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About me

Education

M.Sci, Stockholm University 1988
M.Med.Sc, Karolinska Institutet 1989
Ph.D, Karolinska Institutet 1999
Associate Professor, Karolinska Institutet 2007

Research description

Periodontitis is a chronic inflammatory disease in which bacterial products, host response, genetic and environmental factors are involved. It is generally accepted that the bacterial products activate host immunoinflammatory responses and subsequently the production of inflammatory mediators, prostaglandins and proteolytic enzymes which, directly or indirectly, contribute to the destruction of the periodontal tissues. However, neither the precise molecular mechanism(s) nor the regulatory genes underlying periodontitis are fully understood. 
During past decades, reciprocal effects of periodontal disease have been considered as factors potentially affecting the progression of other chronic inflammatory diseases such as cardiovascular diseases, diabetes mellitus, obesity, and rheumatoid arthritis. The underlying pathologic mechanisms of rheumatoid arthritis and periodontitis are strikingly similar although the link, strength and temporality of the association is still unclear.

Objectives of our research are:

- to identify predictive and diagnostic biomarkers for periodontitis
- to develop anti-inflammatory agents targeting the enzyme prostaglandin E synthases for chronic inflammation/periodontal bone destruction  
- to investigate the relationship between periodontitis/periodontal pathogens and the chronic inflammatory disease rheumatoid arthritis
- to study the interactions between oral microbiome and carcinogenesis

Group members

Tülay Yucel-Lindberg – Associate professor
Natalija Gerasimcik – Postdoc
Kaja Eriksson – Postdoc, associated
Anna Lundmark – Postdoc, associated
Anna Kats – Postdoc, affiliated group member
Caroline Lindström – Graduate Student
Martina Ericson – Graduate Student
Caroline Åwall Blom – Graduate Student
Shigufta Syed – Master Student

Research grants 

Vetenskapsrådet (PI)
Stockholm County Council, KI/SLL for odontological research (PI)
Stockholm County Council, ALF (PI)
Patentmedelsfonden (PI)
Seventh Framework Programme, TRIGGER, FP7-HEALTH-2012 (Co-PI)

 

Dissertations

Tove Båge -  Prostaglandin E synthases in periodontitis-affected gingival tissue and in gingival fibroblasts

Anna Kats - Expression of prostaglandin E synthase-1 in periodontitis : in vivo and in vitro studies

Haleh Davanian - Gene expression profiling in periodontitis

Kaja Eriksson - Studies on the relationship between periodontitis and rheumatoid arthritis

Anna Lundmark - Transcriptomic and taxonomic profiling of periodontitis by massively parallel sequencing

 

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