Tomas Nyman

Publications
Public outreach and news

Articles

Journal article: ANTIVIRAL RESEARCH. 2021;190:105074

Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors.

Akaberi D; Båhlström A; Chinthakindi PK; Nyman T; Sandström A; Järhult JD; Palanisamy N; Lundkvist Å; Lennerstrand J
Article: SCIENTIFIC REPORTS. 2021;11(1):1820

Direct detection of SARS-CoV-2 using non-commercial RT-LAMP reagents on heat-inactivated samples.

Alekseenko A; Barrett D; Pareja-Sanchez Y; Howard RJ; Strandback E; Ampah-Korsah H; Rovšnik U; Zuniga-Veliz S; Klenov A; Malloo J; Ye S; Liu X; Reinius B; Elsässer SJ; Nyman T; Sandh G; Yin X; Pelechano V
Article: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY. 2019;30(8):1385-1388

Gas-Phase Collisions with Trimethylamine-N-Oxide Enable Activation-Controlled Protein Ion Charge Reduction.

Kaldmäe M; Österlund N; Lianoudaki D; Sahin C; Bergman P; Nyman T; Kronqvist N; Ilag LL; Allison TM; Marklund EG; Landreh M
Article: SLAS DISCOVERY. 2018;23(4):353-362

Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol.

Ekblad T; Verheugd P; Lindgren AE; Nyman T; Elofsson M; Schüler H
Article: SCIENTIFIC REPORTS. 2017;7:46370

SnoN Stabilizes the SMAD3/SMAD4 Protein Complex.

Walldén K; Nyman T; Hällberg BM
Article: PROTEIN ENGINEERING DESIGN & SELECTION. 2016;29(10):427-437

Generation and analyses of human synthetic antibody libraries and their application for protein microarrays.

Säll A; Walle M; Wingren C; Müller S; Nyman T; Vala A; Ohlin M; Borrebaeck CAK; Persson H
Article: PLOS ONE. 2015;10(6):e0131507

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate.

Trésaugues L; Lundbäck T; Welin M; Flodin S; Nyman T; Silvander C; Gräslund S; Nordlund P
Article: STRUCTURE. 2014;22(5):744-755

Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.

Trésaugues L; Silvander C; Flodin S; Welin M; Nyman T; Gräslund S; Hammarström M; Berglund H; Nordlund P
Article: JOURNAL OF MOLECULAR BIOLOGY. 2013;425(22):4323-4333

Substrate specificity and oligomerization of human GMP synthetase.

Welin M; Lehtiö L; Johansson A; Flodin S; Nyman T; Trésaugues L; Hammarström M; Gräslund S; Nordlund P
Article: JOURNAL OF LIPID RESEARCH. 2013;54(6):1630-1643

Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase.

Lim SM; Chen D; Teo H; Roos A; Jansson AE; Nyman T; Trésaugues L; Pervushin K; Nordlund P
Article: FEBS JOURNAL. 2010;277(23):4920-4930

Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1.

Welin M; Egeblad L; Johansson A; Stenmark P; Wang L; Flodin S; Nyman T; Trésaugues L; Kotenyova T; Johansson I; Eriksson S; Eklund H; Nordlund P
Article: NUCLEIC ACIDS RESEARCH. 2010;38(20):7308-7319

Structural studies of tri-functional human GART.

Welin M; Grossmann JG; Flodin S; Nyman T; Stenmark P; Trésaugues L; Kotenyova T; Johansson I; Nordlund P; Lehtiö L
Article: PLOS ONE. 2010;5(9):e12907

The crystal structure of the Dachshund domain of human SnoN reveals flexibility in the putative protein interaction surface.

Nyman T; Trésaugues L; Welin M; Lehtiö L; Flodin S; Persson C; Johansson I; Hammarström M; Nordlund P
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2009;65(Pt 11):1091-1096

Structures of BIR domains from human NAIP and cIAP2.

Herman MD; Moche M; Flodin S; Welin M; Trésaugues L; Johansson I; Nilsson M; Nordlund P; Nyman T
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2009;74(1):212-221

The structure of the PP2A regulatory subunit B56 gamma: the remaining piece of the PP2A jigsaw puzzle.

