Tony Jimenez-Beristain received his PhD degree in 2007 from Miguel Hernandez University, (Alicante, Spain), in the Institute of Neuroscience (IN-CSIC, Alicante). In the laboratory of professor De Felipe (IN-CSIC) and professor Li (Institute for Stem Cell Research, The University of Edinburgh). He investigated the role of the transcriptional factor Pitx3 during the differentiation and commitment of embryonic stem cells towards midbrain dopaminergic neurons and their potential use in cell replacement therapy to treat Parkinson's disease. His PhD research was awarded “Doctor Europaeus” by the European Universities Associations (European Community).
Later he moved to Uppsala University for a brief post-doctoral stay at the Biomedical Center to broaden his knowledge in regenerative neurobiology.
In 2011 he joined professor Thomas Hökfelt and Jan Mulder in the creation of first world mouse brain protein atlas (https://www.proteinatlas.org/humanproteome/mouse+brain) as part of the Human Protein Atlas database. The mouse brain atlas has the aim to increase the knowledge of protein expression and distribution in the mammalian nervous system. The atlas presents polyclonal as monoclonal antibody stainings on consecutive sections of the entire mouse brain. The Atlas of the Mouse Brain includes genes selected based on global expression (brain vs. peripheral organs), differential expression in the brain (brain regions), cellular expression (neurons, glia and others) and function (physiology, development or disease).
As a lab manager his experience range from a national facility (Fluorescence Tissue Profiling facility, Scilifelab), an experimental hearing research group (Department of Physiology, Karolinska Institutet) and currently, a team studying the epigenetic defining the oligodendrocyte lineage (Castelo-Branco's group).
For the past 8 years, he has been safety and security officer in several departments belonging to Karolinska Institutet. In 2015 he was nominated for the 2015 Karolinska Institutet’s work environment and health award.
2007 PhD in Neuroscience, Molecular & Cellular Biology. Edinburgh University (United Kingdom) - Miguel Hernández University (Spain).
2003 Master in Molecular & Cellular Biology. Miguel Hernández University (Spain).
2001 Bachelor Degree in Chemistry and Biochemistry. Universidad Autónoma de Aguascalientes (Mexico).
Generation of embryonic stem cells and transgenic mice expressing green fluorescence protein in midbrain dopaminergic neurons.
Zhao S, Maxwell S, Jimenez-Beristain A, Vives J, Kuehner E, Zhao J, O'Brien C, de Felipe C, Semina E, Li M.
Eur J Neuroscience (2004)
Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system.
Borroto-Escuela DO, Narvaez M, Pérez-Alea M, Tarakanov AO, Jiménez-Beristain A, Mudó G, Agnati LF, Ciruela F, Belluardo N, Fuxe K.
Biochem Biophys Res Commun (2015)
Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression.
Borroto-Escuela DO, Pérez-Alea M, Narvaez M, Tarakanov AO, Mudó G, Jiménez-Beristain A, Agnati LF, Ciruela F, Belluardo N, Fuxe K.
Biochem Biophys Res Commun (2015)
On the role of the balance of GPCR homo/heteroreceptor complexes in the brain.
Borroto-Escuela D, Brito I, Di Palma M, Jiménez-Beristain A, Narváez M, Corrales F, Santini S, Ambrogini P, Lattanzi D, Cuppini R, Agnati L & Fuxe K.
Journal of Advance Neuroscience Research (2015)
In Situ Proximity Ligation Assay to study and understand the distribution and balance of GPCR homo and heteroreceptor complexes in the brain.
Borroto-Escuela D, Woolfenden M, Pinton L, Jiménez-Beristain A, Ofiljan J, Narvaez M, Di Palma M, Feltmann K, Sartini S, Ambrogini P, Ciruela F, Cuppini R & Fuxe K.
Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder.
Borroto-Escuela D, Narváez M, Wydra K, Pintsuk J, Pinton L, Jimenez-Beristain A, Di Palma M, Jastrzębska J, Filip M, Fuxe K.
Pharmacology Biochemistry and Behavior (2017)
Existence of Brain 5-HT1A–5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor–Receptor Interactions Regulating 5-HT1A Receptor Recognition.
Borroto-Escuela D, Li X, Tarakanov A, Savelli D, Narváez M, Shumilov K, Andrade-Talavera Y, Jimenez-Beristain A, Pomierny B, Díaz-Cabiale Z, Cuppini R, Ambrogini P, Lindskog M, and Fuxe K.
American Chem Soc Omega (2017)
Effects of long-term alcohol drinking on the dopamine D2 receptor: Gene expression and heteroreceptor complexes in the striatum in rats.Generation of embryonic stem cells and transgenic mice expressing green fluorescence protein in midbrain dopaminergic neurons.
Feltmann, K., Borroto-Escuela, D. O., Rüegg, J., Pinton, L., de Oliveira Sergio, T., Narváez, M., Jimenez-Beristain, A., Ekström, T. J., Fuxe, K. and Steensland P.
Alcohol Clin Exp Res (2017)
Academic honours, awards and prizes
2015 Nominated for the 2015 Karolinska Institute’s work environment and health award (Sweden)
2015 Elected by direct vote Stockholm’s delegate in 2015 national congress. Swedish Association of Professional Scientists Naturvetarna (Sweden)
2007 Doctoral thesis labeled “Doctor Europaeus” by the European Universities Association (European Union)
2004 - 2006 Spanish Ministry of Education and Science’s pre-doctoral grant (Spain)