Tulay Lindberg

M.Sci - Stockholm University 1988
M.Med.Sc - Karolinska Institutet 1989
Ph.D - Karolinska Institutet 1999
Associate Professor - Karolinska Institutet 2007

Periodontitis is a chronic inflammatory disease in which bacterial products,
host response, genetic and environmental factors are involved. It is
generally accepted that the bacterial products activate host
immunoinflammatory responses and subsequently the production of inflammatory
mediators, prostaglandins and proteolytic enzymes which, directly or
indirectly, contribute to the destruction of the periodontal tissues.
However, neither the precise molecular mechanism(s) nor the regulatory genes
underlying periodontitis are fully understood.
During past decades, reciprocal effects of periodontal disease have been
considered as factors potentially affecting the progression of other chronic
inflammatory diseases such as cardiovascular diseases, diabetes mellitus,
obesity, and rheumatoid arthritis. The underlying pathological mechanisms of
periodontitis and rheumatoid arthritis are strikingly similar although the
link, strength and temporality of the association is still not understood.

Objectives of our research
- to identify predictive and diagnostic biomarkers for periodontitis and peri-implantitis
- to investigate the relationship between periodontitis/periodontal pathogens and associated diseases such as rheumatoid arthritis and diabetes
- to study the interactions between oral microbiome and carcinogenesis

Group members
Tülay Yucel-Lindberg – Associate professor

Carina Fie – PhD student


Anders Lindunger – PhD student

Carl Lundgren– PhD student

Kaja Eriksson – associated

Anna Lundmark – associated

Anna Kats – associated

Luis Fernando Delgado Zambrano – associated

Research grants
The Swedish Research Council (Vetenskapsrådet)
The Patent Revenue Fund for Research in Preventive Odontology (Patentmedelsfonden)
Stockholm County Council, KI/SLL for odontological research (SOF)
Stockholm County Council (ALF)
Reumatikerförbundet

Dissertations
Tove Båge -  Prostaglandin E synthases in periodontitis-affected gingival tissue and in gingival fibroblasts [1]
Anna Kats - Expression of prostaglandin E synthase-1 in periodontitis:in vivo and in vitro studies [2]
Haleh Davanian - Gene expression profiling in periodontitis [3]
Kaja Eriksson - Studies on the relationship between periodontitis and rheumatoid arthritis [4]
Anna Lundmark - Transcriptomic and taxonomic profiling of periodontitis by massively parallel sequencing [5]
[1] https://openarchive.ki.se/xmlui/handle/10616/40565
[2] https://openarchive.ki.se/xmlui/handle/10616/42003
[3] https://openarchive.ki.se/xmlui/handle/10616/44495
[4] https://openarchive.ki.se/xmlui/handle/10616/45935
[5] https://openarchive.ki.se/xmlui/handle/10616/45969