Vijay Joshua

About me
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About me

I am a Postdoctoral Researcher at the Rheumatology Unit.

Research

I have been working on studies that try to understand the role of the lungs in the initiation of Rheumatoid Arthritis (RA). More specifically, I have been studying the immunogenetics and Citrulline reactivity of the lung B cells in lungs of risk RA and early untreated RA.

Teaching

Course Organiser Cytokines in Inflammation (PhD Course - 3 ECTS - 2 Weeks ) - 2021, 2022.2024 Teaching Cytokines in Inflammation (PhD Course - 3 ECTS - 2 Weeks ) - 2019, 2021, 2022, 2024

Articles

Article: RHEUMATOLOGY. 2024;:keae146

Identification of early risk factors for anti-citrullinated-protein-antibody positive rheumatoid arthritis-a prospective cohort study.

Cîrciumaru A; Kisten Y; Hansson M; Mathsson-Alm L; Joshua V; Wähämaa H; Haarhaus ML; Lindqvist J; Padyukov L; Catrina S-B; Fei G; Vivar N; Rezaei H; Af Klint E; Antovic A; Réthi B; Catrina AI; Hensvold A
Article: RHEUMATOLOGY. 2024;:keae007

Identification of circulating autoantibodies to non-modified proteins associated with ACPA status in early rheumatoid arthritis.

Lourido L; Joshua V; Hansson M; Sjöberg R; Pin E; Ruiz-Romero C; Nilsson P; Alfredsson L; Klareskog L; Blanco FJ
Article: ARTHRITIS & RHEUMATOLOGY. 2023;75(11):1910-1922

Rheumatoid Arthritis-Specific Autoimmunity in the Lung Before and at the Onset of Disease.

Joshua V; Loberg Haarhaus M; Hensvold A; Wähämaa H; Gerstner C; Hansson M; Israelsson L; Stålesen R; Sköld M; Grunewald J; Klareskog L; Grönwall C; Réthi B; Catrina A; Malmström V
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2023;299(11):105320

Autoreactive B cells against malondialdehyde-induced protein cross-links are present in the joint, lung, and bone marrow of rheumatoid arthritis patients.

Sahlström P; Joshua V; Valkovskaia V; Biese C; Stålesen R; Israelsson L; Végvári Á; Scheel-Toellner D; Klareskog L; Hansson M; Hensvold A; Malmström V; Grönwall C
Article: RESPIROLOGY. 2023;28(10):925-933

Presence of anti-modified protein antibodies in idiopathic pulmonary fibrosis.

Kalafatis D; Joshua V; Hansson M; Mathsson-Alm L; Hensvold A; Sköld M
Article: ARTHRITIS RESEARCH & THERAPY. 2021;23(1):239

The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual "window of treatment success" in RA patients.

Marklein B; Jenning M; Konthur Z; Häupl T; Welzel F; Nonhoff U; Krobitsch S; Mulder DM; Koenders MI; Joshua V; Cope AP; Shlomchik MJ; Anders H-J; Burmester GR; Hensvold A; Catrina AI; Rönnelid J; Steiner G; Skriner K
Article: RMD OPEN. 2021;7(2):e001662

Tocilizumab decreases T cells but not macrophages in the synovium of patients with rheumatoid arthritis while it increases the levels of serum interleukin-6 and RANKL.

Chatzidionysiou K; Circiumaru A; Rethi B; Joshua V; Engstrom M; Hensvold A; Af Klint E; Catrina A
Article: BIO-PROTOCOL. 2021;11(6):e3957

An Image-based Dynamic High-throughput Analysis of Adherent Cell Migration.

Sun M; Rethi B; Krishnamurthy A; Joshua V; Wähämaa H; Catrina S-B; Catrina A
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:627986

A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis.

Grönwall C; Liljefors L; Bang H; Hensvold AH; Hansson M; Mathsson-Alm L; Israelsson L; Joshua V; Svärd A; Stålesen R; Titcombe PJ; Steen J; Piccoli L; Sherina N; Clavel C; Svenungsson E; Gunnarsson I; Saevarsdottir S; Kastbom A; Serre G; Alfredsson L; Malmström V; Rönnelid J; Catrina AI; Lundberg K; Klareskog L
Article: RMD OPEN. 2020;6(2):e001278

Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis.

Joshua V; Hensvold AH; Reynisdottir G; Hansson M; Cornillet M; Nogueira L; Serre G; Nyren S; Karimi R; Eklund A; Sköld M; Grunewald J; Chatzidionysiou K; Catrina A
Article: ANNALS OF THE RHEUMATIC DISEASES. 2020;79(9):1194-1202

Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection-a missing link for ACPA production.

Jenning M; Marklein B; Ytterberg J; Zubarev RA; Joshua V; van Schaardenburg D; van de Stadt L; Catrina AI; Nonhoff U; Häupl T; Konthur Z; Burmester GR; Skriner K
Article: RHEUMATOLOGY. 2020;59(4):852-859

Secretory anti-citrullinated protein antibodies in serum associate with lung involvement in early rheumatoid arthritis.

Roos Ljungberg K; Joshua V; Skogh T; Eklund A; Sköld CM; Karimi R; Nyrén S; Svärd A; Catrina AI; Kastbom A
Article: ANNALS OF THE RHEUMATIC DISEASES. 2019;78(12):1621-1631

Anticitrullinated protein antibodies facilitate migration of synovial tissue-derived fibroblasts.

