018;1689():177-194

eIF5A facilitates translation termination globally and promotes the elongation of many non polyproline-specific tripeptide sequences
Pelechano V, Alepuz P
Nucleic acids research 2017;45(12):7326-7338

From transcriptional complexity to cellular phenotypes: Lessons from yeast
Pelechano V
Yeast (Chichester, England) 2017;34(12):475-482

Long Non Coding RNA Biology Foreword
Steinmetz Lm, Pelechano V
LONG NON CODING RNA BIOLOGY 2017;:V-VI

The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation
Gómez-herreros F, Margaritis T, Rodríguez-galán O, Pelechano V, Begley V, Millán-zambrano G, et al
Nucleic acids research 2017;45(16):9302-9318

A global genetic interaction network maps a wiring diagram of cellular function
Costanzo M, Vandersluis B, Koch En, Baryshnikova A, Pons C, Tan G, et al
Science (New York, N.Y.) 2016;353(6306):-

Biotin-Genomic Run-On (Bio-GRO): A High-Resolution Method for the Analysis of Nascent Transcription in Yeast
Jordán-pla A, Miguel A, Serna E, Pelechano V, Pérez-ortín Je
Methods in molecular biology (Clifton, N.J.) 2016;1361():125-39

Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation
Chlamydas S, Holz H, Samata M, Chelmicki T, Georgiev P, Pelechano V, et al
Nature structural & molecular biology 2016;23(6):580-9

Genome-Wide Identification of Alternative Polyadenylation Events Using 3'T-Fill
Wilkening S, Pelechano V, Steinmetz Lm
Methods in molecular biology (Clifton, N.J.) 2016;1358():295-302

Genome-wide quantification of 5 '-phosphorylated mRNA degradation intermediates for analysis of ribosome dynamics
Pelechano V, Wei W, Steinmetz Lm
NATURE PROTOCOLS 2016;11(2):359-76

Landscape and Dynamics of Transcription Initiation in the Malaria Parasite Plasmodium falciparum
Adjalley Sh, Chabbert Cd, Klaus B, Pelechano V, Steinmetz Lm
Cell reports 2016;14(10):2463-75

Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters
Chen Y, Pai Aa, Herudek J, Lubas M, Meola N, Järvelin Ai, et al
Nature genetics 2016;48(9):984-94

Rpb1 foot mutations demonstrate a major role of Rpb4 in mRNA stability during stress situations in yeast
Garrido-godino Ai, García-lópez Mc, García-martínez J, Pelechano V, Medina Da, Pérez-ortín Je, et al
Biochimica et biophysica acta 2016;1859(5):731-43

The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons
García-martínez J, Delgado-ramos L, Ayala G, Pelechano V, Medina Da, Carrasco F, et al
Nucleic acids research 2016;44(8):3643-58

A high-throughput ChIP-Seq for large-scale chromatin studies
Chabbert Cd, Adjalley Sh, Klaus B, Fritsch Es, Gupta I, Pelechano V, et al
MOLECULAR SYSTEMS BIOLOGY 2015;11(1):777-

Chromatin-dependent regulation of RNA polymerases II and III activity throughout the transcription cycle
Jordan-pla A, Gupta I, De Miguel-jimenez L, Steinmetz Lm, Chavez S, Pelechano V, et al
NUCLEIC ACIDS RESEARCH 2015;43(2):787-802

Single-cell polyadenylation site mapping reveals 3 ' isoform choice variability
Velten L, Anders S, Pekowska A, Jarvelin Ai, Huber W, Pelechano V, et al
MOLECULAR SYSTEMS BIOLOGY 2015;11(6):812-

The Nuclear PolyA-Binding Protein Nab2p Is Essential for mRNA Production
Schmid M, Olszewski P, Pelechano V, Gupta I, Steinmetz Lm, Jensen Th
CELL REPORTS 2015;12(1):128-139

Widespread Co-translational RNA Decay Reveals Ribosome Dynamics
Pelechano V, Wei W, Steinmetz Lm
CELL 2015;161(6):1400-12

A Complete Set of Nascent Transcription Rates for Yeast Genes (vol 5, e15442, 2010)
Pelechano V, Chavez S, Perez-ortin Je
PLOS ONE 2014;9(12):-

Alternative polyadenylation diversifies post-transcriptional regulation by selective RNA-protein interactions
Gupta I, Clauder-munster S, Klaus B, Jarvelin Ai, Aiyar Rs, Benes V, et al
MOLECULAR SYSTEMS BIOLOGY 2014;10(2):719-

Association of condensin with chromosomes depends on DNA binding by its HEAT-repeat subunits
Piazza I, Rutkowska A, Ori A, Walczak M, Metz J, Pelechano V, et al
NATURE STRUCTURAL & MOLECULAR BIOLOGY 2014;21(6):560-8