Magnusdottir A; Stenmark P; Flodin S; Nyman T; Kotenyova T; Gräslund S; Ogg D; Nordlund P
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2008;73(4):1047-1052

The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site.

Trésaugues L; Stenmark P; Schüler H; Flodin S; Welin M; Nyman T; Hammarström M; Moche M; Gräslund S; Nordlund P
Article: FEBS LETTERS. 2008;582(25-26):3590-3594

Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim.

Herman MD; Nyman T; Welin M; Lehtiö L; Flodin S; Trésaugues L; Kotenyova T; Flores A; Nordlund P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(18):11861-11865

The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer.

Nyman T; Stenmark P; Flodin S; Johansson I; Hammarström M; Nordlund P
Article: NATURE METHODS. 2007;4(12):1019-1021

In situ proteolysis for protein crystallization and structure determination.

Dong A; Xu X; Edwards AM; Midwest Center for Structural Genomics; Structural Genomics Consortium; Chang C; Chruszcz M; Cuff M; Cymborowski M; Di Leo R; Egorova O; Evdokimova E; Filippova E; Gu J; Guthrie J; Ignatchenko A; Joachimiak A; Klostermann N; Kim Y; Korniyenko Y; Minor W; Que Q; Savchenko A; Skarina T; Tan K; Yakunin A; Yee A; Yim V; Zhang R; Zheng H; Akutsu M; Arrowsmith C; Avvakumov GV; Bochkarev A; Dahlgren L-G; Dhe-Paganon S; Dimov S; Dombrovski L; Finerty P; Flodin S; Flores A; Gräslund S; Hammerström M; Herman MD; Hong B-S; Hui R; Johansson I; Liu Y; Nilsson M; Nedyalkova L; Nordlund P; Nyman T; Min J; Ouyang H; Park H-W; Qi C; Rabeh W; Shen L; Shen Y; Sukumard D; Tempel W; Tong Y; Tresagues L; Vedadi M; Walker JR; Weigelt J; Welin M; Wu H; Xiao T; Zeng H; Zhu H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(24):17828-17836

Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition.

Walldén K; Stenmark P; Nyman T; Flodin S; Gräslund S; Loppnau P; Bianchi V; Nordlund P
Article: JOURNAL OF NEUROCHEMISTRY. 2007;101(4):906-917

The structure of human collapsin response mediator protein 2, a regulator of axonal growth.

Stenmark P; Ogg D; Flodin S; Flores A; Kotenyova T; Nyman T; Nordlund P; Kursula P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(32):22434-22438

The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions.

Magnusdottir A; Stenmark P; Flodin S; Nyman T; Hammarström M; Ehn M; Bakali H MA; Berglund H; Nordlund P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(18):15828-15833

A cross-linked profilin-actin heterodimer interferes with elongation at the fast-growing end of F-actin.

Nyman T; Page R; Schutt CE; Karlsson R; Lindberg U
Article: JOURNAL OF MOLECULAR BIOLOGY. 2002;317(4):577-589

The role of MeH73 in actin polymerization and ATP hydrolysis.

Nyman T; Schüler H; Korenbaum E; Schutt CE; Karlsson R; Lindberg U
Article: MOLECULAR MICROBIOLOGY. 2001;39(3):606-619

Actin is ADP-ribosylated by the Salmonella enterica virulence-associated protein SpvB.

Tezcan-Merdol D; Nyman T; Lindberg U; Haag F; Koch-Nolte F; Rhen M
Article: EXPERIMENTAL CELL RESEARCH. 2000;256(1):112-121

Effects of cross-linked profilin:beta/gamma-actin on the dynamics of the microfilament system in cultured cells.

Hájková L; Nyman T; Lindberg U; Karlsson R
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Preprint: 2020;medRxiv

Detection of SARS-CoV-2 using non-commercial RT-LAMP reagents and raw samples

Alekseenko A; Barrett D; Pareja-Sanchez Y; J Howard R; Strandback E; Ampah-Korsah H; Rovšnik U; Zuniga-Veliz S; Klenov A; Malloo J; Ye S; Liu X; Reinius B; Elsässer S; Nyman T; Sandh G; Yin X; Pelechano V

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