Sun M; Rethi B; Krishnamurthy A; Joshua V; Circiumaru A; Hensvold AH; Ossipova E; Grönwall C; Liu Y; Engstrom M; Catrina SB; Steen J; Malmstrom V; Klareskog L; Svensson C; Ospelt C; Wähämaa H; Catrina AI
Article: JOURNAL OF IMMUNOLOGY. 2019;202(11):3143-3150

Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts.

Krishnamurthy A; Ytterberg AJ; Sun M; Sakuraba K; Steen J; Joshua V; Tarasova NK; Malmström V; Wähämaa H; Réthi B; Catrina AI
Article: BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY. 2017;31(1):31-41

Role of the lung in individuals at risk of rheumatoid arthritis.

Joshua V; Chatzidionisyou K; Catrina AI
Article: ARTHRITIS RESEARCH & THERAPY. 2016;18(1):284

Antibody responses to de novo identified citrullinated fibrinogen peptides in rheumatoid arthritis and visualization of the corresponding B cells.

Joshua V; Schobers L; Titcombe PJ; Israelsson L; Rönnelid J; Hansson M; Catrina AI; Pruijn GJM; Malmström V
Article: MICROBIOME. 2016;4(1):60

The lung microbiota in early rheumatoid arthritis and autoimmunity.

Scher JU; Joshua V; Artacho A; Abdollahi-Roodsaz S; Öckinger J; Kullberg S; Sköld M; Eklund A; Grunewald J; Clemente JC; Ubeda C; Segal LN; Catrina AI
Article: SCIENTIFIC REPORTS. 2016;6:33811

Compartmentalized gene expression profiling of receptive endometrium reveals progesterone regulated ENPP3 is differentially expressed and secreted in glycosylated form.

Boggavarapu NR; Lalitkumar S; Joshua V; Kasvandik S; Salumets A; Lalitkumar PG; Gemzell-Danielsson K
Article: ANNALS OF THE RHEUMATIC DISEASES. 2016;75(9):1722-1727

Signs of immune activation and local inflammation are present in the bronchial tissue of patients with untreated early rheumatoid arthritis.

Reynisdottir G; Olsen H; Joshua V; Engström M; Forsslund H; Karimi R; Sköld CM; Nyren S; Eklund A; Grunewald J; Catrina AI
Article: ANNALS OF THE RHEUMATIC DISEASES. 2016;75(4):721-729

Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss.

Krishnamurthy A; Joshua V; Haj Hensvold A; Jin T; Sun M; Vivar N; Ytterberg AJ; Engström M; Fernandes-Cerqueira C; Amara K; Magnusson M; Wigerblad G; Kato J; Jiménez-Andrade JM; Tyson K; Rapecki S; Lundberg K; Catrina S-B; Jakobsson P-J; Svensson C; Malmström V; Klareskog L; Wähämaa H; Catrina AI
Article: ARTHRITIS RESEARCH & THERAPY. 2015;17(1):239

Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexate.

Hensvold AH; Joshua V; Li W; Larkin M; Qureshi F; Israelsson L; Padyukov L; Lundberg K; Defranoux N; Saevarsdottir S; Catrina AI
Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(9):1772-1777

Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validation.

Ytterberg AJ; Joshua V; Reynisdottir G; Tarasova NK; Rutishauser D; Ossipova E; Haj Hensvold A; Eklund A; Sköld CM; Grunewald J; Malmström V; Jakobsson PJ; Rönnelid J; Padyukov L; Zubarev RA; Klareskog L; Catrina AI
Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(2):375-380

Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins.

Hensvold AH; Magnusson PKE; Joshua V; Hansson M; Israelsson L; Ferreira R; Jakobsson P-J; Holmdahl R; Hammarström L; Malmström V; Askling J; Klareskog L; Catrina AI
Article: ARTHRITIS & RHEUMATOLOGY. 2014;66(1):31-39

Structural changes and antibody enrichment in the lungs are early features of anti-citrullinated protein antibody-positive rheumatoid arthritis.

Reynisdottir G; Karimi R; Joshua V; Olsen H; Hensvold AH; Harju A; Engström M; Grunewald J; Nyren S; Eklund A; Klareskog L; Sköld CM; Catrina AI
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All other publications

Corrigendum: ARTHRITIS RESEARCH & THERAPY. 2021;23(1):255

Correction to: The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual "window of treatment success" in RA patients.

Marklein B; Jenning M; Konthur Z; Häupl T; Welzel F; Nonhoff U; Krobitsch S; Mulder DM; Koenders MI; Joshua V; Cope AP; Shlomchik MJ; Anders H-J; Burmester GR; Hensvold A; Catrina AI; Rönnelid J; Steiner G; Skriner K
Corrigendum: ANNALS OF THE RHEUMATIC DISEASES. 2019;78(6):866

Correction: Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss.
Other: JOURNAL OF EXPERIMENTAL MEDICINE. 2019;216(1):245

Retraction: Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition.

Amara K; Steen J; Murray F; Morbach H; Fernandez-Rodriguez BM; Joshua V; Engström M; Snir O; Israelsson L; Catrina AI; Wardemann H; Corti D; Meffre E; Klareskog L; Malmström V
KI thesis / dissertation: 2017

Antibody-associated inflammation in and outside the joint in rheumatoid arthritis

Joshua, Vijay
Review: IMMUNOLOGICAL REVIEWS. 2016;269(1):162-174

Mechanisms involved in triggering rheumatoid arthritis.

Catrina AI; Joshua V; Klareskog L; Malmström V

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