Dynamic remodeling of histone modifications in response to osmotic stress in Saccharomyces cerevisiae
Magraner-pardo L, Pelechano V, Coloma Md, Tordera V
BMC GENOMICS 2014;:247-

Genome-wide identification of transcript start and end sites by transcript isoform sequencing
Pelechano V, Wei W, Jakob P, Steinmetz Lm
NATURE PROTOCOLS 2014;9(7):1740-59

An efficient method for genome-wide polyadenylation site mapping and RNA quantification
Wilkening S, Pelechano V, Jarvelin Ai, Tekkedil Mm, Anders S, Benes V, et al
NUCLEIC ACIDS RESEARCH 2013;41(5):e65-

An efficient method for genome-wide polyadenylation site mapping and RNA quantification (vol 41, pg e65, 2013)
Wilkening S, Pelechano V, Jarvelin Ai, Tekkedil Mm, Anders S, Benes V, et al
NUCLEIC ACIDS RESEARCH 2013;41(12):6370-6370

Extensive transcriptional heterogeneity revealed by isoform profiling
Pelechano V, Wei W, Steinmetz Lm
NATURE 2013;497(7447):127-31

NON-CODING RNA Gene regulation by antisense transcription
Pelechano V, Steinmetz Lm
NATURE REVIEWS GENETICS 2013;14(12):880-93

Polyadenylation site-induced decay of upstream transcripts enforces promoter directionality
Ntini E, Jarvelin Ai, Bornholdt J, Chen Y, Boyd M, Jorgensen M, et al
NATURE STRUCTURAL & MOLECULAR BIOLOGY 2013;20(8):923-8

Profiling transcriptional heterogeneity
Pelechano V
NATURE METHODS 2013;10(7):607-607

Genome-Wide Polyadenylation Site Mapping
Pelechano V, Wilkening S, Jarvelin Ai, Tekkedil Mm, Steinmetz Lm
NUCLEOSOMES, HISTONES & CHROMATIN, PT B 2012;:271-96

Rrp6p Controls mRNA Poly(A) Tail Length and Its Decoration with Poly(A) Binding Proteins
Schmid M, Poulsen Mb, Olszewski P, Pelechano V, Saguez C, Gupta I, et al
MOLECULAR CELL 2012;47(2):267-80

The relative importance of transcription rate, cryptic transcription and mRNA stability on shaping stress responses in yeast
García-martínez J, Ayala G, Pelechano V, Chávez S, Herrero E, Pérez-ortín Je
Transcription 2012;3(1):39-44

A genomic view of mRNA turnover in yeast
Perez-ortin Je, Jordan-pla A, Pelechano V
COMPTES RENDUS BIOLOGIES 2011;334(8-9):647-54

Functional consequences of bidirectional promoters
Wei W, Pelechano V, Jarvelin Ai, Steinmetz Lm
TRENDS IN GENETICS 2011;27(7):267-76

Genomic-wide methods to evaluate transcription rates in yeast
García-martínez J, Pelechano V, Pérez-ortín Je
Methods in molecular biology (Clifton, N.J.) 2011;734():25-44

The Conserved Foot Domain of RNA Pol II Associates with Proteins Involved in Transcriptional Initiation and/or Early Elongation
Garcia-lopez Mc, Pelechano V, Miron-garcia Mc, Garrido-godino Ai, Garcia A, Calvo O, et al
GENETICS 2011;189(4):1235-48

A Complete Set of Nascent Transcription Rates for Yeast Genes
Pelechano V, Chavez S, Perez-ortin Je
PLOS ONE 2010;5(11):e15442-

The distribution of active RNA polymerase II along the transcribed region is gene-specific and controlled by elongation factors
Rodriguez-gil A, Garcia-martinez J, Pelechano V, Munoz-centeno Md, Geli V, Perez-ortin Je, et al
NUCLEIC ACIDS RESEARCH 2010;38(14):4651-64

There is a steady-state transcriptome in exponentially growing yeast cells
Pelechano V, Perez-ortin Je
YEAST 2010;27(7):413-22

Regulon-Specific Control of Transcription Elongation across the Yeast Genome
Pelechano V, Jimeno-gonzalez S, Rodriguez-gil A, Garcia-martinez J, Perez-ortin Je, Chavez S
PLOS GENETICS 2009;5(8):e1000614-

The transcriptional inhibitor thiolutin blocks mRNA degradation in yeast
Pelechano V, Perez-ortin Je
YEAST 2008;25(2):85-92

A genomic study of the inter-ORF distances in Saccharomyces cerevisiae
Pelechano V, Garcia-martinez J, Perez-ortin Je
YEAST 2006;23(9):689-99

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