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About me


- Histology

- Neurobiology

- Antibody validation

- Immunofluorescence

- Stem cell biology

- Transgenic mouse colony management

- Laboratory safety & security 




2007     PhD in Neuroscience, Molecular & Cellular Biology. Edinburgh University (United Kingdom) - Miguel Hernández University (Spain).

2003     Master in Molecular & Cellular Biology. Miguel Hernández University (Spain). 

2001     Bachelor Degree in Chemistry and Biochemistry. Universidad Autónoma de Aguascalientes (Mexico).


2007     Post doctoral research fellow, Department of Neuroscience, Biomedical Centre. Uppsala University (Sweden)  

2011-2016       Biomedical Scientist, Fluorescence Tissue Profiling platform. Science for Life Laboratory (Sweden).

2016-2017      Laboratory manager. Karolinska Institutet. Department of Physiology & Pharmacology.



Research description


Generation of embryonic stem cells and transgenic mice expressing green fluorescence protein in midbrain dopaminergic neurons.

Zhao S, Maxwell S, Jimenez-Beristain A, Vives J, Kuehner E, Zhao J, O'Brien C, de Felipe C, Semina E, Li M.

Eur J Neuroscience (2004)

Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system.

Borroto-Escuela DO, Narvaez M, Pérez-Alea M, Tarakanov AO, Jiménez-Beristain A, Mudó G, Agnati LF, Ciruela F, Belluardo N, Fuxe K.

Biochem Biophys Res Commun (2015)

Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression.

Borroto-Escuela DO, Pérez-Alea M, Narvaez M, Tarakanov AO, Mudó G, Jiménez-Beristain A, Agnati LF, Ciruela F, Belluardo N, Fuxe K.

Biochem Biophys Res Commun (2015)

On the role of the balance of GPCR homo/heteroreceptor complexes in the brain.

Borroto-Escuela D, Brito I, Di Palma M, Jiménez-Beristain A, Narváez M, Corrales F, Santini S, Ambrogini P, Lattanzi D, Cuppini R, Agnati L & Fuxe K.

Journal of Advance Neuroscience Research (2015)

In Situ Proximity Ligation Assay to study and understand the distribution and balance of GPCR homo and heteroreceptor complexes in the brain.

Borroto-Escuela D, Woolfenden M, Pinton L, Jiménez-Beristain A, Ofiljan J, Narvaez M, Di Palma M, Feltmann K, Sartini S, Ambrogini P, Ciruela F, Cuppini R & Fuxe K. 

Neuromethods (2016)

Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder.

Borroto-Escuela D, Narváez M, Wydra K, Pintsuk J, Pinton L, Jimenez-Beristain A, Di Palma M, Jastrzębska J, Filip M, Fuxe K.

Pharmacology Biochemistry and Behavior (2017)

Existence of Brain 5-HT1A–5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor–Receptor Interactions Regulating 5-HT1A Receptor Recognition.

Borroto-Escuela D, Li X, Tarakanov A, Savelli D, Narváez M, Shumilov K, Andrade-Talavera Y, Jimenez-Beristain A, Pomierny B, Díaz-Cabiale Z, Cuppini R, Ambrogini P, Lindskog M, and Fuxe K.
American Chem Soc Omega (2017) 

Effects of long-term alcohol drinking on the dopamine D2 receptor: Gene expression and heteroreceptor complexes in the striatum in rats.Generation of embryonic stem cells and transgenic mice expressing green fluorescence protein in midbrain dopaminergic neurons.

Feltmann, K., Borroto-Escuela, D. O., Rüegg, J., Pinton, L., de Oliveira Sergio, T., Narváez, M., Jimenez-Beristain, A., Ekström, T. J., Fuxe, K. and Steensland P. 

Alcohol Clin Exp Res (2017)




Teaching portfolio



Academic honours, awards and prizes

2015     Nominated for the 2015 Karolinska Institute’s work environment and health award (Sweden)

2015     Elected by direct vote Stockholm’s delegate in 2015 national congress. Swedish Association of Professional Scientists Naturvetarna (Sweden)

2007     Doctoral thesis labeled “Doctor Europaeus” by the European Universities Association (European Union)

2004 - 2006   Spanish Ministry of Education and Science’s pre-doctoral grant (Spain)


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