Tuomas Näreoja

Affiliated to Research
Visiting address: Alfred Nobels allé 8, plan 8, 14152 Huddinge
Postal address: H5 Laboratoriemedicin, H5 Patologi Näreoja, 141 52 Huddinge
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About me

  • Early 2017 I got funding to start assembling an independent research group
    working on regulation of bone remodeling and development of in vitro model to
    replicate the bone remodeling cycle. Later the same year a starting grant
    from Swedish Research Council allowed for its expansion. I did my PhD at
    University of Turku in Finland. Then I moved to Department Neurosciences at
    Karolinska institutet for a postdoc project on regulation synaptic vesicle
    membrane trafficking. After that I joined Division of Pathology in Department
    of Laboratory Medicine for another postdoc to study differentiation of
    osteoclasts.
    Funding
    Vetenskapsrådet
    Jane and Aatos Erkko foundation
    Loo and Hans Osterman foundation
    Maud Kuistila memorial foundation
    Publications [1]
    [1] http://bibliometrics.ki.se/public/publicProfile/2040

Research

  • We will develop an in vitro model recreating the entire bone remodeling cycle
    to examine in detail processes regulating bone remodeling and bone
    generation. My group’s long-term aim is to screen better small molecule
    drugs for osteoporosis and to produce bone for regenerative medicine. Bone
    remodeling is a constantly undergoing process where bone resorbing
    osteoclasts (OC), osteocytes (OY) inhabiting channels inside bone and bone
    mineralizing osteoblasts (OB) work together in order to heal damage and
    remake the skeleton, respond to mechanical stimulus and adapt bone structure
    to environmental factors and maintain Ca2+ and phosphate homeostasis. These
    cells receive regulatory signals through hormonal signaling network and
    transmit information to each other directly with cell-cell contacts, with
    soluble ligands as well as through surrounding extracellular matrix. I have
    developed an in vitro model of bone composed of sedimented bone nanoparticles
    facilitating easy high-resolution imaging to extract molecular detail in a
    relevant biological context. The primary aims of the proposed project are to:
    1. further develop this model to include OYs, OCs, and OBs, and
    functionalization (e.g. proteins NO and pH-probes).
    2. Elucidate and understand the coupling mechanisms in the intertwined
    signaling between OCs, OBs and OYs in mineralization. While OYs stimulate
    differentiation of OCs and OBs they also inhibit it by osteoprotegerin and
    sclerostin, respectively. In our model we can examine the impact of the
    signals in a sub-cellular resolution enabling us to establish precise
    molecular mechanisms.
    3. Learn how to modulate balance between mineralization and resorption in an
    in vitro model replicating the bone-remodeling unit and to screen for drug
    candidates affecting the balance of the bone remodeling cycle.
    *Research team*
    Tuomas Näreoja
    Laia Mira Pascual (PhD-student shared with G. Andersson and P. Lång)
    Students wishing to do their M.Sc. thesis work in the group are welcome to
    contact tuomas.nareoja@ki.se

Articles

Employments

  • Affiliated to Research, Department of Laboratory Medicine, Karolinska Institutet, 2021-2024

Supervisor

  • Suchita Desai, The role of mechanical loading, sex and TRAP/ACP5 on bone properties, https://openarchive.ki.se/xmlui/handle/10616/48681
  • Laia Mira Pascual, Role of tartrate-resistant acid phosphatase in bone remodeling, https://openarchive.ki.se/xmlui/handle/10616/46930

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